From Flashlight to Searchlight: A Sustainable Information Program for Sex Trafficking Victims in Texas

This project is a product of the Bush School of Government and Public Service Capstone Program. It expands upon a previous project that mapped the legal pathways for domestic minor sex trafficking victims and the resources available to them in the Brazos Valley. It expands victim information and resource models by applying them to broader geographic areas and additional categories of victims for the Human Trafficking and Transnational/Organized Crime Section of the Texas Office of the Attorney General. This project lasted one academic year and involved ten second-year Master students. They have reviewed the literature on trafficking, validated and revised the previous project, created a visual model for the legal pathways of international trafficking victims, mapped the victim resources available in two additional Texas counties, and developed a more comprehensive, bilingual resource model and website that can be updated by community leaders into specific resource guides for any Texas region.Human Trafficking and Transnational/Organized Crime Section within the Office of the Attorney General of Texa

An Anglo-Saxon execution cemetery at Walkington Wold, Yorkshire

This paper presents a re-evaluation of a cemetery excavated over 30 years ago at Walkington Wold in east Yorkshire. The cemetery is characterized by careless burial on diverse alignments, and by the fact that most of the skeletons did not have associated crania. The cemetery has been variously described as being the result of an early post-Roman massacre, as providing evidence for a ‘Celtic’ head cult or as an Anglo-Saxon execution cemetery. In order to resolve the matter, radiocarbon dates were acquired and a re-examination of the skeletal remains was undertaken. It was confirmed that the cemetery was an Anglo-Saxon execution cemetery, the only known example from northern England, and the site is set into its wider context in the paper

The Belt and Road Initiative for an intercontinental ecosystem: Strategic implications for multinational enterprises around the world

[Extract] International trade and foreign direct investment (FDI), as well as other forms of cross-border economic activities, are essential to globalization, even in the emerging era of neoglobalization as a unique balance between globalization and deglobalization. Despite the hype, globalization is a relatively new phenomenon

The efficacy of unsupervised home-based exercise regimens in comparison to supervised lab-based exercise training upon cardio-respiratory health facets

Supervised high-intensity interval training (HIIT) can rapidly improve cardiorespiratory fitness (CRF). However, the effectiveness of time-efficient unsupervised home-based interventions is unknown. Eighteen volunteers completed either: laboratory-HIIT (L HIIT); home-HIIT (H-HIIT) or home-isometric hand-grip training (H-IHGT). CRF improved significantly in L-HIIT and H-HIIT groups, with blood pressure improvements in the H-IHGT group only. H-HIIT offers a practical, time-efficient exercise mode to improve CRF, away from the laboratory environment. H-IHGT potentially provides a viable alternative to modify blood pressure in those unable to participate in whole-body exercise

Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

Background A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples. Whether discordant tick rates between tissue-specific and general epigenetic clocks play a role in health and disease has not yet been explored. Results Here we analyze 1941 cervical cytology samples, which contain a mixture of hormone-sensitive cervical epithelial cells and immune cells, and develop the WID general clock (Women’s IDentification of risk), an epigenetic clock that is shared by epithelial and immune cells and optimized for cervical samples. We then develop the WID epithelial clock and WID immune clock, which define epithelial- and immune-specific clocks, respectively. We find that the WID-relative-epithelial-age (WID-REA), defined as the difference between the epithelial and general clocks, is significantly reduced in cervical samples from pre-menopausal women with breast cancer (OR 2.7, 95% CI 1.28-5.72). We find the same effect in normal breast tissue samples from pre-menopausal women at high risk of breast cancer and show that potential risk reducing anti-progesterone drugs can reverse this. In post-menopausal women, this directionality is reversed. Hormone replacement therapy consistently leads to a significantly lower WID-REA in cancer-free women, but not in post-menopausal women with breast or ovarian cancer. Conclusions Our findings imply that there are multiple epigenetic clocks, many of which are tissue-specific, and that the differential tick rate between these clocks may be an informative surrogate measure of disease risk.publishedVersio

Febrile Neutropenia in Children: Etiologies, Outcomes, and Risk Factors with Prolonged Fever

Most studies of children with prolonged fever and neutropenia (PFN) have focused on invasive fungal disease (IFD) as the etiology of fever and not on other causes. Data are lacking regarding risk factors and adverse outcomes in pediatric cancer patients with PFN compared with those whose fevers resolve more rapidly. Retrospective medical record review was performed for all cancer patients with febrile neutropenia (FN) in the pediatric oncology unit at University of Chicago Medicine Comer Children’s Hospital from March 2009 to July 2016. Resolving febrile neutropenia (RFN), lasting less than 96 hours, and PFN episodes (≥ 96 hours) were compared to identify risk factors and outcomes associated with PFN. A total of 572 FN episodes were identified in 265 patients. PFN occurred in 119 (21%) FN episodes (50 patients) and RFN occurred in 453 (79%) FN episodes (215 patients). In multivariable analysis, autologous stem cell transplant (odds ratio [OR] 6.5, P 39°C at the time of presentation (OR 2.4, P<0.01) and absolute monocyte count (AMC) <100 cells/m3 (OR 2.7, P=<0.01) were independently associated with PFN. Pneumonia, neutropenic enterocolitis and IFD were more common etiologies of fever in PFN compared with RFN. Patients with PFN were more likely to be admitted to the pediatric intensive care unit [OR 3, (95%CI, 1.66%-5.28%), P<0.001] and had a trend toward higher 30-day mortality [OR 3.8, (95%CI, 0.52%-29.32%), P=0.07]. Patients with PFN are at increased risk for serious illness and death. A better understanding of the etiologies of PFN other than IFD is needed to be able to appropriately diagnose and treat this high-risk group

I Blame Therefore it Was: Rape Myth Acceptance, Victim Blaming, and Memory Reconstruction

We examined the causal order of relationships between rape myth acceptance (RMA), victim blaming, and memory reconstruction. In Study 1, RMA-congruent memory (or alternatively, victim blaming) mediated the relationship between RMA and victim blaming (memory reconstruction). In Study 2, similar relationships emerged between RMA, victim blaming, and memory reconstruction. Although no mediation of RMA occurred in Study 2 independently, a mini meta-analysis of Studies 1 and 2 data replicated both patterns of mediation observed in Study 1. In Study 3, memory accuracy for neutral details of a rape scenario was unrelated to RMA. Manipulating memory to be more (vs. less) RMA congruent had no effect on victim blaming (Study 4), although manipulating perceived victim blameworthiness (Studies 5 and 6) produced RMA-congruent memory reconstruction when the victim was more (vs. less) blameworthy. The results suggest that, via victim blaming, RMA motivates a memory reconstruction process that explains and justifies victim blaming after the fact