Photonic synthesis of continuous-wave millimeter-wave signals using a passively mode-locked laser diode and selective optical filtering

We report a photonic synthesis scheme for CW mm-wave signal generation using a single Passively Mode-Locked Laser Diode (PMLLD), optical filtering and photomixing in a fast photodiode. The phase noise of the photonically synthesized signals is evaluated and inherits the characteristics of the PMLLD electrical power spectrum.Publicad

Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes

Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with other substituents is currently one of the most attractive methods undergoing wide-ranging development. In this review article, we discuss the most significant contributions made in this area during the last decade (2012−2021). The reactions reviewed in this work include chloro-, bromo-, iodo-, fluoro- and cyano-trifluoromethylation of alkenes and alkynes

Determinación del estado hídrico del viñedo mediante el uso de imágenes térmicas y su influencia en la calidad y producción de la uva

[SPA] El contenido de agua en el viñedo, es actualmente un factor de elevada importancia, que afecta directamente a la producción y calidad final de la cosecha, cada vez más exigente por el consumidor. El uso de las nuevas tecnologías en el viñedo, es cada día más utilizado entre los viticultores. El empleo de drones que disponen de cámaras térmicas, permiten analizar información con respecto al estado hídrico del viñedo a lo largo de la campaña, pudiendo establecer de este modo, sistemas de riego eficientes, que aporten a la planta las necesidades hídricas en el momento adecuado, así como una buena gestión de un insumo tan relevante como es el agua. En el presente estudio, se han realizado dos vuelos de dron próximos a las fechas de envero y floración en la campaña 2019, de un viñedo de 10 ha situado en Rías Baixas y plantado con la variedad ‘Albariño’. Con estas imágenes se han podido generar mapas térmicos, que dividen el viñedo en zonas en las que las necesidades hídricas de las plantas muestran un comportamiento homogéneo. Se midió el potencial hídrico de tallo en 32 puntos de muestreo repartidos sobre una malla de 30x30 m, realizando las mediciones con una cámara de presión Scholander a mediodía solar. El principal objetivo, es el análisis a partir de la temperatura de vegetación y el Crop Water Stress Index (CWSI), siendo los métodos más utilizados para determinar el estado hídrico del viñedo, que permiten evaluar la respuesta de las imágenes térmicas obtenidas con el dron, con la influencia del estado hídrico de la planta en la producción y calidad de la cosecha final. Según los resultados obtenidos, el empleo de imágenes térmicas resulta un buen indicador del estado hídrico del viñedo, que permite realizar un manejo eficiente del mismo, para poder obtener una cosecha con buenos niveles de producción y calidad.[ENG] The water content in the vineyard is currently a important factor, that affects the production and quality of the harvest, which is increasingly demanding by the consumer. The use of new technologies in the vineyard is increasingly used among winegrowers. The use of drones that have thermal cameras, allow analyzing information regarding the water state of the vineyard throughout the campaign, that being able to establish efficient irrigation systems that provide the plant with water needs at the right time, as well as good management of an input as relevant as water. In the present study, two drone flights have been made close to the dates of ripening and flowering in the 2019 campaign, from a vineyard of 10 ha located in Rias Baixas and planted with ‘Albariño’ variety. With these images it has been posible to generate thermal maps, that show water needs balanced zones. Although, the stem water potential was measured at 32 sampling points spread over a 30x30 m mesh, making the measurements with a Scholander pressure chamber at solar noon. The main objective is the analysis based on the vegetation temperature and the Crop Water Stress Index (CWSI), one of the most widely used methods to determine the water state of the ineyard, which allows evaluating the response of the thermal images obtained with the drone. As well as the influence of the hydric state of the plant on the production and quality of the final harvest. According to the results obtained, the use of thermal images is a good indicator of the water status of the vineyard, which allows efficient management, in order to obtain a harvest with good levels of production and quality.Al proyecto “ALBASOUL” Mar de Frades – Zamora Company

