Experience of phototherapy in dermatological praxis in complex therapy of psoriasis patients

Publisher Copyright: © 2016 Ilona Hartmane et al., published by De Gruyter Open 2016.Psoriasis is a chronic relapsing skin disease presenting with erythematous and papulous lesions with infiltration and extensive desquamation on the skin surface. It is a genetically determined, multifactorial dermatosis where genetic, immune, and environmental factors play significant roles in its development. In Latvia in treatment of different forms of extensively spreading psoriasis, PUVA (psoralen and ultraviolet A light therapy), a combined method, is administered, applying long-wave UVA radiation with wavelength 320-400 nm in combination with photosensibilisator 8-metoxypsoralen and medium wave length UVB radiation narrow-band phototherapy - 311 nm using specialised TL-01 lamps. The aim of our clinical investigation was to determine the efficacy of narrow-band phototherapy (UVB 311 nm) in the complex treatment of patients with different severity of extensive psoriatic lesions treated in the Clinical Centre of Skin and Sexually Transmitted Diseases. Cases of clinical data of 260 patients with widely spread psoriasis were analysed. In the Group 1 (n = 102) receiving narrow-band UVB therapy, the mean and cumulative UVB dosage was 1.8 ± 0.6 and 21.5 ± 3.8 J/cm2, respectively, whereas in Group 2 (n = 91) it was 2.2 ± 0.1 and 27.7 ± 8.0 J/cm2. To obtain clinical recovery, 18 to 30 procedures were necessary (average 22 ± 4.1) with total irradiation dose received 110 ± 4.6 J/cm2. In 67 patients of the control group, PUVA therapy was administered, and positive therapeutic efficacy was observed in all patients. Clinical recovery was obtained in 86.2% in patients of the Group 1, in 82.4% - of Group 2, and in 80% - in 67 patients of the control group. Narrow-band (311 nm) UVB phototherapy is currently one of the leading pathogenetical methods of treatment of patients with widespread psoriasis. It has high efficacy, good tolerability, does not have severe side effects and restrictions in use, in comparison with traditional PUVA therapy.publishersversionPeer reviewe

Identification de résines végétales datant de l'Egypte ancienne par Chromatographie en phase gazeuse couplée à un spectromètre de masse

Trois échantillons, respectivement référencés L24, L42 et L36 provenant de la collection Victor Loret de l'Institut d'Egyptologie (Université Lyon II, Pr J.-C. Goyon), ont été analysés. Ils ont été prélevés lors de fouilles effectuées par l'archéologue J. de Morgan sur le site de Dashour dans les années 1894 et 1895. L'analyse de ces matériaux, menée par Chromatographic en Phase Gazeuse couplée à un Spectromètre de Masse (CPG/SM), a mis en évidence l'existence de véritables formulations. Le prélèvement L24 a été identifié comme étant un mélange constitué d'une résine appartenant à la famille des Ombellifères et plus précisément au genre Ferula, d'un corps gras ainsi que d'une résine de conifère.Three samples, respectively referred L24, L42 and L36 coming from the collection Victor Loret of the Egyptologic Institute (University Lyon II, Pr J.-C. Goyon), were analyzed. They were recovered from excavations at Dashour in 1894-1895 by the archaeologist J. de Morgan. The analysis of these materials carried out by Gas Chromatography coupled to a Mass Spectrometer (GC/MS) and the results show the existence of real formulations. L24 was identified as a mixture of a resin belonging to the family of Umbellifereae and more precisely to the Ferula genus, a fatty substance and a resin of conifer

Status of evaluated data files for 238U in the resonance region

Experimental data and evaluated data libraries related to neutron induced reaction cross sections for 238U in the resonance region are reviewed. Based on this review a set of test files is produced to study systematic effects such as the impact of the upper boundary of the resolved resonance region (RRR) and the representation of the infinite diluted capture and in-elastic cross section in the unresolved resonance region (URR). A set of Benchmark experiments was selected and used to verify the test files. Based on these studies recommendations to perform a new evaluation have been defined. This report has been prepared in support to the CIELO (Collaborative International Evaluated Library Organisation) project. The objective of this project is the creation of a world-wide recognised nuclear data file with a focus on six nuclides, i.e. 1H, 16O, 56Fe, 235U, 238U and 239Pu. Within the CIELO project, the Joint Research Centre (JRC) at Geel (B) is in charge of the production of an evaluated cross section data file for neutron induced reaction of 238U in the resonance region.JRC.D.4-Standards for Nuclear Safety, Security and Safeguard