621 research outputs found
Aspekte der Sauerstoffversorgung bei Verwesungsprozessen im Unterboden
Mittels eines Sauerstoff zehrenden Prozesses wurde in Säulenversuchen der Einfluss des Bodens auf Verwesungsprozesse im Unterboden untersucht. Aus den gewonnenen Daten wurden Modelle zur Prognose der Verwesungszeiten und der Sauerstoffkonzentrationen im Tiefenprofil von Böden erstellt
Applicability of general grief theory to Swedish women's experience after early miscarriage, with factor analysis of Bonanno's taxonomy, using the Perinatal Grief Scale
A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae
Streptococcus pneumoniae (S. pneumoniae) infections are the leading cause of child mortality globally. Current vaccines fail to induce a protective immune response towards a conserved part of the pathogen, resulting in new serotypes causing disease. Therefore, new vaccine strategies are urgently needed. Described is a two-pronged approach combining S. pneumoniae proteins, pneumolysin (Ply) and pneumococcal surface protein A (PspA), with a precisely defined synthetic oligosaccharide, whereby the carrier protein acts as a serotype-independent antigen to provide additional protection. Proof of concept in mice and swine models revealed that the conjugates inhibited colonization of the nasopharynx, decreased the bacterial load and reduced disease severity in the bacteria challenge model. Immunization of piglets provided the first evidence for the immunogenicity and protective potential of synthetic glycoconjugate vaccine in a large animal model. A combination of synthetic oligosaccharides with proteins from the target pathogen opens the path to create broadly cross-protective (“universal”) pneumococcal vaccines
High-E_T dijet photoproduction at HERA
The cross section for high-E_T dijet production in photoproduction has been
measured with the ZEUS detector at HERA using an integrated luminosity of 81.8
pb-1. The events were required to have a virtuality of the incoming photon,
Q^2, of less than 1 GeV^2 and a photon-proton centre-of-mass energy in the
range 142 < W < 293 GeV. Events were selected if at least two jets satisfied
the transverse-energy requirements of E_T(jet1) > 20 GeV and E_T(jet2) > 15 GeV
and pseudorapidity requirements of -1 < eta(jet1,2) < 3, with at least one of
the jets satisfying -1 < eta(jet) < 2.5. The measurements show sensitivity to
the parton distributions in the photon and proton and effects beyond
next-to-leading order in QCD. Hence these data can be used to constrain further
the parton densities in the proton and photon.Comment: 36 pages, 13 figures, 20 tables, including minor revisions from
referees. Accepted by Phys. Rev.
Reconstruction of ancient microbial genomes from the human gut
Loss of gut microbial diversity1–6 in industrial populations is associated with chronic diseases7, underscoring the importance of studying our ancestral gut microbiome. However, relatively little is known about the composition of pre-industrial gut microbiomes. Here we performed a large-scale de novo assembly of microbial genomes from palaeofaeces. From eight authenticated human palaeofaeces samples (1,000–2,000 years old) with well-preserved DNA from southwestern USA and Mexico, we reconstructed 498 medium- and high-quality microbial genomes. Among the 181 genomes with the strongest evidence of being ancient and of human gut origin, 39% represent previously undescribed species-level genome bins. Tip dating suggests an approximate diversification timeline for the key human symbiont Methanobrevibacter smithii. In comparison to 789 present-day human gut microbiome samples from eight countries, the palaeofaeces samples are more similar to non-industrialized than industrialized human gut microbiomes. Functional profiling of the palaeofaeces samples reveals a markedly lower abundance of antibiotic-resistance and mucin-degrading genes, as well as enrichment of mobile genetic elements relative to industrial gut microbiomes. This study facilitates the discovery and characterization of previously undescribed gut microorganisms from ancient microbiomes and the investigation of the evolutionary history of the human gut microbiota through genome reconstruction from palaeofaeces.Ethics Overview of samples Reference-based taxonomic composition De novo genome reconstruction Methanobrevibacter smithii tip dating Functional genomic analysis Discussion Online content Method
Measurement of (anti)deuteron and (anti)proton production in DIS at HERA
The first observation of (anti)deuterons in deep inelastic scattering at HERA
has been made with the ZEUS detector at a centre-of-mass energy of 300--318 GeV
using an integrated luminosity of 120 pb-1. The measurement was performed in
the central rapidity region for transverse momentum per unit of mass in the
range 0.3<p_T/M<0.7. The particle rates have been extracted and interpreted in
terms of the coalescence model. The (anti)deuteron production yield is smaller
than the (anti)proton yield by approximately three orders of magnitude,
consistent with the world measurements.Comment: 26 pages, 9 figures, 5 tables, submitted to Nucl. Phys.
Search for First-generation Leptoquarks at HERA
A search for first-generation leptoquarks was performed in electron-proton and positron-proton collisions recorded with the ZEUS detector at HERA in 2003-2007 using an integrated luminosity of 366pb-1. Final states with an electron and jets or with missing transverse momentum and jets were analyzed, searching for resonances or other deviations from the standard model predictions. No evidence for any leptoquark signal was found. The data were combined with data previously taken at HERA, resulting in a total integrated luminosity of 498pb-1. Limits on the Yukawa coupling, λ, of leptoquarks were set as a function of the leptoquark mass for different leptoquark types within the Buchmüller-Rückl-Wyler model. Leptoquarks with a coupling λ=0.3 are excluded for masses up to 699 GeV. © 2012 American Physical Society
Measurement of Inelastic J/ψ and ψ′ Photoproduction at HERA
The cross sections for inelastic photoproduction of J/ψ and ψ′ mesons have been measured in ep collisions with the ZEUS detector at HERA, using an integrated luminosity of 468 pb-1 collected in the period 1996-2007. The ψ′ to J/ψ cross section ratio was measured in the range 0.55 \u3c z \u3c 0.9 and 60 \u3c W \u3c 190 GeV as a function of W, z and pT. Here W denotes the photon-proton centre-of-mass energy, z is the fraction of the incident photon energy carried by the meson and p T is the transverse momentum of the meson with respect to the beam axis. The J/ψ cross sections were measured for 0.1 \u3c z \u3c 0.9, 60 \u3c W \u3c 240 GeV and pT \u3e 1 GeV. Theoretical predictions within the non-relativistic QCD framework including NLO colour-singlet and colour-octet contributions were compared to the data, as were predictions based on the k T-factorisation approach. © 2013 SISSA
Measurement of Heavy-quark Jet Photoproduction at HERA
The Author(s) 2011. Photoproduction of beauty and charm quarks in events with at least two jets has been measured with the ZEUS detector at HERA using an integrated luminosity of 133 pb−1. The fractions of jets containing b and c quarks were extracted using the invariant mass of charged tracks associated with secondary vertices and the decay-length significance of these vertices. Differential cross sections as a function of jet transverse momentum, pjetT, and pseudora pidity, ηjet, were measured. The data are compared with previous measurements and are well described by next-toleading- order QCD predictions
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