Reseñas

1º RESEÑA de : Gozalbes Cravioto, Enrique. La Ciudad Antigua de Rusadir. Aportaciones a la Historia de Melilla en la Antigüedad. Melilla : Ayuntamiento. Servicio de Publicaciones, 1991. 2º RESEÑA de : Bravo Nieto, Antonio; Moga Romero, Vicente. Melilla, Imágenes de su Historia : Álbum de cromos. Melilla : Ayuntamiento, 1991. 3º RESEÑA de : Moga Romero, Vicente; Rodríguez Picazo, Julia; Reyes López, Amelia. Melilla. Las edades históricas de una ciudad mediterránea : Historia ilustrada de Melilla. Melilla : Ayuntamiento, 1991. 4º RESEÑA de : Carcaño Mas, Francisco. Melilla. Rifeñerías; Las Plazas Menores de África. Melilla : Ayuntamiento, 1991. 5º RESEÑA de : López-Casanova, Arcadio. Razón de Iniquidad. Melilla : Ayuntamiento-UNED, 1991

3D printing of a palladium-alumina cermet monolithic catalyst: catalytic evaluation in microwave-assisted cross-coupling reactions

A straightforward manufacture strategy is proposed to obtain an efficient and robust palladium-alumina (Pd0/Al2O3) cermet monolithic catalyst, specifically designed to perform safe microwave assisted organic synthesis (MAOS). In this approach, a cermet catalyst with high surface area, controlled composition and adapted shape and dimensions to a microwave reactor vessel is generated via 3D printing technology and sintering. The resulting catalyst has been explored in heterogeneous Suzuki, Sonogashira, Stille and Heck cross-coupling reactions, in MAOS. The Pd0 catalyst is permanently active, stable, without leaching and can be recycled and reused at least 200 reaction cycles. The generation of hot spots, sparking or hazardous discharges is controlled by the effective immobilization of the palladium in the monolithic structure during the reaction. The palladium content is forming part of both the internal and external structure, providing greater mechanical resistance and catalytic activity with respect to the basic ceramic material (alumina)This work was financially supported by the Consellería de Cultura, Educación e Ordenación Universitaria of the Galician Government: EM2014/022 to A.C., ED431B2016/028 to F.G. The Strategic Grouping AEMAT grant No. ED431E2018/08 and the Spanish Ministry of Science, Innovation and Universities with grant No: MAT2017-90100-C2-1-P "MA thanks Xunta de Galicia and the ERDF (ED431C 2021/21)"S

The medieval town of Handoga (Djibouti): A report of the 2021 field season

The article presents the results of the first campaign carried out at the medieval site of Handoga (Djibouti) by the StateHorn project, based at the Institute of Heritage Sciences of the Spanish National Research Council. The aim of the campaign was to assess the site's potential in order to launch a long-term project focusing on the study of the town's urbanism and way of life. The campaign included a systematic survey of the site and the excavation of four test pits, which revealed evidence for two archaeological phases at Handoga. The results of the campaign suggest that Handoga was an important urban centre on the medieval routes linking the Gulf of Tadjoura with the interior of Africa, of which very little is known

Utilidad de los mapas de intensidad de señal basados en secuencias de realce tardía 3D para caracterizar el sustrato arritmogénico en pacientes con taquicardía ventricular isquémica

La escara miocárdica constituye el sustrato arritmogénico de los pacientes con TV isquémica. Los mapas de intensidad de señal (IS) obtenidos a partir de mágenes de realce tardío (RT) pueden ser una alternativa no invasiva a los mapas electroanatómicos para estudiar la arquitectura de la escara. El objetivo de este trabajo es describir las características de las escaras observadas en los pacientes (p) con TV isquémicas

Protein profile in chronic myeloproliferative neoplasms (MPN)

Comunicaciones a congreso

HIV coinfection predicts failure of ledipasvir/sofosbuvir in treatment-naïve noncirrhotic patients with HCV genotype

