Polymorphisms of plasminogen activator inhibitor-1, angiotensin converting enzyme and coagulation factor XIII genes in patients with recurrent spontaneous abortion

We investigated polymorphisms of plasminogen activator inhibitor-1 (PAI-1), angiotensin converting enzyme (ACE ) and coagulation factor XIII (FXIII) genes and their association with recurrent spontaneous abortion (RSA) in Iranian patients and normal healthy controls. Ten (18.5%) patients were homozygote (4G/4G) for PAI-1 polymorphism, in contrast with two (2%) controls (p = 0.001). Patients with homozygote 4G mutation were significantly more prone to RSA in contrast to others (odds ratio: 11.0, 95% CI: 2.3-52.4). Nineteen (30.2%) patients and 25 (26.6%) controls were homozygote (DD) for ACE polymorphism. We observed only two patients and one control with homozygosity (34leu) for FXIII polymorphism. 4G/4G polymorphism for PAI-1 gene could be a thrombophilic mutation leading to abortion in Iranian population

Substitutional doping of Cu in diamond: Mott physics with pp orbitals

Discovery of superconductivity in the impurity band formed by heavy doping of boron into diamond (C:B) as well as doping of boron into silicon (Si:B) has provided a rout for the possibility of new families of superconducting materials. Motivated by the special role played by copper atoms in high temperature superconducting materials where essentially Cu $d$ orbitals are responsible for a variety of correlation induced phases, in this paper we investigate the effect of substitutional doping of Cu into diamond. Our extensive first principle calculations averaged over various geometries based on density functional theory, indicates the formation of a mid-gap band, which mainly arises from the $t_{2g}$ and $4p$ states of Cu. For impurity concentrations of more than $\sim 1$2p$bands of neighboring carbon atoms can be ignored. Based on our detailed analysis, we suggest a two band model for the mid-gap states consisting of a quarter-filled hole like$t_{2g}$band, and a half-filled band of$4p$states. Increasing the concentration of the Cu impurity beyond$\sim 5%, completely closes the spectral gap of the host diamond.Comment: 5 figure

Mechanical stress and deformation analyses of pressurized cylindrical shells based on a higher-order modeling

In this research, mechanical stress, static strain and deformation analyses of a cylindrical pressure vessel subjected to mechanical loads are presented. The kinematic relations are developed based on higher-order sinusoidal shear deformation theory. Thickness stretching formulation is accounted for more accurate analysis. The total transverse deflection is divided into bending, shear and thickness stretching parts in which the third term is responsible for change of deflection along the thickness direction. The axisymmetric formulations are derived through principle of virtual work. A parametric study is presented to investigate variation of stress and strain components along the thickness and longitudinal directions. To explore effect of thickness stretching model on the static results, a comparison between the present results with the available results of literature is presented. As an important output, effect of micro-scale parameter is studied on the static stress and strain distributio

Promethazine and Treatment Refractory Agitation in Clonidine Toxicity

Background:Delirium is an acute and transient turmoil disorder in consciousness which is often caused by drugs.One of the adverse effects of clonidine is agitation. Clonidine is an agonist of α2-receptor which functionally overlaps with μ-receptor of opioids. Promethazine is H1-receptor antagonist and has antipsychotic properties. The necessary dose for initial control of agitation is 25-50 milligrams. Case Presentation: A 27 year old man has been sent to emergency department following consumption of clonazepam 1 milligram, clonidine 0.1 milligram and alprazolam 0.5 milligram. Upon arrival at the toxicity emergency of the hospital, the patient's pulse rate suddenly dropped to 20 per min along with widening of QRS and increase of QTc as well as severe agitation. At the end of the second day due to continuous bradycardia pace maker was devised. The patient showed hallucination. In the third day, the patient's delirium increased. Due to no control of agitation by benzodiazepine, haloperidol, Promethazine 25 milligram was injected then slept after 5 minute. Conclusion:In such patient with above restrictions, prescription of promethazine not only maintained blood pressure and caused no disorder in electrocardiogram, but also it immediately and certainly controlled patient's agitation

Non-linear Finite-Time Tracking Control of Uncertain Robotic Manipulators Using Time-Varying Disturbance Observer-Based Sliding Mode Method

