FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1

FOXE1 is a thyroid-specific transcription factor essential for thyroid gland development and maintenance of the differentiated state. Interestingly, a strong association has been recently described between FOXE1 expression and susceptibility to thyroid cancer, but little is known about the mechanisms underlying FOXE1-induced thyroid tumorigenesis. Here, we used a panel of human thyroid cancer-derived cell line s covering the spectrum of thyroid cancer phenotypes to examine FOXE1 expression and to test for correlations between FOXE1 expression, the allele frequency of two SNPs and a length polymorphism in or near the FOXE1 locus associated with cancer susceptibility, and the migration ability of thyroid cancer cell lines. Results showed that FOXE1 expression correlated with differentiation status according to histological sub-type, but not with SNP genotype or cell migration ability. However, loss-and-gain-of-function experiments revealed that FOXE1 modulates cell migration, suggesting a role in epithelial-to-mesenchymal transition (EMT). Our previous genome-wide expression analysis identified Zeb1, a major EMT inducer, as a putative Foxe1 target gene. Indeed, gene silencing of FOXE1 decreased ZEB1 expression, whereas its overexpression increased ZEB1 transcriptional activity. FOXE1 was found to directly interact with the ZEB1 promoter. Lastly, ZEB1 silencing decreased the ability of thyroid tumoral cells to migrate and invade, pointing to its im portance in thyroid tumor mestastases. In conclusion, we have identified ZEB1 as a bona fide target of FOXE1 in thyroid cancer cells, which provides new insights into the role of FOXE1 in regulating cell migration and invasion in thyroid cancerThis work was supported by grants SAF2016-75531-R from Ministerio de Ciencia, Innovación y Universidades (MICIU), Spain, Fondo Europeo de Desarrollo Regional FEDER, B2017/BMD-3724 from Comunidad de Madrid, and GCB14142311CRES from Fundación Española Contra el Cáncer (AECC)

Ni normales ni anormales : vida cotidiana y personas con discapacidad, un estudio de caso en Bogotá

Sociólogo (a)Pregrad

Research trends in occupational health and social responsibility: A bibliometric analysis

Occupational Health & Safety (OHS) and Corporate Social Responsibility (CSR) are domains of research char- acterised by a great complexity due to their interdisciplinary nature. Although the interest in Occupational Health & Safety issues in the context of Corporate Social Responsibility has recently increased, more effort is needed to address the complexity of both research areas and to understand the dynamic and implications of their relationship. This research describes and analyses the state of the art in the literature and potential areas for further research regarding OHS and CSR. In total, 289 articles published between 1995 and 2018 related to both CSR and OHS were identified in the most reliable database, Web of Science Core Collection. The publications cover 932 authors, 142 journals, 53 countries or territories and 489 institutions, which include 313 universities in the entire world. We employ bibliometric methods to describe the evolution of publication activity, the most relevant contributors, the methodologies applied as well as the content of the articles in order to examine the main topics and research trends. Moreover, we explore the mapping of bibliographic coupling, co-word analysis of keywords and clusters analysis, which provides maps of knowledge based on data of bibliographic nature. Our study allows us to identify potential avenues for future research that could be meaningful to advance in the consolidation of CSR as an integral framework to support OHS

