Corporate digital responsibility

We propose that digital technologies and related data become increasingly prevalent and that, consequently, ethical concerns arise. Looking at four principal stakeholders, we propose corporate digital responsibility (CDR) as a novel concept. We define CDR as the set of shared values and norms guiding an organization\u27s operations with respect to four main processes related to digital technology and data. These processes are the creation of technology and data capture, operation and decision making, inspection and impact assessment, and refinement of technology and data. We expand our discussion by highlighting how to managerially effectuate CDR compliant behavior based on an organizational culture perspective. Our conceptualization unlocks future research opportunities, especially regarding pertinent antecedents and consequences. Managerially, we shed first light on how an organization\u27s shared values and norms regarding CDR can get translated into actionable guidelines for users. This provides grounds for future discussions related to CDR readiness, implementation, and success

First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma.

PurposeGDC-0084 is an oral, brain-penetrant small-molecule inhibitor of PI3K and mTOR. A first-in-human, phase I study was conducted in patients with recurrent high-grade glioma.Patients and methodsGDC-0084 was administered orally, once daily, to evaluate safety, pharmacokinetics (PK), and activity. Fluorodeoxyglucose-PET (FDG-PET) was performed to measure metabolic responses.ResultsForty-seven heavily pretreated patients enrolled in eight cohorts (2-65 mg). Dose-limiting toxicities included 1 case of grade 2 bradycardia and grade 3 myocardial ischemia (15 mg), grade 3 stomatitis (45 mg), and 2 cases of grade 3 mucosal inflammation (65 mg); the MTD was 45 mg/day. GDC-0084 demonstrated linear and dose-proportional PK, with a half-life (∼19 hours) supportive of once-daily dosing. At 45 mg/day, steady-state concentrations exceeded preclinical target concentrations producing antitumor activity in xenograft models. FDG-PET in 7 of 27 patients (26%) showed metabolic partial response. At doses ≥45 mg/day, a trend toward decreased median standardized uptake value in normal brain was observed, suggesting central nervous system penetration of drug. In two resection specimens, GDC-0084 was detected at similar levels in tumor and brain tissue, with a brain tissue/tumor-to-plasma ratio of >1 and >0.5 for total and free drug, respectively. Best overall response was stable disease in 19 patients (40%) and progressive disease in 26 patients (55%); 2 patients (4%) were nonevaluable.ConclusionsGDC-0084 demonstrated classic PI3K/mTOR-inhibitor related toxicities. FDG-PET and concentration data from brain tumor tissue suggest that GDC-0084 crossed the blood-brain barrier

Benefitting from IS Research -- Who and How? A Panel on the Value of IS Research

This panel reexamines the perennial debate on the relevance of IS from the point of view of the value of IS research, who benefits from it and how these benefits are realized. Following up on previous panels, it promotes a discussion on the kinds of knowledge the IS community produces, the visibility of the IS research, its contributions and what could or should the IS community be working on in the future. Four panelists, who have demonstrated outstanding accomplishments in their respective careers, weigh in and respond to questions on who benefits from their research, what they view as grand challenges that the IS community has addressed, and how as a research community, we can create value. Their discussions on these critical issues are expected to inspire the IS community towards addressing impactful issues that matter to society

Constraints on the preservation of proxy data in carbonate archives – lessons from a marine limestone to marble transect, Latemar, Italy

This work evaluates an exceptionally complex natural laboratory, the Middle Triassic Latemar isolated platform in the northern Italian Dolomite Mountains and explores spatial and temporal gradients in processes and products related to contact metamorphism, dolomitization and dedolomitization of marine limestones. The relation between petrographic change and re-equilibration of geochemical proxy data is evaluated from the perspective of carbonate-archive research. Hydrothermal dolomitization of the limestone units is triggered by dykes and associated hydrothermal fluids radiating from the nearby Predazzo Intrusion. Detailed petrography, fluid inclusion analysis, δ13C and δ18O data and 87Sr/86Sr isotope ratios shed light on the extreme textural and geochemical complexity. Metamorphic and diagenetic patterns include: (i) peak-metamorphic and retrograde-metamorphic phases including three dolomite marbles, two dedolomite marbles, brucite, magnesium silicates and late-stage meteoric/vadose cement at the contact aureole; (ii) four spatially defined episodes of dolomitization, authigenic quartz, low magnesium calcite and late-stage meteoric cement at the Latemar isolated platform; and (iii) kilometre-scale gradients in δ13C values from the contact aureole towards the platform interior. Results shown here are relevant for two reasons: first, the spatial analysis of alteration products ranging from high-grade metamorphic overprint of marbles at temperatures of 700˚C in the contact aureole to moderately altered limestones in the platform interior at temperatures 20 km. Second, under rock-buffered conditions, and irrespective of metamorphic to diagenetic fluid-rock interactions, both marbles, and low-temperature hydrothermal dolomites have conservative marine δ13C and δ18O values. The fact that metamorphism and hydrothermal dolomitization of precursor limestones and early diagenetic dolostones did not per se reset environmental proxy data is of interest for those concerned with carbonate archive research in Earth’s deep time

Overview of Advanced LIGO Adaptive Optics

This is an overview of the adaptive optics used in Advanced LIGO (aLIGO), known as the thermal compensation system (TCS). The thermal compensation system was designed to minimize thermally-induced spatial distortions in the interferometer optical modes and to provide some correction for static curvature errors in the core optics of aLIGO. The TCS is comprised of ring heater actuators, spatially tunable CO$_{2}$ laser projectors and Hartmann wavefront sensors. The system meets the requirements of correcting for nominal distortion in Advanced LIGO to a maximum residual error of 5.4nm, weighted across the laser beam, for up to 125W of laser input power into the interferometer

Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem - New insight

We report the appearance of a Mycoplasma haemocanis infection in laboratory dogs, which has been reported previously, yet, never before in Europe. Outbreak of the disease was triggered by a splenectomy intended to prepare the dogs for a hemorrhagic shock study. The clinical course of the dogs was dramatic including anorexia and hemolytic anemia. Treatment included allogeneic transfusion, prednisone, and oxytetracycline. Systematic follow-up (n=12, blood smears, antibody testing and specific polymerase chain reaction) gives clear evidence that persistent eradication of M. haemocanis is unlikely. We, therefore, had to abandon the intended shock study. In the absence of effective surveillance and screening for M. haemocanis, the question arises whether it is prudent to continue shock research in splenectomized dogs. Copyright (C) 2004 S. Karger AG, Basel

A study of three southern high-mass star-forming regions

Based on color-selected IRAS point sources, we have started to conduct a survey of 47 high-mass star-forming regions in the southern hemisphere in 870um dust continuum and molecular line emission in several frequency ranges between 290 GHz and 806 GHz. This paper describes the pilot study of the three sources IRAS12326-6245, IRAS16060-5146, and IRAS16065-5158. To characterize the physical and chemical properties of southern massive star-forming regions, the three high-luminosity southern hemisphere hot cores were observed with APEX in five frequency setups aimed at groups of lines from the following molecules: CH3OH, H2CO, and CH3CN. Using the LTE approximation, temperatures, source sizes, and column densities were determined through modeling of synthetic spectra with the XCLASS program. Dust continuum observations were done with the Large APEX BOlometer CAmera (LABOCA) at 870um and the 3mm continuum was imaged with the ATCA. Based on the detection of high-excitation CH3CN lines and lines from complex organic species, the three sources are classified as line rich, hot core type sources. For all three, the modeling indicates that the line emission emerges from a combination of an extended, cooler envelope, and a hot compact component. All three sources show an overabundance of oxygen-bearing species compared to nitrogen-bearing species. Based on the results obtained in the three sources, which served as templates for the survey, the most promising (and feasible) frequency setups for the remaining 44 sources were decided upon.Comment: 18 pages, 28 figures plus 23 pages online material; accepted for publication in A&

Locomotor adaptability in persons with unilateral transtibial amputation

Background Locomotor adaptation enables walkers to modify strategies when faced with challenging walking conditions. While a variety of neurological injuries can impair locomotor adaptability, the effect of a lower extremity amputation on adaptability is poorly understood. Objective Determine if locomotor adaptability is impaired in persons with unilateral transtibial amputation (TTA). Methods The locomotor adaptability of 10 persons with a TTA and 8 persons without an amputation was tested while walking on a split-belt treadmill with the parallel belts running at the same (tied) or different (split) speeds. In the split condition, participants walked for 15 minutes with the respective belts moving at 0.5 m/s and 1.5 m/s. Temporal spatial symmetry measures were used to evaluate reactive accommodations to the perturbation, and the adaptive/de-adaptive response. Results Persons with TTA and the reference group of persons without amputation both demonstrated highly symmetric walking at baseline. During the split adaptation and tied post-adaptation walking both groups responded with the expected reactive accommodations. Likewise, adaptive and de-adaptive responses were observed. The magnitude and rate of change in the adaptive and de-adaptive responses were similar for persons with TTA and those without an amputation. Furthermore, adaptability was no different based on belt assignment for the prosthetic limb during split adaptation walking. Conclusions Reactive changes and locomotor adaptation in response to a challenging and novel walking condition were similar in persons with TTA to those without an amputation. Results suggest persons with TTA have the capacity to modify locomotor strategies to meet the demands of most walking conditions despite challenges imposed by an amputation and use of a prosthetic limb

LC-HRMS suspect screening to show spatial patterns of New Psychoactive Substances use in Australia

New Psychoactive Substances (NPS) are an ever-changing class of compounds designed to imitate the effects of current recreational drugs. Such a diverse market is difficult to assess by traditional means, while collected information can become obsolete before it is available. Wastewater-based epidemiology is one technique which can capture information on where and when NPS appear at the community level. The aim of this study was to identify NPS in wastewater samples using a suspect screening approach. Weekend samples were collected from 50 wastewater treatment plants from Australian capital cities and regional areas across all eight States and Territories and screened against a database containing almost 200 NPS. A total of 22 different NPS were found across all regional and metropolitan wastewater treatment plants. Results showed that the most detected compounds were of the cathinone class, with both Alpha-PVP and methcathinone found in every region. In addition, five different synthetic cannabinoids were detected, at least once in half of the regions analysed. Herein, we report the first comprehensive nationwide analysis of NPS and show the utility of liquid chromatography-high resolution mass spectrometry screening for delivering spatial information of the NPS being consumed in communities