In this paper, a time-varying chattering-free disturbance observer-based position tracking control law of serial robotic manipulators is presented to track a reference signal in a finite time. The key idea is to employ a positive-increasing function associated with the control/observer objectives to improve the control performance. First, the model of an uncertain robotic manipulator is presented as the case study of the proposed strategy. Then, the time-varying form of the robotic manipulator model is obtained to provide finite-time boundedness using the first-order sliding mode method. Moreover, without any knowledge about the upper bounds of the uncertainties, a reduced-order observer is presented to estimate the uncertainties in a finite time. Subsequently, a disturbance observer-based finite-time position tracking control law is designed. The time-varying gains are provided to converge the position tracking error to a neighborhood of zero in a finite time. Finally, comparative simulations are presented to show the effectiveness of the proposed scheme compared to other existing strategies

PERSIAN CUED SPEECH: THE EFFECT ON PHONOLOGICAL COMBINATION AND SEGMENTATION SKILLS OF CHILDREN WITH INTELLECTUAL DISABILITY

The aim of this paper was to study the effect of a Persian Cued Speech training program for increasing the phonological combination and segmentation skills of intellectually disabled children. This study was a quasi–experimental study. A convenience sample was selected and divided in two groups, namely an experimental group and a control group (n = 5). The study used the Phonological Awareness Questionnaire as the tool of analysis. The Cued Speech training is a forty 90-minute session program, which was implemented on the experimental group. At the end of the program, they were again assessed with the questionnaire. The findings from the study show the efficacy of our intervention on increasing the Phonological Combination and Segmentation skills (P < 0/10, P < 0/05). Using Cued Speech with the intellectually disabled children can be helpful to develop their pre reading skills such as phonological awareness

Rethinking RAFT for Efficient Optical Flow

Despite significant progress in deep learning-based optical flow methods, accurately estimating large displacements and repetitive patterns remains a challenge. The limitations of local features and similarity search patterns used in these algorithms contribute to this issue. Additionally, some existing methods suffer from slow runtime and excessive graphic memory consumption. To address these problems, this paper proposes a novel approach based on the RAFT framework. The proposed Attention-based Feature Localization (AFL) approach incorporates the attention mechanism to handle global feature extraction and address repetitive patterns. It introduces an operator for matching pixels with corresponding counterparts in the second frame and assigning accurate flow values. Furthermore, an Amorphous Lookup Operator (ALO) is proposed to enhance convergence speed and improve RAFTs ability to handle large displacements by reducing data redundancy in its search operator and expanding the search space for similarity extraction. The proposed method, Efficient RAFT (Ef-RAFT),achieves significant improvements of 10% on the Sintel dataset and 5% on the KITTI dataset over RAFT. Remarkably, these enhancements are attained with a modest 33% reduction in speed and a mere 13% increase in memory usage. The code is available at: https://github.com/n3slami/Ef-RAFTComment: 7 pages, 5 figures, 4 table

The sound of new urbanism

Understanding the nexus between soundscape and urban form is challenging. This research explores soundscapes in new urbanist (NU) developments to contribute to the urban form studies of sound environment. NU developments promote the quality of life (QoL) in dense, walkable settings with mixed-use buildings. An under-examined, yet critical aspect of New Urbanism approach is the soundscape. To study the relationship between soundscape and NU, this research investigates soundscapes from NU developments by assessing preference of 95 residents and visitors as well as on-site sound pressure level (SPL) measurements within five NU developments in the Dallas-Fort Worth metropolitan area. Findings suggest that soundscapes of NU developments are overall at the high SPLs and differ at various development typologies with significant implications for urban form. The research proposes recognizing the sound-related attributes of urban form so that sound-related resolutions can be applied to other geographical and planning practices. © 2020 Informa UK Limited, trading as Taylor & Francis Group

