Il sonetto di Veronica Gambara sulla predestinazione in Du Bellay

Proseguendo nella direzione che qui ha indicato Jean Balsamo, e volendo applicare il suo insegnamento circa la circolazione e la ricezione in Francia delle antologie di rime italiane come libri a scopo utilitario, come « des livres de poètes et d’écrivains »,possiamo tentare l’analisi di una riscrittura francese di un componimento presente in un’antologia. I volumi di Giolito, che inaugurano, o meglio inventano il genere delle antologie,sono il nostro naturale punto di partenza, insieme alla ..

Integrating gender medicine into the workplace health and safety policy in the scientific research institutions: a mandatory task

Background. Gender medicine is a multi-faceted field of investigation integrating various aspects of psycho-social and biological sciences but it mainly deals with the impact of the gender on human physiology, pathophysiology, and clinical features of diseases. In Italy, the Decree Law 81/2008 recently introduced the gender issue in the risk assessment at the workplaces. aims. This review briefly describes our current knowledge on gender medicine and on the Italian legislation in risk management. Conclusions. Public or private scientific institutions should be the first to pay attention to the safety of their workers, who are simultaneously subjected to biological, chemical and physical agents. Main tasks of risk manage - ment in scientific research institutions are here analyzed and discussed in a gender perspective

Antibacterial Fusion Proteins Enhance Moraxella catarrhalis Killing

Moraxella catarrhalis is a human-specific commensal of the respiratory tract and an opportunistic pathogen. It is one of the leading cause of otitis media in children and of acute exacerbations in patients with chronic obstructive pulmonary disease, resulting in significant morbidity and economic burden. Vaccines and new immunotherapeutic strategies to treat this emerging pathogen are needed. Complement is a key component of innate immunity that mediates the detection, response, and subsequent elimination of invading pathogens. Many pathogens including M. catarrhalis have evolved complement evasion mechanisms, which include the binding of human complement inhibitors such as C4b-binding protein (C4BP) and Factor H (FH). Inhibiting C4BP and FH acquisition by M. catarrhalis may provide a novel therapeutic avenue to treat infections. To achieve this, we created two chimeric proteins that combined the Moraxella-binding domains of C4BP and FH fused to human immunoglobulin Fcs: C4BP domains 1 and 2 and FH domains 6 and 7 fused to IgM and IgG Fc, respectively. As expected, FH6-7/IgG displaced FH from the bacterial surface while simultaneously activating complement via Fc-C1q interactions, together increasing pathogen elimination. C4BP1-2/IgM also increased serum killing of the bacteria through enhanced complement deposition, but did not displace C4BP from the surface of M. catarrhalis. These Fc fusion proteins could act as anti-infective immunotherapies. Many microbes bind the complement inhibitors C4BP and FH through the same domains as M. catarrhalis, therefore these Fc fusion proteins may be promising candidates as adjunctive therapy against many different drug-resistant pathogens

GASP XXIII: a jellyfish galaxy as an astrophysical laboratory of the baryonic cycle

© 2019. The American Astronomical Society. All rights reserved. With MUSE, Chandra, VLA, ALMA, and UVIT data from the GASP program, we study the multiphase baryonic components in a jellyfish galaxy (JW100) with a stellar mass 3.2 × 1011 M o hosting an active galactic nucleus (AGN). We present its spectacular extraplanar tails of ionized and molecular gas, UV stellar light, and X-ray and radio continuum emission. This galaxy represents an excellent laboratory to study the interplay between different gas phases and star formation and the influence of gas stripping, gas heating, and AGNs. We analyze the physical origin of the emission at different wavelengths in the tail, in particular in situ star formation (related to Hα, CO, and UV emission), synchrotron emission from relativistic electrons (producing the radio continuum), and heating of the stripped interstellar medium (ISM; responsible for the X-ray emission). We show the similarities and differences of the spatial distributions of ionized gas, molecular gas, and UV light and argue that the mismatch on small scales (1 kpc) is due to different stages of the star formation process. We present the relation Hα-X-ray surface brightness, which is steeper for star-forming regions than for diffuse ionized gas regions with a high [O i]/Hα ratio. We propose that ISM heating due to interaction with the intracluster medium (either for mixing, thermal conduction, or shocks) is responsible for the X-ray tail, observed [O i] excess, and lack of star formation in the northern part of the tail. We also report the tentative discovery in the tail of the most distant (and among the brightest) currently known ULX, a pointlike ultraluminous X-ray source commonly originating in a binary stellar system powered by either an intermediate-mass black hole or a magnetized neutron star

