810 research outputs found
A numerical study of two-photon ionization of helium using the Pyprop framework
Few-photon induced breakup of helium is studied using a newly developed ab
initio numerical framework for solving the six-dimensional time-dependent
Schroedinger equation. We present details of the method and calculate
(generalized) cross sections for the process of two-photon nonsequential
(direct) double ionization at photon energies ranging from 39.4 to 54.4 eV, a
process that has been very much debated in recent years and is not yet fully
understood. In particular, we have studied the convergence property of the
total cross section in the vicinity of the upper threshold (54.4 eV), versus
the pulse duration of the applied laser field. We find that the cross section
exhibits an increasing trend near the threshold, as has also been observed by
others, and show that this rise cannot solely be attributed to an unintended
inclusion of the sequential two-photon double ionization process, caused by the
bandwidth of the applied field.Comment: 7 pages, 3 figure
Recognizability bias in citizen science photographs
Citizen science and automated collection methods increasinglydepend on image recognition to provide the amountsof observational data research and management needs.Recognition models, meanwhile, also require large amounts ofdata from these sources, creating a feedback loop between themethods and tools. Species that are harder to recognize, bothfor humans and machine learning algorithms, are likely to beunder-reported, and thus be less prevalent in the trainingdata. As a result, the feedback loop may hamper trainingmostly for species that already pose the greatest challenge. Inthis study, we trained recognition models for various taxa, andfound evidence for aârecognizability biasâ, where species thatare more readily identified by humans and recognitionmodels alike are more prevalent in the available image data.This pattern is present across multiple taxa, and does notappear to relate to differences in picture quality, biologicaltraits or data collection metrics other than recognizability. Thishas implications for the expected performance of futuremodels trained with more data, including such challenging species. citizen science, image recognition, machinelearning, recognizability, artificial intelligence/environmental science/ecology, Ecology, conservation and global change biologypublishedVersio
Long-term glycaemic control with metforminâ sulphonylureaâpioglitazone triple therapy in PROactive (PROactive 17)
peer reviewedAims We assessed the long-term glycaemic effects and the safety profile of triple therapy with the addition of pioglitazone vs. placebo in patients with Type 2 diabetes treated with combined metforminâsulphonylurea therapy in the PROspective pioglitAzone Clinical Trial In macroVascular Events (PROactive).
Methods In a post-hoc analysis, we identified patients treated with metformin plus sulphonylurea combination therapy and not receiving insulin at baseline (n = 1314). In those patients, we compared the effects of pioglitazone (force-titrated to 45 mgâ day, n = 654) vs. placebo (n = 660) on glycated haemoglobin (HbA1c) reduction, concomitant changes in medications
and initiation of permanent insulin use (defined as daily insulin use for a period of ⥠90 days or ongoing use at death â final visit).
Results Significantly greater reductions in HbA1c and greater proportions of patients with HbA1c at target were noted with pioglitazone vs, placebo, despite a decrease in the use of other oral glucose-lowering agents. Therewas an approximate twofold increase in progression to permanent insulin use in the placebo group vs. the pioglitazone group: 31.1 vs. 16.1%, respectively,
when added to combination therapy. The overall safety of themetforminâsulphonylureaâpioglitazone triple therapy was good.
Conclusions Intensifying an existing dual oral therapy regimen to a triple oral regimen by adding pioglitazone to the classical metforminâsulphonylurea combination resulted in sustained improvements in glycaemic control and reduced progression to insulin therapy. The advantages and disadvantages of adding pioglitazone instead of adding basal insulin should be assessed
further
Quantum Chessboards in the Deuterium Molecular Ion
We present a new algorithm for vibrational control in deuterium molecules
that is feasible with current experimental technology. A pump mechanism is used
to create a coherent superposition of the D2+ vibrations. A short, intense
infrared control pulse is applied after a chosen delay time to create selective
interferences. A `chessboard' pattern of states can be realized in which a set
of even- or odd-numbered vibrational states can be selectively annihilated or
enhanced. A technique is proposed for experimental realization and observation
of this effect using 5 fs pulses of 790 nm radiation, with intermediate
intensity (5e13 W/cm2)Comment: 12 pages, 5 figure
Quantum effects on Lagrangian points and displaced periodic orbits in the Earth-Moon system
Recent work in the literature has shown that the one-loop long distance quantum corrections to the Newtonian potential imply tiny but observable effects in the restricted three-body problem of celestial mechanics, i.e., at the Lagrangian libration points of stable equilibrium the planetoid is not exactly at equal distance from the two bodies of large mass, but the Newtonian values of its coordinates are changed by a few millimeters in the Earth-Moon system. First, we assess such a theoretical calculation by exploiting the full theory of the quintic equation, i.e., its reduction to Bring-Jerrard form and the resulting expression of roots in terms of generalized hypergeometric functions. By performing the numerical analysis of the exact formulas for the roots, we confirm and slightly improve the theoretical evaluation of quantum corrected coordinates of Lagrangian libration points of stable equilibrium. Second, we prove in detail that also for collinear Lagrangian points the quantum corrections are of the same order of magnitude in the Earth-Moon system. Third, we discuss the prospects to measure, with the help of laser ranging, the above departure from the equilateral triangle picture, which is a challenging task. On the other hand, a modern version of the planetoid is the solar sail, and much progress has been made, in recent years, on the displaced periodic orbits of solar sails at all libration points, both stable and unstable. The present paper investigates therefore, eventually, a restricted three-body problem involving Earth, Moon and a solar sail. By taking into account the one-loop quantum corrections to the Newtonian potential, displaced periodic orbits of the solar sail at libration points are again found to exist
