Cómo contribuir al cuidado del medio ambiente desde las aulas de educación infantil: Propuesta didáctica.

Este trabajo tiene como objetivo empezar a desarrollar en las aulas de infantil una educación ambiental que contribuya al cuidado del medio ambiente. Para ello en primer lugar se ha profundizado en conceptos como la conciencia ambiental, la problemática ambiental a lo largo de la historia y en la actualidad, introduciendo los ODS. Después se ha llevado a cabo una propuesta didáctica mediante el diseño de una serie de sesiones y actividades con el objetivo de contribuir al medio ambiente y a realizar actividades en nuestros entornos naturales cercanos, teniendo en cuenta el currículo de educacióninfantil en Aragón. <br /

Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer

CDC42 is an oncogenic Rho GTPase overexpressed in colorectal cancer (CRC). Although CDC42 has been shown to regulate gene transcription, the specific molecular mechanisms regulating the oncogenic ability of CDC42 remain unknown. Here, we have characterized the transcriptional networks governed by CDC42 in the CRC SW620 cell line using gene expression analysis. Our results establish that several cancer-related signaling pathways, including cell migration and cell proliferation, are regulated by CDC42. This transcriptional signature was validated in two large cohorts of CRC patients and its clinical relevance was also studied. We demonstrate that three CDC42-regulated genes offered a better prognostic value when combined with CDC42 compared to CDC42 alone. In particular, the concordant overexpression of CDC42 and silencing of the putative tumor suppressor gene CACNA2D2 dramatically improved the prognostic value. The CACNA2D2/CDC42 prognostic classifier was further validated in a third CRC cohort as well as in vitro and in vivo CRC models. Altogether, we show that CDC42 has an active oncogenic role in CRC via the transcriptional regulation of multiple cancer-related pathways and that CDC42-mediated silencing of CACNA2D2 is clinically relevant. Our results further support the use of CDC42 specific inhibitors for the treatment of the most aggressive types of CRCThis work has been supported by grants to JCL from Ministerio de Ciencia e Innovación (SAF2008- 03750, RD06-0020-0016 and RD12/0036/0019) and to DGO Cancer Institute New South Wales (2017/CDF625). FVM is a National Breast Cancer Foundation/Cure Cancer Australia Foundation Postdoctoral Training Fellow

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Radiografía actual de TVE en Aragón: Análisis del modelo analógico de trabajo del centro territorial del ente público en Zaragoza

El centro territorial de Televisión Española en Aragón ha sido un referente mediático desde que comenzó sus emisiones el 6 de julio de 1979. Aunque el centro contó con las más modernas tecnologías, en la actualidad su sistema de trabajo ha quedado desfasado y no llega a adaptarse a la era digital. El presente trabajo analiza cómo se llevan a cabo las labores de información en el centro aragonés ayudándose de una mezcla entre la mecánica analógica y el mundo digital. Una situación que ya no se da en el resto de medios de comunicación

Mujeres extraviadas: psicología y prostitución en la España de postguerra

The brutal economic depression in which post-Civil War Spain sank pushed many women to resort to prostitution as their only means of subsistence. The pro-Franco authorities had annulled the republican abolitionist decree and sexual commerce was again tolerated. Nevertheless, the uncontrolled height of prostitution compelled the authorities to react and special jails for “misled” women were created. We analyze the publications of this postwar period related to the psychology of prostitution by three individuals working in key institutions at the time: Antonio Vallejo Nágera (University of Madrid, National Health Council), Eduardo Martinez Martinez (Penitentiary for Women Psychiatric Clinic) and Francisco J. Echalecu y Canino (Patronage for the Protection of Women). The publications by these three authors and their investigations on Spanish prostitutes led them to characterize these women as innate chronic sexual psychopaths, with mental deficiency and amorality. This diagnosis was used to justify their confinement for reform in special jails for “fallen” women. In this way, the publications by Vallejo, Martinez and Echalecu y Canino were instrumental to justify the establishment of these special jails. The conceptual frame of the biopsychology of German inspiration was used to service the social project of the pro-Franco biopolitics.La brutal depresión económica en que se sumió la España de postguerra empujó a muchas mujeres a recurrir a la prostitución como único medio de subsistencia. Las autoridades franquistas habían anulado el decreto abolicionista republicano por lo que el comercio sexual era tolerado. Sin embargo, el auge incontrolado de la prostitución hizo reaccionar a las autoridades y se establecieron cárceles especiales para prostitutas. En el presente artículo, se analizan los trabajos de postguerra sobre la psicología de la prostitución de tres personajes situados en instituciones claves de la época: Antonio Vallejo Nágera (Universidad de Madrid, Consejo Nacional de Sanidad), Eduardo Martínez Martínez (Clínica Psiquiátrica Penitenciaria de Mujeres) y Francisco J. Echalecu y Canino (Patronato de Protección a la Mujer). Los textos de estos tres autores y sus investigaciones sobre prostitutas españolas les llevan a caracterizarlas como afectas innatas de psicopatía sexual, deficiencia mental y amoralidad. Este diagnóstico les conduce a justificar su internamiento en las cárceles especiales para prostitutas, para reforma. De este modo, los trabajos de Vallejo, Martínez y Echalecu fueron instrumentales para la justificación del establecimiento de las cárceles especiales. El marco conceptual de la biopsicología de inspiración alemana se puso al servicio del proyecto social de la biopolítica franquista

Mujeres extraviadas: psicología y prostitución en la España de postguerra

The brutal economic depression in which post-Civil War Spain sank pushed many women to resort to prostitution as their only means of subsistence. The pro-Franco authorities had annulled the republican abolitionist decree and sexual commerce was again tolerated. Nevertheless, the uncontrolled height of prostitution compelled the authorities to react and special jails for “misled” women were created. We analyze the publications of this postwar period related to the psychology of prostitution by three individuals working in key institutions at the time: Antonio Vallejo Nágera (University of Madrid, National Health Council), Eduardo Martinez Martinez (Penitentiary for Women Psychiatric Clinic) and Francisco J. Echalecu y Canino (Patronage for the Protection of Women). The publications by these three authors and their investigations on Spanish prostitutes led them to characterize these women as innate chronic sexual psychopaths, with mental deficiency and amorality. This diagnosis was used to justify their confinement for reform in special jails for “fallen” women. In this way, the publications by Vallejo, Martinez and Echalecu y Canino were instrumental to justify the establishment of these special jails. The conceptual frame of the biopsychology of German inspiration was used to service the social project of the pro-Franco biopolitics.La brutal depresión económica en que se sumió la España de postguerra empujó a muchas mujeres a recurrir a la prostitución como único medio de subsistencia. Las autoridades franquistas habían anulado el decreto abolicionista republicano por lo que el comercio sexual era tolerado. Sin embargo, el auge incontrolado de la prostitución hizo reaccionar a las autoridades y se establecieron cárceles especiales para prostitutas. En el presente artículo, se analizan los trabajos de postguerra sobre la psicología de la prostitución de tres personajes situados en instituciones claves de la época: Antonio Vallejo Nágera (Universidad de Madrid, Consejo Nacional de Sanidad), Eduardo Martínez Martínez (Clínica Psiquiátrica Penitenciaria de Mujeres) y Francisco J. Echalecu y Canino (Patronato de Protección a la Mujer). Los textos de estos tres autores y sus investigaciones sobre prostitutas españolas les llevan a caracterizarlas como afectas innatas de psicopatía sexual, deficiencia mental y amoralidad. Este diagnóstico les conduce a justificar su internamiento en las cárceles especiales para prostitutas, para reforma. De este modo, los trabajos de Vallejo, Martínez y Echalecu fueron instrumentales para la justificación del establecimiento de las cárceles especiales. El marco conceptual de la biopsicología de inspiración alemana se puso al servicio del proyecto social de la biopolítica franquista