54 research outputs found
O que é um aborígene? Modos de categorização racial no sudeste da Austrália
- Author
- AVANZA Martina
- Bastien Bosa
- BECKETT Jeremy
- BELL James
- BRIGGS-SMITH Noeline
- BURMA John H
- CALLEY Malcolm
- CHESTERMAN John
- DAVIS James F
- DAY Caroline Bond
- DENIS Vincent
- DOMINGUEZ Virginia
- FINK Ruth
- GRAY Geoffrey
- KERTZER David
- McCORQUODALE John
- NOIRIEL Gérard
- PATTEN John Thomas
- READ Peter
- READ Peter
- REAY Marie
- ROWLEY Charles D.
- SAADA Emmanuelle
- WOOD Marilyn
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Distribuição de metais pesados em plantas de milho cultivadas em Argissolo tratado com lodo de esgoto
- Author
- Adriana Maria de Aguiar Accioly
- AL-JALOUD A.A.
- ANJOS A.R.M. DOS
- ARAÚJO J.C.T.
- BECKETT P.H.T.
- BERTI W.R.
- BERTON R.S.
- Caroline Miranda Biondi
- Clístenes Williams Araújo do Nascimento
- De FILIPPO B.V.
- FERNANDES F.
- JARAUSCH-WEHRHEIM B.
- KIEHL E.J.
- LINDSAY W.L.
- LOGAN T.J.
- MARTINS A.L.C.
- NASCIMENTO C.W.A.
- OLIVEIRA F.C.
- Samuel Belo Venâncio Gomes
- SILVA J.E.
- WINDER L.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Curran Joanne E
- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
- Dale Anders M
- Dalley Jeffrey
- Dalrymple-Alford John C
- Dalvie Shareefa
- Dang Mimi
- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo Tânia K
- de Geus Eco J C
- de Zubicaray Greig I
- de Zwarte Sonja M C
- Deary Ian J
- Deary Ian J
- Debette Stephanie
- Debette Stephanie
- Decarli Charles
- DeCarli Charles
- Deeley Cheryl
- Degenhardt Franziska
- Delanty Norman
- DeMarco Kathryn
- den Braber Anouk
- Dennis Michelle F
- Depondt Chantal
- Desrivieres Sylvane
- Desrivières Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doan Nhat Trung
- Doherty Colin P
- Dohm Katharina
- Dolen Sara
- Donohoe Gary
- Donohue Michael
- Doody Rachelle S
- Dooley Eoin
- Doraiswamy P Murali
- Drost Dick
- Duara Ranjan
- Dubow Jordan S
- Dunlop Becky
- Egebjerg Jan
- Ehrlich Stefan
- El Khouli Riham
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espay Alberto
- Espay Kristy
- Espeseth Thomas
- Espiritu Ryan
- Faber Kelley
- Factor Stewart
- Fan Chun Chieh
- Fargher Kristin
- Farlow Martin R
- Fatica Parianne
- Fedko Iryna O
- Feldman Howard
- Fernandez Hubert
- Fernández Guillén
- Figurski Michal
- Filippi Irina
- Fillit Howard
- Fillmer Ariane
- Finger Elizabeth
- Fisher Simon E
- Flashman Laura A
- Fleisher Adam
- Fletcher Evan
- Flor Herta
- Flor Herta
- Foley Sonya F
- Fontaine Deborah
- Fontoura Paulo
- Ford Judith M
- Fornage Myriam
- Fornage Myriam
- Foroud Tatiana
- Foroud Tatiana M
- Forstner Andreas J
- Foster Eric
- Foster Norm
- Fox Nick
- Francks Clyde
- Frank Richard
- Frank Samuel
- Franke Barbara
- Franklin Erin
- Franz Carol E
- Frasier Mark
- Frouin Vincent
- Fröhner Juliane
- Fukunaga Masaki
- Gaikwad Mrunalini
- Galasko Douglas
- Garavan Hugh
- Garijo Daniel
- Garrett Melanie E
- Gauss Katharina
- Ge Tian
- Geldmacher David
- Gessert Devon
- Ghanbari Mohsen
- Giddaluru Sudheer
- Gigliotti Christina
- Gil Yolanda
- Gillespie Nathan A
- Glahn David C
- Gloer Katherine
- Goldman Aaron L
- Goldstein Bonnie S
- Goldstein David B
- Gollub Randy L
- Gowland Penny
- Gowland Penny A
- Grabe Hans J
- Grabe Hans Jörgen
- Grachev Igor D
- Graff-Radford Neill R
- Grasby Katrina L
- Green Davis Robert C
- Green Melissa J
- Green Robert C
- Green Robert C
- Greig-Custo Maria T
- Griffith Randall
- Grimmer Yvonne
