Modeling the gas-phase chemistry of the transitional disk around HD 141569A

Aims: The chemistry, distribution and mass of the gas in the transitional disk around the 5 Myr old B9.5 V star HD 141569A are constrained. Methods: A quasi 2-dimensional (2D) chemistry code for photon dominated regions (PDR) is used to calculate the chemistry and gas temperatures in the disk. The calculations are performed for several gas distributions, PAH abundances and values of the total gas mass. The resulting CO J=2-1 and J=3-2 emission lines are computed with a 2D radiative transfer code and are compared to observations. Results: The CO abundance is very sensitive to the total disk mass because the disk is in a regime where self-shielding just sets in. The observed CO emission lines are best fit by a power-law gas distribution of 80 M_earth starting at 80 AU from the central star, indicating that there is some gas in the inner hole. Predictions are made for intensities of atomic fine-structure lines. [C I], which is the dominant form of carbon in large parts of the disk, is found to be a good alternative tracer of the gas mass.Comment: 11 pages, 9 figures. Accepted for publication in A&

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes

Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly those in humans, can be quite stable, usually because one centromere is functionally silenced. Molecular mechanisms of centromere inactivation are poorly understood since there are few systems to experimentally create dicentric human chromosomes. Here, we describe a human cell culture model that enriches for de novo dicentrics. We demonstrate that transient disruption of human telomere structure non-randomly produces dicentric fusions involving acrocentric chromosomes. The induced dicentrics vary in structure near fusion breakpoints and like naturally-occurring dicentrics, exhibit various inter-centromeric distances. Many functional dicentrics persist for months after formation. Even those with distantly spaced centromeres remain functionally dicentric for 20 cell generations. Other dicentrics within the population reflect centromere inactivation. In some cases, centromere inactivation occurs by an apparently epigenetic mechanism. In other dicentrics, the size of the alpha-satellite DNA array associated with CENP-A is reduced compared to the same array before dicentric formation. Extrachromosomal fragments that contained CENP-A often appear in the same cells as dicentrics. Some of these fragments are derived from the same alpha-satellite DNA array as inactivated centromeres. Our results indicate that dicentric human chromosomes undergo alternative fates after formation. Many retain two active centromeres and are stable through multiple cell divisions. Others undergo centromere inactivation. This event occurs within a broad temporal window and can involve deletion of chromatin that marks the locus as a site for CENP-A maintenance/replenishment.This work was supported by the Tumorzentrum Heidelberg/Mannheim grant (D.10026941)and by March of Dimes Research Foundation grant #1-FY06-377 and NIH R01 GM069514

U-Pb zircon and monazite geochronology of Variscan magmatism related to syn-convergence extension in Central Northern Portugal

The Viseu area is located in the Central Iberian Zone of the Iberian Variscan Belt and hosts numerous post-thickening, collision-related granitoids intruded into upper and middle crustal levels. The present paper reports high precision U-Pb zircon and monazite ages for four plutons of the Viseu area: The syn-kinematic granitoids of Maceira (314±5 Ma), Casal Vasco (311±1 Ma) and Junqueira (307.8±0.7 Ma) and the late-kinematic biotite monzogranites of Cota (306±9 Ma). This points to a synchronous emplacement of the different syn-kinematic plutons shortly followed by the intrusion of the late-kinematic granites and shows that the Upper Carboniferous plutonism occurred within a short time span of ca. 10 million years. The ascent of granite magmas took place after an extensional tectonic event (D2) and is coeval with dextral and sinistral crustal-scale transcurrent shearing (D3). Field and petrographical evidence suggest a narrow time-span between peak T metamorphic conditions and the intrusion of granitic melts which implies very fast uplift rates accommodated through active tectonic exhumation. Magma compositions evolve through time, reflecting an increasing involvement of mid-crustal sources and the underplating effect of an upwelling asthenospheric mantle at the base of a thinning and stretching continental crust. © 2005 Elsevier B.V. All rights reserved

Palaeotectonic setting of the south-eastern Kédougou-Kéniéba Inlier, West Africa: new insights from igneous trace element geochemistry and U-Pb zircon ages