Impact Assessment ans Evaluation Tools

This handbook provides tools for evaluation / impact assessment of any project/initiative involving interactive innovation

C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation

Dysregulated NLRP3 inflammasome activation drives a wide variety of diseases, while endogenous inhibition of this pathway is poorly characterised. The serum protein C4b-binding protein (C4BP) is a well-established inhibitor of complement with emerging functions as an endogenously expressed inhibitor of the NLRP3 inflammasome signalling pathway. Here, we identified that C4BP purified from human plasma is an inhibitor of crystalline- (monosodium urate, MSU) and particulate-induced (silica) NLRP3 inflammasome activation. Using a C4BP mutant panel, we identified that C4BP bound these particles via specific protein domains located on the C4BP α-chain. Plasma-purified C4BP was internalised into MSU- or silica-stimulated human primary macrophages, and inhibited MSU- or silica-induced inflammasome complex assembly and IL-1β cytokine secretion. While internalised C4BP in MSU or silica-stimulated human macrophages was in close proximity to the inflammasome adaptor protein ASC, C4BP had no direct effect on ASC polymerisation in in vitro assays. C4BP was also protective against MSU- and silica-induced lysosomal membrane damage. We further provide evidence for an anti-inflammatory function for C4BP in vivo, as C4bp-/- mice showed an elevated pro-inflammatory state following intraperitoneal delivery of MSU. Therefore, internalised C4BP is an inhibitor of crystal- or particle-induced inflammasome responses in human primary macrophages, while murine C4BP protects against an enhanced inflammatory state in vivo. Our data suggests C4BP has important functions in retaining tissue homeostasis in both human and mice as an endogenous serum inhibitor of particulate-stimulated inflammasome activation

Toll-Like Receptor 4 Regulates Chronic Stress-Induced Visceral Pain in Mice

Background Functional gastrointestinal disorders, which have visceral hypersensitivity as a core symptom, are frequently comorbid with stress-related psychiatric disorders. Increasing evidence points to a key role for toll-like receptor 4 (TLR4) in chronic pain states of somatic origin. However, the central contribution of TLR4 in visceral pain sensation remains elusive. Methods With pharmacological and genetic approaches, we investigated the involvement of TLR4 in the modulation of visceral pain. The TLR4-deficient and wild-type mice were exposed to chronic stress. Visceral pain was evaluated with colorectal distension. Protein expression levels for TLR4, Cd11b, and glial fibrillary acidic protein (glial cells markers) were quantified in the lumbar region of the spinal cord, prefrontal cortex (PFC), and hippocampus. To evaluate the effect of blocking TLR4 on visceral nociception, TAK-242, a selective TLR4 antagonist, was administered peripherally (intravenous) and centrally (intracerebroventricular and intra-PFC) (n = 10–12/experimental group). Results The TLR4 deficiency reduced visceral pain and prevented the development of chronic psychosocial stress-induced visceral hypersensitivity. Increased expression of TLR4 coupled with enhanced glia activation in the PFC and increased levels of proinflammatory cytokines were observed after chronic stress in wild-type mice. Administration of a TLR4 specific antagonist, TAK-242, attenuated visceral pain sensation in animals with functional TLR4 when administrated centrally and peripherally. Moreover, intra-PFC TAK-242 administration also counteracted chronic stress-induced visceral hypersensitivity. Conclusions Our results reveal a novel role for TLR4 within the PFC in the modulation of visceral nociception and point to TLR4 as a potential therapeutic target for the development of drugs to treat visceral hypersensitivity.The work described herein was supported by the Alimentary Pharmabiotic Centre, funded by Science Foundation Ireland (SFI), through the Irish Government’s National Development Plan. The authors and their work were supported by SFI (Grant Numbers 02/CE/B124 and 07/CE/B1368 and SFI/12/RC/2273)

