Book review: American transitional justice: writing cold war history in human rights litigation

Book review of American transitional justice: writing cold war history in human rights litigation: by Natalie R. Davidson, Cambridge, Cambridge University Press, 2020, 218 pp., AUD$156.95 (hardback), ISBN 9781108477703, USD$80.00 (e-book), ISBN 9781108774529, ISBN 9781108702553 (paperback

Teaching legal research subversively

This article presents a novel approach to teaching the compulsory law subject Legal Research. It considers that while Legal Research is traditionally a non-substantive subject that does not explain the law, let alone question or critique the law, it can in fact be taught in a way that encourages law students to think critically about legal institutions and the broader social context that gives rise to them. The article explores ways to pursue such legal instruction, with reference to activities administered in a legal research subject at the Law and Justice Faculty of the University of [withheld for peer review], Australia. It concludes that the discipline of legal research presents valuable opportunities for providing law students with a deeper social education in the law

An evaluation of planned exercises in meaningful writing situations as an aid to transfer of spelling ability

Thesis (Ed.M.)--Boston Universit

Mattering: A Recreation of the Realism of Charles S. Peirce

Mattering' is the process and the product of Reality. It is One from nothing. Whether there is more than one universe as the string theorists argue, is beyond my ken. Fortunately I am not concerned here with epistemology but with understanding. Nor am I preoccupied with revealing Truth. Rather, my purpose is to explore the meaning and consequences of 'mattering': to be able to say that, beyond reasonable doubt, I believe that 'it' matters – that 'it' is 'mattering'. This can be made intelligible by way of reflection on the Pragmatic Maxim of the American polymath Charles S. Peirce [1839-1914] and validated with his systematic method of inquiry. Part 1 of my thesis explores and presents Peirce's work. Part 2 is an exposition of my three part hypothesis of 'mattering', that: 1. value functions as a condition of intelligibility - purpose, as the ground of 'mattering' is dependent on value; 2. power - where power is the capacity to cause - is the enabler of force functioning as actual 'mattering'; 3. 'mattering' is evolutionary realization of universal telos. For Peirce, inquiry is triggered by genuine doubt. His method begins with imagination: with the generation of a hypotheses that, if valid, will relieve the irritation of doubt. Creating my hypothesis of 'mattering' free of consideration of truth was liberating. This is what Peirce called abduction: active imagination which can be considered as reasonable, but only in so far as it can be reasoned from by deduction and induction. This is Mathematics, the first of the heuretic sciences (the branch of sciences which treats of discovery or invention) and its aim is to draw necessary conclusions; Philosophy is the next class of the heuretic sciences, followed by the Special Sciences. The first order of Peirce's second class, Philosophy, is his Phenomenology - his doctrine of categories - the purpose of which is to describe what is before the mind and to show that the description is correct. It is the beginning of discovering meaning, and involves observation of what Peirce called the phaneron (whatever is before the mind) - in my case, my hypothesis. Through differentiation, abstraction or prescision, and dissociation it identifies the three irreducible categories of reality identified by Peirce as First (possibility), Second (actuality) and Third (probability). The second order of his philosophical method is the Normative Sciences of Esthetics (aesthetics), the ideal, Ethics, going for the ideal, and Semeiotic or logic, what can reasonably be hoped for. By practicing what he preached, Peirce built the third order of Philosophy, his Metaphysics of Tychism (chance), Synechism (continuity), and Agape. [In physics, Agape arguably is gravity and the still to be discovered something that will deliver the Holy Grail: the theory of everything.] This is 'mattering'. I argue it is grounded in the values of integrity, respect and transparency, values which are expressed through the enactment (or powering) of 'mattering's' purpose or telos which grows and develops. This is, 'mattering': universal realisation of evolutionary telos. Our species, which evolved, as did the Universe, from the Universe - the process and product of 'mattering' - appears set on a trajectory of ecocide for which we are responsible. One model for understanding this travesty is Freud's scheme of Id (desire) Ego (mediator) Superego (should). If Ego, which makes choices, sides with and empowers the unmitigated, individual wanting that is Id, by ignoring Superego - cooperative imperatives for universal growth and development - Earth's evolutionary trajectory is jeopardised. We ignore the categorial values of integrity, respect, and transparency with which evolutionary universal telos is co-dependent, at our peril. The global dysfunction of Egos, especially those that have commandeered power by disempowering others, can be healed. Together, but only together, we can get back on track and reclaim Earth's and our future. This one Universe from which we evolved and with which we are evolving, can do it, and, even granted that it has been practicing longer, we too can do it: we can make it matter. It matters. It is 'mattering'

