15 research outputs found
Recommended from our members
Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs.
A number of important drugs used to treat cancer-many of which serve as the backbone of modern chemotherapy regimens-have outdated prescribing information in their drug labeling. The Food and Drug Administration is undertaking a pilot project to develop a process and criteria for updating prescribing information for longstanding oncology drugs, based on the breadth of knowledge the cancer community has accumulated with the use of these drugs over time. This article highlights a number of considerations for labeling updates, including selecting priorities for updating; data sources and evidentiary criteria; as well as the risks, challenges, and opportunities for iterative review to ensure prescribing information for oncology drugs remains relevant to current clinical practice
The Galaxy Content of SDSS Clusters and Groups
Imaging data from the Sloan Digital Sky Survey are used to characterize the
population of galaxies in groups and clusters detected with the MaxBCG
algorithm. We investigate the dependence of Brightest Cluster Galaxy (BCG)
luminosity, and the distributions of satellite galaxy luminosity and satellite
color, on cluster properties over the redshift range 0.1 < z < 0.3. The size of
the dataset allows us to make measurements in many bins of cluster richness,
radius and redshift. We find that, within r_200 of clusters with mass above
3e13 h-1 M_sun, the luminosity function of both red and blue satellites is only
weakly dependent on richness. We further find that the shape of the satellite
luminosity function does not depend on cluster-centric distance for magnitudes
brighter than ^{0.25}M_i - 5log(h) < -19. However, the mix of faint red and
blue galaxies changes dramatically. The satellite red fraction is dependent on
cluster-centric distance, galaxy luminosity and cluster mass, and also
increases by ~5% between redshifts 0.28 and 0.2, independent of richness. We
find that BCG luminosity is tightly correlated with cluster richness, scaling
as L_{BCG} ~ M_{200}^{0.3}, and has a Gaussian distribution at fixed richness,
with sigma_{log L} ~ 0.17 for massive clusters. The ratios of BCG luminosity to
total cluster luminosity and characteristic satellite luminosity scale strongly
with cluster richness: in richer systems, BCGs contribute a smaller fraction of
the total light, but are brighter compared to typical satellites. This study
demonstrates the power of cross-correlation techniques for measuring galaxy
populations in purely photometric data.Comment: 22 pages, 14 figures, submitted to Ap
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Recommended from our members
Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs.
A number of important drugs used to treat cancer-many of which serve as the backbone of modern chemotherapy regimens-have outdated prescribing information in their drug labeling. The Food and Drug Administration is undertaking a pilot project to develop a process and criteria for updating prescribing information for longstanding oncology drugs, based on the breadth of knowledge the cancer community has accumulated with the use of these drugs over time. This article highlights a number of considerations for labeling updates, including selecting priorities for updating; data sources and evidentiary criteria; as well as the risks, challenges, and opportunities for iterative review to ensure prescribing information for oncology drugs remains relevant to current clinical practice
Recommended from our members
Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs.
A number of important drugs used to treat cancer-many of which serve as the backbone of modern chemotherapy regimens-have outdated prescribing information in their drug labeling. The Food and Drug Administration is undertaking a pilot project to develop a process and criteria for updating prescribing information for longstanding oncology drugs, based on the breadth of knowledge the cancer community has accumulated with the use of these drugs over time. This article highlights a number of considerations for labeling updates, including selecting priorities for updating; data sources and evidentiary criteria; as well as the risks, challenges, and opportunities for iterative review to ensure prescribing information for oncology drugs remains relevant to current clinical practice