Balanced harvesting can emerge from fishing decisions by individual fishers in a small-scale fishery

Catching fish in proportion to their productivity, termed balanced harvesting, has been suggested as a basis for the ecosystem approach to fishing. Balanced harvesting has been criticized as uneconomical and unachievable because of the level of micromanagement it would require. Here, we investigate the consequences of allowing a fixed number of fishers in a small-scale fishery to choose what size fish to attempt to catch. We examine this from a game-theoretic perspective and test our predictions using an agent-based model for fishers' decisions coupled with a size-spectrum model for the dynamics of a single fish species. We show that small-scale gillnet fishers, operating without size-based regulations, would end up catching small and large fish in proportion to their productivity, in other words balanced harvesting. This is significant because it shows that, far from being unachievable, balanced harvesting can emerge without external intervention under some circumstances. Controls are needed to prevent overfishing, but minimum size regulations alone are not sufficient to achieve this, and actually reduce the sustainable yield by confining fishing to a relatively unproductive part of the size-spectrum. Our findings are particularly relevant for small-scale fisheries in areas where there is poverty and malnutrition because here provision of biomass for food is more important than the market value of the catch

Assessment of worm control practices recommended by equine veterinarians in Australia

This study aimed to assess Australian veterinarians’ knowledge, perceptions and treatment strategies for worm control in horses with an online questionnaire. The questionnaire comprised 64 questions covering various aspects of: (i) veterinary practice; (ii) the veterinarian’s knowledge of gastrointestinal nematodes (GINs) and the importance of parasites in different age groups of horses; (iii) the diagnosis and control of worms; (iv) anthelmintics and anthelmintic resistance (AR); (v) grazing management; and (vi) the means of communication and the discussion between veterinarians and their clients regarding worm control. Following a pilot survey, a link for the questionnaire survey was sent to all (n = 1,148) registered members of Equine Veterinarians Australia in April 2020. The response rate for the questionnaire was 10% (118 of 1,148). The findings of this study illustrate veterinarians’ good understanding of aspects of equine parasites, including control. However, respondents mainly recommended frequent, interval-based prophylactic deworming in young horses, and only 40% (96 of 239) diagnosed GIN infections based on faecal egg count (FEC) results in all age groups of horses. Furthermore, only 27% (88 of 330) of the respondents made deworming decisions based on FECs. Most of the respondents recommended macrocyclic lactones (MLs) for all age groups of horses (71%, 481 of 677), and the most frequently used method to calculate the dose of anthelmintics was by estimating the weight of animals visually (53%, 63 of 118). Although the majority of respondents (97%, 115 of 118) perceived AR to be a critical issue in managing worms in horses, 58% (67 of 118) of them were unaware of the status of AR on their clients’ properties. Forty-two percent (50 of 118) of the respondents perceived the presence of AR in worms, including pinworms (16%), strongylins (15%), species of Draschia and Habronema (6%), Strongyloides westeri (2%) and tapeworms (1%). Twenty-seven percent (32 of 118) of the respondents rarely discussed equine worm control practices with their clients. This study provides insights into the perception and worm control practices recommended by Australian veterinarians to manage equine parasites. The findings highlight the importance of continued education and awareness of AR, and the use of non-chemical methods as well as consideration of the legislation of prescription-only use of anthelmintics based on FECs to achieve sustainable control of GINs in Australian horses

Theoretical study of large conformational transitions in DNA: the B↔A conformational change in water and ethanol/water

We explore here the possibility of determining theoretically the free energy change associated with large conformational transitions in DNA, like the solvent-induced B⇔A conformational change. We find that a combination of targeted molecular dynamics (tMD) and the weighted histogram analysis method (WHAM) can be used to trace this transition in both water and ethanol/water mixture. The pathway of the transition in the A→B direction mirrors the B→A pathway, and is dominated by two processes that occur somewhat independently: local changes in sugar puckering and global rearrangements (particularly twist and roll) in the structure. The B→A transition is found to be a quasi-harmonic process, which follows closely the first spontaneous deformation mode of B-DNA, showing that a physiologically-relevant deformation is in coded in the flexibility pattern of DNA

Institutional Solutions to Precariousness and Inequality in Labour Markets

It has become widely assumed that the standard employment relationship (SER) is in irreversible decline in industrialized societies. However, non-standard and precarious work relationships often complement the SER via labour market transitions, and are not displacing it as the focal point of labour market regulation. The co-ordination and risk management functions of the SER continue to be relevant in market economies, and the SER is adjusting to new conditions. The SER has a complex and evolving relationship to gender and to social stratification. In the European context where the SER originated and achieved its clearest legal expression, institutional solutions to precariousness and inequality are being developed, the most innovative of which avoid simple deregulation in favour of integrated policy responses involving a range of complementary regulatory mechanisms.We are grateful for funding from the Cambridge Political Economy Society TrustThis is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1111/bjir.1210

A systematic molecular dynamics study of nearest-neighbor effects on base pair and base pair step conformations and fluctuations in B-DNA

