Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study

A41 Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study In: Addiction Science & Clinical Practice 2017, 12(Suppl 1): A4

7th Drug hypersensitivity meeting: part two

No abstract availabl

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Paracoccidioidomicose entre o grupo indígena Suruí de Rondônia, Amazônia, Brasil: registro de caso Paracoccidioidoniycosis among the Surui Indians, State of Rondonia, Amazonia, Brazil: a case report

Os Autores apresentam um caso de paracoccidioidomicose em indígena da tribo Suruí, Estado de Rondônia. Trata-se de paciente adulto, sexo masculino, tendo sido o diagnóstico confirmado com base em exame micológico, sorológico e radiográfico. Foi insitituída terapêutica com a associação sulfametoxazol 800 mg + trimetoprima 160 mg a cada 12 horas. A avaliação do paciente realizada seis meses após o início do tratamento revelou melhora no estado geral, regressão do quadro radiológico, negativação da prova de precipitação em tubo capilar e positivação da intradermorcação com paracoccidioidina. Os Autores também revêem os casos de paracoccidioidomicose descritos na região, em particular no que ser refere ao grupo indígena Suruí.<br>The Authors report a case of paracoccidioidomycosis in a Surui Indian patient from the state of Rondonia, Brazilian Amazon. The subject is an adult male, having been diagnosed on the basis of mycologic, Serologic, and radiographic exams. The prescribed therapy was sulfametoxazol 800 mg associated with trimetoprim 160 mg every 12 hours. A revaluation of the patient conducted six months after the beginning of chemotherapy indicated overall improvement of his physical condition and of the radiologic picture, negativeness of the test of precipitin in capillary tube, and positiveness of the skin test with paracoccidioidin. The Authors also reviewed the cases of paracoccidioidomycosis described in the region, especially among the Surui Indian population

Evaluation of a dynamic simulation model for milk production systems Avaliação de modelo dinâmico de simulação de sistemas de produção de leite

The objective of this study was to develop and to evaluate a dynamic simulation model, with stochastic components in order to assess milk production systems. The simulation model was developed by using STELLA 9.0, ZooCalc 1.0 and electronic data sheets. The physical structure of the herd was divided into 15 interlinked modules that represented categories or subdivisions of categories. Mathematical models obtained from the literature were used to simulate the body weight of growing and lactating animals and milk production and milk composition. Electronic data sheets were used to calculate the nutritional requirements and dietary balance. After cost minimization, each feed was evaluated by using ZooCalc 1.0. Some average responses of farm size, zootechnical and economic index, the change in the area used for com silage production, the calving interval and age at first insemination were obtained to evaluate whether the simulation model was working consistently with the expected. To assess the capacity of the model to gene rate simulated values that approach reality, the degree of linear association was measured between the values generated by the model and the values observed in practice. Sensitivity analyses showed that the values produced by the simulation model were in agreement with the expected results, in response to changes in the area of com crop used for com silage production, the calving interval and the age at first insemination. There was correlation between the values generated by the simulation model and the values observed in practice and the degree of linear association for the variables could be considered high.<br>Objetivou-se desenvolver e avaliar um modelo dinâmico de simulação com componentes estocásticos para avaliação de sistemas de produção de leite. O modelo de simulação foi desenvolvido utilizando-se os programas STELLA 9.0, ZooCalc 1.0 e planilhas eletrónicas. A estrutura física do rebanho foi dividida em 15 módulos interligados, que representam categorias ou subdivisões de categorias. Para simulação do peso corporal dos animals em crescimento e em lactação, assim como da produção e composição do leite, foram utilizados modelos matemáticos obtidos na literatura e, para cálculo de exigências nutricionais e balanceamento das dietas dos animals, planilhas eletrónicas. Após a redução do custo, cada ração foi avaliada pelo programa ZooCalc 1.0. Para avaliar se o modelo de simulação estaria funcionando de forma coerente com o esperado, foram obtidas as respostas médias de alguns indicadores de tamanho, de indicadores zootécnicos e económicos e a variação da área utilizada para produção de milho para silagem, do intervalo de partos e da idade à primeira inseminação. Para avaliar a capacidade do modelo em gerar valores simulados que se aproximem da realidade, foi medido o grau de associação linear entre os valores gerados pelo modelo e observados em situação prática. As análises de sensibilidade comprovaram que os valores produzidos pelo modelo de simulação se comportam de acordo com o esperado, em resposta às variações da área utilizada para produção de milho para silagem, do intervalo de partos e da idade à primeira inseminação. Existe correlação entre os valores gerados pelo modelo de simulação e os observados na prática, e o grau de associação linear pode ser considerado elevado