Safety of anti-rheumatic drugs for rheumatoid arthritis in pregnancy and lactation

Women with rheumatoid arthritis (RA) are often of childbearing age and therefore questions regarding reproductive health and the use of medications, including disease-modifying anti-rheumatic drugs (DMARDs) may arise during the clinical consultation. Each patient requires individual assessment in order to effectively manage the disease while minimizing any treatment-associated risks to the fetus. Although good-quality controlled trials are lacking, there is an increasing volume of evidence surrounding the use of immunosuppressive therapies in pregnancy and lactation. This review summarizes the currently available information which can be of benefit to clinicians guiding patients and their families through the risks and benefits of continuing RA therapy during pregnancy and lactation. Further studies and ongoing surveillance of drug safety in pregnancy are required to resolve the uncertainties that remain regarding synthetic and biologic DMARDs

Observation of an Excited Bc+ State

Using pp collision data corresponding to an integrated luminosity of 8.5 fb-1 recorded by the LHCb experiment at center-of-mass energies of s=7, 8, and 13 TeV, the observation of an excited Bc+ state in the Bc+π+π- invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(Bc+) MeV/c2, where the last uncertainty is due to the limited knowledge of the Bc+ mass. It is consistent with expectations of the Bc∗(2S31)+ state reconstructed without the low-energy photon from the Bc∗(1S31)+→Bc+γ decay following Bc∗(2S31)+→Bc∗(1S31)+π+π-. A second state is seen with a global (local) statistical significance of 2.2σ (3.2σ) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(Bc+) MeV/c2, and is consistent with the Bc(2S10)+ state. These mass measurements are the most precise to date

Removing critical gaps in chemical test methods by developing new assays for the identification of thyroid hormone system-disrupting chemicals—the athena project

The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood–brain and blood–placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation

Observation of B(s)0→J/ψpp¯ decays and precision measurements of the B(s)0 masses

The first observation of the decays B 0 ( s ) → J / ψ p ¯ p is reported, using proton-proton collision data corresponding to an integrated luminosity of 5.2     fb − 1 , collected with the LHCb detector. These decays are suppressed due to limited available phase space, as well as due to Okubo-Zweig-Iizuka or Cabibbo suppression. The measured branching fractions are B ( B 0 → J / ψ p ¯ p ) = [ 4.51 ± 0.40 ( stat ) ± 0.44 ( syst ) ] × 10 − 7 , B ( B 0 s → J / ψ p ¯ p ) = [ 3.58 ± 0.19 ( stat ) ± 0.39 ( syst ) ] × 10 − 6 . For the B 0 s meson, the result is much higher than the expected value of O ( 10 − 9 ) . The small available phase space in these decays also allows for the most precise single measurement of both the B 0 mass as 5279.74 ± 0.30 ( stat ) ± 0.10 ( syst )     MeV and the B 0 s mass as 5366.85 ± 0.19 ( stat ) ± 0.13 ( syst )     MeV

Measurement of D s ^± production asymmetry in pp collisions at √s=7 and 8 TeV

The inclusive $D_s^{\pm}$ production asymmetry is measured in $pp$ collisions collected by the LHCb experiment at centre-of-mass energies of $\sqrt{s} =7$ and 8 TeV. Promptly produced $D_s^{\pm}$ mesons are used, which decay as $D_s^{\pm}\to\phi\pi^{\pm}$, with $\phi\to K^+K^-$. The measurement is performed in bins of transverse momentum, $p_{\rm T}$, and rapidity, $y$, covering the range $2.5<p_{\rm T}<25.0$ GeV$/c$ and $2.0<y<4.5$. No kinematic dependence is observed. Evidence of nonzero $D_s^{\pm}$ production asymmetry is found with a significance of 3.3 standard deviations.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2018-010.htm