GASP XXIII: A jellyfish galaxy as an astrophysical laboratory of the baryonic cycle

With MUSE, Chandra, VLA, ALMA and UVIT data from the GASP programme we study the multiphase baryonic components in a jellyfish galaxy (JW100) with a stellar mass 3.2 X 10^{11} M_sun hosting an AGN. We present its spectacular extraplanar tails of ionized and molecular gas, UV stellar light, X-ray and radio continuum emission. This galaxy represents an excellent laboratory to study the interplay between different gas phases and star formation, and the influence of gas stripping, gas heating, and AGN. We analyze the physical origin of the emission at different wavelengths in the tail, in particular in-situ star formation (related to Halpha, CO and UV emission), synchrotron emission from relativistic electrons (producing the radio continuum) and heating of the stripped interstellar medium (ISM) (responsible for the X-ray emission). We show the similarities and differences of the spatial distributions of ionized gas, molecular gas and UV light, and argue that the mismatch on small scales (1kpc) is due to different stages of the star formation process. We present the relation Halpha--X-ray surface brightness, which is steeper for star-forming regions than for diffuse ionised gas regions with high [OI]/Halpha ratio. We propose that ISM heating due to interaction with the intracluster medium (either for mixing, thermal conduction or shocks) is responsible for the X-ray tail, the observed [OI]-excess and the lack of star formation in the northern part of the tail. We also report the tentative discovery in the tail of the most distant (and among the brightest) currently known ULX, a point-like ultraluminous X-ray source commonly originating in a binary stellar system powered either by an intermediate-mass black hole or a magnetized neutron star.Comment: accepted for publication in Ap

The wide-field, multiplexed, spectroscopic facility WEAVE : survey design, overview, and simulated implementation

Funding for the WEAVE facility has been provided by UKRI STFC, the University of Oxford, NOVA, NWO, Instituto de Astrofísica de Canarias (IAC), the Isaac Newton Group partners (STFC, NWO, and Spain, led by the IAC), INAF, CNRS-INSU, the Observatoire de Paris, Région Île-de-France, CONCYT through INAOE, Konkoly Observatory (CSFK), Max-Planck-Institut für Astronomie (MPIA Heidelberg), Lund University, the Leibniz Institute for Astrophysics Potsdam (AIP), the Swedish Research Council, the European Commission, and the University of Pennsylvania.WEAVE, the new wide-field, massively multiplexed spectroscopic survey facility for the William Herschel Telescope, will see first light in late 2022. WEAVE comprises a new 2-degree field-of-view prime-focus corrector system, a nearly 1000-multiplex fibre positioner, 20 individually deployable 'mini' integral field units (IFUs), and a single large IFU. These fibre systems feed a dual-beam spectrograph covering the wavelength range 366-959 nm at R ∼ 5000, or two shorter ranges at R ∼ 20,000. After summarising the design and implementation of WEAVE and its data systems, we present the organisation, science drivers and design of a five- to seven-year programme of eight individual surveys to: (i) study our Galaxy's origins by completing Gaia's phase-space information, providing metallicities to its limiting magnitude for ∼ 3 million stars and detailed abundances for ∼ 1.5 million brighter field and open-cluster stars; (ii) survey ∼ 0.4 million Galactic-plane OBA stars, young stellar objects and nearby gas to understand the evolution of young stars and their environments; (iii) perform an extensive spectral survey of white dwarfs; (iv) survey  ∼ 400 neutral-hydrogen-selected galaxies with the IFUs; (v) study properties and kinematics of stellar populations and ionised gas in z 1 million spectra of LOFAR-selected radio sources; (viii) trace structures using intergalactic/circumgalactic gas at z > 2. Finally, we describe the WEAVE Operational Rehearsals using the WEAVE Simulator.PostprintPeer reviewe