2,154 research outputs found

    Adoption of innovation in agriculture:A critical review of economic and psychological models

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    Two main models have been used to analyse farmers’ decisions toadopt an innovation; the first is based on the concept of utility maximisation(UM) and the second is based on the theory of planned behaviour (TPB). Thisstudy uses a vote-count method to identify the effect of different variables onfarmers’ adoption decisions in 36 studies using either UM or the TPB. Resultsfrom the UM studies show that the explanatory variables mostly have aninsignificant effect on the adoption decision. When the effects are significant,the sign of the effect is inconsistent across studies. Results from the TPBstudies show that correlations between the psychological constructs used in thistype of model are significant in most cases. However, most variables are onlyused in one or two studies and it is therefore no

    Inhibition of Asaia in adult mosquitoes causes male-specific mortality and diverse transcriptome changes

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    Mosquitoes can transmit many infectious diseases, such as malaria, dengue, Zika, yellow fever, and lymphatic filariasis. Current mosquito control strategies are failing to reduce the severity of outbreaks that still cause high human morbidity and mortality worldwide. Great expectations have been placed on genetic control methods. Among other methods, genetic modification of the bacteria colonizing different mosquito species and expressing anti-pathogen molecules may represent an innovative tool to combat mosquito-borne diseases. Nevertheless, this emerging approach, known as paratransgenesis, requires a detailed understanding of the mosquito microbiota and an accurate characterization of selected bacteria candidates. The acetic acid bacteria Asaia is a promising candidate for paratransgenic approaches. We have previously reported that Asaia symbionts play a beneficial role in the normal development of Anopheles mosquito larvae, but no study has yet investigated the role(s) of Asaia in adult mosquito biology. Here we report evidence on how treatment with a highly specific anti-Asaia monoclonal antibody impacts the survival and physiology of adult Anopheles stephensi mosquitoes. Our findings offer useful insight on the role of Asaia in several physiological systems of adult mosquitoes, where the influence differs between males and females

    Elastic scattering, inelastic excitation, and neutron transfer for Li 7 + Sn 120 at energies around the Coulomb barrier

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    Experimental angular distributions for the 7 Li + 120 Sn elastic and inelastic (projectile and target excitations) scattering, and for the neutron stripping reaction, have been obtained at E LAB = 20, 22, 24, and 26 MeV, covering an energy range around the Coulomb barrier ( V (LAB) B ≈ 21 . 4 MeV). Coupled channel and coupled reaction channel calculations were performed and both describe satisfactorily the experimental data sets. The 1 2 − state 7 Li inelastic excitation (using a rotational model), as well as the projectile coupling to the continuum ( α plus a tritium particle) play a fundamental role on the proper description of elastic, inelastic, and transfer channels. Couplings to the one-neutron stripping channel do not significantly affect the theoretical elastic scattering angular distributions. The spectroscopic amplitudes of the transfer channel were obtained through a shell model calculation. The theoretical angular distributions for the one-neutron stripping reaction agreed with the experimental data

    Parsec-scale Properties of Brightest Cluster Galaxies

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    We present new VLBI observations at 5 GHz of a complete sample of Brightest Cluster Galaxies (BCGs) in nearby Abell Clusters (distance class <3). Combined with data from the literature, this provides parsec-scale information for 34 BCGs. Our analysis of their parsec scale radio emission and cluster X-ray properties shows a possible dichotomy between BCGs in cool core clusters and those in non cool core clusters. Among resolved sources, those in cool core clusters tend to have two-sided parsec-scale jets, while those in less relaxed clusters have predominantly one-sided parsec-scale jets. We suggest that this difference could be the result of interplay between the jets and the surrounding medium. The one-sided structure in non cool core clusters could be due to Doppler boosting effects in relativistic, intrinsically symmetric jets; two-sided morphology in cool core clusters is likely related to the presence of heavy and mildly relativistic jets slowed down on the parsec-scale. Evidence of recurrent activity are also found in BCGs in cool core clusters.Comment: 20 pages, 10 figures, accepted for publication in A&

    The parsec-scale properties of the radio galaxy 4C 26.42 in the dense cooling core cluster A1795

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    The aim of the present work is to study the radio emission on the parsec scale of 4C 26.42, the Brightest cluster galaxy in Abell 1795, in the framework of radiosources in a dense cool core cluster. We present Very Long Baseline Array (VLBA) observations at 1.6, 5, 8.4 and 22 GHz. We performed a spectral index and multiepoch analysis. The source appears two-sided with a well defined and symmetric Z-structure at ~5 mas from the core. The kiloparsec-scale morphology is similar to the parsec-scale structure, but reversed in P.A., with symmetric 90 deg. bends at about 2 arcsec from the nuclear region. Comparing data obtained at 3 different epochs we derive a 3σ\sigma limit to the apparent proper motion of βa\beta_a < 0.04. We suggest that the parsec-scale jets are sub-relativistic, in contrast with the high velocities found for most low-power radio galaxies. The origin of the unusual radio morphology remains a puzzle. We suggest that the identification of the parent galaxy with the central cD in a cooling cluster plays an important role in the properties and structure of the jets.Comment: 8 pages, 4 figures, 4 tables, Accepted for pubblication in Astronomy & Astrophysic

    Unique genomic profile of fibrolamellar hepatocellular carcinoma

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    BACKGROUND & AIMS: Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer that develops in children and young adults without cirrhosis. Little is known about its pathogenesis, and it can be treated only with surgery. We performed an integrative genomic analysis of a large series of patients with FLC to identify associated genetic factors. METHODS: By using 78 clinically annotated FLC samples, we performed whole-transcriptome (n = 58), single-nucleotide polymorphism array (n = 41), and next-generation sequencing (n = 48) analyses; we also assessed the prevalence of the DNAJB1-PRKACA fusion transcript associated with this cancer (n = 73). We performed class discovery using non-negative matrix factorization, and functional annotation using gene-set enrichment analyses, nearest template prediction, ingenuity pathway analyses, and immunohistochemistry. The genomic identification of significant targets in a cancer algorithm was used to identify chromosomal aberrations, MuTect and VarScan2 were used to identify somatic mutations, and the random survival forest was used to determine patient prognoses. Findings were validated in an independent cohort. RESULTS: Unsupervised gene expression clustering showed 3 robust molecular classes of tumors: the proliferation class (51% of samples) had altered expression of genes that regulate proliferation and mammalian target of rapamycin signaling activation; the inflammation class (26% of samples) had altered expression of genes that regulate inflammation and cytokine enriched production; and the unannotated class (23% of samples) had a gene expression signature that was not associated previously with liver tumors. Expression of genes that regulate neuroendocrine function, as well as histologic markers of cholangiocytes and hepatocytes, were detected in all 3 classes. FLCs had few copy number variations; the most frequent were focal amplification at 8q24.3 (in 12.5% of samples), and deletions at 19p13 (in 28% of samples) and 22q13.32 (in 25% of samples). The DNAJB1-PRKACA fusion transcript was detected in 79% of samples. FLC samples also contained mutations in cancer-related genes such as BRCA2 (in 4.2% of samples), which are uncommon in liver neoplasms. However, FLCs did not contain mutations most commonly detected in liver cancers. We identified an 8-gene signature that predicted survival of patients with FLC. CONCLUSIONS: In a genomic analysis of 78 FLC samples, we identified 3 classes based on gene expression profiles. FLCs contain mutations and chromosomal aberrations not previously associated with liver cancer, and almost 80% contain the DNAJB1-PRKACA fusion transcript. By using this information, we identified a gene signature that is associated with patient survival time
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