Intermodal | Multimodal

The intent is to confront waste on both a global and local level using architecture to engage and educate the public. Global waste, in this case, is defined as intermodal containers and local waste is defined as municipally collected solid waste. I intend to show through my designs that architecture need not be the source of yet more energy use and material waste. Instead, design can be the vehicle through which we begin to lessen our impact on Planet Earth by reusing the materials already at hand to create architecture and energy. A waste to energy approach [both architectural and functional] provides a closed loop system in which waste can be reused in a way that is both locally beneficial and ecologically responsible. By creating a Waste-to-Energy Power Plant using recycled building materials the public can begin to understand and manage waste in ways that enhance their own everyday life. The proposed facility located at the Bluffs Road Landfill in Lincoln, NE will actually invite the public to be a part of the disposal/generation process by allowing people to bring their waste, literally ‘throw it on the pile’ and then witness the step by step process of their waste being converted into electricity. The intermodal containers are an added layer of education; what was once industrial waste will be used to create the architectural experience. Architecturally, intermodal containers embody a potential “energy” that is easily transferable to a kinetic “energy” by taking the containers from their inactive positions in container yards and giving them purpose through human use and programmatic function. Likewise, solid waste can easily be changed from a potential to a kinetic energy through the process of burning its combustible elements to generate clean electricity. These layers of engaging and education will begin to teach people about waste and its effects on the landscape, environment, economy, etc. This idea of reuse is key to engaging and enlightening the public. It invites people to reformulate their preconceptions about unwanted materials and view those materials as purposeful instead of useless. Traditional recycling may be a part of the solution, but it cannot be the answer alone. In order to overcome the indoctrinated practice of disposal without consequence, reuse and repurposement need to be brought to the forefront of people’s minds, in this case through architecture and the function it provides

A matrix isolation and computational study of molecular palladium fluorides : does PdF₆ exist?

Palladium atoms generated by thermal evaporation and laser ablation were reacted with and trapped in F₂ /Ar, F₂ /Ne, and neat F₂ matrices. The products were characterized by electronic absorption and infrared spectroscopy, together with relativistic density functional theory calculations as well as coupled cluster calculations. Vibrational modes at 540 and 617 cm⁻¹ in argon matrices were assigned to molecular PdF and PdF₂ , and a band at 692 cm⁻¹ was assigned to molecular PdF₄ . A band at 624 cm⁻¹ can be assigned to either PdF₃ or PdF₆, with the former preferred from experimental considerations. Although calculations might support the latter assignment, our conclusion is that in these detailed experiments there is no convincing evidence for PdF₆

An ALMA Constraint on the GSC 6214-210 B Circum-Substellar Accretion Disk Mass

We present Atacama Large Millimeter/submillimeter Array (ALMA) observations of GSC 6214-210 A and B, a solar-mass member of the 5-10 Myr Upper Scorpius association with a 15 $\pm$ 2 Mjup companion orbiting at $\approx$330 AU (2.2"). Previous photometry and spectroscopy spanning 0.3-5 $\mu$m revealed optical and thermal excess as well as strong H$\alpha$ and Pa~$\beta$ emission originating from a circum-substellar accretion disk around GSC 6214-210 B, making it the lowest mass companion with unambiguous evidence of a subdisk. Despite ALMA's unprecedented sensitivity and angular resolution, neither component was detected in our 880 $\mu$m (341 GHz) continuum observations down to a 3-$\sigma$ limit of 0.22 mJy/beam. The corresponding constraints on the dust mass and total mass are <0.15 Mearth and <0.05 Mjup, respectively, or <0.003% and <0.3% of the mass of GSC 6214-210 B itself assuming a 100:1 gas-to-dust ratio and characteristic dust temperature of 10-20 K. If the host star possesses a putative circum-stellar disk then at most it is a meager 0.0015% of the primary mass, implying that giant planet formation has certainly ceased in this system. Considering these limits and its current accretion rate, GSC 6214-210 B appears to be at the end stages of assembly and is not expected to gain any appreciable mass over the next few Myr.Comment: Accepted to ApJ

Dosimetric validation for an automatic brain metastases planning software using single-isocenter dynamic conformal arcsDosimetric validation for an automatic brain metastases planning software using single-isocenter dynamic conformal arcs.