- Groenewold Nynke A
- Grossman Hillel
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gunter Jeff
- Gurholt Tiril P
- Guthrie Stephanie
- Gutman Boris A
- Hake Ann Marie
- Hansell Narelle K
- Hardy Peter
- Hariri Ahmad R
- Harlan Sherry
- Harless Kelly
- Harris Mat
- Harris Mathew A
- Harrison Marc B
- Hart David
- Hartman Catharina A
- Harvey Danielle
- Hashimoto Ryota
- Haswell Courtney C
- Hauser Michael
- Hauser Robert
- Hawkins Keith A
- Hefti Franz
- Heidebrink Judith L
- Heindel Walter
- Heinz Andreas
- Heinz Andreas
- Heinzen Erin L
- Henskens Frans A
- Hergesheimer Lindsey
- Herms Stefan
- Hernando Raymundo
- Herring Scott
- Heslenfeld Dirk J
- Hetelle Joel
- Hewitt David L
- Heyn Chris Chinthaka
- Hibar Derrek P
- Hillegers Manon H J
- Himali Jayandra J
- Ho Beng-Choon
- Ho New Fei
- Hoehn David
- Hoekstra Pieter J
- Hofer Edith
- Hofer Edith
- Hoffmann Per
- Hoffmann Wolfgang U
- Hofman Albert
- Hogarth Penelope
- Hohmann Sarah
- Holleran Laurena
- Holmes Avram J
- Holsboer Florian
- Holtzman David
- Homuth Georg
- Hong L Elliot
- Honig Lawrence S
- Hoogman Martine
- Hopkins William D
- Hosein Chris
- Hosten Norbert
- Hottenga Jouke-Jan
- Hsiao John
- Hsiung Ging-Yuek Robin
- Hu Shu-Ching
- Hulshoff Pol Hilleke E
- Hunter Christine
- Hynes Mary L
- Häusler Alexander N
- Håberg Asta K
- Ihlenfeld Albrecht
- Ikeda Masashi
- Ikram M Arfan
- Ikram M Arfan
- Ing Alex
- Initiative Alzheimer’s Disease Neuroimaging
- Initiative Parkinson’s Progression Markers
- Iranzo Alex
- Isaacson Stuart
- Isensee Corinna
- Ismail M Saleem
- Ittermann Bernd
- Jack Clifford R
- Jack Clifford R
- Jagust William
- Jahanshad Neda
- James Angela
- James Olga
- James Raymond
- Jang MiHyun
- Jankovic Joseph
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E
- Jennings Danna
- Jernigan Terry L
- Jia Tianye
- Jia Tianye
- Jian Xueqiu
- Jiang Jiyang
- Jicha Greg
- Jimenez Gustavo
- Jockwitz Christiane
- Johnson Kathleen
- Johnson Keith A
- Johnson Kris
- Johnson Nancy
- Johnson Patricia Lynn
- Johnson Sterling
- Jones David
- Jönsson Erik G
- Kahn René S
- Kanai Ryota
- Kantarci Kejal
- Karama Sherif
- Karama Sherif
- Karlawish Jason H
- Kasperaviciute Dalia
- Kass Joseph S
- Kataki Maria
- Kaufmann Tobias
- Kaye Jeffrey A
- Kelly Sinead
- Keltz Melanie
- Kennedy Martin A
- Kertesz Andrew
- Kerwin Diana
- Khachaturian Zaven
- Kieburtz Karl
- Kielb Stephanie
- Kikuchi Masataka
- Killiany Ronald
- Kim Sungeun
- Kimbrel Nathan A
- Kircher Tilo T J
- Kittur Smita
- Kiyasova Vera
- Klein Marieke
- Knapp Michael
- Knodt Annchen R
- Knol Maria J
- Knopman David
- Kochunov Peter
- Koeppe Robert A
- Koleva Hristina
- Kolskår Knut
- Koops Sanne
- Kopil Catherine
- Korecka Magdalena
- Kowalksi Nancy
- Kowall Neil
- Kremen Sarah
- Kremen William S
- Krug Axel
- Krämer Bernd
- Kuller Lew
- Kwok John B
- Kwok John B J
- Lah James J
- Lam Max
- Lamar Melissa
- Lamb Ashley
- Lancaster Thomas M
- Landau Susan
- Lane Barton
- Lasch Shirley
- Launer Lenore
- Le Hellard Stephanie
- Leach Christi
- Leary Laura
- Lee Athena
- Lee Phil H
- Lee T-Y
- Lee Virginia
- Lemaitre Hervé
- Lenahan Art
- Leonard Gabriel
- Lerner Alan
- Lethbridge Emma
- Lett Tristram A
- Leverenz James
- Levey Allan I
- Lewis Lindsay
- Lewis Lindsay B
- Li Shuo
- Liang Grace
- Lim Kelvin O
- Lin Honghuang
- Lin Michael
- Lind Betty
- Lind Penelope A
- Linder Carly
- Lipowski Kristine
- Loeffler Markus
- Logovinsky Veronika
- Logue Mark
- Longstreth W. T.