Sub-mm/mm optical properties of real protoplanetary matter derived from Rosetta/MIRO observations of comet 67P

Optical properties are required for the correct understanding and modelling of protoplanetary and debris discs. By assuming that comets are the most pristine bodies in the solar system, our goal is to derive optical constants of real protoplanetary material. We determine the complex index of refraction of the near-surface material of comet 67P/Churyumov-Gerasimenko by fitting the sub-millimetre/millimetre observations of the thermal emission of the comet's sub-surface made by the Microwave Instrument for the Rosetta Orbiter (MIRO) with synthetic temperatures derived from a thermophysical model and radiative-transfer models. According to the two major formation scenarios of comets, we model the sub-surface layers to consist of pebbles as well as of homogeneously packed dust grains. In the case of a homogeneous dusty surface material, we find a solution for the length-absorption coefficient of $\alpha \approx 0.22~\mathrm{cm^{-1}}$ for a wavelength of 1.594 mm and $\alpha \geq 3.84~\mathrm{cm^{-1}}$ for a wavelength of 0.533 mm and a constant thermal conductivity of $0.006~\mathrm{Wm^{-1}K^{-1}}$. For the pebble scenario, we find for the pebbles and a wavelength of 1.594 mm a complex refractive index of $n = (1.074 - 1.256) + \mathrm{i} \, (2.580 - 7.431)\cdot 10^{-3}$ for pebble radii between 1 mm and 6 mm. Taking into account other constraints, our results point towards a pebble makeup of the cometary sub-surface with pebble radii between 3 mm and 6 mm. The derived real part of the refractive index is used to constrain the composition of the pebbles and their volume filling factor. The optical and physical properties are discussed in the context of protoplanetary and debris disc observations.Comment: Accepted for publication in MNRA

Frequent capsule switching in 'ultra-virulent' meningococci - Are we ready for a serogroup B ST-11 complex outbreak?

The meningococcal ST-11 complex (cc11) causes large invasive disease outbreaks with high case fatality rates, such as serogroup C (MenC) epidemics in industrialised nations in the 1990s and the serogroup W epidemic currently expanding globally. Glycoconjugate vaccines are available for serogroups A, C, W and Y. Broad coverage protein-based vaccines have recently been licensed against serogroup B meningococci (MenB), however, these do not afford universal MenB protection. Capsular switching from MenC to MenB among cc11 organisms is concerning because a large MenB cc11 (B:cc11) outbreak has the potential to cause significant morbidity and mortality. This study aimed to assess the potential for licensed and developmental non-capsular meningococcal vaccines to protect against B:cc11. The population structure and vaccine antigen distribution was determined for a panel of >800 geo-temporally diverse, predominantly MenC cc11 and B:cc11 genomes. The two licensed vaccines potentially protect against many but not all B:cc11 meningococci. Furthermore, strain coverage by these vaccines is often due to a single vaccine antigen and both vaccines are highly susceptible to vaccine escape owing to the apparent dispensability of key proteins used as vaccine antigens. cc11 strains with MenB and MenC capsules warrant special consideration when formulating future non-capsular meningococcal vaccines

Multicentre study on the reproducibility of MALDI-TOF MS for nontuberculous mycobacteria identification

The ability of MALDI-TOF for the identification of nontuberculous mycobacteria (NTM) has improved recently thanks to updated databases and optimized protein extraction procedures. Few multicentre studies on the reproducibility of MALDI-TOF have been performed so far, none on mycobacteria. The aim of this study was to evaluate the reproducibility of MALDI-TOF for the identification of NTM in 15 laboratories in 9 European countries. A total of 98 NTM clinical isolates were grown on Lowenstein-Jensen. Biomass was collected in tubes with water and ethanol, anonymized and sent out to the 15 participating laboratories. Isolates were identified using MALDI Biotyper (Bruker Daltonics). Up to 1330 MALDI-TOF identifications were collected in the study. A score >= 1.6 was obtained for 100% of isolates in 5 laboratories (68.2-98.6% in the other). Species-level identification provided by MALDI-TOF was 100% correct in 8 centres and 100% correct to complex-level in 12 laboratories. In most cases, the misidentifications obtained were associated with closely related species. The variability observed for a few isolates could be due to variations in the protein extraction procedure or to MALDI-TOF system status in each centre. In conclusion, MALDI-TOF showed to be a highly reproducible method and suitable for its implementation for NTM identification

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC