Can sexual selection drive female life histories? A comparative study on Galliform birds

Sexual selection is an important driver of many of the most spectacular morphological traits that we find in the animal kingdom (for example see Andersson, 1994). As such, sexual selection is most often emphasized as

Rules versus Discretion in Committee Decision Making: An Application to the 2001 RAE for UK Economics Departments

The question of rules versus discretion has generated a great deal of debate in many areas of the social sciences. Recently, much of the discussion among academics and stakeholders about the assessment of research in UK higher education institutions has focused on the means that should be used to determine research quality. We present a model of committee decision-making when both rules and discretion are available. Some of the predictions of the model are tested empirically using the UK RAE 2001 results

AD51B in Familial Breast Cancer

Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study was to investigate the role of RAD51B variants in breast cancer predisposition, particularly in the context of familial breast cancer in Finland. We sequenced the coding region of RAD51B in 168 Finnish breast cancer patients from the Helsinki region for identification of possible recurrent founder mutations. In addition, we studied the known rs999737, rs2588809, and rs1314913 SNPs and RAD51B haplotypes in 44,791 breast cancer cases and 43,583 controls from 40 studies participating in the Breast Cancer Association Consortium (BCAC) that were genotyped on a custom chip (iCOGS). We identified one putatively pathogenic missense mutation c.541C>T among the Finnish cancer patients and subsequently genotyped the mutation in additional breast cancer cases (n = 5259) and population controls (n = 3586) from Finland and Belarus. No significant association with breast cancer risk was seen in the meta-analysis of the Finnish datasets or in the large BCAC dataset. The association with previously identified risk variants rs999737, rs2588809, and rs1314913 was replicated among all breast cancer cases and also among familial cases in the BCAC dataset. The most significant association was observed for the haplotype carrying the risk-alleles of all the three SNPs both among all cases (odds ratio (OR): 1.15, 95% confidence interval (CI): 1.11–1.19, P = 8.88 x 10−16) and among familial cases (OR: 1.24, 95% CI: 1.16–1.32, P = 6.19 x 10−11), compared to the haplotype with the respective protective alleles. Our results suggest that loss-of-function mutations in RAD51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk

Bosschere. Object-relative addressing: Compressed pointers in 64-bit java virtual machines

Abstract. 64-bit address spaces come at the price of pointers requiring twice as much memory as 32-bit address spaces, resulting in increased memory usage. This paper reduces the memory usage of 64-bit pointers in the context of Java virtual machines through pointer compression, called Object-Relative Addressing (ORA). The idea is to compress 64-bit raw pointers into 32-bit offsets relative to the referencing object’s virtual address. Unlike previous work on the subject using a constant base address for compressed pointers, ORA allows for applying pointer compression to Java programs that allocate more than 4GB of memory. Our experimental results using Jikes RVM and the SPECjbb and DaCapo benchmarks on an IBM POWER4 machine show that the overhead introduced by ORA is statistically insignificant on average compared to raw 64-bit pointer representation, while reducing the total memory usage by 10 % on average and up to 14.5 % for some applications.