- Longstreth William T
- Lopes-Cendes Iscia
- Lopez Oscar L
- Lopez Oscar L
- Lord Joanne L
- Loughland Carmel M
- Love Marissa Natelson
- Lu Po H
- Luciano Michelle
- Luciano Michelle
- Luykx Jurjen J
- Lyons Michael J
- Macciardi Fabio
- Maillard Pauline
- Maingault Sophie
- Makino Kelly M
- Malferrari Giulia
- Malloy Paul
- Marek Kenneth
- Mari Zoltan
- Marquand Andre F
- Marshall Gad A
- Marson Daniel
- Martin Kim
- Martin Nicholas G
- Martinot Jean-Luc
- Martinot Jean-Luc
- Martinot Marie-Laure Paillère
- Mason Sara S
- Mathalon Daniel H
- Mather Karen A
- Mather Karen A
- Mathews Dana
- Mathias Samuel R
- Mathis Chet
- Mattay Venkata S
- Matthews Brandy R
- Matthews Sarah
- Mayoral Van Son Jaqueline
- Mazoyer Bernard
- Mazoyer Bernard
- McCoy Arita
- McDonald Colm
- McEwen Sarah C
- McMahon Katie L
- McMahon Mary Agnes B
- Medland Sarah E
- Melle Ingrid
- Melzer Tracy R
- Mendick Susan
- Mesulam M Marcel
- Mesulam Marek-Marsel
- Meyer Javier Villanueva
- Meyer-Lindenberg Andreas
- Michie Patricia T
- Milaneschi Yuri
- Millenet Sabina
- Miller Bruce L
- Miller Delwyn D
- Miller Sarah
- Minton Mark
- Mintun Mark A
- Mintz Akiva
- Mintzer Jacobo
- Miranda Ruben
- Mirza-Schreiber Nazanin
- Mishra Aniket
- Mitsis Effie
- Mollenhauer Brit
- Monahan Nancy
- Montine Tom
- Moreira Jose C V
- Morey Rajendra A
- Morris Derek W
- Morris John
- Morris John C
- Mosley Thomas H
- Mosley Thomas H
- Mota Nina Roth
- Mowry Bryan
- Mudge Benita
- Mueller Bryon A
- Muglia Pierandrea
- Mule Jennifer
- Muni Donna
- Mühleisen Thomas W
- Müller-Myhsok Bertram
- Najt Pablo
- Nakahara Soichiro
- Nam Ki Won
- Nauck Matthias
- Neale Michael C
- Nees Frauke
- Neu Scott
- Nho Kwangsik
- Nho Kwangsik
- Niessen Wiro J
- Norbash Alexander
- Nordvik Jan E
- Nyberg Lars
- Nöthen Markus M
- O'Leary Daniel S
- Oakley MaryAnn
- Oates Elizabeth
- Obisesan Thomas O
- Obradov Sanja
- Ogrocki Paula
- Ogunlana Olu
- Olde Loohuis Loes M
- Olichney John
- Oliver Angela
- Onyike Chiadi
- Oosterlaan Jaap
- Opel Nils
- Ophoff Roel A
- Orfanos Dimitri Papadopoulos
- Ostrowizki Suzanne
- Ott Brian R
- Ottmann Ruth
- Oyonumo Ntekim E
- Pacini Nathaniel
- Paillere Marie-Laure
- Painter Jodie N
- Panizzon Matthew S
- Pantelis Christos
- Papadopoulos Dimitri
- Parfitt Francine
- Pasternak Stephen
- Paul Steven
- Paus Tomas
- Paus Tomáš
- Pausova Zdenka
- Pausova Zdenka
- Pavese Nicola
- Pavlik Valory
- Pavlosky William
- Pawluczyk Sonia
- Pearlson Godfrey D
- Pearson John F
- Penninx Brenda W J H
- Pentilla Jani
- Perron Michel
- Perry David
- Petersen Ronald
- Petrella Jeffrey R
- Pierce Aimee
- Pike G Bruce
- Pike G Bruce
- Pirpamer Lukas
- Pitcher Toni L
- Pizzagalli Fabrizio
- Poewe Werner
- Poki-Walker Kim
- Polderman Tinca J C
- Poline Jean-Baptiste
- Pomara Nunzio
- Porsteinsson Anton P
- Portillo Alicia
- Posthuma Danielle
- Potkin Steven
- Potter William
- Poustka Luise
- Preda Adrian
- Psaty Bruce M
- Pütz Benno
- Quiceno Mary
- Quidé Yann
- Quinlan Erin B
- Quinlan Erin Burke
- Quinn Joseph
- Rachinsky Irina
- Radtke Rodney
- Ragothaman Anjanibhargavi
- Raichle Marc
- Rainka Michelle
- Raj Balebail Ashok
- Ranola Madelaine
- Rapp Michael
- Rashid Faisal M
- Rasser Paul E
- Ratnakar Varun
- Ravdin Lisa
- Ravina Bernard
- Rawlins Ashlee
- Reay William R
- Redlich Ronny
- Reeder Stephanie
- Rees Linda
- Reiman Eric M
- Reinbold Céline S
- Reith Alastair D
- Relkin Norman
- Reppermund Simone
- Repple Jonathan
- Reynolds Brigid
- Richard Geneviève
- Richard Irene
- Richer Louis