The energy-water nexus: Renewable energy and water desalination

The essential connection between energy and water, also defined as the energy-water nexus, has been recognized by scientists and policy makers worldwide. Integrated solutions and policies that consider both energy and water aspects into future planning have been developing at a fast pace. In this paper, we review the state of the art of the energy-water nexus, with particular focus on the integration between renewable energy and desalination technologies. We also model the integration of reverse osmosis (RO) desalination and solar photovoltaics in an edge-of-grid coastal town in Western Australia. The current literature agrees on the sustainable use of renewable energy sources to improve the water-energy nexus in the context of water desalination. Although the integration of solar and wind energy with desalination technologies is a mature and well-proven solution at both small and large scales, the intermittency and fluctuating nature of wind and solar power still constitute the main technical challenge that has limited the diffusion of renewable energy powered desalination on a large scale. Several successful applications of renewable energy powered desalination in remote, off the grid, locations have tackled the issue of power intermittency by the use of batteries and diesel generators. Such systems often couple reverse osmosis desalination with solar photovoltaic energy. Large desalination plants have been successfully connected to wind farms and grid electricity to secure uninterrupted plant operations, thus meeting water targets in large-scale systems. Our review identifies a knowledge gap in the integration of decentralized energy systems, e.g. rooftop solar photovoltaic, with small scale RO desalination. Such configuration would benefit those regional towns that have historically suffered from weak and unreliable connections to the electricity grid, thus helping them secure both their energy and water requirements. The modelling exercise on a renewable energy powered RO plant in an edge-of-grid town in Western Australia has identified an operating strategy that maximizes the renewable energy fraction and secures the annual supply of water. The system involves operating the RO unit for six months of the year at a daily variable load and integrating solar energy with grid electricity. Careful evaluation of the RO performance under such operating conditions is necessary to ensure a safe and reliable water treatment process. A niche in the literature of the energy-water nexus has been identified in the integration of rooftop solar photovoltaic, grid electricity and desalination technologies applied in a regional context. A future study will consider the rollout of rooftop solar photovoltaic installations across the whole town, thus enabling the active engagement of the community by integrating the households’ energy demand response patterns to the operations of both rooftop photovoltaics and the desalination unit

The energy-water nexus: Renewable energy and water desalination

The essential connection between energy and water, also defined as the energy-water nexus, has been recognized by scientists and policy makers worldwide. Integrated solutions and policies that consider both energy and water aspects into future planning have been developing at a fast pace. In this paper, we review the state of the art of the energy-water nexus, with particular focus on the integration between renewable energy and desalination technologies. We also model the integration of reverse osmosis (RO) desalination and solar photovoltaics in an edge-of-grid coastal town in Western Australia. The current literature agrees on the sustainable use of renewable energy sources to improve the water-energy nexus in the context of water desalination. Although the integration of solar and wind energy with desalination technologies is a mature and well-proven solution at both small and large scales, the intermittency and fluctuating nature of wind and solar power still constitute the main technical challenge that has limited the diffusion of renewable energy powered desalination on a large scale. Several successful applications of renewable energy powered desalination in remote, off the grid, locations have tackled the issue of power intermittency by the use of batteries and diesel generators. Such systems often couple reverse osmosis desalination with solar photovoltaic energy. Large desalination plants have been successfully connected to wind farms and grid electricity to secure uninterrupted plant operations, thus meeting water targets in large-scale systems. Our review identifies a knowledge gap in the integration of decentralized energy systems, e.g. rooftop solar photovoltaic, with small scale RO desalination. Such configuration would benefit those regional towns that have historically suffered from weak and unreliable connections to the electricity grid, thus helping them secure both their energy and water requirements. The modelling exercise on a renewable energy powered RO plant in an edge-of-grid town in Western Australia has identified an operating strategy that maximizes the renewable energy fraction and secures the annual supply of water. The system involves operating the RO unit for six months of the year at a daily variable load and integrating solar energy with grid electricity. Careful evaluation of the RO performance under such operating conditions is necessary to ensure a safe and reliable water treatment process. A niche in the literature of the energy-water nexus has been identified in the integration of rooftop solar photovoltaic, grid electricity and desalination technologies applied in a regional context. A future study will consider the rollout of rooftop solar photovoltaic installations across the whole town, thus enabling the active engagement of the community by integrating the households’ energy demand response patterns to the operations of both rooftop photovoltaics and the desalination unit