Discrete element modelling of flexible fibre packing

This paper presents Discrete Element Model simulations of packing of non-cohesive flexible fibres in a cylindrical vessel. No interstitial fluid effects are modelled. Each fibre-particle is modelled as a series of connected sphero-cylinders. In an initial study each particle is modelled a single rigid sphero-cylinder; the method has been used before but this study considers higher aspect ratios up to 30. This posed some modelling challenges in terms of stability which were overcome by imposing limits on the particle angular velocity. The results show very good agreement with experimental data in the literature and more detailed in-house experiments for packing volume fraction. Model results on particle orientation are also shown. The model is developed to include flexibility by connecting sphero-cylinders as sub-elements to describe a particle. Some basic tests are shown for the joint model that connects the sub-elements. The simulation results show similar trends to the rigid particle results with increased packing fraction. The effects of number of sub-elements, joint properties and contact friction are examined. The model has the potential for predicting packing of fibrous particles and fibre bundles relevant to the preparation of preforms for the production of discontinuously-reinforced polymer, ceramic and metallic matrix composites

A Mobile Prenatal Care App to Reduce In-Person Visits: Prospective Controlled Trial.

BACKGROUND: Risk-appropriate prenatal care has been asserted as a way for the cost-effective delivery of prenatal care. A virtual care model for prenatal care has the potential to provide patient-tailored, risk-appropriate prenatal educational content and may facilitate vital sign and weight monitoring between visits. Previous studies have demonstrated a safe reduction in the frequency of in-person prenatal care visits among low-risk patients but have noted a reduction in patient satisfaction. OBJECTIVE: The primary objective of this study was to test the effectiveness of a mobile prenatal care app to facilitate a reduced in-person visit schedule for low-risk pregnancies while maintaining patient and provider satisfaction. METHODS: This controlled trial compared a control group receiving usual care with an experimental group receiving usual prenatal care and using a mobile prenatal care app. The experimental group had a planned reduction in the frequency of in-person office visits, whereas the control group had the usual number of visits. The trial was conducted at 2 diverse outpatient obstetric (OB) practices that are part of a single academic center in Washington, DC, United States. Women were eligible for enrollment if they presented to care in the first trimester, were aged between 18 and 40 years, had a confirmed desired pregnancy, were not considered high-risk, and had an iOS or Android smartphone that they used regularly. We measured the effectiveness of a virtual care platform for prenatal care via the following measured outcomes: the number of in-person OB visits during pregnancy and patient satisfaction with prenatal care. RESULTS: A total of 88 patients were enrolled in the study, 47 in the experimental group and 41 in the control group. For patients in the experimental group, the average number of in-person OB visits during pregnancy was 7.8 and the average number in the control group was 10.2 (P=.01). There was no statistical difference in patient satisfaction (P\u3e.05) or provider satisfaction (P\u3e.05) in either group. CONCLUSIONS: The use of a mobile prenatal care app was associated with reduced in-person visits, and there was no reduction in patient or provider satisfaction. TRIAL REGISTRATION: ClinicalTrials.gov NCT02914301; https://clinicaltrials.gov/ct2/show/NCT02914301 (Archived by WebCite at http://www.webcitation.org/76S55M517)

Balance as bias, resolute on the retreat? Updates & analyses of newspaper coverage in the United States, United Kingdom, New Zealand, Australia and Canada over the past 15 years

Through this research, we systematically updated and expanded understanding of how the print media represent evidence of human contributions to climate change. We built on previous research that examined how the journalistic norm of balanced reporting contributed to informationally biased print media coverage in the United States (U.S.) context. We conducted a content analysis of coverage across 4856 newspaper articles over 15 years (2005&ndash;2019) and expanded previous research beyond U.S. borders by analyzing 17 sources in five countries: the United Kingdom (U.K.), Australia, New Zealand, Canada, and the U.S. We found that across all the years of analysis, 90% of the sample accurately represented climate change. In addition, our data suggests that scientifically accurate coverage of climate change is improving over time. We also found that media coverage was significantly less accurate in 2010 and significantly more accurate in 2015, in comparison to the sample average. Additionally, Canada&rsquo;s National Post, Australia&rsquo;s Daily Telegraph and Sunday Telegraph, and the U.K.&rsquo;s Daily Mail and Mail on Sunday (all historically conservative outlets) had significantly less accurate coverage of climate change over this time period than their counterparts.</p

Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study.

Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real-world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first-line therapeutic antibody ustekinumab. The impact of differing dosing strategies on response was explored. Data were collected from a UK prospective multicenter observational cohort (491 patients on ustekinumab monotherapy, drug levels, and anti-drug antibody measurements on 797 serum samples, 1,590 measurements of Psoriasis Area Severity Index (PASI)). Ustekinumab PKs were described with a linear one-compartment model. A maximum effect (Emax ) model inhibited progression of psoriatic skin lesions in the turnover PD mechanism describing PASI evolution while on treatment. A mixture model on half-maximal effective concentration identified a potential nonresponder group, with simulations suggesting that, in future, the model could be incorporated into a Bayesian therapeutic drug monitoring "dashboard" to individualize dosing and improve treatment outcomes

Rapid dynamic activation of a marine-based Arctic ice cap

We use satellite observations to document rapid acceleration and ice loss from a formerly slow-flowing, marine-based sector of Austfonna, the largest ice cap in the Eurasian Arctic. During the past two decades, the sector ice discharge has increased 45-fold, the velocity regime has switched from predominantly slow (~ 101 m/yr) to fast (~ 103 m/yr) flow, and rates of ice thinning have exceeded 25 m/yr. At the time of widespread dynamic activation, parts of the terminus may have been near floatation. Subsequently, the imbalance has propagated 50 km inland to within 8 km of the ice cap summit. Our observations demonstrate the ability of slow-flowing ice to mobilize and quickly transmit the dynamic imbalance inland; a process that we show has initiated rapid ice loss to the ocean and redistribution of ice mass to locations more susceptible to melt, yet which remains poorly understood.This work was supported by the UK Natural Environment Research Council.This article was originally published in Geophysical Research Letters (M McMillan, A Shepherd, N Gourmelen, A Dehecq, A Leeson, A Ridout, T Flament, A Hogg, L Gilbert, T Benham, M van den Broeke, JA Dowdeswell, X Fettweis, B Noël, T Strozzi, Geophysical Research Letters 2014, 41, 8902–8909)

Selective adsorption of sulfur dioxide in a robust metal-organic framework material

Selective adsorption of SO2 is realized in a porous metal–organic framework material, and in-depth structural and spectroscopic investigations using X-rays, infrared, and neutrons define the underlying interactions that cause SO2 to bind more strongly than CO2 and N2

The first mitotic division of human embryos is highly error prone

Human beings are made of ~50 trillion cells which arise from serial mitotic divisions of a single cell - the fertilised egg. Remarkably, the early human embryo is often chromosomally abnormal, and many are mosaic, with the karyotype differing from one cell to another. Mosaicism presumably arises from chromosome segregation errors during the early mitotic divisions, although these events have never been visualised in living human embryos. Here, we establish live cell imaging of chromosome segregation using normally fertilised embryos from an egg-share-to-research programme, as well as embryos deselected during fertility treatment. We reveal that the first mitotic division has an extended prometaphase/metaphase and exhibits phenotypes that can cause nondisjunction. These included multipolar chromosome segregations and lagging chromosomes that lead to formation of micronuclei. Analysis of nuclear number and size provides evidence of equivalent phenotypes in 2-cell human embryos that gave rise to live births. Together this shows that errors in the first mitotic division can be tolerated in human embryos and uncovers cell biological events that contribute to preimplantation mosaicism

Optimisation of Fluid Mixing in a Hydrosacc⃝ Growing Module

A mathematical model is sought for the flow of nutrients in the Hydrosac⃝c growing module being developed by Phytoponics. The basic operation involves long fluid-filled bags with periodic growing zones from which root systems emerge into the bulk fluid. The system is periodically perturbed via two main processes: partial drainage and refilling of each bag with nutrient infused water, with inlet and outlet at opposite ends of the bag; and a more violent oxygenation of the water through bubbles that rise from the pores of an aeration tube that runs underneath the central long axis of the bag. The aim of the modelling is to determine the key parameters and fluid regimes underlying the nutrient mixing process, to ensure that required nutrient levels are maintained through- out the root zones, and to enable optimal scheduling of the nutrient and bubble flow. Simple experiments were performed via the injection of dye into an operating Hydrosac⃝c that contained semi-mature plants. This enabled a basic understanding of the time and lengthscales of nutrient flow, and also the extent to which mixing occurs in different zones within the bag. Four different flow regimes are identified. At the scale of a single root, a Stokes-flow approximation may be used. At the scale of the individual plant, a so-called Brinkman flow regime may be employed which is describes a transition between slow porous- medium flow and fast channel flow. These equations may be homogenised into a 1D model that can be used to estimate the macro-scale flow of nutrients along the length of the bag. A shear flow model is used to predict the extent to which this flow permeates into regions dominated by plant roots. This leads to the requirement to model the bubble-driven flow within a bag cross-section containing a plant. Simplified two-phase flow equations are de- rived and solved within the software COMSOL. The results suggest that the bubble flow is sufficient to drive recirculating flow, which is also found to be consistent with previous literature. The overall conclusion is that both the periodic flow of nutrients and the aeration are re- quired in order to enable even nutrient spread in the Hydrosac⃝c . Wave effects can be ignored, as can the effect of stagnated nutrient diffusion. The longitudinal nutrient flow enables the whole sack to be reached on the time scale of several cycles of the main inlet flow, while the recirculation from the bubble flow enables enables nutrients to spread within the plant roots. Nevertheless, regions of stagnation can occur via this process near any sharp corners of the bag. It is recommend that the various analyses are combined into a a reduced-order mathemat- ical model that can be used to optimise the dynamic operation of the Hydrosac⃝c , which can also be adaptable to other geometries and growing conditions