- Riedel Brandalyn C
- Rietschel Marcella
- Riordan Cheryl
- Risacher Shannon L
- Robbins Trevor
- Robert Gabriel
- Rocha Cristiane S
- Rodriguez Rosemarie
- Roffman Joshua L
- Rogalski Emily
- Rogers John
- Rosen Allyson
- Rosen Howard J
- Roshchupkin Gennady V
- Roshchupkin Gennady V
- Rotter Jerome I
- Rountree Susan
- Rowe Dominic
- Rowland Laura M
- Rudolph Alice
- Ruggeri Barbara
- Russell David
- Saba Barbara
- Saba Yasaman
- Sachdev Perminder S
- Sachdev Perminder S
- Sadowski Martin
- Sadowsky Carl
- Salazar Jennifer
- Salloway Stephen
- Salminen Lauren
- Samuels Patricia
- Santulli Robert B
- Saremi Arvin
- Sarrael Antero
- Satizabal Claudia L
- Satizabal Claudia L
- Saykin Andrew J
- Saykin Andrew J
- Schall Ulrich
- Scharre Douglas W
- Schlag Fenja
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schmidt Reinhold
- Schneider Lon S
- Schneider Stacy
- Schofield Peter R
- Schofield Peter R
- Scholz Markus
- Schuff Norbert
- Schultz Susan K
- Schumann Gunter
- Schumann Gunter
- Scott Rodney J
- Secolin Rodrigo
- Seibyl John
- Seiler Stephan
- Seltzer Marc
- Senjem Matt
- Seppi Klaus
- Seshadri Sudha
- Seshadri Sudha
- Shah Bina
- Shah Raj C
- Shapland Chin Yang
- Shatokhina Natalia
- Shaw Leslie M
- Sheikh Mohammed O
- Shen Li
- Shen Li
- Sherer Todd
- Shianna Kevin
- Shibley Victoria
- Shill Holly
- Shim Hyungsub
- Shin Jean
- Shumskaya Elena
- Siderowf Andrew
- Silbert Lisa C
- Silverman Daniel H S
- Silverstein Rebecca
- Sim Kang
- Simpson Donna M
- Simuni Tanya
- Singleton Andrew
- Singleton-Garvin Jamika
- Sink Kaycee M
- Sirrel Sherye A
- Sisodiya Sanjay M
- Smith Amanda
- Smith Charles D
- Smith Karen Ekstam
- Smolka Michael
- Smoller Jordan W
- Snyder Peter
- Snyder Peter J
- Soares Holly
- Sommer Iris E
- Sorensen Greg
- Sosa Elizabeth
- Sossi Vesna
- Spann Bryan M
- Sperling Reisa A
- Spicer Kenneth
- Sprenger Fabienne
- Sprooten Emma
- St Pourcain Beate
- Standaert David
- Steen Vidar M
- Stefanovic Bojana
- Stein Dan J
- Stein Jason L
- Stern Matthew
- Stern Yaakov
- Strike Lachlan T
- Stringaris Argyris
- Swerdlow Russell H
- Sämann Philipp G
- Sønderby Ida E
- Tanner Caroline
- Tansey Katherine E
- Tarawneh Rawan
- Tariot Pierre
- Tatsuoka Curtis
- Taylor Joy L
- Taylor Peggy
- Taylor-Reinwald Lisa
- Teng Edmond
- Teodoro Liberty
- Tetrud James
- Teumer Alexander
- Teumer Alexander
- Thai Gaby
- Thal Leon
- Thalamuthu Anbupalam
- Thalamuthu Anbupalam
- Thomas Cathi-Ann
- Thomopoulos Sophia I
- Thompson Paul
- Thompson Paul M
- Tingus Kathleen
- Tinklenberg Jared
- Todd Gretchen
- Toga Arthur
- Toga Arthur W
- Toga Arthur W
- Tolosa Eduardo
- Tooney Paul A
- Tordesillas-Gutiérrez Diana
- Torres Fábio R
- Tran Baochan
- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q
- Trollor Julian
- Trollor Julian N
- Turner Jessica A
- Turner Raymond Scott
- Tzourio Christophe
- Uhlmann Anne
- Uitterlinden André G
- Ulysse Anaztasia
- Umek Robert
- Uribe Liz
- Vaishnavi Sanjeev
- Vallerga Costanza Ludovica
- van 't Ent Dennis
- van der Brug Marcel
- van der Lee Sven J
- van der Meer Dennis
- Van der Wee Nic J A
- van Donkelaar Marjolein M J
- van Duijn Cornelia M
- van Dyck Christopher H
- van Eijk Liza
- van Erp Theo G M
- van Haren Neeltje E M
- van Noort Betteke
- van Rooij Daan
- van Tol Marie-José
- Vanderswag Helen
- Varma Pradeep
- Veillette Suzanne
- Veldink Jan H
- Veltman Dick J
- Vemuri Prashanthi
- Venkov Heli
- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant
- Author
- Aanensen David M.
