Is combining massive bone allograft with free vascularized fibular flap the children's reconstruction answer to lower limb defects following bone tumour resection?

SummaryPurpose of the studyBone tumours are frequent conditions in children, and their surgical resection may lead to extensive defects which reconstruction is often challenging. Indeed, local conditions do not promote bone healing, and the achieved surgical result requires to be life-lasting. Capanna suggested a reconstruction technique combining massive allograft and free vascularized fibular flap. The first one is intended to withstand mechanical stress, and the second one offers biological and vascular support to improve bone healing and prevent infections.Materiel and methodsWe report our experience with this technique when applied to the lower limb in a prospective study including seven children, with a mean follow-up of 44 months.ResultsBone healing was achieved by one single procedure in 85.7% of the cases, usually 7 months after surgery. Six out of seven patients achieved a final and long-lasting outcome, five of them following a simple surgical history. Partial weight-bearing was post-operatively allowed at about 2 months, full weight-bearing was initiated at about 5.5 months.DiscussionA low complication rate was reported despite the extent of the disease and the type of the surgical procedure. Capanna's combined reconstructive technique appears very efficient in the management of massive bone defects following tumour resection in children's lower limb.Level of evidenceLevel IV. Retrospective therapeutic study

Some Chemical Aspects of Tetrahydro-1-thiopyran-4-one Derivatives

3,5-Diarylmethylene-2,6-diphenyltetrahydrothiopyran-4-thiones, 2, reacted with two or four moles of bromine to form 3-aryimethylene 5-bromoarylmethylene- 2,6-dipheny1tetrahydrothiopyran- -4-thione, 3, and 3-arylmethylene-5-bromoarylmethylene-2,6-dibromo- 2,6-diphenyltetrahydrothiopyran-4-thione, 5, respectively. Compound 2a reacted with amines giving 2,6-diphenyl-5-iminophenylmethyl- 3-phenylmethylenetetrahydrothiopyran-4-thiones, 6. Diphenydiazomethane and 9-diazofluorene converted 2a into 4-diphenylethylene- 2,6-dipheny1-3,5 diphenylmethylenetetrahydrothiopyran, 7, and 2,6-diphenyl-3,5-diphenylmethylene-4-(9-fluorenylidene) tetrahydrothiopyran, 8, respectively. Compounds 2 with copper-bronze afforded 3,3\u27,5,5\u27-tetraarylmethylene-2,2\u27 ,6,6\u27-tetraphenyl-Lr-thio- 4,4\u27 dipyranylidenes

Electron spectroscopy of carbon materials: Experiment and theory

We present a comparative spectroscopic study of carbon as graphite, diamond and C60 using C1s K-edge electron energy-loss spectroscopy (EELS), X-ray emission spectroscopy, and theoretical modelling. The first principles calculations of these spectra are obtained in the local density approximation using a self-consistent Gaussian basis pseudo-potential method. Calculated spectra show excellent agreement with experiment and are able to discriminate not only between various carbon hybridisations but also local variation in environment. Core-hole effects on the calculated spectra are also investigated. For the first time, the EEL spectrum of carbyne is calculated

