Collective modes of coupled phase oscillators with delayed coupling

We study the effects of delayed coupling on timing and pattern formation in spatially extended systems of dynamic oscillators. Starting from a discrete lattice of coupled oscillators, we derive a generic continuum theory for collective modes of long wavelength. We use this approach to study spatial phase profiles of cellular oscillators in the segmentation clock, a dynamic patterning system of vertebrate embryos. Collective wave patterns result from the interplay of coupling delays and moving boundary conditions. We show that the phase profiles of collective modes depend on coupling delays.Comment: 5 pages, 2 figure

Speech into Sign Language Statistical Translation System for Deaf People

This paper presents a set of experiments used to develop a statistical system from translating speech to sign language for deaf people. This system is composed of an Automatic Speech Recognition (ASR) system, followed by a statistical translation module and an animated agent that represents the different signs. Two different approaches have been used to perform the translations: a phrase-based system and a finite state transducer. For the evaluation, the followings figures have been considered: WER (Word Error Rate), BLEU and NIST. The paper presents translation results of reference sentences and sentences from the automatic speech recognizer. Also three different configurations have been evaluated for the speech recognizer. The best results were obtained with the finite state transducer, with a word error rate of 28.21% for the reference text, and 29.27% using the ASR output

Hunting long-lived gluinos at the Pierre Auger Observatory

Eventual signals of split sypersymmetry in cosmic ray physics are analyzed in detail. The study focusses particularly on quasi-stable colorless R-hadrons originating through confinement of long-lived gluinos (with quarks, anti-quarks, and gluons) produced in pp collisions at astrophysical sources. Because of parton density requirements, the gluino has a momentum which is considerable smaller than the energy of the primary proton, and so production of heavy (mass ~ 500 GeV) R-hadrons requires powerful cosmic ray engines able to accelerate particles up to extreme energies, somewhat above 10^{13.6} GeV. Using a realistic Monte Carlo simulation with the AIRES engine, we study the main characteristics of the air showers triggered when one of these exotic hadrons impinges on a stationary nucleon of the Earth atmosphere. We show that R-hadron air showers present clear differences with respect to those initiated by standard particles. We use this shower characteristics to construct observables which may be used to distinguish long-lived gluinos at the Pierre Auger Observatory.Comment: 13 pages revtex, 9 eps figures. A ps version with high resolution figures is available at http://www.hep.physics.neu.edu/staff/doqui/rhadron_highres.p

The MIDAS experiment: A prototype for the microwave emission of Ultra-High Energy Cosmic Rays

Recent measurements suggest that extensive air showers initiated by ultra-high energy cosmic rays (UHECR) emit signals in the microwave band of the electromagnetic spectrum caused by the collisions of the free-electrons with the atmospheric neutral molecules in the plasma produced by the passage of the shower. Such emission is isotropic and could allow the detection of air showers with 100% duty cycle and a calorimetric-like energy measurement, a significant improvement over current detection techniques. We have built MIDAS (MIcrowave Detection of Air Showers), a prototype of microwave detector, which consists of a 4.5 m diameter antenna with a cluster of 53 feed-horns in the 4 GHz range. The details of the prototype and first results will be presented.Comment: To appear in the proceedings of 12th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD10), Siena, Italy, 7 - 10 June 201

The MIDAS telescope for microwave detection of ultra-high energy cosmic rays

We present the design, implementation and data taking performance of the MIcrowave Detection of Air Showers (MIDAS) experiment, a large field of view imaging telescope designed to detect microwave radiation from extensive air showers induced by ultra-high energy cosmic rays. This novel technique may bring a tenfold increase in detector duty cycle when compared to the standard fluorescence technique based on detection of ultraviolet photons. The MIDAS telescope consists of a 4.5 m diameter dish with a 53-pixel receiver camera, instrumented with feed horns operating in the commercial extended C-Band (3.4 -- 4.2 GHz). A self-trigger capability is implemented in the digital electronics. The main objectives of this first prototype of the MIDAS telescope - to validate the telescope design, and to demonstrate a large detector duty cycle - were successfully accomplished in a dedicated data taking run at the University of Chicago campus prior to installation at the Pierre Auger Observatory.Comment: 13 pages, 18 figure