- Adams Helen
- Aggarwal Dinesh
- Ainslie Kylie E. C.
- Alderton Alex
- Alikhan Nabil-Fareed
- Amato Roberto
- Andersson Monique
- Ariani Cristina V.
- Ash Amy
- Ashby Deborah
- Atchison Christina
- Awan Ali R.
- Barclay Wendy
- Barrett Jeff
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Beale Mathew A.
- Beckett Angela H.
- Bellis Katherine L.
- Berry Lisa
- Blane Beth
- Bonsall David
- Bosworth Andrew
- Bourgeois Yann
- Boyes John
- Breuer Judith
- Brown Julianne Rose
- Bucca Giselda
- Buck David
- Bull Matthew
- Campbell Sharon
- Carabelli Alessandro M.
- Carlile Matthew
- Casey Anna
- Chand Meera
- Chauhan Anoop J.
- Clark Gemma
- Collins Jennifer
- Connor Thomas R.
- Constantinidou Chrystala
- Cook Kate
- Cooke Graham
- Corden Sally
- Cottrell Simon
- Cox Alison
- Craine Noel
- Curran Martin D.
- da Silva Filipe Ana
- Darby Alistair C.
- Darzi Ara
- Davies Robert
- Davis Thomas
- de Cesare Mariateresa
- de Silva Thushan I.
- Dent Hannah
- Dervisevic Samir
- Dewar Rebecca
- Diggle Peter J.
- Donnelly Christl A.
- Dorman Matthew J.
- Drury Eleanor
- du Plessis Louis
- Durham Jillian
- Eales Oliver
- Edgeworth Jonathan
- Elliott Paul
- Elliott Scott
- Eltringham Gary
- Fairley Derek J.
- Fearn Christopher
- Fenton Melisa Louise
- Fraser Christophe
- Fronterre Claudio
- Girgis Sophia T.
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian G.
- Goudarzi Salman
- Graham Clive
- Grammatopoulos Dimitris
- Green Angie
- Gupta Ravi Kumar
- Hadjirin Nazreen F.
- Haldenby Sam T.
- Halstead Fenella
- Hamilton William L.
- Haque Tanzina
- Harris Kathryn Ann
- Harrison Ewan M.
- Hart Jennifer
- Hassan-Ibrahim Mohammed O.
- Haw David
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- Heyburn David
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- Holden Matthew T.G.
- Holmes Christopher
- Holmes Nadine
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- Jackson Leigh M.
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- Jones Christopher R.
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- Kay Gemma L.
- Kay Sally
- Knight Bridget A.
- Koshy Cherian
- Kristiansen Mark
- Kwiatkowski Dominic
- Langford Cordelia F.
- Lawniczak Mara
- Leonard Steven
- Letchford Laura
- Li Kathy K.
- Liggett Steven
- Livett Rich
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- Loose Matthew W.
- Loveson Katie F.
- Lowe Hannah
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Madona Pinglawathee
- Mahanama Adhyana I.K.
- Mahungu Tabitha W.
- Martincorena Inigo
- Martinez Nunez Rocio T.
- Masoli Jane A.H.
- McCann Clare
- McClure Patrick C.
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McMurray Claire
- McNally Alan
- Meader Emma J.
- Michell Stephen L.
- Moore Catherine
- Moore Christopher
- Moses Samuel
- Muir Peter
- Nelson Andrew
- Nelson Rachel
- Nicholls Sam
- O'Toole Áine
- Oliver Karen
- Osman Husam
- Ott Sascha
- O’Grady Justin
- Pacchiarini Nicole
- Page Andrew J.
- Page Andrew J.
- Palmer Steve
- Pandey Sarojini
- Park Naomi R.
- Parker Matthew D.
- Parmar Surendra
- Paterson Steve
- Paul Hannah
- Peacock Sharon J.
- Pelosi Emanuela
- Perry Malorie
- Poplawski Radoslaw
- Prestwood Liam
- Price Anna
- Prieto Jacqui A.
- Prosolek Sophie J.
- Pybus Oliver G.
- Pymont Hannah M.
- Quick Joshua
- Rajatileka Shavanthi
- Rambaut Andrew
- Randell Paul Anthony
- Ratcliffe Liz
- Rey Sara
- Riley Steven
- Robertson David L.
- Robinson Esther
- Robson Samuel C.
- Rooke Stefan
- Roy Sunando
- Ruis Chris
- Saeed Kordo
- Saluja Tranprit
- Samaraweera Buddhini
- Shaaban Sharif
- Shah Rajiv N.
- Shepherd James G.
- Sillitoe John
- Silveira Siona
- Simpson David A.
- Sivaprakasam Venkat
- Sloan Tim J.
- Smith Colin P.
- Smith Darren
- Snell Luke B.
- Spencer Chapman Michael H.
- Stark Richard
- Storey Nathaniel
- Swindells Emma
- Taha Yusri
- Taylor Graham
- Temperton Ben
- Templeton Kate E.
- Thomson Emma C.
- Todd John A.
- Torok M. Estee
- Trotter Alexander J.
