"Hilf mir es selbst zu tun"

Bezug nehmend auf diesen vielleicht bekanntesten Satz Maria Montessoris wird eine eigene, mathematikdidaktisch geprägte Typisierung von Lehrerinterventionen vorgeschlagen. Dabei werden einerseits qualitative Laborstudien aus dem aktuellen DFG-Forschungsprojekt DISUM 1, andererseits ausgewählte Literatur zum Thema "teacher interventions" berücksichtigt. Aus Platzgründen stellen wir unser Vorgehen nur exemplarisch dar. Eine ausführlichere Darstellung findet sich in Leiß & Wiegand 200

Long-Term Memory Motion-Compensated Prediction

Long-term memory motion-compensated prediction extends the spatial displacement vector utilized in block-based hybrid video coding by a variable time delay permitting the use of more frames than the previously decoded one for motion compensated prediction. The long-term memory covers several seconds of decoded frames at the encoder and decoder. The use of multiple frames for motion compensation in most cases provides significantly improved prediction gain. The variable time delay has to be transmitted as side information requiring an additional bit rate which may be prohibitive when the size of the long-term memory becomes too large. Therefore, we control the bit rate of the motion information by employing rate-constrained motion estimation. Simulation results are obtained by integrating long-term memory prediction into an H.263 codec. Reconstruction PSNR improvements up to 2 dB for the Foreman sequence and 1.5 dB for the Mother–Daughter sequence are demonstrated in comparison to the TMN-2.0 H.263 coder. The PSNR improvements correspond to bit-rate savings up to 34 and 30%, respectively. Mathematical inequalities are used to speed up motion estimation while achieving full prediction gain

Comparison of two methods of cardiopulmonary exercise testing for assessing physical fitness in children and adolescents with extreme obesity

It is well-known that children and adolescents with obesity have increased over recent decades which in turn carries greater risk of co-morbidities and poses a preventive as well as a therapeutic challenge. Currently, there are limited recommendations available on proven methods for recording physical fitness in children and adolescents presenting with extreme obesity. In this study, twenty participants, aged 12–17 years, with a body mass index (BMI) above the 99.5th percentile, were comparatively assessed, using a correlation between their physical fitness on a bicycle (BC) and treadmill (TM) cardiopulmonary exercise testing (CPET) with a lactate diagnostic. The results of the BC and the TM were as follows: maximum heart rate ( HRmax) 186.4 ± 8.6 beats per minute (bpm) vs. 190.8 ± 8.8 bpm, peak oxygen consumption ( VO2peak/kg) 23.5 ± 2.9 ml/min/ kg vs. 25.4 ± 3.1 ml/min/kg, and maximum lactate ( Lamax) 6.4 ± 1.6 mmol/l vs. 5.6 ± 1.4 mmol/l. The values of HRmax and VO2peak/ kg were significantly higher for adolescents tested on the TM. However, no significant difference was observed in either Lamax values or between the genders. Conclusions: The higher values of HRmax and VO2peak/ kg could be attributed to the activation of a higher percentage of muscle mass on the TM. Lower Lamax values on the TM suggest maximum physical exertion was not achieved. This could be due to the extreme body weight carried by the participants. Both the BC and the TM CPET could be used for assessing physical fitness in children and adolescents with extreme obesity but should not be used interchangeably.Peer Reviewe

Durch Athen auf Frankfurt blicken ‚Austerity Urbanism‘, Uneven Development und Alltäglichkeit – Reflektionen aus zwei Workshops

Aufbauend auf den Erfahrungen zweier Workshops zu (urbaner) Austerität in Griechenland und Deutschland diskutiert der Beitrag die (unterschiedliche) Geschichte und Geographie der Austerität mit besonderem Blick auf die Regionen Frankfurt/Rhein-Main und Athen. Die Erfahrungen der multiplen Krise seit 2008, die sich in Griechenland vor dem Hintergrund einer austeritätspolitischen ‚Shock Doctrine’ und in der BRD im Kontext eines langfristigen Projekts der ‚scheibchenweisen’ Austerität entwickelten, eröffnen dabei die Möglichkeit, die Debatten um urbane Austerität einem kritischen Blick zu unterziehen. Der Beitrag sieht insbesondere im Bereich der Krisen der (urbanen) sozialen Reproduktion sowie der Krisen der (städtischen) Politik und Repräsentation weiteren Forschungsbedarf

Standardized Diagnostic Workup and Patient-Centered Decision Making for Surgery and Neck Dissection Followed by Risk-Factor Adapted Adjuvant Therapy Improve Loco-Regional Control in Local Advanced Oral Squamous Cell Carcinoma

