Constraints on Interpretation

Proceedings of the Sixteenth Annual Meeting of the Berkeley Linguistics Society (1990), pp. 363-37

Why communication isn\u27t a joke : relevance and content

英国サルフォード大学教授ダイアン・ブレイクモアを1998年10月13日, 本校に迎えて上記のタイトルで講演会をもった。本稿はSperber&Wilson (1986,1996)の提唱した, 関連性理論(Relevance Theory)の名で知られるコミュニケーション理論のよって立つ基盤と, 基本的概念を紹介するものである。言葉がコミュニケーションの道具として最たるものであるから, 言葉の実際の使用を扱う語用論の理論である。相手に伝達しようとする意図を持った話し手が, そのとき, その場で発する文(発話)の解釈が何故そのようになされるのか, あるいは時として失敗するのか, これは心理的事象と見なされ, 単一の認知的原理に支配されているとRTは訴える。聞き手の復元する発話解釈について, RTは二つのタイプを区別する。一つは統語論の出力としての理論形式を下敷きにして, これに肉付けをしていくことによって得られるもので, 発意(explicature)と呼ばれる。たとえば, She blew up the mattress. においては, (a)sheが誰を指すのか(指示付与), (b) blew upはinflated with airの意味なのかuse explosive to destroyの意味なのか(一義化), (c)どの, 何のために使うマットレスなのか(指示付与と富化)を復元しなければならない。言語形式の持つ意味を越えての肉付けは, さらに(d)どういう発話行為をしているのか, (e)命題に対する話し手の態度といったものの復元も含む

A discourse-based approach for Arabic question answering

The treatment of complex questions with explanatory answers involves searching for arguments in texts. Because of the prominent role that discourse relations play in reflecting text-producers’ intentions, capturing the underlying structure of text constitutes a good instructor in this issue. From our extensive review, a system for automatic discourse analysis that creates full rhetorical structures in large scale Arabic texts is currently unavailable. This is due to the high computational complexity involved in processing a large number of hypothesized relations associated with large texts. Therefore, more practical approaches should be investigated. This paper presents a new Arabic Text Parser oriented for question answering systems dealing with لماذا “why” and كيف “how to” questions. The Text Parser presented here considers the sentence as the basic unit of text and incorporates a set of heuristics to avoid computational explosion. With this approach, the developed question answering system reached a significant improvement over the baseline with a Recall of 68% and MRR of 0.62

Neural mechanisms of social influence in adolescence

During the transformative period of adolescence, social influence plays a prominent role in shaping young people’s emerging social identities, and can impact their propensity to engage in prosocial or risky behaviors. In this study, we examine the neural correlates of social influence from both parents and peers, two important sources of influence. Nineteen adolescents (age 16–18 years) completed a social influence task during a functional magnetic resonance imaging (fMRI) scan. Social influence from both sources evoked activity in brain regions implicated in mentalizing (medial prefrontal cortex, left temporoparietal junction, right temporoparietal junction), reward (ventromedial prefrontal cortex), and self-control (right ventrolateral prefrontal cortex). These results suggest that mental state reasoning, social reward and self-control processes may help adolescents to evaluate others’ perspectives and overcome the prepotent force of their own antecedent attitudes to shift their attitudes toward those of others. Findings suggest common neural networks involved in social influence from both parents and peers

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Understanding Utterances

191 hlm, 24 c

Discourse and Relevance Theory

(no abstract available