- Underwood Anthony P.
- Unnikrishnan Meera
- Vipond Ian B.
- Volz Erik M.
- Walters Caroline E.
- Wang Dennis
- Wang Haowei
- Ward Helen
- Warne Ben
- Watkins Joanne
- Weldon Danni
- Williams Chris
- Williams Rachel J.
- Williams Thomas
- Wilson-Davies Eleri
- Witele Eric
- Wyles Matthew
- Xu-McCrae Li
- Young Greg
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 17/12/2021
- Field of study
SARS-CoV-2 infections were rising during early summer 2021 in many countries associated with the Delta variant. We assessed RT-PCR swab-positivity in the REal-time Assessment of Community Transmission-1 (REACT-1) study in England. We observed sustained exponential growth with average doubling time (June-July 2021) of 25 days driven by complete replacement of Alpha variant by Delta, and by high prevalence at younger less-vaccinated ages. Unvaccinated people were three times more likely than double-vaccinated people to test positive. However, after adjusting for age and other variables, vaccine effectiveness for double-vaccinated people was estimated at between ~50% and ~60% during this period in England. Increased social mixing in the presence of Delta had the potential to generate sustained growth in infections, even at high levels of vaccination
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
- Author
- Abani Obbina
- Abbas Ali
- Abbas Fatima
- Abbas Mustafa
- Abbasi Sadia
- Abbass Hakam
- Abbott Alfie
- Abdallah Nabeel
- Abdelaziz Ashraf
- Abdelfattah Mohamed
- Abdelqader Bushra
- Abdo David
- Abdul Rasheed Althaf
- Abdul Basir
- Abdul-Kadir Rezan
- Abdul-Raheem Rasheed
- Abdulakeem Ajibode
- Abdulle Amina
- Abdulmumeen Abdulfatahi
- Abdulshukkoor Niyaz
- Abdusamad Kula
- Abed El Khaleq Yazeed
- Abedalla Mai
- Abeer Ul Amna Abeer Ul Amna
- Abernethy Katrina
- Abo-Leyah Hani
- Aboaba Adebanke
- Abou-Haggar Ahmed
- Abouibrahim Mahmoud
- Abraham Miriam
- Abraham Tizzy
- Abraheem Abraheem
- Abrams Judith
- Abu Hyacinth-John
- Abu-Arafeh Ahmed
- Abubacker Syed M
- Abung Akata
- Aceampong Yaa
- Achara Amaka
- Acharya Devikumar
- Acheampong Sarah
- Acheson Janet
- Acosta Andres
- Acton Catherine
- Adabie-Ankrah Jacqueline
- Adair Sara
- Adam Fiona
- Adam Matthew
- Adamali Huzaifa
- Adams Carol
- Adams Charlotte
- Adams Kate
- Adams Lisa
- Adams Richard
- Adams Tim
- Adcock Kirsty
- Addai Jemaimah
- Adebiyi Ade
- Adegoke Ken
- Adell Vicki
- Ademokun Debo
- Adenwalla Sherna
- Adesemoye Oluwasegun A
- Adewunmi Emmanuel O
- Adeyemi Joyce
- Adhikary Rina
- Adkins Gabrielle
- Adnan Adnan
- Aeron-Thomas John
- Affleck Debbie
- Affron Dominic
- Afnan Carmel
- Afridi Muhammad
- Aftab Zainab A
- Agarwal Meenakshi
- Agbeko Rachel
- Agbo Chris
- Agent Penny
- Aggarwal Sunil
- Aghababaie Arameh
- Ahamed Sadiq Shafana
- Ahammed Nazeer Mohamed H
- Ahmad Humayun
- Ahmad Mohammad
- Ahmad Syed
- Ahmed Ali Roa
- Ahmed Asim
- Ahmed Bilal
- Ahmed Forizuddin
- Ahmed Hamze
- Ahmed Iram
- Ahmed Irshad
- Ahmed Khaled
- Ahmed Liban
- Ahmed Mahin
- Ahmed Maria C
- Ahmed Muhammad S
- Ahmed Naseer
- Ahmed Nausheen
- Ahmed Osama
- Ahmed Rajia A
- Ahmed Rizwan
- Ahmed Saif
- Ahmed Sammiya
- Ahmed Sana
- Ahmed Sara
- Ahmed Sophia
- Ahmed Syed
- Ahmed Syed Haris
- Ahmer Sana
- Ail Dhiraj
- Ainsworth Mark
- Airoldi Giulia
- Aissa Myriam
- Aitken Lindianne
- Ajay Bini
- Ajeneye Francis
- Ajibode Abdulakeem
- Ajmi Ayesha
- Akbar Tahir
- Akhtar Naim
- Akhtar Nasim
- Akhtar Nauman
- Akili Suha
- Akindolie Oludoyinsola
- Akinfenwa Yinka
- Akinkugbe Olugbenga
- Akinpelu Ibrahim
- Akinwumiju Olajide
- Aktinade Olugbenro
- Al Aaraj Ahmad
- Al Balushi Asma
- Al Dakhola Majd
- Al Swaifi Aladdin
- Al-Abadi Eslam
- Al-Asadi Abbas
- Al-Asadi Karina
- Al-Bayati Manaf
- Al-Fori Julyan
- Al-Hakim Bahij
- Al-Hity Shams
- Al-Jibury Maithem
- Al-Juboori Saba
- Al-Khalil Majid
- Al-Moasseb Hassan
- Al-Obaidi Magda
- Al-Rabahi Akram
- Al-Ramadhani Bahar
- Al-Saadi Zayneb
- Al-Shahi Salman Rustam
- Al-Shamkhani Warkaq
- Al-Sheklly Bashar
- Aladangady Narendra
- Alam Ayaz
- Alam Sajid
- Alatzoglou Kyriaki
- Albert Paul
- Albon Lorraine
- Alcorn Gemma
- Alcorn Stephen
- Aldana Aggie
- Alderdice David
- Aldouri Rayan
- Aldridge Jonathan
- Aldridge Nicolas
- Alegria Ana
- Alexander Alison
- Alexander John
- Alexander Peter D G
- Alford Charlotte