The Air Microwave Yield (AMY) experiment - A laboratory measurement of the microwave emission from extensive air showers

The AMY experiment aims to measure the microwave bremsstrahlung radiation (MBR) emitted by air-showers secondary electrons accelerating in collisions with neutral molecules of the atmosphere. The measurements are performed using a beam of 510 MeV electrons at the Beam Test Facility (BTF) of Frascati INFN National Laboratories. The goal of the AMY experiment is to measure in laboratory conditions the yield and the spectrum of the GHz emission in the frequency range between 1 and 20 GHz. The final purpose is to characterise the process to be used in a next generation detectors of ultra-high energy cosmic rays. A description of the experimental setup and the first results are presented.Comment: 3 pages -- EPS-HEP'13 European Physical Society Conference on High Energy Physics (July, 18-24, 2013) at Stockholm, Swede

Non-conventional yeasts as hosts for heterologous protein production

Creative Commons-Attribution-Non-Commercial-Share Alike 3.0 Spain.-- et al.Yeasts are an attractive group of lower eukaryotic microorganisms, some of which are used in several industrial processes that include brewing, baking and the production of a variety of biochemical compounds. More recently, yeasts have been developed as host organisms for the production of foreign (heterologous) proteins. Saccharomyces ccrevisiae has usually been the yeast of choice, but an increasing number of alternative non-Saccharomyces yeasts has now become accessible for modern molecular genetics techniques. Some of them exhibit certain favourable traits such as high-level secretion or very strong and tightly regulated promoters, offering significant advantages over traditional bakers' yeast. In the present work, the current status of Kluyveromyces lactis, Yarrowia lipolytica, Hansennla polymorpha and Picliia pastoris (the best-known alternative yeast systems) is reviewed. The advantages and limitations of these systems are discussed in relation to S. cerevisiae. © Springer-Verlag 1998.This work was partially supported by grants from the CICYT (BIO92-0304 and BIO 95-0518) and EU (BIO4-CT96-0003).Peer Reviewe

Non-conventional yeasts as hosts for heterologous protein production.

Yeasts are an attractive group of lower eukaryotic microorganisms, some of which are used in several industrial processes that include brewing, baking and the production of a variety of biochemical compounds. More recently, yeasts have been developed as host organisms for the production of foreign (heterologous) proteins. Saccharomyces cerevisiae has usually been the yeast of choice, but an increasing number of alternative non-Saccharomyces yeasts has now become accessible for modern molecular genetics techniques. Some of them exhibit certain favourable traits such as high-level secretion or very strong and tightly regulated promoters, offering significant advantages over traditional bakers' yeast. In the present work, the current status of Kluyveromyces lactis, Yarrowia lipolytica, Hansenula polymorpha and Pichia pastoris (the best-known alternative yeast systems) is reviewed. The advantages and limitations of these systems are discussed in relation to S. cerevisiae.Spanish Society for Microbiolog

Catálogo de monumentos megalíticos en Navarra. Homenaje a Francisco Ondarra (1925-2005)

Este trabajo pretende llenar el vacío que existe actualmente en relación con el megalitismo de esta región. Se da a conocer un catálogo actualizado, de más de 1500 megalitos, resultado de una prospección y revisión de datos intensa llevada a cabo por los firmantes del mismo durante años. El listado que aquí se incluye es paso previo a la publicación individualizada de las fichas de todos estos monumentos, como contribución a la Carta Arqueológica de Navarra

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions develop in the mouse thymus, but the factors driving their differentiation remain unclear. Here we show that hypomorphic alleles of Zap70 or chemical inhibition of Zap70 catalysis leads to an increase of IFN-gamma-producing iNKT cells (NKT1 cells), suggesting that NKT1 cells may require a lower TCR signal threshold. Zap70 mutant mice develop IL-17-dependent arthritis. In a mouse experimental arthritis model, NKT17 cells are increased as the disease progresses, while NKT1 numbers negatively correlates with disease severity, with this protective effect of NKT1 linked to their IFN-gamma expression. NKT1 cells are also present in the synovial fluid of arthritis patients. Our data therefore suggest that TCR signal strength during thymic differentiation may influence not only IFN-gamma production, but also the protective function of iNKT cells in arthritis