17,754 research outputs found
Involving experts by experience in craniofacial research
Many areas of health research increasingly involve end users of research (typically patients and their families/caregivers) in study design, management, and dissemination. Beyond recruiting patients as research participants, the shift is towards engaging patients, parents and caregivers as active partners on the research team, who are recognised and valued as āexperts-by-experienceā (EbyE). Currently, involving EbyE is not routine in global craniofacial research. This paper highlights the value of EbyE involvement, addresses how to incorporate EbyE at all stages of research and discusses key considerations in facilitating positive experiences for EbyE
A search for rotating radio transients and fast radio bursts in the Parkes high-latitude pulsar survey
Discoveries of rotating radio transients and fast radio bursts (FRBs) in
pulsar surveys suggest that more of such transient sources await discovery in
archival data sets. Here we report on a single-pulse search for dispersed radio
bursts over a wide range of Galactic latitudes (|b| < ) in data
previously searched for periodic sources by Burgay et al. We re-detected 20 of
the 42 pulsars reported by Burgay et al. and one rotating radio transient
reported by Burke-Spolaor. No FRBs were discovered in this survey. Taking into
account this result, and other recent surveys at Parkes, we corrected for
detection sensitivities based on the search software used in the analyses and
the different backends used in these surveys and find that the all-sky FRB
event rate for sources with a fluence above 4.0 Jy ms at 1.4 GHz to be FRBs day sky, where the
uncertainties represent a confidence interval. While this rate is lower
than inferred from previous studies, as we demonstrate, this combined event
rate is consistent with the results of all systematic FRB searches at Parkes to
date and does not require the need to postulate a dearth of FRBs at
intermediate latitudes.Comment: Accepted, 10 pages, 6 figure
Origin of the āaccelerated growth an lactoseā (āAGLā) trait
Origin of AGL trai
Continental-scale patterns of pathogen prevalence: a case study on the corncrake
Pathogen infections can represent a substantial threat to wild populations, especially those already limited in size. To determine how much variation in the pathogens observed among fragmented populations is caused by ecological factors, one needs to examine systems where host genetic diversity is consistent among the populations, thus controlling for any potentially confounding genetic effects. Here, we report geographic variation in haemosporidian infection among European populations of corncrake. This species now occurs in fragmented populations, but there is little genetic structure and equally high levels of genetic diversity among these populations. We observed a longitudinal gradient of prevalence from western to Eastern Europe negatively correlated with national agricultural yield, but positively correlated with corncrake census population sizes when only the most widespread lineage is considered. This likely reveals a possible impact of local agriculture intensity, which reduced host population densities in Western Europe and, potentially, insect vector abundance, thus reducing the transmission of pathogens. We conclude that in the corncrake system, where metapopulation dynamics resulted in variations in local census population sizes, but not in the genetic impoverishment of these populations, anthropogenic activity has led to a reduction in host populations and pathogen prevalence
The effect of topology on the structure and free energy landscape of DNA kissing complexes
We use a recently developed coarse-grained model for DNA to study kissing
complexes formed by hybridization of complementary hairpin loops. The binding
of the loops is topologically constrained because their linking number must
remain constant. By studying systems with linking numbers -1, 0 or 1 we show
that the average number of interstrand base pairs is larger when the topology
is more favourable for the right-handed wrapping of strands around each other.
The thermodynamic stability of the kissing complex also decreases when the
linking number changes from -1 to 0 to 1. The structures of the kissing
complexes typically involve two intermolecular helices that coaxially stack
with the hairpin stems at a parallel four-way junction
Radiative recombination data for modeling dynamic finite-density plasmas
We have calculated partial final-state resolved radiative recombination (RR) rate coefficients from the initial ground and metastable levels of all elements up to and including Zn, plus Kr, Mo, and Xe, for all isoelectronic sequences up to Na-like forming Mg-like. The data are archived according to the Atomic Data and Analysis Structure (ADAS) data class adf48, which spans a temperature range of z2(101-107) K, where z is the initial ion charge. Fits to total rate coefficients have been determined, for both the ground and metastable levels, and those for the ground are presented here. Comparison is made both with previous RR rate coefficients and with (background) R-matrix photoionization cross sections. This RR database complements a dielectronic recombination (DR) database already produced, and both are being used to produce updated ionization balances for both (electron) collisionally ionized and photoionized plasmas
Finite to infinite steady state solutions, bifurcations of an integro-differential equation
We consider a bistable integral equation which governs the stationary
solutions of a convolution model of solid--solid phase transitions on a circle.
We study the bifurcations of the set of the stationary solutions as the
diffusion coefficient is varied to examine the transition from an infinite
number of steady states to three for the continuum limit of the
semi--discretised system. We show how the symmetry of the problem is
responsible for the generation and stabilisation of equilibria and comment on
the puzzling connection between continuity and stability that exists in this
problem
Induction of tyrosinase by B-lactose in Neurospora crassa
Induction of tyrosinase by lactose in Neurospora crass
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