- Alghazawi Laith
- Ali Ali
- Ali Asad
- Ali Fawzia R
- Ali Hoodo
- Ali Jawad
- Ali Mariam
- Ali Mohammad
- Ali Nayab
- Ali Oudai
- Ali Sabira
- Ali Sakina
- Ali Syed
- Alina Abid
- Aliyuda Fine
- Alizadeh Katrin
- Alkhusheh Moutaz
- Allameddine Allameddine
- Allan Fiona
- Allan Rachel
- Allanson Alison
- Allcock Robert
- Allen Beverley
- Allen Eireann
- Allen Jess
- Allen Kerry
- Allen Laura
- Allen Louise
- Allen Poppy
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- Allman Bethan
- Allsop Lynne
- Alomari Lina
- Alshaer Inji
- Altaf Sara
- Alvarez Mary
- Alyas Balaal
- Alzetani Maysaa
- Amamou Susan
- Amar Noor
- Ambalavanan Sakkarai
- Ambler Sarah-Jayne
- Ambrogetti Robert
- Ambrose Chris
- Ameen Amir
- Amenyah Kenneth
- Amezaga Maria R
- Amin Allison
- Amin Amina
- Amin Kanish
- Amin Syed
- Amin Tara
- Amjad Amjad
- Amjad Neelma
- Ammoun Mariam
- Amosun Victoria
- Amsha Khaled
- Amy Pugh
- Anand Atul
- Anand Rekha
- Anandappa Samantha
- Anderson Julie
- Anderson Kevin
- Anderson Laura
- Anderson Michelle
- Anderson Nicola
- Anderson Rachel
- Anderson Rory
- Anderson Wendy
- Andreou Prematie
- Andrews Angela
- Andrews Antonette
- Andrews Jill
- Andrews Susan
- Andrikopoulos Gregory
- Aneke Kanayochukwu
- Ang Andrew
- Ang Wan Wei
- Angel Tammy
- Angela Aramburo
- Angelini Paola
- Anguvaa Lazarus
- Anichtchik Oleg
- Anim-Somuah Millicent
- Aniruddhan Krishnan
- Annett Jessica
- Anstey Patrick J
- Anstey Rebekah
- Anthony Alpha
- Anthony-Pillai Aaron
- Antill Philip
- Antonina Zhelyazkova
- Anu Varghese
- Anwar Muhammad
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- Apostolopoulos Aristeidis
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- Appleyard Diane
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- Ashford Ben
- Ashgar Suhail
- Ashish Abdul
- Ashman-Flavell Sally
- Ashok Sundar
- Ashour Abd-El-Aziz
- Ashraf Muhammad Z
- Ashraf Saima
- Ashraq Mohammad B
- Ashton Deborah
- Ashton Susan
- Ashworth Andrew
- Ashworth Rebecca
- Aslam Arshia
- Asogan Harshini
- Asquith Abigail
- Asrar Atif
- Assaf Omar
- Astin-Chamberlain Raine
- Athay-Hunt Richard
- Athorne Deborah
- Atkins Billie
- Atkins Christopher
- Atkins Stacey
- Atkinson John
- Atkinson Vicki
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- Atugonza Rita
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- Awan Atia
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- Azam Jawwad
- Azharuddin Mohammed
- Aziz Ghazala
- Aziz N
- Azkoul Ali
- Azman Shah Ashaari
- Azzopardi Giada
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- Babatunde Fiyinfoluwa
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- Babirecki Matthew
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- Bacon Gina
- Bacon Jenny
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- Badhan Gurpreet R
- Badhrinarayanan Shreya
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- Bancroft Hollie
- Bancroft Tanya
- Banda Joyce
- Bandaru Krishna
- Bandi Srini
- Bandla Nageswar
- Bandyopadhyam Somaditya
- Banerjee Amit
- Banerjee Millie
- Banerjee Ritwik
- Banks Harrison
- Banks Lauren
- Banks Luke
- Banks Paul
- Bannister Oliver
- Bansal Bharat
- Banthorpe Robert
- Banton Laura
- Baptist Mariamma
- Baqai Tanya
- Baral Ananya Mouli
- Baramova Desislava
- Barber Alex
- Barber Russel
- Barbon Emma
- Barbosa Miriam
- Barbosa Monica
- Barbour Jamie
- Barclay Alexander
- Barclay Claire
- Bardsley George
- Bareford Stephanie
- Bari Shahedal
- Barker Amy
- Barker Debbie
- Barker Helen
- Barker Joseph
- Barker Leon
- Barker Oliver
- Barker-Williams Kerry
- Barkha Sinha
- Barla Juliana
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- Barlow Richard
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- Barnes Theresa
- Barnetson Calum
- Barnett Amy
- Barnett Matthew
- Barnett-Vanes Ashton
- Barnsley William
- Barr Andrew
- Barr David
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- Baruah Rosaleen
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- Bashyal Archana
- Basker Betsy
- Basoglu Ayten
- Bass Gilda
- Bassett G
- Bassett John
- Bassford Chris
- Bassi Pavinder
- Bassis Betsy
- Bassoy Bengisu
- Bastion Victoria
- Basumatary Anupam
- Bate Tristan
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- Bateman Ian
- Bateman Kathryn