Background: Standardized staging procedures and presentation of oral squamous cell carcinoma (OSCC) patients in multidisciplinary tumor boards (MDTB) before treatment and utilization of elective neck dissection (ND) are expected to improve the outcome, especially in local advanced LAOSCC (UICC stages III–IVB). As standardized diagnostics but also increased heterogeneity in treatment applied so far have not been demonstrated to improve outcome in LAOSCC, a retrospective study was initiated. Methods: As MDTB was introduced into clinical routine in 2007, 316 LAOSCC patients treated during 1991-2017 in our hospital were stratified into cohort 1 treated before (n=104) and cohort 2 since 2007 (n=212). Clinical characteristics, diagnostic procedures and treatment modality of patients were compared using Chi-square tests and outcome analyzed applying Kaplan-Meier plots and log-rank tests as well as Cox proportional hazard regression. Propensity scores (PS) were used to elucidate predictors for impaired distant metastasis-free survival (DMFS) in PS-matched patients. Results: Most patient characteristics and treatment modalities applied showed insignificant alteration. Surgical treatment included significantly more often resection of the primary tumor plus neck dissection, tracheostomy and percutaneous endoscopic gastrostomy tube use. Cisplatin-based chemo-radiotherapy was the most frequent. Only insignificant improved disease- (DFS), progression- (PFS) and event-free (EFS) as well as tumor-specific (TSS) and overall survival (OS) were found after 2006 as local (LC) and locoregional control (LRC) were significantly improved but DMFS significantly impaired. Cox regression applied to PS-matched patients elucidated N3, belonging to cohort 2 and cisplatin-based chemo-radiotherapy as independent predictors for shortened DMFS. The along chemo-radiotherapy increased dexamethasone use in cohort 2 correlates with increased DM. Conclusions: Despite standardized diagnostic procedures, decision-making considering clear indications and improved therapy algorithms leading to improved LC and LRC, shortened DMFS hypothetically linked to increased dexamethasone use had a detrimental effect on TSS and OS

Myocarditis and sports in the young: data from a nationwide registry on myocarditis—“MYKKE-Sport”

BackgroundMyocarditis represents one of the most common causes of Sudden Cardiac Death in children. Myocardial involvement during a viral infection is believed to be higher as a consequence of intensive exertion. Recommendations for return to sports are based on cohort and case studies only. This study aims to investigate the relationship between physical activity and myocarditis in the young.PatientEvery patient in the MYKKE registry fulfilling criteria for suspicion of myocarditis was sent a questionnaire regarding the physical activity before, during and after the onset of myocarditis.MethodThis study is a subproject within the MYKKE registry, a multicenter registry for children and adolescents with suspected myocarditis. The observation period for this analysis was 93 months (September 2013–June 2021). Anamnestic, cardiac magnetic resonance images, echocardiography, biopsy and laboratory records from every patient were retrieved from the MYKKE registry database.Results58 patients (mean age 14.6 years) were enrolled from 10 centers. Most patients participated in curricular physical activity and 36% in competitive sports before the onset of myocarditis. There was no significant difference of heart function at admission between the physically active and inactive subjects (ejection fraction of 51.8 ± 8.6% for the active group vs. 54.4 ± 7.7% for the inactive group). The recommendations regarding the return to sports varied widely and followed current guidelines in 45%. Most patients did not receive an exercise test before returning to sports.ConclusionSports before the onset of myocarditis was not associated with a more severe outcome. There is still a discrepancy between current literature and actual recommendations given by health care providers. The fact that most participants did not receive an exercise test before being cleared for sports represents a serious omission

EuReCa ONE—27 Nations, ONE Europe, ONE Registry A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

AbstractIntroductionThe aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.MethodsThis was an international, prospective, multi-centre one-month study. Patients who suffered an OHCA during October 2014 who were attended and/or treated by an Emergency Medical Service (EMS) were eligible for inclusion in the study. Data were extracted from national, regional or local registries.ResultsData on 10,682 confirmed OHCAs from 248 regions in 27 countries, covering an estimated population of 174 million. In 7146 (66%) cases, CPR was started by a bystander or by the EMS. The incidence of CPR attempts ranged from 19.0 to 104.0 per 100,000 population per year. 1735 had ROSC on arrival at hospital (25.2%), Overall, 662/6414 (10.3%) in all cases with CPR attempted survived for at least 30 days or to hospital discharge.ConclusionThe results of EuReCa ONE highlight that OHCA is still a major public health problem accounting for a substantial number of deaths in Europe.EuReCa ONE very clearly demonstrates marked differences in the processes for data collection and reported outcomes following OHCA all over Europe. Using these data and analyses, different countries, regions, systems, and concepts can benchmark themselves and may learn from each other to further improve survival following one of our major health care events

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis

Motion-Compensating Long-Term Memory Prediction

Motion-compensating long-term memory prediction extends the spatial displacement utilized in block-based hybrid video coding by a variable time delay permitting the use of more frames than the previously decoded one for motion compensation. The long-term memory covers the decoded frames of some seconds at encoder and decoder. We investigate the influence of memory size in our motion compensation scheme and analyze the trade-off between the bit-rates spent for motion compensated prediction and residual coding. Simulation results are obtained by integrating long-term memory prediction into an H.263 codec. PSNR improvements up to 2 dB for the Foreman sequence and 1.5 dB for the Mother-Daughter sequence are demonstrated in comparison to the TMN-2.0 H.263 coder