Etude technico-économique d’un système hybride (aérogénérateur et moteur diesel) pour la production d’électricité.

Technico-economic study of a hybrid system (Aerogenerator and Diesel engine) for the electricity productionIn this article one is interested in the technico-economic study of a hybrid system (aerogenerator and Diesel engine) on the site of Tlemcen by using the data of measurement of the stations of the ONM (National office of Meteorology), one evaluates the annual aver  age power available on the site as well as the annual average power provided by the aerogenerator and the diesel engine thus the determination of the number of hearths which can be to feed in electric power finally this study continues with an economic aspect because the development of the aerogenerators and the diesel engines come under the technical field but also of the economic field, so that the production of electrical energy is viable that is to say less low than that of that produced by a Diesel engine or a turbine, the output and the cost are two factors dependent between them. The viability of the installation would be little interest for an output and a cost of high cost or for an output and a weak cost of cost

Influence of Al-doped ZnO Transparent Contacts Deposited by a Spray Pyrolysis Technique on Performance of HIT Solar Cells

AbstractTransparent and conductive Al-doped ZnO (AZO) thin films were deposited by spray pyrolysis and analysed in the aim to improve optical and electrical properties involved in the efficiency of Heterostructure with Intrinsic Thin Layer (HIT) solar cell. X-ray diffraction measurement shows that AZO film grown on glass has (002) preferred orientation. High optical transmittance value of ∼80% in the visible region was observed and the optical band gap was found to be 3.31eV at room temperature. The influence of AZO thin films as transparent conductive oxide TCO on heterojunction with intrinsic thin-layer (HIT) solar cell performance was investigated using software simulation. The beneficial effect of implementing AZO front contact for increasing electrical energy conversion properties of HIT solar cell compared to the reference cell without the AZO layer

Sound Multi-Party Business Protocols for Service Networks

Service networks comprise large numbers of long-running, highly dynamic complex end-to-end service interactions reflecting asynchronous message flows that typically transcend several organizations and span several geographical locations. At the communication level, service network business protocols can be flexible ranging from conventional inter-organizational point-to-point service interactions to fully blown dynamic multi-party interactions of global reach within which each participant may contribute its activities and services. In this paper we introduce a formal framework enriched with temporal constraints to describe multiparty business protocols for service networks. We extend this framework with the notion of multi-party business protocol soundness and show how it is possible to execute a multi-party protocol consistently in a completely distributed manner while guaranteeing eventual termination

OPTIMAL SIZING OF A HYBRID PHOTOVOLTAIC/WIND SYSTEM SUPPLYING A DESALINATION UNIT

This work presents the dimensioning of a wind-photovoltaic hybrid system for the supply of a seawater desalination plant (reverse osmosis desalination) located in Honaïne in the Tlemcen coastal region of Algeria. The plant has a production capacity of 200,000 m3 /day and supplies potable water for a population of about 555,000 people (the plant's energy demand is 1,825 MW). The main idea is to present a method for sizing and optimizing a hybrid system by introducing two scenarios: the first scenario treats the operation of the plant under good weather conditions. The second one introduces the notion of the worst month (poor weather conditions). For it, we developed a calculation code (Programming under the MATLAB environment) that allowed us to determine the size and optimization of the system, as well as the optimal technical and economic configuration (numbers of photovoltaic panels, wind turbines and batteries), as well as the total cost. The results obtained show on the one hand: the complementarity of the two scenarios, which allows a better reliability of the system, and this by using a number well defined of panels, wind turbines and batteries to ensure the long-term operation of the plant. On the other hand, the use of the hybrid system has allowed us to obtain a 51.46% benefit compared to fossil fuels, which gives the proposed study an important reliability, since it offers a very advantageous benefit in terms of cost and efficiency

Synthesis, characterization, and enhanced electrochemical behavior of polypyrrole doped ZrO2–ZnO electrode materials for supercapacitor applications

