Clinical signs, diagnosis and treatment of three dogs with angiostrongylosis in Ireland

<p/> <p>Infection with <it>Angiostrongylus vasorum </it>was diagnosed at necropsy on a dog that died from acute pulmonary haemorrhage, and on recovery of L1 larvae by Baermann examination of faeces from two dogs, one of which had abdominal pain and retroperitoneal haemorrhage, while the other had right-sided heart failure due to cor pulmonale. The presenting signs included syncope (one dog), exercise intolerance (two dogs), cough (two dogs), abdominal pain (one dog) and depression (one dog). One-stage prothrombin time and activated partial thromboplastin time were prolonged in two dogs, buccal mucosal bleeding time was prolonged in one dog and globulin was elevated in all three dogs. Two dogs were treated with fenbendazole and recovered.</p

Digital human modelling and the ageing workforce

Digital human modelling (DHM) has often focused on user populations that could be characterised as able-bodied and in the working age group. It is clear however that demographic changes are resulting in older populations in developed countries but this is also becoming increasingly true even in developing countries. The economic pressures of increased life expectancy are resulting in demands for workers to remain in employment well past what would previously have been considered a normal retirement age. In many countries legislation is increasing retirement ages for entitlement to state pensions, and enforceable retirement ages are being outlawed. As a consequence older working populations can be expected. Age in the workforce has many positive aspects including increased experience, wisdom, loyalty and motivation, but an inevitable consequence of ageing is negative effects such as the loss of capabilities in strength, mobility, vision and hearing. The challenge of including older workers is recognised as an important aspect of Inclusive Design and DHM is recognised as a potentially useful method for its implementation. Today’s highly demanding and competitive working environments require the highest levels of productivity from individuals so that overall operational and business objectives can be achieved. DHM-based workplace risk assessment methods have successfully been used to improve working environments by conducting virtual posture based ergonomic risk analysis. Older workers are significantly different from younger workers in terms of their physical, physiological and cognitive capabilities and these capabilities directly or indirectly affect human work performance. This article suggests the use of human capability data in a virtual environment to explore the level of acceptability of a working strategy based on real capability data (joint mobility in this case) of older workers. A case study shows that the proposed DHM-based inclusive design method is useful recommending working strategies that are acceptable for older workers in terms of work productivity, well-being and safety

Multilayer distortion in the reconstructed (110) surface of Au

A new LEED intensity analysis of the reconstructed Au(110)-(1×2) surface results in a modification of the missing row model with considerable distortions which are at least three layers deep. The top layer spacing is contracted by about 20%, the second layer exhibits a lateral pairing displacement of 0.07 Å and the third layer is buckled by 0.24 Å. Distortions in deeper layers seem to be probable but have not been considered in this analysis. The inter-atomic distances in the distorted surface region show both an expansion and a contraction compared to the bulk value and range from 5% contraction to about 4% expansion

High Altitude Venus Operational Concept (HAVOC): Proofs of Concept

The atmosphere of Venus is an exciting destination for both further scientific study and future human exploration. A recent internal NASA study of a High Altitude Venus Operational Concept (HAVOC) led to the development of an evolutionary program for the exploration of Venus, with focus on the mission architecture and vehicle concept for a 30-day crewed mission into Venus's atmosphere at 50 kilometers. Key technical challenges for the mission include performing the aerocapture maneuvers at Venus and Earth, inserting and inflating the airship at Venus during the entry sequence, and protecting the solar panels and structure from the sulfuric acid in the atmosphere. Two proofs of concept were identified that would aid in addressing some of the key technical challenges. To mitigate the threat posed by the sulfuric acid ambient in the atmosphere of Venus, a material was needed that could protect the systems while being lightweight and not inhibiting the performance of the solar panels. The first proof of concept identified candidate materials and evaluated them, finding FEP-Teflon (Fluorinated Ethylene Propylene-Teflon) to maintain 90 percent transmittance to relevant spectra even after 30 days of immersion in concentrated sulfuric acid. The second proof of concept developed and verified a packaging algorithm for the airship envelope to inform the entry, descent, and inflation analysis

