Persons as Self-consciously Concerned Beings

This dissertation is an analysis of the concept of a person. According to this analysis, persons are beings capable of being responsible for their actions, which requires possession of the capacities for self-consciousness, in the sense of critical awareness of one\u27s first-order desires and beliefs and concern, meaning emotional investment in the satisfaction of one\u27s desires and truth of one\u27s beliefs. The persistence of a person over time requires uninterrupted maintenance of those capacities. This view is in conflict with the more popular account of persistence in terms of the continuity of distinctive psychological states. Furthermore, this account of personhood has the consequence that contrary to most alternative conceptions, the possession of rights to life and good treatment and the concern for others are neither necessary nor sufficient for being a person. In chapter one I explain and argue for my account of personhood in terms of self-consciousness and concern, illustrating that a being lacking either capacity would not be capable of responsible action and therefore would not be a person. In chapter two I argue for the claim that the persistence of a person requires only that those capacities are maintained uninterruptedly. Chapter three concerns the ontology of persons. There I argue for a Reductionist view of persons and defuse the objection that such a view necessarily slides into Eliminativism. In chapter four I draw a distinction between the concepts of \u27person\u27 and \u27self,\u27 arguing that the latter is not unique to persons and is best understood in neuro-cognitive terms. The fifth and final chapter deals with the implications of my account of personhood for ethics, as regards rights and concern for others

Measuring the Usability and Capability of App Inventor to Create Mobile Applications

MIT App Inventor is a web service that enables users with little to no previous programming experience to create mobile applications using a visual blocks language. We analyze a sample of 5,228 random projects from the corpus of 9.7 million and group projects by functionality. We then use the number of unique blocks in projects as a metric to better understand the usability and realized capability of using App Inventor to implement specific functionalities. We introduce the notion of a usability score and our results indicate that introductory tutorials heavily influence the usability of App Inventor to implement particular functionalities. Our findings suggest that the sequential nature of App Inventor’s learning resources results in users realizing only a portion of App Inventor’s capabilities and propose improvements to these learning resources that are transferable to other programming environments and tools.Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Google Research and Innovation Scholarship

Declines in erythrocyte sedimentation rates in patients with rheumatoid arthritis over the second half of the 20th century

ABSTRACT. Objective. To analyze baseline erythrocyte sedimentation rates (ESR) in cohorts of patients with rheumatoid arthritis (RA), which had been included in a review concerning longterm mortality, in reports published between 1973 and 2008, with An elevated erythrocyte sedimentation rate (ESR) traditionally has been regarded as a primary indicator of inflammation in diagnosis and monitoring of patients with rheumatoid arthritis (RA). Recent textbooks state that "the erythrocyte sedimentation rate is increased in nearly all patients with active RA" 1 , and "at least 5% of patients with clinically active disease may have a normal ESR" 2 , implying that a normal value is unusual. One report published in 1994 indicated that mean ESR was 37 mm/h in women and 34 mm/h in men, and about 40% of patients with RA had a normal ESR 3 . This observation suggested that ESR may have declined over the years, concomitant with better clinical status of patients with RA in recent years compared to previous decades 5 . Baseline ESR data were available in 23 of 84 cohorts included in a recent review concerning mortality in RA, with baseline observations from 1954 to 2000, published between 1973 and 2008 6 . These data are analyzed in our report. MATERIALS AND METHODS A database of 84 unique RA cohorts for which mortality outcomes had been reported was compiled for a review article concerning mortality in RA 6 . Patients in these cohorts had been recruited initially between 1954 and 1996, with total period of recruitment between 1954 and 2000, and reported between 1973 and 2008. Only one report for each unique cohort was included in the analyses. Baseline ESR was reported for 23 of the 84 cohorts Age at baseline, disease duration, and percentages of patients who had a positive test for rheumatoid factor (RF) were available for 22, 20, and 19 of the 23 cohorts, respectively. Mean and median ESR, age, disease duration, and percentage of RF-positive patients were compiled and calculated in the tertiles defined by first year of recruitment. Spearman rank order correlations of ESR with age, disease duration, and percentage RF-positive were computed for the entire group