Observation of confined current ribbon in JET plasmas
we report the identification of a localised current structure inside the JET
plasma. It is a field aligned closed helical ribbon, carrying current in the
same direction as the background current profile (co-current), rotating
toroidally with the ion velocity (co-rotating). It appears to be located at a
flat spot in the plasma pressure profile, at the top of the pedestal. The
structure appears spontaneously in low density, high rotation plasmas, and can
last up to 1.4 s, a time comparable to a local resistive time. It considerably
delays the appearance of the first ELM.Comment: 10 pages, 6 figure
Predictors of survival after total laryngectomy for recurrent/persistent laryngeal squamous cell carcinoma
BackgroundTotal laryngectomy remains the treatment of choice for recurrent/persistent laryngeal squamous cell carcinoma (SCC) after radiotherapy (RT) or chemoradiotherapy (CRT). However, despite attempts at aggressive surgical salvage, survival in this cohort remains suboptimal.MethodsA prospectively maintained singleâinstitution database was queried for patients undergoing total laryngectomy for recurrent/persistent laryngeal SCC after initial RT/CRT between 1998 and 2015(n = 244). Demographic, clinical, and survival data were abstracted. The KaplanâMeier survival curves and hazard ratios (HRs) were calculated.ResultsFiveâyear overall survival (OS) was 49%. Fiveâyear diseaseâfree survival (DFS) was 58%. Independent predictors of OS included severe comorbidity (Adult Comorbidity Evaluationâ27 [ACEâ27] scale; HR 3.76; 95% confidence interval [CI] 1.56â9.06), and positive recurrent clinical nodes (HR 2.91; 95% CI 1.74â4.88).ConclusionSevere comorbidity status is the strongest predictor of OS, suggesting that increased attention to mitigating competing risks to health is critical. These data may inform a risk prediction model to allow for focused shared decision making, preoperative health optimization, and patient selection for adjuvant therapies.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139972/1/hed24918.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139972/2/hed24918_am.pd
Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men
<p>Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hbmass) and maximal oxygen uptake (vË O2 max).</p>
<p>Purpose: This study defined the time course of changes in Hbmass, vË O2 max as well as running time trial performance
following 4 weeks of rHuEpo administration to determine whether the laboratory observations would translate into actual
improvements in running performance in the field.</p>
<p>Methods: 19 trained men received rHuEpo injections of 50 IUNkg21 body mass every two days for 4 weeks. Hbmass was
determined weekly using the optimized carbon monoxide rebreathing method until 4 weeks after administration. vË O2 max
and 3,000 m time trial performance were measured pre, post administration and at the end of the study.</p>
<p>Results: Relative to baseline, running performance significantly improved by ,6% after administration (10:3061:07 min:sec
vs. 11:0861:15 min:sec, p,0.001) and remained significantly enhanced by ,3% 4 weeks after administration
(10:4661:13 min:sec, p,0.001), while vË O2 max was also significantly increased post administration
(60.765.8 mLNmin21Nkg21 vs. 56.066.2 mLNmin21Nkg21, p,0.001) and remained significantly increased 4 weeks after
rHuEpo (58.065.6 mLNmin21Nkg21, p = 0.021). Hbmass was significantly increased at the end of administration compared to
baseline (15.261.5 gNkg21 vs. 12.761.2 gNkg21, p,0.001). The rate of decrease in Hbmass toward baseline values post
rHuEpo was similar to that of the increase during administration (20.53 gNkg21Nwk21, 95% confidence interval (CI) (20.68,
20.38) vs. 0.54 gNkg21Nwk21, CI (0.46, 0.63)) but Hbmass was still significantly elevated 4 weeks after administration
compared to baseline (13.761.1 gNkg21, p<0.001).</p>
<p>Conclusion: Running performance was improved following 4 weeks of rHuEpo and remained elevated 4 weeks after
administration compared to baseline. These field performance effects coincided with rHuEpo-induced elevated vË O2 max and
Hbmass.</p>
Integrated Genomic Analysis of the 8q24 Amplification in Endometrial Cancers Identifies ATAD2 as Essential to MYC-Dependent Cancers
Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC. To explore the roles of the genes most frequently included in 8q24 amplifications, we analyzed the relation between copy number alterations and gene expression in three sets of endometrial cancers (N = 252); and in glioblastoma, ovarian, and breast cancers profiled by TCGA. Among the genes neighbouring MYC, expression of the bromodomain-containing gene ATAD2 was the most associated with amplification. Bromodomain-containing genes have been implicated as mediators of MYC transcriptional function, and indeed ATAD2 expression was more closely associated with expression of genes known to be upregulated by MYC than was MYC itself. Amplifications of 8q24, expression of genes downstream from MYC, and overexpression of ATAD2 predicted poor outcome and increased from primary to metastatic lesions. Knockdown of ATAD2 and MYC in seven endometrial and 21 breast cancer cell lines demonstrated that cell lines that were dependent on MYC also depended upon ATAD2. These same cell lines were also the most sensitive to the histone deacetylase (HDAC) inhibitor Trichostatin-A, consistent with prior studies identifying bromodomain-containing proteins as targets of inhibition by HDAC inhibitors. Our data indicate high ATAD2 expression is a marker of aggressive endometrial cancers, and suggest specific inhibitors of ATAD2 may have therapeutic utility in these and other MYC-dependent cancers
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