A Calibration of NICMOS Camera 2 for Low Count-Rates

NICMOS 2 observations are crucial for constraining distances to most of the existing sample of z > 1 SNe Ia. Unlike the conventional calibration programs, these observations involve long exposure times and low count rates. Reciprocity failure is known to exist in HgCdTe devices and a correction for this effect has already been implemented for high and medium count-rates. However observations at faint count-rates rely on extrapolations. Here instead, we provide a new zeropoint calibration directly applicable to faint sources. This is obtained via inter-calibration of NIC2 F110W/F160W with WFC3 in the low count-rate regime using z ~ 1 elliptical galaxies as tertiary calibrators. These objects have relatively simple near-IR SEDs, uniform colors, and their extended nature gives superior signal-to-noise at the same count rate than would stars. The use of extended objects also allows greater tolerances on PSF profiles. We find ST magnitude zeropoints (after the installation of the NICMOS cooling system, NCS) of 25.296 +- 0.022 for F110W and 25.803 +- 0.023 for F160W, both in agreement with the calibration extrapolated from count-rates 1,000 times larger (25.262 and 25.799). Before the installation of the NCS, we find 24.843 +- 0.025 for F110W and 25.498 +- 0.021 for F160W, also in agreement with the high-count-rate calibration (24.815 and 25.470). We also check the standard bandpasses of WFC3 and NICMOS 2 using a range of stars and galaxies at different colors and find mild tension for WFC3, limiting the accuracy of the zeropoints. To avoid human bias, our cross-calibration was "blinded" in that the fitted zeropoint differences were hidden until the analysis was finalized.Comment: Accepted for Publication in the Astronomical Journal. New version contains added referenc

Rest-Frame R-band Lightcurve of a z~1.3 Supernova Obtained with Keck Laser Adaptive Optics

We present Keck diffraction limited H-band photometry of a z~1.3 Type Ia supernova (SN) candidate, first identified in a Hubble Space Telescope (HST) search for SNe in massive high redshift galaxy clusters. The adaptive optics (AO) data were obtained with the Laser Guide Star facility during four observing runs from September to November 2005. In the analysis of data from the observing run nearest to maximum SN brightness, the SN was found to have a magnitude H=23.9 +/- 0.14 (Vega). We present the H-band (approximately rest-frame R) light curve and provide a detailed analysis of the AO photometric uncertainties. By constraining the aperture correction with a nearby (4" separation) star we achieve 0.14 magnitude photometric precision, despite the spatially varying AO PSF.Comment: 11 pages, 8 figures, Accepted for Publication in AJ Updated the citations, fixed typo

The Hubble Space Telescope Cluster Supernova Survey: V. Improving the Dark Energy Constraints Above z>1 and Building an Early-Type-Hosted Supernova Sample

We present ACS, NICMOS, and Keck AO-assisted photometry of 20 Type Ia supernovae SNe Ia from the HST Cluster Supernova Survey. The SNe Ia were discovered over the redshift interval 0.623 < z < 1.415. Fourteen of these SNe Ia pass our strict selection cuts and are used in combination with the world's sample of SNe Ia to derive the best current constraints on dark energy. Ten of our new SNe Ia are beyond redshift $z=1$, thereby nearly doubling the statistical weight of HST-discovered SNe Ia beyond this redshift. Our detailed analysis corrects for the recently identified correlation between SN Ia luminosity and host galaxy mass and corrects the NICMOS zeropoint at the count rates appropriate for very distant SNe Ia. Adding these supernovae improves the best combined constraint on the dark energy density \rho_{DE}(z) at redshifts 1.0 < z < 1.6 by 18% (including systematic errors). For a LambdaCDM universe, we find \Omega_\Lambda = 0.724 +0.015/-0.016 (68% CL including systematic errors). For a flat wCDM model, we measure a constant dark energy equation-of-state parameter w = -0.985 +0.071/-0.077 (68% CL). Curvature is constrained to ~0.7% in the owCDM model and to ~2% in a model in which dark energy is allowed to vary with parameters w_0 and w_a. Tightening further the constraints on the time evolution of dark energy will require several improvements, including high-quality multi-passband photometry of a sample of several dozen z>1 SNe Ia. We describe how such a sample could be efficiently obtained by targeting cluster fields with WFC3 on HST.Comment: 27 pages, 11 figures. Submitted to ApJ. This first posting includes updates in response to comments from the referee. See http://www.supernova.lbl.gov for other papers in the series pertaining to the HST Cluster SN Survey. The updated supernova Union2.1 compilation of 580 SNe is available at http://supernova.lbl.gov/Unio

Assembly of the Red Sequence in Infrared-Selected Galaxy Clusters from the IRAC Shallow Cluster Survey