Arenavirus budding resulting from viral-protein-associated cell membrane curvature

Viral replication occurs within cells, with release (and onward infection) primarily achieved through two alternative mechanisms: lysis, in which virions emerge as the infected cell dies and bursts open; or budding, in which virions emerge gradually from a still living cell by appropriating a small part of the cell membrane. Virus budding is a poorly understood process that challenges current models of vesicle formation. Here, a plausible mechanism for arenavirus budding is presented, building on recent evidence that viral proteins embed in the inner lipid layer of the cell membrane. Experimental results confirm that viral protein is associated with increased membrane curvature, whereas a mathematical model is used to show that localized increases in curvature alone are sufficient to generate viral buds. The magnitude of the protein-induced curvature is calculated from the size of the amphipathic region hypothetically removed from the inner membrane as a result of translation, with a change in membrane stiffness estimated from observed differences in virion deformation as a result of protein depletion. Numerical results are based on experimental data and estimates for three arenaviruses, but the mechanisms described are more broadly applicable. The hypothesized mechanism is shown to be sufficient to generate spontaneous budding that matches well both qualitatively and quantitatively with experimental observations

Secret Signals from Another World: Walter Benjamin’s Concept of Innervation

Walter Benjamin refers to the “idea of revolution as an innervation of the technical organs of the collective” as one of the articles of his politics. The significance of this assertion has received relatively little attention in the philosophical reception of his political thought compared to the alternative model of revolution – made famous from the paralipomena to the late theses ‘On the Concept of History’ – as the emergency handbrake of history. Drawing on some of the debates and tensions generated by the work of Miriam Bratu Hansen, this discussion aims at an exegesis of some of the lesser known intellectual sources that influenced Benjamin’s theory of innervation. The purpose in doing so is not an attempt to reconcile or integrate these sources with dominant philosophical reconstructions of what is sometimes characterized as Benjamin’s “Western Marxism” and elaborated, in the more familiar context of Surrealist innervation, as a synthesis of Freud and Marx, but rather to reveal an alternative constellation of Soviet biomechanics and reactionary anti-capitalist Lebensphilosophie, united in their shared rejection of Freudian psychoanalysis

Catalytic intramolecular hydroamination of aminoallenes using titanium complexes of chiral, tridentate, dianionic imine-diol ligands

Alkylation of D- or L-phenylalanine or valine alkyl esters was carried out using methyl or phenyl Grignard reagents. Subsequent condensation with salicylaldehyde, 3,5-di-tert-butylsalicylaldehyde, or 5-fluorosalicylaldehyde formed tridentate, X_2L type, Schiff base ligands. Chiral shift NMR confirmed retention of stereochemistry during synthesis. X-ray crystal structures of four of the ligands show either inter- or intramolecular hydrogen bonding interactions. The ligands coordinate to the titanium reagents Ti(NMe_2)_4 or TiCl(NMe_2)_3 by protonolysis and displacement of two equivalents of HNMe_2. The crystal structure of one example of Ti(X_2L)Cl(NMe_2) was determined and the complex has a distorted square pyramidal geometry with an axial NMe_2 ligand. The bis-dimethylamide complexes are active catalysts for the ring closing hydroamination of di- and trisubstituted aminoallenes. The reaction of hepta-4,5-dienylamine at 135 °C with 5 mol% catalyst gives a mixture of 6-ethyl-2,3,4,5-tetrahydropyridine (40–72%) and both Z- and E-2-propenyl-pyrrolidine (25–52%). The ring closing reaction of 6-methyl-hepta-4,5-dienylamine at 135 °C with 5 mol% catalyst gives exclusively 2-(2-methyl-propenyl)-pyrrolidine. The pyrrolidine products are obtained with enantiomeric excesses up to 17%