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- Bates Michelle
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- Bautista Carina
- Bawa Fareha
- Bawani Fatima S
- Bax Simon
- Baxter Lydia
- Baxter Matt
- Baxter Nicola
- Baxter Zachary
- Bayes Hannah
- Baylem Charlotte
- Bayliss Lee
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- Brown Pauline
- Brown Rachel
- Brown Richard
- Brown Robert
- Brown Steven
- Brown Tom
- Brown Wayne
- Browne Bria
- Browne Charlotte
- Browne Duncan
- Browne Mitchell
- Brownlee Stephen
- Brraka Alba
- Bruce David
- Bruce Johanna
- Bruce Michelle
- Brudlo Wojciech
- Brunskill Nigel
- Brunton Alan
- Brunton Margaret
- Bryan Mandy
- Bryant Meera
- Buazon April
- Buch Maya
- Buchan Julie
- Buchan Ruaridh
- Buchanan Alexis
- Buchanan Ruaridh
- Buche Danielle
- Buck Amanda
- Buckland Matthew
- Buckley Laura
- Buckley Philip
- Buckley Sarah
- Buckman Carol
- Buckmire Kathleen
- Bugg George
- Bujazia Ramadan
- Bukhari Marwan
- Bukhari Shanze
- Bulbulia Richard
- Bull Alex
- Bull Damian
- Bull Rhian
- Bull Thomas
- Bulteel Naomi
- Bumunarachchi Kasun
- Bungue-Tuble Roneleeh
- Burchett Caroline
- Burda Dorota
- Burden Christy
- Burden Thomas G
- Burgess Mika
- Burgess Paula
- Burgess Richard
- Burgess Sophia
- Burgett Paula
- Burman Adrian
- Burnard Sara
- Burnett Caroline
- Burnett John
- Burns Amanda
- Burns Amy
- Burns Collette
- Burns James
- Burns Karen
- Burns Samuel
- Burns Sarah
- Burrage Daniel
- Burrage Sadie
- Burrows Kate
- Burston Claire
- Burton Ben
- Burton Fiona
- Burton Matthew
- Busby Angela
- Butcher Deborah
- Butler Aaron
- Butler Jessica
- Butler Joanne
- Butler Joshua
- Butler Lesley
- Butler Peter
- Butler Susan
- Butt Al-Tahoor
- Butt Mohammad M
- Butt Sophia
- Butterworth Caryl
- Butterworth-Cowin Nicola
- Buttery Robert
- Buttle Tom
- Button Heather
- Buttress Daniel
- Publication venue
- 'Elsevier BV'
- Publication date
- 13/02/2021
- Field of study
SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
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- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
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- Arbane Gill
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- Wootton Daniel G.
- Wormleighton J
- Worsley J.
- Wraith D
- Wrey Brown Caroline
- Wright C.
- Wright L
- Wright S.
- Wyles J.
- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
- Yip K P
- Young A.
- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
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- Balboni Tracy
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- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
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- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
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- Bauer Todd W
- Bauman Julie
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- Berzofsky Jay A
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- Bian Zhen
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- Biniszkiewicz Detlev M
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- Bommareddy Praveen K
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- Brockstedt Dirk G
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- Zeng Xue
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- Zhang Jing
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- Zhang Yanping
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- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2021
- Field of study
Background:
In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936).
Findings:
Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001).
Interpretation:
In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
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- Publication venue
- 'Elsevier BV'
- Publication date
- 29/05/2021
- Field of study
Background:
Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.
Findings:
Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79).
Interpretation:
In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
A comparison of rapists and sexual murderers on selected psychological measures
- Publication venue
- Publication date
- 01/06/2007
- Field of study
- …