The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Time Series Analysis of Individual Music Therapy in Dementia: Effects on Communication Behavior and Emotional Well-being

Abstract. This pilot study evaluated the effects of individual music therapy on communication behavior and emotional well-being in persons with advanced dementia. Contrary to more common qualitative designs in dementia-related music therapy research, we used time series analysis of videographed music therapy sessions. This quantitative statistical method for modeling and explaining time-dependent processual data has not been employed in this research area before. Based on aggregated time series data, the results showed positive and statistically significant intervention effects on participants’ communication behavior, situational well-being, and their expression of positive emotions. The study results indicate that, by choosing appropriate outcomes, video-based time series analysis is sensitive and well suited to displaying the effects of music therapy in dementia care. (PsycINFO Database Record (c) 2016 APA, all rights reserved

The Psychosocial and Physiological Effects of Choir-Singing in People with Dementia

<jats:p> Abstract: We conducted a pilot study to assess the expected effects of regular choir-singing in persons with dementia. We measured psychosocial and physiological outcomes in the 19 choir members ( M<jats:sub>age</jats:sub> = 76.95) with mild-to-moderate dementia. We evaluated the weekly choir rehearsals individually (situational measurements) and overall (pre-/posttests). Our data suggested significant increases in emotional well-being during the choir sessions and significant reductions in cortisol levels in saliva as an indicator of stress. Observations by the caregiving relatives confirmed the positive influence of choir-singing on participants’ emotional and communication behavior. The results of the pilot study reveal the therapeutic potential of choir-based music interventions in persons with dementia and show that these effects can be demonstrated in community-based singing programs. </jats:p&gt

Attitudes Toward People with Dementia in Germany and China

<jats:p> Abstract: Attitudes toward people with dementia influence how these patients are treated. Knowledge of intercultural differences in attitudes enables specific concepts of care. We validated the Dementia Attitudes Scale (DAS) for Mandarin Chinese to gather preliminary data on differences between Germany and China. Internal consistency was good for both versions of the DAS (Cronbach’s alpha > 0.7). Principal component analysis revealed three main components in each country, along with slight differences in composition. The study revealed differences in attitudes toward people with dementia, but it is unclear whether this reflects cultural influences, differences in healthcare structures, or personal experience. Future studies should address these factors to improve care for people with dementia in a culturally sensitive manner. </jats:p&gt

Tuning Patchy Bonds Induced by Critical Casimir Forces

Experimental control of patchy interactions promises new routes for the assembly of complex colloidal structures, but remains challenging. Here, we investigate the role of patch width in the assembly of patchy colloidal particles assembled by critical Casimir forces. The particles are composed of a hydrophobic dumbbell with an equatorial hydrophilic polymer shell, and are synthesized to have well-defined patch-to-shell area ratios. Patch-to-patch binding is achieved in near-critical binary solvents, in which the particle interaction strength and range are controlled by the temperature-dependent solvent correlation length. Upon decreasing the patch-to-shell area ratio, we observe a pronounced change of the bonding morphology towards directed single-bonded configurations, as clearly reflected in the formation of chain-like structures. Computer simulations using an effective critical Casimir pair potential for the patches show that the morphology change results from the geometric exclusion of the increasingly thick hydrophilic particle shells. These results highlight the experimental control of patchy interactions through the engineering of the building blocks on the way towards rationally designed colloidal superstructures

Tuning Patchy Bonds Induced by Critical Casimir Forces

Experimental control of patchy interactions promises new routes for the assembly of complex colloidal structures, but remains challenging. Here, we investigate the role of patch width in the assembly of patchy colloidal particles assembled by critical Casimir forces. The particles are composed of a hydrophobic dumbbell with an equatorial hydrophilic polymer shell, and are synthesized to have well-defined patch-to-shell area ratios. Patch-to-patch binding is achieved in near-critical binary solvents, in which the particle interaction strength and range are controlled by the temperature-dependent solvent correlation length. Upon decreasing the patch-to-shell area ratio, we observe a pronounced change of the bonding morphology towards directed single-bonded configurations, as clearly reflected in the formation of chain-like structures. Computer simulations using an effective critical Casimir pair potential for the patches show that the morphology change results from the geometric exclusion of the increasingly thick hydrophilic particle shells. These results highlight the experimental control of patchy interactions through the engineering of the building blocks on the way towards rationally designed colloidal superstructures

General practitioners’ communication on complementary and integrative medicine for cancer patients: findings from an analysis of consultations with standardised patients

Objective: Our aim was to explore whether general practitioners (GPs) communicate with cancer patients on complementary and integrative medicine (CIM) in a patient-centred and case-specific manner. Methods: We designed two cases of standardised breast cancer patients and allocated 29 GPs to hold a consultation either with Case 1 or Case 2. Case 1 presented with fears of possible physical side effects of hormone treatment. Case 2 feared a loss in social functioning because of nausea and emesis as possible side effects of chemotherapy. Consultations were audiotaped and analysed using the Roter Interaction Analysis System (RIAS). We analysed whether recommended CIM treatments and GPs' focus on psychosocial or medical and therapy-related content differed according to whether they were counselling Case 1 or Case 2. Results: In consultations with Case 1, GPs rather focused on medical and therapy-related content and most often recommended mistletoe, diets and sports. In contrast, GPs focused on psychosocial content and they most often recommended methods of self-care when counselling Case 2. Conclusion: The GPs in our sample reacted case-specifically to the patients' interest in CIM. Such responsive and patient-centred communication is a valuable resource but is often time-consuming. Adequate training and reimbursement should therefore be considered for GPs

Compliance with CBT referral in nursing home residents diagnosed with depression: Results from a feasibility study

Objectives: Patient-level factors that influence compliance with a recommendation for CBT in nursing home residents diagnosed with depression were identified. Methods: Within a cluster-randomized trial on stepped care for depression in nursing homes (DAVOS-study, Trial registration: DRKS00015686), participants received an intake interview administered by a licensed psychotherapist. If psychotherapy was required, patients were offered a referral for CBT. Sociodemographic characteristics, severity of depression, loneliness, physical health, antidepressant medication, prior experience with psychotherapy, and attitudes towards own aging were assessed. A binary regression determined predictors of compliance with referral. Results: Of 123 residents receiving an intake interview, 80 were recommended a CBT. Forty-seven patients (58.8 %) followed the recommendation. The binary logistic regression model on compliance with recommended CBT was significant, χ2(9) = 21.64, p = .010. Significant predictors were age (Odds Ratio (OR) = 0.9; 95 % Confidence Interval (CI) = 0.82, 0.99; p = .024) and depression (OR = 1.33; 95 % CI = 1.08, 1.65; p = .008). Conclusion: Within the implemented setting compliance rate was comparable to other age groups. Future interventions should include detailed psychoeducation on the benefits of psychotherapy on mild depressive symptoms in older age and evidence-based interventions to address the stigma of depression. Interventions such as reminiscence-based methods or problem-solving could be useful to increase compliance with referral, especially in very old patients (80+). Language barriers and a culturally sensitive approach should be considered when screening residents