Measurement of the mass and production rate of Ξ−b baryons

The first measurement of the production rate of Xi(-)(b) baryons in pp collisions relative to that of Lambda(0 )(b)baryons is reported, using data samples collected by the LHCb experiment, and corresponding to integrated luminosities of 1, 2 and 1.6 fb(-1) at root s = 7, 8 and 13 TeV, respectively. In the kinematic region 2 &lt; eta &lt; 6 and p(T) &lt; 20 GeV/c, we measure f(Xi b-)/f(Lambda b0) B(Xi(-)(b)-&gt; J/psi Xi(-))/B(Lambda(0)(b)-&gt; J/psi Lambda)= (10.8 +/- 0.9 +/- 0.8) x 10(-2) [root s = 7,8 TeV], f(Xi b-)/f(Lambda b0) B(Xi(-)(b)-&gt; J/psi Xi(-))/B(Lambda(0)(b)-&gt; J/psi Lambda) =(13.1 +/- 1.1 +/- 1.0) x 10(-2) [root s = 13 TeV], where and f(Xi b-) and f(Lambda)(b0) the fragmentation fractions of b quarks into Xi(-)(b) and Lambda(0)(b) baryons, respectively; B represents branching fractions; and the uncertainties are due to statistical and experimental systematic sources. The values of f(Xi b-)/f(Lambda b0) are obtained by invoking SU(3) symmetry in the Xi(-)(b)-&gt; J/psi Xi(-) and Lambda(0)(b)-&gt; J/psi Lambda decays. Production asymmetries between Xi(-)(b) and (Xi) over bar (+)(b) baryons are also reported. The mass of the Xi(-)(b) baryon is also measured relative to that of the Lambda(0)(b) baryon, from which it is found that m(Xi(-)(b)) = 5796.70 +/- 0.39 +/- 0.15 +/- 0.17 MeV/c(2), where the last uncertainty is due to the precision on the known Lambda(0)(b) mass. This result represents the most precise determination of the Xi(-)(b) mass

Search for CP violation using triple product asymmetries in Λ _b⁰ → pK⁻π⁺π⁻, Λ _b⁰ → pK−K+K− and Ξ _b⁰ → pK⁻K⁻π⁺decays

A search for $C$P and $P$ violation using triple-product asymmetries is performed with $\Lambda^{0}_{b}\to pK^{-}\pi^{+}\pi^{-}$, $\Lambda^{0}_{b}\to pK^{-}K^{+}K^{-}$ and $\Xi^{0}_{b}\to pK^{-}K^{-}\pi^{+}$ decays. The data sample corresponds to integrated luminosities of 1.0fb$^{-1}$ and 2.0fb$^{-1}$, recorded with the LHCb detector at centre-of-mass energies of 7TeV and 8TeV, respectively. The $CP$- and $P$-violating asymmetries are measured both integrating over all phase space and in specific phase-space regions. No significant deviation from $CP$ or $P$ symmetry is found. The first observation of $\Lambda^{0}_{b}\to pK^{-}\chi_{c0}(1P)(\to\pi^{+}\pi^{-}, K^{+}K^{-})$ decay is also reported.Comment: 26 pages including author list, 10 figure

Measurement of the ratio of branching fractions of the decays Λ0 → ψ(2S)Λ and Λ0 → J/ψΛ

Using pp collisions corresponding to 3 fb integrated luminosity, recorded by the LHCb experiment at centre- of- mass energies of 7 and 8TeV, the ratio of branching fractions B (0b ! (2 S) ) =B (0b ! J= ) = 0 : 513 0 : 023 (stat) 0 : 016 (syst) 0 : 011 (B) is determined. The fi rst uncertainty is statistical, the second is systematic and the third is due to the external branching fractions used

Measurement of fs /fu Variation with Proton-Proton Collision Energy and B -Meson Kinematics

The ratio of the Bs0 and B+ fragmentation fractions fs and fu is studied with Bs0→J/ψφ and B+→J/ψK+ decays using data collected by the LHCb experiment in proton-proton collisions at 7, 8, and 13 TeV center-of-mass energies. The analysis is performed in bins of B-meson momentum, longitudinal momentum, transverse momentum, pseudorapidity, and rapidity. The fragmentation-fraction ratio fs/fu is observed to depend on the B-meson transverse momentum with a significance of 6.0σ. This dependency is driven by the 13 TeV sample (8.7σ), while the results for the other collision energies are not significant when considered separately. Furthermore, the results show a 4.8σ evidence for an increase of fs/fu as a function of collision energy

Measurement of the Charm-Mixing Parameter y(CP)

A measurement of the charm-mixing parameter Y-CP using D-0 -&gt; K+K-, D-0 -&gt; pi(+)pi(-), and D-0 -&gt; K-pi(+)decays is reported. The D-0 mesons are required to originate from semimuonic decays of B- and (B) over bar (0)mesons. These decays are partially reconstructed in a data set of proton-proton collisions at center-of-mass energies of 7 and 8 TeV collected with the LHCb experiment and corresponding to an integrated luminosity of 3 fb(-1). The y c p parameter is measured to be (0.57 +/- 0.13(stat) +/- 0.09(syst))%, in agreement with, and as precise as, the current world-average value