Selección de hardware para ambientes virtuales: un análisis multicriterio

En las últimas dos décadas el concepto de nube (en términos de la computación) se ha vuelto tan relevante, que en la actualidad se ha convertido en un estándar dentro de la cultura de la infraestructura tecnológica: nube privada, nube publica, nube híbrida, son adaptaciones que buscan proveer de servicios a las compañías. (M Armbrust. 2010). Se podría entonces definir a la computación en la nube como un paradigma que permite ofrecer servicios de computación a través de internet o una red extendida (IEEE Computer Society – IEEE International conference on Cloud Computing). Ahora, una nube no es más que la agrupación de varios equipos de hardware (cómputo, almacenamiento y redes: infraestructura tecnológica) que, en conjunto, ofrecen un servicio tecnológico. El objetivo principal de este artículo es presentar un modelo de selección de toma de decisiones basado en AHP para la selección de infraestructura de hardware para ambientes virtuales, dado que es un proceso crítico para las empresas consultoras y prestadoras de servicios de TI en Colombia. A lo largo de este documento, se presentará los resultados obtenidos al aplicar un método empírico desarrollado por una empresa de consultoría de Tecnologías de la Información (TI) colombiana para el proceso de comprar de una infraestructura de hardware la cual sería implementada sobre una empresa cliente de esta. A partir del análisis obtenido por este método empírico, se solucionará el problema de selección dos veces utilizando el método AHP; el primer acercamiento abordará la solución del problema aplicando el mismo agrupamiento de los criterios y alternativas utilizadas en el método empírico, pero bajo el método de AHP. El segundo, tratará de realizar ajustes sobre el agrupamiento de los clusters y criterios, con el fin de mejorar la calidad de los resultados y a su vez facilitar el proceso de selecciónAbstract. Over the last two decades the concept of cloud (in terms of computing) has become a very relevant topic that nowadays, it’s has become an standard IT culture; terms like private cloud, public cloud, hybrid cloud, are adaptations that look to provide services to multiple companies (M. Arbursts, 2010) Based on the above it’s possible to define cloud computing as a paradigm that allows to offer computing services through internet or over an extended network (WAN) (IEEE Computer Society – IEEE International conference on Cloud computing). Now, a cloud is nothing more than a group of multiple hardware devices (of compute, storage and networking) that together can offer an IT service. The main objective of this document is to present a model of multicriteria decision analysis based in AHP (Analytical Hierarchic Process ) for the selection of a hardware infrastructure in virtualized environments as part of a critical process for the consulting companies and the IT service providers in Colombia. Through this document, it will be presented the results obtained applying an empirical method developed by an IT consultancy company in Colombia during the process of buying computer hardware that would be installed and configured for a customer. Based on the analysis made from this empiric method, the problem will be solved using two different approaches; the first one will use the same distribution of the criteria’s and alternatives using AHP, and the second method will be resolved using a different distribution of the criteria with the only purpose of improve the quality of the results and facilitate the selection process.Maestrí

Views on sustainability and the willingness to adopt an environmental management system in the Mexican vegetable sector

In Mexico, agriculture’s main environmental problems are related to water resources, deforestation and soil erosion. These problems are more acute in arid or semiarid regions such as in the state of Zacatecas. Environmental management systems (EMS) can be an alternate means for improving environmental conditions. In this study, factors that determine willingness to adopt an EMS in the vegetable production units of the state of Zacatecas were identified. We also analysed views on sustainability and production practices oriented toward environmental management and care of natural resources, as well as drivers and barriers to EMS adoption. Factors determining EMS adoption were level of education, awareness of the importance of caring for and protecting natural resources, application of agricultural practices oriented toward protecting the environment, and ignorance of environmental problems

Assessing Environmental Management of Tomato Production under Protected Agriculture

This study examines the impact of environmental strategies on profitability of protected agriculture production systems in the state of Zacatecas, Mexico using the approach of Total Quality Environmental Management (TQEM) and Total Cost Assessment (TCA). We identified environmental management practices currently used by production units and analyzed the existing situation, plus two hypothetical scenarios. Profitability indicators show that adopting conservation production practices will not only improve the image of the organization but permit better access to markets, maintain positive profitability and contribute to the conservation of natural resources

Total cost assessment of greenhouse tomato production in Zacatecas, Mexico

Agriculture in the state of Zacatecas, Mexico, consumes 77% of the available groundwater. In this region, the main source of water is 34 aquifers, of which 44% are over exploited. Over extraction of the aquifers damages the environment, increases pumping costs and decreases water quality. Greenhouse tomato production systems have increased considerably in recent years. Besides the environmental problems that agriculture generates, there is also the problem of emissions and solid waste. The objective of this paper is to assess the environmental impact on profitability of protected agriculture systems in the state of Zacatecas. The methodology used was total cost assessment. This study assesses the total cost of four production units in their present situation, as well as in two scenarios: one denominated sustainable and the other unsustainable. Profitability indicators in the sustainable and unsustainable scenarios show that adopting conservation production practices, besides improving the image of the organization and permitting better access to markets, will maintain profitability and contribute to the conservation of natural resources