The polypyrrole@ZrO2–ZnO (PPy@ZrO2–ZnO) electrodes were synthesized using an in situ chemical oxidative method. The samples were characterized by XRD, FTIR, XPS, UV-vis, TGA, and BET. In addition, the electrochemical characteristics of the electrodes are tested by cyclic voltammetry (CV), galvanostatic charge and discharge (G.C.D.), and electrochemical impedance spectroscopy (E.I.S.). The values of the specific capacitances and the energy densities of PPy@ZrO2–ZnO (1.0) and PPy@ZrO2–ZnO (0.5) at a current density of 0.5 A g−1 are recorded as (395.3 F g−1 and 508.5 Wh·kg−1) and (195.3 F g−1 and 351.5 Wh·kg−1), respectively. Furthermore, the electrode stability for the formed samples was also determined, which exhibited specific capacitance retention at 90.2% for PPy@ZrO2–ZnO (1.0) and 82.4% for PPy@ZrO2–ZnO (0.5) after cycling up to 4,000 cycles. This work provides an efficient approach to the potential of the synthesized samples for application as electrodes in a supercapacitor

Overview of biologically digested leachate treatment using adsorption

Biological process is effective in treating most biodegradable organic matter present in leachate; however, a significant amount of ammonia, metals and refractory organic compounds may still remain in this biologically digested leachate. This effluent cannot be released to receiving bodies until the discharge limit is met. Several physical/chemical processes have been practiced as post-treatment to remove the remaining pollutants including coagulation–flocculation, oxidation and adsorption. Adsorption is often applied in leachate treatment as it enhances removal of refractory organic compounds. This chapter will focus on works related to adsorption as one of the commonly used methods to treat biologically digested leachate further down to acceptable discharge limit

Overview of biologically digested leachate treatment using adsorption

Biological process is effective in treating most biodegradable organic matter present in leachate; however, a significant amount of ammonia, metals and refractory organic compounds may still remain in this biologically digested leachate. This effluent cannot be released to receiving bodies until the discharge limit is met. Several physical/chemical processes have been practiced as post-treatment to remove the remaining pollutants including coagulation–flocculation, oxidation and adsorption. Adsorption is often applied in leachate treatment as it enhances removal of refractory organic compounds. This chapter will focus on works related to adsorption as one of the commonly used methods to treat biologically digested leachate further down to acceptable discharge limit

Engineering of Insulin Receptor Isoform-Selective Insulin Analogues

BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to the region where the A and B isoforms differ. The aim of this study was to investigate the importance of the C-terminus of the B chain in IR isoform binding in order to explore the possibility of engineering tissue-specific/liver-specific insulin analogues. METHODOLOGY/PRINCIPAL FINDINGS: Insulin analogue libraries were constructed by total amino acid scanning mutagenesis. The relative binding affinities for the A and B isoform of the IR were determined by competition assays using scintillation proximity assay technology. Structural information was obtained by X-ray crystallography. Introduction of B25A or B25N mutations resulted in analogues with a 2-fold preference for the B compared to the A isoform, whereas the opposite was observed with a B25Y substitution. An acidic amino acid residue at position B27 caused an additional 2-fold selective increase in affinity for the receptor B isoform for analogues bearing a B25N mutation. Furthermore, the combination of B25H with either B27D or B27E also resulted in B isoform-preferential analogues (2-fold preference) even though the corresponding single mutation analogues displayed no differences in relative isoform binding affinity. CONCLUSIONS/SIGNIFICANCE: We have discovered a new class of IR isoform-selective insulin analogues with 2-4-fold differences in relative binding affinities for either the A or the B isoform of the IR compared to human insulin. Our results demonstrate that a mutation at position B25 alone or in combination with a mutation at position B27 in the insulin molecule confers IR isoform selectivity. Isoform-preferential analogues may provide new opportunities for developing insulin analogues with improved clinical benefits