New U-Pb zircon ages and geochemistry from the eastern Kédougou-Kéniéba Inlier are presented and integrated with published data to generate a revised tectonic framework for the westernmost Birimian terranes. The Falémé Volcanic Belt and Kofi Series are highly prospective, hosting several multi-million ounce gold deposits and a significant iron ore resource, but remain under-researched. It is therefore important to constrain the fundamental geological setting. The igneous rocks of the eastern Kédougou-Kéniéba Inlier are dominantly of high-K calc-alkaline affinity, with fractionated REE patterns and negative Nb-Ta anomalies. The plutonic rocks in the Falémé Belt are dioritic to granodioritic in composition, with moderately fractionated REE patterns and metaluminous A/CNK signatures. Felsic, peraluminous granite stocks, dykes and plutons with fractionated REE patterns and negative Eu, Ti and P anomalies intruded both the Falémé Belt and Kofi Series. Albitisation masks the affinity of some units, although use of the Th-Co diagram shows that prior to albitisation, all igneous units belonged to the high-K calc-alkaline series. New U-Pb age data for the Boboti and Balangouma plutons indicate crystallisation at 2088.5 ± 8.5 Ma and at 2112 ± 13 Ma, respectively. Inherited zircons in the Boboti pluton indicate magmatic activity in the Falémé Belt at 2218 ± 83 Ma coincided with the oldest dated units in the Mako Belt to the West. Systematic changes in Dy/Yb, Sm/La, Nb/Zr, Rb concentration, Eu-anomaly and ɛNdt over ∼200 Ma reveal that the tectonic setting in the KKI evolved from a volcanic island arc environment to an active continental margin. Crustal thickening, as a result of a shift to collisional tectonic setting, combined with magmatic differentiation, led to the generation of peraluminous, granitic melts with a significant crustal component. A small suite of more basic intrusive and extrusive rocks on the eastern margin of the Dialé-Daléma basin are highly metaluminous and display limited LILE enrichment, with normalised HREE values close to unity. The Daléma igneous rocks may have formed in an extensional back arc, related to the arc system

Near-IR spectroscopy of planetary nebulae precursors

We present near-IR spectroscopy of a sample of 30 IRAS sources recently identified as late AGB stars, post-AGB stars or early PNe. The spectra obtained are centered at various wavelengths covering the molecular hydrogen v=1-0 S(1) and v=2-1 S(1) emission lines, the recombination lines of hydrogen Br-gamma, Pf-gamma and Br-alpha, and the CO[v=2-0] first overtone bandhead at 2.294 microns. As a result of these observations we have increased from 4 to 13 the total number of proto-PNe detected in molecular hydrogen. When the molecular hydrogen is fluorescence-excited the detection rate is found to be directly correlated with the evolutionary stage of the central star, rather than with the nebular morphology. In contrast, shocked-excited molecular hydrogen is detected only in strongly bipolar proto-PNe, sometimes even at an early stage in the post-AGB phase. The strong correlation of shocked-excited molecular hydrogen emission with bipolarity found confirms the result previously reported by Kastner et al. (1996) in evolved PNe. However, our results show that this correlation does not exist in the case of fluorescence-excited molecular hydrogen.Comment: Accepted for publication in A&

Food Use and Health Effects of Soybean and Sunflower Oils

This review provides a scientific assessment of current knowledge of health effects of soybean oil (SBO) and sunflower oil (SFO). SBO and SFO both contain high levels of polyunsaturated fatty acids (PUFA) (60.8 and 69%, respectively), with a PUFA:saturated fat ratio of 4.0 for SBO and 6.4 for SFO. SFO contains 69% C18:2n-6 and less than 0.1% C18:3n-3, while SBO contains 54% C18:2n-6 and 7.2% C18:3n-3. Thus, SFO and SBO each provide adequate amounts of C18:2n-6, but of the two, SBO provides C18:3n-3 with a C18:2n-6:C18:3n-3 ratio of 7.1. Epidemiological evidence has suggested an inverse relationship between the consumption of diets high in vegetable fat and blood pressure, although clinical findings have been inconclusive. Recent dietary guidelines suggest the desirability of decreasing consumption of total and saturated fat and cholesterol, an objective that can be achieved by substituting such oils as SFO and SBO for animal fats. Such changes have consistently resulted in decreased total and low-density-lipoprotein cholesterol, which is thought to be favorable with respect to decreasing risk of cardiovascular disease. Also, decreases in high-density-lipoprotein cholesterol have raised some concern. Use of vegetable oils such as SFO and SBO increases C18:2n-6, decreases C20:4n-6, and slightly elevated C20:5n-3 and C22:6n-3 in platelets, changes that slightly inhibit platelet generation of thromboxane and ex vivo aggregation. Whether chronic use of these oils will effectively block thrombosis at sites of vascular injury, inhibit pathologic platelet vascular interactions associated with atherosclerosis, or reduce the incidence of acute vascular occlusion in the coronary or cerebral circulation is uncertain. Linoleic acid is needed for normal immune response, and essential fatty acid (EFA) deficiency impairs B and T cell-mediated responses. SBO and SFO can provide adequate linoleic acid for maintenance of the immune response. Excess linoleic acid has supported tumor growth in animals, an effect not verified by data from diverse human studies of risk, incidence, or progression of cancers of the breast and colon. Areas yet to be investigated include the differential effects of n-6- and n-3-containing oil on tumor development in humans and whether shorter-chain n-3 PUFA of plant origin such as found in SBO will modulate these actions of linoleic acid, as has been shown for the longer-chain n-3 PUFA of marine oil

ICAR: endoscopic skull‐base surgery

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