Fiscalidade, centralização e separação na Tolima e Huíla, 1886-1930

As a result of the transition from a federal to a centralist system between 1886 and 1930, the Colombian state underwent a process of administrative transformation, in which the government sought to reduce the fiscal autonomy of the regions. This article describes how the process of fiscal centralization was experienced from a regional perspective, exposing the tax policy and the income and expenditure levels of two of the new territorial entities created. This exercise showed that centralization was not an immediate process, but a phenomenon characterized by particular advances and setbacks in the regions.Entre 1886 y 1930 el Estado colombiano sufrió un proceso de transformación administrativa como producto del paso de un régimen federal a uno centralista, en el que el gobierno buscó reducir la autonomía fiscal de las regiones. En este artículo se describe cómo desde un espacio regional se experimentó el proceso de centralización fiscal, exponiendo la política impositiva y los niveles de ingreso y egreso de dos de las nuevas entidades territoriales creadas. Ejercicio que permitió constatar que la centralización no fue un proceso inmediato, sino un fenómeno caracterizado por avances y retrocesos particulares en las regiones.Entre 1886 et 1930, l'État Colombien a subi un processus de transformation administrative a conséquence d'un régime fédéral, au centralisme, dans lequel le gouvernement avait poursuivi la réduction de l'autonomie fiscale des régions. Cet article décrit la façon comme le pays a expérimenté le processus de centralisation fiscal, exposant la politique fiscale et les niveaux d'entrée et sortie de deux des nouvelles entités territoriales ayant été créés. Cet exercice a permis constater le fait que la centralisation n'a pas été un processus immédiat, mais un phénomène caractérise par les avances et les régressions particulaires dans les régions.Este artigo mostra a integração documental que o Tesouro Real do Novo Reino de Granada implantou em matéria de contabilidade no final do século XVIII. Para este efeito, é realizado um estudo de caso sobre a tesouraria real de Cartago, com base na documentação contabilística que o funcionário real da tesouraria teve de apresentar ao Tribunal de Contas de Santafé de Bogotá em 1798. Um procedimento que nos permite observar a estruturação hierárquica e o controlo que a autoridade fiscal tinha conseguido a partir da supervisão contabilística

El valor percibido y la satisfacción del cliente en actividades dirigidas virtuales y con técnico en centros de fitness

En la actualidad la industria del fitness se encuentra en la senda del crecimiento. Uno de los servicios que mayor presencia está teniendo en los centros de fitness son las actividades dirigidas con técnico, las cuales han evolucionado hacia actividades dirigidas virtuales debido a la inclusión de la tecnología. Esta investigación analiza el valor percibido y la satisfacción de los clientes en ambas actividades, explorando las diferencias existentes entre dichos servicios y la relación entre ambas variables. La muestra se compuso de 572 usuarios de un centro de fitness (319 mujeres y 253 hombres) con edades comprendidas entre los 15 y 63 años. Los resultados muestran diferencias significativas entre el valor percibido y la satisfacción entre los dos servicios deportivos, obteniendo valores más positivos en las que requieren un técnico deportivo. Asimismo, la satisfacción del cliente mostró ser dependiente del valor percibido, obteniendo un mayor vínculo en el caso de las actividades dirigidas virtuales. Estos resultados suscitan a la reflexión por parte de los gestores de las instalaciones deportivas sobre la incorporación o no de este tipo de servicios deportivos.At present, the fitness industry is on a growth path. One of the most prominent services in fitness centres is trainer-guided group fitness activities, which have evolved into virtual fitness activities with the inclusion of technology. This research analyses perceived value and customer satisfaction in both activities, exploring the differences between them and the relationship between the two variables. The sample consisted of 572 subjects belonging to a private fitness centre (319 women and 253 men), between 15 and 63 years old. The results show significant differences between perceived value and satisfaction in the two sports services, with sports requiring a trainer getting more positive values. Furthermore, customer satisfaction shows a dependence on perceived value, with a stronger link being obtained in the case of virtual fitness activities. These results and an in-depth analysis on the inclusion, or not, of these sport services are thought-provoking for managers of these facilities.Na actualidade a indústria do fitness encontra-se na senda do crescimento. Um dos serviços que maior presença está a ter nos centros de fitness são as actividades dirigidas com um técnico, as quais têm evoluído para actividades virtuais dirigidas devido à inclusão da tecnologia. Esta investigação analisa o valor percebido e a satisfação dos clientes em ambas as actividades, explorando as diferenças existentes entre estes serviços e a relação entre ambas as variáveis. A amostra foi composta por 572 utentes de um centro de fitness (319 mulheres e 253 homens) com idades compreendidas entre os 15 e os 63 anos. Os resultados revelam diferenças significativas entre o valor percebido e a satisfação entre os dois serviços desportivos, obtendo valores mais positivos as que requerem um técnico desportivo. Assim mesmo, a satisfação do cliente mostrou ser dependente do valor percebido, obtendo um maior vínculo no caso das actividades virtuais dirigidas. Estes resultados suscitam a reflexão por parte dos gestores das instalações desportivas sobre a incorporação ou não deste tipo de serviços desportivos