It is well recognized that base sequence exerts a significant influence on the properties of DNA and plays a significant role in protein–DNA interactions vital for cellular processes. Understanding and predicting base sequence effects requires an extensive structural and dynamic dataset which is currently unavailable from experiment. A consortium of laboratories was consequently formed to obtain this information using molecular simulations. This article describes results providing information not only on all 10 unique base pair steps, but also on all possible nearest-neighbor effects on these steps. These results are derived from simulations of 50–100 ns on 39 different DNA oligomers in explicit solvent and using a physiological salt concentration. We demonstrate that the simulations are converged in terms of helical and backbone parameters. The results show that nearest-neighbor effects on base pair steps are very significant, implying that dinucleotide models are insufficient for predicting sequence-dependent behavior. Flanking base sequences can notably lead to base pair step parameters in dynamic equilibrium between two conformational sub-states. Although this study only provides limited data on next-nearest-neighbor effects, we suggest that such effects should be analyzed before attempting to predict the sequence-dependent behavior of DNA

No caminho para o urbanismo. Saturnino de Brito e Édouard Imbeaux, trajetórias profissionais entre Brasil e França

The aim of this work is to establish a dialogue between the professional trajectories of two engineers: Saturnino de Brito (1864-1929) and Édouard Imbeaux (1861-1943). They both focussed on the city as object of action and reflection based on an innovative knowledge of hygiene and sanitation issues. The specificity of these trajectories is the association of practice, theoretical reflection and dissemination: these two professionals respectively contributed, in their countries, to the construction of Town planning as a discipline, in particular in relation to its technical approach. The international scene is an important dimension of their activity as it made possible the circulation / comparison of technical knowledge between Europe and Brazil and it contributed to find a specific and appropriate response to the problems of the city. The interaction of local, national and international scene allows another perspective of the professional trajectories of Saturnino de Brito and Edouard Imbeaux.O objetivo deste trabalho é estabelecer um diálogo entre duas trajetórias profissionais, a de Saturnino de Brito (1864-1929) e a de Édouard Imbeaux (1861-1943), que privilegiaram a cidade como objeto de ação e de reflexão, as quais são construídas a partir de um conhecimento inovador sobre as questões de higiene e saneamento. A especificidade desses percursos é a associação da prática com a reflexão teórica e sua difusão: estes dois profissionais contribuíram, assim, cada um em seu país, para a construção da disciplina urbanística, especialmente em sua abordagem técnica. O cenário internacional constitui uma dimensão importante de sua ação, que tornou possível a circulação/confronto de saberes técnicos entre Europa e Brasil e contribuiu com a pesquisa de uma resposta concreta e adaptada aos problemas da cidade. A interação do cenário local, nacional e internacional permite trazer um outro olhar sobre as trajetórias profissionais de Saturnino de Brito e Édouard Imbeaux

COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records

BACKGROUND: Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwide linked electronic health records (EHR) using an extensible framework. METHODS: In this cohort study, we used eight linked National Health Service (NHS) datasets for people in England alive on Jan 23, 2020. Data on COVID-19 testing, vaccination, primary and secondary care records, and death registrations were collected until Nov 30, 2021. We defined ten COVID-19 phenotypes reflecting clinically relevant stages of disease severity and encompassing five categories: positive SARS-CoV-2 test, primary care diagnosis, hospital admission, ventilation modality (four phenotypes), and death (three phenotypes). We constructed patient trajectories illustrating transition frequency and duration between phenotypes. Analyses were stratified by pandemic waves and vaccination status. FINDINGS: Among 57 032 174 individuals included in the cohort, 13 990 423 COVID-19 events were identified in 7 244 925 individuals, equating to an infection rate of 12·7% during the study period. Of 7 244 925 individuals, 460 737 (6·4%) were admitted to hospital and 158 020 (2·2%) died. Of 460 737 individuals who were admitted to hospital, 48 847 (10·6%) were admitted to the intensive care unit (ICU), 69 090 (15·0%) received non-invasive ventilation, and 25 928 (5·6%) received invasive ventilation. Among 384 135 patients who were admitted to hospital but did not require ventilation, mortality was higher in wave 1 (23 485 [30·4%] of 77 202 patients) than wave 2 (44 220 [23·1%] of 191 528 patients), but remained unchanged for patients admitted to the ICU. Mortality was highest among patients who received ventilatory support outside of the ICU in wave 1 (2569 [50·7%] of 5063 patients). 15 486 (9·8%) of 158 020 COVID-19-related deaths occurred within 28 days of the first COVID-19 event without a COVID-19 diagnoses on the death certificate. 10 884 (6·9%) of 158 020 deaths were identified exclusively from mortality data with no previous COVID-19 phenotype recorded. We observed longer patient trajectories in wave 2 than wave 1. INTERPRETATION: Our analyses illustrate the wide spectrum of disease trajectories as shown by differences in incidence, survival, and clinical pathways. We have provided a modular analytical framework that can be used to monitor the impact of the pandemic and generate evidence of clinical and policy relevance using multiple EHR sources. FUNDING: British Heart Foundation Data Science Centre, led by Health Data Research UK