We present results for the assembly and star formation histories of massive (~L*) red sequence galaxies in 11 spectroscopically confirmed, infrared-selected galaxy clusters at 1.0 < z < 1.5, the precursors to present-day massive clusters with M ~ 10^15 M_sun. Using rest-frame optical photometry, we investigate evolution in the color and scatter of the red sequence galaxy population, comparing with models of possible star formation histories. In contrast to studies of central cluster galaxies at lower redshift (z < 1), these data are clearly inconsistent with the continued evolution of stars formed and assembled primarily at a single, much-earlier time. Specifically, we find that the colors of massive cluster galaxies at z = 1.5 imply that the bulk of star formation occurred at z ~ 3, whereas by z = 1 their colors imply formation at z ~ 2; therefore these galaxies exhibit approximately the same luminosity-weighted stellar age at 1 < z < 1.5. This likely reflects star formation that occurs over an extended period, the effects of significant progenitor bias, or both. Our results generally indicate that massive cluster galaxy populations began forming a significant mass of stars at z >~ 4, contained some red spheroids by z ~ 1.5, and were actively assembling much of their final mass during 1 < z < 2 in the form of younger stars. Qualitatively, the slopes of the cluster color-magnitude relations are consistent with no significant evolution relative to local clusters.Comment: 24 pages, 9 figures, accepted to Ap

Precision Measurement of The Most Distant Spectroscopically Confirmed Supernova Ia with the Hubble Space Telescope

We report the discovery of a redshift 1.71 supernova in the GOODS North field. The Hubble Space Telescope (HST) ACS spectrum has almost negligible contamination from the host or neighboring galaxies. Although the rest frame sampled range is too blue to include any Si ii line, a principal component analysis allows us to confirm it as a Type Ia supernova with 92% confidence. A recent serendipitous archival HST WFC3 grism spectrum contributed a key element of the confirmation by giving a host-galaxy redshift of 1.713 +/- 0.007. In addition to being the most distant SN Ia with spectroscopic confirmation, this is the most distant Ia with a precision color measurement. We present the ACS WFC and NICMOS 2 photometry and ACS and WFC3 spectroscopy. Our derived supernova distance is in agreement with the prediction of LambdaCDM.Comment: 13 pages, 6 figures, published in ApJ with updated analysi

The Extinction Properties of and Distance to the Highly Reddened Type Ia Supernova SN 2012cu

Correction of Type Ia Supernova brightnesses for extinction by dust has proven to be a vexing problem. Here we study the dust foreground to the highly reddened SN 2012cu, which is projected onto a dust lane in the galaxy NGC 4772. The analysis is based on multi-epoch, spectrophotometric observations spanning 3,300 - 9,200 {\AA}, obtained by the Nearby Supernova Factory. Phase-matched comparison of the spectroscopically twinned SN 2012cu and SN 2011fe across 10 epochs results in the best-fit color excess of (E(B-V), RMS) = (1.00, 0.03) and total-to-selective extinction ratio of (RV , RMS) = (2.95, 0.08) toward SN 2012cu within its host galaxy. We further identify several diffuse interstellar bands, and compare the 5780 {\AA} band with the dust-to-band ratio for the Milky Way. Overall, we find the foreground dust-extinction properties for SN 2012cu to be consistent with those of the Milky Way. Furthermore we find no evidence for significant time variation in any of these extinction tracers. We also compare the dust extinction curve models of Cardelli et al. (1989), O'Donnell (1994), and Fitzpatrick (1999), and find the predictions of Fitzpatrick (1999) fit SN 2012cu the best. Finally, the distance to NGC4772, the host of SN 2012cu, at a redshift of z = 0.0035, often assigned to the Virgo Southern Extension, is determined to be 16.6$\pm$1.1 Mpc. We compare this result with distance measurements in the literature.Comment: 48 pages, 13 figures. Accepted for publication in The Astrophysical Journal. The spectral time series data presented in this article can be found at http://snfactory.lbl.gov/snf/data