9 research outputs found
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined similar to 18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p <5 x 10(-8)) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p <5 x 10(-8)). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling MSRA, EBF2).Peer reviewe
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide geneâsmoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129â913 individuals in stage 1 and follow-up analysis in 480â178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through geneâsmoking interaction analysis and 38 were newly identified (Pâ<â5âĂâ10â8, false discovery rateâ<â0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene-smoking interaction analysis and 38 were newly identified (P <5 x 10(-8), false discovery rate <0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.Peer reviewe
Um soldado na frente de batalha, um cientista no laboratĂłrio. A vanguarda de Aleksandr Rodchenko entre a cultura visual e a cultura polĂtica
Este artigo busca retomar o perĂodo anterior Ă adoção da fotografia como meio artĂstico privilegiado por Aleksandr Rodchenko (1891-1956), por entender que a fotografia significou nĂŁo uma ruptura, mas, ao contrĂĄrio, fez parte de uma experimentação visual mais abrangente que ele conduziu na dĂ©cada de 1920. Busca-se tambĂ©m recolocar esta produção artĂstica dentro da cultura polĂtica com a qual travou um constante e Ăntimo diĂĄlogo. Ao refazer os caminhos que levaram Rodchenko da pintura Ă fotografia, buscamos assim melhor compreender e detalhar o compromisso polĂtico que animou a produção artĂstica da Ă©poca, e a de Rodchenko em particular, entendida entĂŁo como uma prĂĄxis polĂtica e social mais ampla, da qual a fotografia foi uma das partes constitutivas
. 84 (2013) enero-abril. Historias. Revista de la DirecciĂłn de Estudios HistĂłricos
- 1968, un año inolvidable por Eric Hobsbawm. - Una carta de Alfred H. Barr Jr. al editor de College Art Journal porAlfred H. Barr Jr. - Una encuesta sobre las artes lejanas ÂżSe las admitirĂĄ en el Louvre? por FĂ©lix FĂ©nĂ©on. - Fray Francisco XimĂ©nez y el Popol Vuh por Rodrigo MartĂnez Baracs. - La experiencia del orden en las fiestas de Independencia porfirianas de la ciudad de MĂ©xico (1887-1900) por JosĂ© Rodrigo Moreno. - La novela folletinesca y Manuel Payno por JosĂ© JoaquĂn Blanco. - Leer la ausencia: las ciudades de Indias y las Cortes de Castilla, elementos para su estudio (siglos XVI y XVII) por Ăscar MazĂn. - Manifestaciones culturales en las crĂłnicas de los soldados de la conquista de Nueva España por Guillermo Turner R. - La noche de Carlota por Salvador Rueda Smithers. - La empresa elĂ©ctrica por Carlos Marichal. - Retratos de pasiĂłn por Rebeca Monroy Nasr. - De la mina empresa a la regiĂłn por Alma Parra. - CrestomanĂa por JosĂ© Mariano Leyva
Underrepresented Minority High School and College Students Report STEM-Pipeline Sustaining Gains After Participating in the Loma Linda University Summer Health Disparities Research Program
Theories and Documents of Contemporary Art : A Sourcebook of Artists' Writings
Edited by Stiles and Selz, this collection of well known artists' writings and critical texts by North American and European artists/authors draws attention to key moments in the evolution of late-modern art. The texts â manifestos, theoretical essays, interviews, letters, etc. â are placed within one of the following nine categories: Gestural Abstraction; Geometric Abstraction; Figuration; Material Culture and Everyday Life; Art and Technology; Installations, Environments and Sites; Process; Language and Concepts. Includes brief introductions to each chapter. Bibliography. Index. Circa 1300 bibl. ref