The efficacy of licensed direct-acting antiviral (DAA) regimens is assumed to be the same for hepatitis C virus (HCV)–monoinfected patients (HCV-Mono) and HIV/HCV-coinfected patients (HCV-Co). However, the high sustained viral response (SVR) rates of DAA regimens and the small number of HIV-infected patients included in registration trials have made it difficult to identify predictors of treatment failure, including the presence of HIV. Methods. We compared treatment outcomes for ledipasvir/sofosbuvir (LDV/SOF) against HCV G1 in treatment-naïve HCV-Mono and HCV-Co without cirrhosis in a prospective registry of individuals receiving DAAs for HCV. Results. Up to September 2017, a total of 17 269 patients were registered, and 1358 patients (1055 HCV-Mono/303 HCV-Co) met the inclusion criteria. Significant differences between HCV-Mono and HCV-Co were observed for age, gender, and G1 subtype distribution. Among HCV-Co, 99.0% were receiving antiretroviral therapy. SVR rates for LDV/SOF at 8 weeks did not differ significantly between HCV-Mono and HCV-Co (96.9% vs 94.0%; P = .199). However, the SVR rate for LDV/SOF at 12 weeks was significantly higher for HCV-Mono than HCV-Co (97.2% vs 91.8%; P = .001). A multivariable logistic regression model including age, sex, liver stiffness, G1 subtype, HCV-RNA, HIV, and treatment duration showed the factors associated with treatment failure to be male sex (adjusted odds ratio [aOR], 2.49; 95% confidence interval [CI], 1.27–4.91; P = .008) and HIV infection (aOR, 2.23; 95% CI, 1.13–4.38; P = .020). Conclusions. The results of this large prospective study analyzing outcomes for LDV/SOF against HCV G1 in treatment-naïve noncirrhotic patients suggest that HIV infection is a predictor of treatment failure in patients with chronic hepatitis C.This work was supported by the Spanish AIDS Research Network (RD16/0025/0017), which is included in the Spanish I+D+I Plan and is co-financed by ISCIII-Subdirección General de Evaluacion and European Funding for Regional Development (FEDER), and the Fondo de Investigación de Sanidad en España (FIS)/Instituto de Salud Carlos III (Spanish Health Research Funds; PI17/00657)

Prevalence of dementia and major dementia subtypes in Spanish populations: A reanalysis of dementia prevalence surveys, 1990-2008

Background This study describes the prevalence of dementia and major dementia subtypes in Spanish elderly. Methods We identified screening surveys, both published and unpublished, in Spanish populations, which fulfilled specific quality criteria and targeted prevalence of dementia in populations aged 70 years and above. Surveys covering 13 geographically different populations were selected (prevalence period: 1990-2008). Authors of original surveys provided methodological details of their studies through a systematic questionnaire and also raw age-specific data. Prevalence data were compared using direct adjustment and logistic regression. Results The reanalyzed study population (aged 70 year and above) was composed of Central and North-Eastern Spanish sub-populations obtained from 9 surveys and totaled 12,232 persons and 1,194 cases of dementia (707 of Alzheimer's disease, 238 of vascular dementia). Results showed high variation in age- and sex-specific prevalence across studies. The reanalyzed prevalence of dementia was significantly higher in women; increased with age, particularly for Alzheimer's disease; and displayed a significant geographical variation among men. Prevalence was lowest in surveys reporting participation below 85%, studies referred to urban-mixed populations and populations diagnosed by psychiatrists. Conclusion Prevalence of dementia and Alzheimer's disease in Central and North-Eastern Spain is higher in females, increases with age, and displays considerable geographic variation that may be method-related. People suffering from dementia and Alzheimer's disease in Spain may approach 600,000 and 400,000 respectively. However, existing studies may not be completely appropriate to infer prevalence of dementia and its subtypes in Spain until surveys in Southern Spain are conductedFinancial aid was obtained from the Spanish RECSP C03-09, CIEN C03-06 and CIBERNED networks, and from the Pfizer Foundation in particularS