Calculating the solar potential of the urban fabric with SketchUp and HTB2

This paper introduces a new tool for analysing annual solar insolation potentials for façades and roofs at an urban scale using Trimble SketchUp and the dynamic simulation model HTB2. The tool is in the form of a plugin which 1) generates shading masks for every façade and roof in a model, 2) exports geometries to HTB2 for analysis, 3) invokes HTB2 from within SketchUp, and 4) returns outputs into SketchUp for review. Its capability to calculate the effects of complex terrain (imported from Google Earth) on façade and roof solar insolation levels is demonstrated. Case studies of the tool applied to both urban and rural areas of Wales and Europe are examined and results discussed. The simplicity of the tool in performing complex solar potential analyses is demonstrated, and its broader application as an analysis tool for calculating urban energy demands are presented

Exploring the waveform characteristics of tidal breathing carbon dioxide, measured using the N-Tidal C device in different breathing conditions (The General Breathing Record Study): protocol for an observational, longitudinal study

Background: In an increasingly comorbid population, there are significant challenges to diagnosing the cause of breathlessness, and once diagnosed, considerable difficulty in detecting deterioration early enough to provide effective intervention. The burden of the breathless patient on the health care economy is substantial, with asthma, chronic heart failure, and pneumonia affecting over 6 million people in the United Kingdom alone. Furthermore, these patients often have more than one contributory factor to their breathlessness symptoms, with conditions such as dysfunctional breathing pattern disorders—an under-recognized component. Current methods of diagnosing and monitoring breathless conditions can be extensive and difficult to perform. As a consequence, home monitoring is poorly complied with. In contrast, capnography (the measurement of tidal breath carbon dioxide) is performed during normal breathing. There is a need for a simple, easy-to-use, personal device that can aid in the diagnosis and monitoring of respiratory and cardiac causes of breathlessness.Objective: The aim of this study was to explore the use of a new, handheld capnometer (called the N-Tidal C) in different conditions that cause breathlessness. We will study whether the tidal breath carbon dioxide (TBCO2) waveform, as measured by the N-Tidal C, has different characteristics in a range of respiratory and cardiac conditions.Methods: We will perform a longitudinal, observational study of the TBCO2 waveform (capnogram) as measured by the N-Tidal C capnometer. Participants with a confirmed diagnosis of asthma, breathing pattern disorders, chronic heart failure, motor neurone disease, pneumonia, as well as volunteers with no history of lung disease will be asked to provide twice daily, 75-second TBCO2 collection via the N-Tidal C device for 6 months duration. The collated capnograms will be correlated with the underlying diagnosis and disease state (stable or exacerbation) to determine if there are different TBCO2 characteristics that can distinguish different respiratory and cardiac causes of breathlessness.Results: This study’s recruitment is ongoing. It is anticipated that the results will be available in late 2018.Conclusions: The General Breathing Record Study will provide an evaluation of the use of capnography as a diagnostic and home-monitoring tool for various diseases

Colliding Branes and Formation of Spacetime Singularities

We construct a class of analytic solutions with two free parameters to the five-dimensional Einstein field equations, which represents the collision of two timelike 3-branes. We study the local and global properties of the spacetime, and find that spacelike singularities generically develop after the collision, due to the mutual focus of the two branes. Non-singular spacetime can be constructed only in the case where both of the two branes violate the energy conditions.Comment: four figure

Embodied energy at an urban scale: A paradigm shift in calculations

Embodied energy has long been a focus of research, and improved operational energy demands in modern structures cause the proper analyses of embodied energies to be critical for full building life cycle analysis. Many different calculation techniques exist to arrive at an embodied energy value, and literature is full of the application of these values to predominantly single or small numbers of buildings. Embodied energy at an urban scale is studied in this paper, and a new software tool for estimating embodied energy impacts at the design stage is introduced. Two case studies are discussed using the software, and embodied energies are calculated and presented in context with their operational energy savings. The importance of choosing an embodied energy value calculated according to the process-based hybrid analysis method when looking at the urban scale is discussed