A Comparative Structural Bioinformatics Analysis of the Insulin Receptor Family Ectodomain Based on Phylogenetic Information

The insulin receptor (IR), the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor-related receptor (IRR) are covalently-linked homodimers made up of several structural domains. The molecular mechanism of ligand binding to the ectodomain of these receptors and the resulting activation of their tyrosine kinase domain is still not well understood. We have carried out an amino acid residue conservation analysis in order to reconstruct the phylogeny of the IR Family. We have confirmed the location of ligand binding site 1 of the IGF1R and IR. Importantly, we have also predicted the likely location of the insulin binding site 2 on the surface of the fibronectin type III domains of the IR. An evolutionary conserved surface on the second leucine-rich domain that may interact with the ligand could not be detected. We suggest a possible mechanical trigger of the activation of the IR that involves a slight ‘twist’ rotation of the last two fibronectin type III domains in order to face the likely location of insulin. Finally, a strong selective pressure was found amongst the IRR orthologous sequences, suggesting that this orphan receptor has a yet unknown physiological role which may be conserved from amphibians to mammals

Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS): a double-blind, randomised controlled trial

Background Third-generation aromatase inhibitors are more effective than tamoxifen for preventing recurrence in postmenopausal women with hormone-receptor-positive invasive breast cancer. However, it is not known whether anastrozole is more effective than tamoxifen for women with hormone-receptor-positive ductal carcinoma in situ (DCIS). Here, we compare the efficacy of anastrozole with that of tamoxifen in postmenopausal women with hormone-receptor-positive DCIS. Methods In a double-blind, multicentre, randomised placebo-controlled trial, we recruited women who had been diagnosed with locally excised, hormone-receptor-positive DCIS. Eligible women were randomly assigned in a 1:1 ratio by central computer allocation to receive 1 mg oral anastrozole or 20 mg oral tamoxifen every day for 5 years. Randomisation was stratified by major centre or hub and was done in blocks (six, eight, or ten). All trial personnel, participants, and clinicians were masked to treatment allocation and only the trial statistician had access to treatment allocation. The primary endpoint was all recurrence, including recurrent DCIS and new contralateral tumours. All analyses were done on a modified intention-to-treat basis (in all women who were randomised and did not revoke consent for their data to be included) and proportional hazard models were used to compute hazard ratios and corresponding confidence intervals. This trial is registered at the ISRCTN registry, number ISRCTN37546358. Results Between March 3, 2003, and Feb 8, 2012, we enrolled 2980 postmenopausal women from 236 centres in 14 countries and randomly assigned them to receive anastrozole (1449 analysed) or tamoxifen (1489 analysed). Median follow-up was 7·2 years (IQR 5·6–8·9), and 144 breast cancer recurrences were recorded. We noted no statistically significant difference in overall recurrence (67 recurrences for anastrozole vs 77 for tamoxifen; HR 0·89 [95% CI 0·64–1·23]). The non-inferiority of anastrozole was established (upper 95% CI <1·25), but its superiority to tamoxifen was not (p=0·49). A total of 69 deaths were recorded (33 for anastrozole vs 36 for tamoxifen; HR 0·93 [95% CI 0·58–1·50], p=0·78), and no specific cause was more common in one group than the other. The number of women reporting any adverse event was similar between anastrozole (1323 women, 91%) and tamoxifen (1379 women, 93%); the side-effect profiles of the two drugs differed, with more fractures, musculoskeletal events, hypercholesterolaemia, and strokes with anastrozole and more muscle spasm, gynaecological cancers and symptoms, vasomotor symptoms, and deep vein thromboses with tamoxifen. Conclusions No clear efficacy differences were seen between the two treatments. Anastrozole offers another treatment option for postmenopausal women with hormone-receptor-positive DCIS, which may be be more appropriate for some women with contraindications for tamoxifen. Longer follow-up will be necessary to fully evaluate treatment differences