Sex differences in lower urinary tract biology and physiology

Abstract Females and males differ significantly in gross anatomy and physiology of the lower urinary tract, and these differences are commonly discussed in the medical and scientific literature. However, less attention is dedicated to investigating the varied development, function, and biology between females and males on a cellular level. Recognizing that cell biology is not uniform, especially in the lower urinary tract of females and males, is crucial for providing context and relevance for diverse fields of biomedical investigation. This review serves to characterize the current understanding of biological sex differences between female and male lower urinary tracts, while identifying areas for future research. First, the differences in overall cell populations are discussed in the detrusor smooth muscle, urothelium, and trigone. Second, the urethra is discussed, including anatomic discussions of the female and male urethra followed by discussions of cellular differences in the urothelial and muscular layers. The pelvic floor is then reviewed, followed by an examination of the sex differences in hormonal regulation, the urinary tract microbiome, and the reticuloendothelial system. Understanding the complex and dynamic development, anatomy, and physiology of the lower urinary tract should be contextualized by the sex differences described in this review

Power analysis, sample size, and assessment of statistical assumptions—improving the evidential value of lighting research

The reporting of accurate and appropriate conclusions is an essential aspect of scientific research, and failure in this endeavor can threaten the progress of cumulative knowledge. This is highlighted by the current reproducibility crisis, and this crisis disproportionately affects fields that use behavioral research methods, as in much lighting research. A sample of general and topic-specific lighting research papers was reviewed for information about sample sizes and statistical reporting. This highlighted that lighting research is generally underpowered and, given median sample sizes, is unlikely to be able to reveal small effects. Lighting research most commonly uses parametric statistical tests, but assessment of test assumptions is rarely carried out. This risks the inappropriate use of statistical tests, potentially leading to type I and type II errors. Lighting research papers also rarely report measures of effect size, and this can hamper cumulative science and power analyses required to determine appropriate sample sizes for future research studies. Addressing the issues raised in this article related to sample sizes, statistical test assumptions, and reporting of effect sizes can improve the evidential value of lighting research

Geobiology of a lower Cambrian carbonate platform, Pedroche Formation, Ossa Morena Zone, Spain

The Cambrian Pedroche Formation comprises a mixed siliciclastic-carbonate succession recording subtidal deposition on a marine platform. Carbonate carbon isotope chemostratigraphy confirms previous biostratigraphic assignment of the Pedroche Formation to the Atdabanian regional stage of Siberia, correlative to Cambrian Series 2. At the outcrop scale, thrombolitic facies comprise ~. 60% of carbonate-normalized stratigraphy and coated-grains another ~. 10%. Petrographic point counts reveal that skeletons contribute at most 20% to thrombolitic inter-reef and reef-flank lithologies; on average, archaeocyath clasts make up 68% of skeletal materials. In contrast, petrographic point counts show that skeletons comprise a negligible volume of biohermal and biostromal thrombolite, associated nodular carbonate facies, and ooid, oncoid and peloid grainstone facies. As such, archaeocyathan reefal bioconstructions represent a specific and limited locus of skeletal carbonate production and deposition. Consistent with data from coeval, globally dispersed lower Cambrian successions, our analysis of the Pedroche Formation supports the view that lower Cambrian carbonates have more in common with earlier, Neoproterozoic deposits than with younger carbonates dominated by skeletal production and accumulation. © 2013 Elsevier B.V.Jessica R. Creveling, David Fernández-Remolar, Marta Rodríguez-Martínez, Silvia Menéndez, Kristin D. Bergmann, Benjamin C. Gill, John Abelson, Ricardo Amils, Bethany L. Ehlmann, Diego C. García-Bellido, John P. Grotzinger, Christian Hallmann, Kathryn M. Stack, Andrew H. Knol