Icelandic plus English: language differentiation and functional categories in a successively bilingual child

This thesis investigates the formal and functional properties of the linguistic knowledge of a young bilingual child 'Katla' who successively acquires Icelandic (L1, from birth) and English (L2, from age 1:3). I present new longitudinal natural speech data which I collected in both Icelandic and English from Katla at regular intervals. Audio-recordings were made roughly three times per month at age 1 ;0-4;7 and transcribed in adapted CHILDES/CHAT format. Using a generative framework, I analyse Katla's data qualitatively and quantitatively, focusing on her morphology and syntax during the period 1;6-3;6: determiners and word order in nominals, copula constructions, progressive constructions, imperatives, negation, verb placement, verb inflections, auxiliaries, and periphrastic do. Katla's development is compared with monolingual English-speaking and Icelandic-speaking children, and, where applicable, with other bilinguals. Particular attention is paid to early grammar differentiation and cross- language influence, and to the relationship between child language and input (construction types and frequencies). The empirical results are evaluated in the light of current theories of language acquisition and generative approaches to syntax. Katla's first multi-word combinations (1;6) show productive use of functional morphology (determiners, copulas). Early on, there is evidence of movement into the DP, IP and CP domains, indicating continuity of these functional categories. Moreover, translational equivalents, language-specific functional morphemes and language-specific word orders in Katla's Icelandic and English bear evidence of early language differentiation in successive child bilingualism. The longitudinal development of morpho-syntax largely progresses along separate lines for Katla's two languages; there is no cross- language influence as regards head parameter and movement parameter settings. Some construction transfer occurs where L1 and L2 linear orders are similar. Ensuing implications for transfer and (de)learnability are addressed

How to start a V2 declarative clause: Transfer of syntax vs. information structure in L2 German

This paper discusses V2 word order and information structure in Swedish, German and non-native German. Concentrating on the clause-initial position of V2 declaratives, the ‘prefield’, we investigate the extent of L1 transfer in a closely related L2. The prefield anchors the clause in discourse, and although almost any type of element can occur in this position, naturalistic text corpora of native Swedish and native German show distinct language-specific patterns. Certain types of elements are more common than others in clause-initial position, and their frequencies in Swedish differ substantially from German (subjects, fronted objects, certain adverbs). Nonnative cross-sectional production data from Swedish learners of German at beginner, intermediate and advanced levels are compared with native control data, matched for age and genre (Bohnacker 2005, 2006, Rosén 2006). The learners’ V2 syntax is largely targetlike, but their beginnings of sentences are unidiomatic. They have problems with the language-specific linguistic means that have an impact on information structure: They overapply the Swedish principle of “rheme later” in their L2 German, indicating L1 transfer at the interface of syntax and discourse pragmatics, especially for structures that are frequent in the L1 (subject-initial and expletive-initial clauses, and constructions with så (‘so’) and object det (‘it/that’))

Character introductions in oral narratives of Swedish-German bilingual preschoolers

Closely related Swedish and German both mark information status of referents morphologically, though little is known about its acquisition. This study investigates character introductions in the narratives of 4- and 6-year-old Swedish–German bilinguals (N = 40) in both languages, elicited with MAIN Cat/Dog. We analyse effects of age group, language and animacy (human vs nonhuman characters) on the type of referring expression (indefinite NP and pronoun), as well as effects of language proficiency and exposure on the use of indefinite NPs for each language. We also explore which syntactic constructions indefinite NPs occur in. A significant difference was found between the two age groups, but not between languages. No effect was found of language skills or exposure. Four-year-olds used more pronouns and a lower proportion of indefinite NPs than 6-year-olds. Pronouns were more frequent for the human character than for nonhuman animate characters. Whilst animacy (humanness) promoted the use of pronouns, it did not affect the choice of morphological form for lexical NPs (indefinite/definite). The age groups differed in how indefinite NPs were used. Four-year-olds produced fewer narrative presentations (where a character is introduced as part of a typical story opening, e.g. Once upon a time there was a cat) than 6-year-olds, and more labellings (with only an NP, or a clausal predicative, e.g. That’s a cat). Qualitative analyses suggest that the children’s indefinite NPs in labelling constructions can be both referential (when setting the narrative scene), and type-denoting (when naming referents in individual pictures). Whilst the children’s abilities to introduce story characters develop measurably from 4 to 6 years in Swedish and German, appropriateness of character introductions not only depends on whether an indefinite NP is chosen, but also on the syntactic construction this indefinite NP is used in.Peer Reviewe

Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

13 p.-7 fig. Bohnacker, Thomas et al.BKM120 (Buparlisib) is one of the most advanced phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of cancer, but it interferes as an off-target effect with microtubule polymerization. Here, we developed two chemical derivatives that differ from BKM120 by only one atom.We show that these minute changes separate the dual activity of BKM120 into discrete PI3K and tubulin inhibitors. Analysis of the compounds cellular growth arrest phenotypes and microtubule dynamics suggest that the antiproliferative activity of BKM120 is mainly due to microtubule-dependent cytotoxicity rather than through inhibition of PI3K.Crystal structures of BKM120 and derivatives in complex with tubulin and PI3K provide insights into the selective mode of action of this class of drugs. Our results raise concerns over BKM120’s generally accepted mode of action, and provide a unique mechanistic basis for next-generation PI3K inhibitors with improved safety profiles and flexibility for use in combination therapies.This work was supported by the Swiss Commission for Technology and Innovation (CTI) by PFLS-LS grants 14032.1,15811.2 and 17241.1; the Stiftung für Krebsbekämpfung grant 341, Swiss National Science Foundation grants 310030_153211 and 316030_133860 (to M.P.W.), and 310030B_138659 and 31003A_166608 (to M.O.S.); in part by European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement 675392, and grants BIO2013-42984-R (Ministerio de Economia y Competitividad), S2010/BMD-2457 BIPEDD2 (Comunidad Autónoma de Madrid) to J.F.D.; and by the MRC to R.L.W. (U105184308Peer reviewe

Turkish- and German-speaking bilingual 4-to-6-year-olds living in Sweden: Effects of age, SES and home language input on vocabulary production

This paper investigates vocabulary production in the minority home languages of 40 Turkish-Swedish and 38 German-Swedish bilingual preschoolers aged 4;0–6;11, growing up in Sweden. We explore how age, SES, and exposure via mother-tongue instruction and home language use in the family affect child vocabulary skills. This has not previously been investigated in Sweden. Cross-linguistic Lexical Tasks (CLTs; Haman, Łuniewska & Pomiechowska, 2015) were used to test noun and verb production in Turkish and German. Background information was collected using a parental questionnaire. The two bilingual groups performed equally well in their respective home languages, Turkish and German. There were no effects of age, socio-economic status (SES) or mother-tongue instruction on vocabulary. However, input in the home setting had a clear effect. Children whose parents used the home language to the child and to each other had significantly higher vocabulary production scores. Having additional home-language input providers such as friends also affected the scores. These results from a Swedish context echo findings from studies of other language combinations and reveal the importance of input for the development of expressive vocabulary

ESID: A Visual Analytics Tool to Epidemiological Emergencies

Visual analysis tools can help illustrate the spread of infectious diseases and enable informed decisions on epidemiology and public health issues. To create visualisation tools that are intuitive, easy to use, and effective in communicating information, continued research and development focusing on user-centric and methodological design models is extremely important. As a contribution to this topic, this paper presents the design and development of the visual analytics application ESID (Epidemiological Scenarios for Infectious Diseases). The goal of ESID is to provide a platform for rapid assessment of the most effective interventions for infectious disease control. ESID provides spatial-temporal analysis, forecasting, comparison of simulations, interactive filters, and accessibility options. In its current form, it shows the simulations of a hybrid graph-equation-based model as introduced in for infection control. The model can be stratified for different age groups and takes into account the properties of the infectious disease as well as human mobility and contact behaviour.Comment: 6 pages, 5 images and 1 table, Eurovis workshop on visual analytics (EuroVA) 202

New molecular and therapeutic insights into canine diffuse large B cell lymphoma elucidates the role of the dog as a model for human disease

open21siopenAresu, Luca; Ferraresso, Serena; Marconato, Laura; Cascione, Luciano; Napoli, Sara; Gaudio, Eugenio; Kwee, Ivo; Tarantelli, Chiara; Testa, Andrea; Maniaci, Chiara; Ciulli, Alessio; Hillmann, Petra; Bohnacker, Thomas; Wymann, Matthias P; Comazzi, Stefano; Milan, Massimo; Riondato, Fulvio; Dalla Rovere, Giulia; Giantin, Mery; Giannuzzi, Diana; Bertoni, FrancescoAresu, Luca; Ferraresso, Serena; Marconato, Laura; Cascione, Luciano; Napoli, Sara; Gaudio, Eugenio; Kwee, Ivo; Tarantelli, Chiara; Testa, Andrea; Maniaci, Chiara; Ciulli, Alessio; Hillmann, Petra; Bohnacker, Thomas; Wymann, Matthias P; Comazzi, Stefano; Milan, Massimo; Riondato, Fulvio; Dalla Rovere, Giulia; Giantin, Mery; Giannuzzi, Diana; Bertoni, Francesc

Localizing the lipid products of PI3Kγ in neutrophils

Class I phosphoinositide 3-kinases (PI3Ks) are important regulators of neutrophil migration in response to a range of chemoattractants. Their primary lipid products PtdIns(3,4,5)P3 and PtdIns(3,4)P2 preferentially accumulate near to the leading edge of migrating cells and are thought to act as an important cue organizing molecular and morphological polarization. We have investigated the distribution and accumulation of these lipids independently in mouse neutrophils using eGFP-PH reporters and electron microscopy (EM). We found that authentic mouse neutrophils rapidly polarized their Class I PI3K signalling, as read-out by eGFP-PH reporters, both at the up-gradient leading edge in response to local stimulation with fMLP as well as spontaneously and randomly in response to uniform stimulation. EM studies revealed these events occurred at the plasma membrane, were dominated by accumulation of PtdIns(3,4,5)P3, but not PtdIns(3,4)P2, and were dependent on PI3Kγ and its upstream activation by both Ras and Gβγs.Publisher PDFPeer reviewe