An automatic brain-metastases planning (ABMP) software has been installed in our institution. It is dedicated for treating multiple brain metastases with radiosurgery on linear accelerators (linacs) using a single-setup isocenter with noncoplanar dynamic conformal arcs. This study is to validate the calculated absolute dose and dose distribution of ABMP. Three types of measurements were performed to validate the planning software: 1, dual micro ion chambers were used with an acrylic phantom to measure the absolute dose; 2, a 3D cylindrical phantom with dual diode array was used to evaluate 2D dose distribution and point dose for smaller targets; and 3, a 3D pseudo-in vivo patient-specific phantom filled with polymer gels was used to evaluate the accuracy of 3D dose distribution and radia-tion delivery. Micro chamber measurement of two targets (volumes of 1.2 cc and 0.9 cc, respectively) showed that the percentage differences of the absolute dose at both targets were less than 1%. Averaged GI passing rate of five different plans measured with the diode array phantom was above 98%, using criteria of 3% dose difference, 1 mm distance to agreement (DTA), and 10% low-dose threshold. 3D gel phantom measurement results demonstrated a 3D displacement of nine targets of 0.7 ± 0.4 mm (range 0.2 ~ 1.1 mm). The averaged two-dimensional (2D) GI passing rate for several region of interests (ROI) on axial slices that encompass each one of the nine targets was above 98% (5% dose difference, 2 mm DTA, and 10% low-dose threshold). Measured D95, the minimum dose that covers 95% of the target volume, of the nine targets was 0.7% less than the calculated D95. Three different types of dosimetric verification methods were used and proved the dose calculation of the new automatic brain metastases planning (ABMP) software was clinical acceptable. The 3D pseudo-in vivo patient-specific gel phantom test also served as an end-to-end test for validating not only the dose calculation, but the treatment delivery accuracy as well

ALMA Measurements of Circumstellar Material in the GQ Lup System

We present ALMA observations of the GQ Lup system, a young Sun-like star with a substellar mass companion in a wide-separation orbit. These observations of 870 $\mu$m continuum and CO J=3-2 line emission with beam size $\sim0.3''$ ($\sim45$ AU) resolve the disk of dust and gas surrounding the primary star, GQ Lup A, and provide deep limits on any circumplanetary disk surrounding the companion, GQ Lup b. The circumprimary dust disk is compact with a FWHM of $59\pm12$ AU, while the gas has a larger extent with a characteristic radius of $46.5\pm1.8$ AU. By forward-modeling the velocity field of the circumprimary disk based on the CO emission, we constrain the mass of GQ Lup A to be $M_* = (1.03\pm0.05)*(d/156\text{ pc})$ $M_\odot$, where $d$ is a known distance, and determine that we view the disk at an inclination angle of $60.5^\circ\pm0.5^\circ$ and a position angle of $346^\circ \pm1^\circ$. The $3\sigma$ upper limit on the 870 $\mu$m flux density of any circumplanetary disk associated with GQ Lup b of $<0.15$ mJy implies an upper limit on the dust disk mass of $<0.04$ $M_\oplus$ for standard assumptions about optically thin emission. We discuss proposed mechanisms for the formation of wide-separation substellar companions given the non-detection of circumplanetary disks around GQ Lup b and other similar systems.Comment: 11 pages, 4 figure

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling

Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with inflammation is limited. This may be particularly so in the case of granulomatous inflammation, where an excessive number and / or excessively florid granulomas can have significant pathological consequences. Here, we have combined transcriptomics, agent-based modeling and in vivo experimental approaches to study constraints on hepatic granuloma formation in a murine model of experimental leishmaniasis. We demonstrate that chemokine production by non-infected Kupffer cells in the Leishmania donovani-infected liver promotes competition with infected KCs for available iNKT cells, ultimately inhibiting the extent of granulomatous inflammation. We propose trans-activation for chemokine production as a novel broadly applicable mechanism that may operate early in infection to limit excessive focal inflammation

An Observational Perspective of Transitional Disks

archiveprefix: arXiv primaryclass: astro-ph.SR keywords: Astrophysics - Solar and Stellar Astrophysics adsurl: http://adsabs.harvard.edu/abs/2014arXiv1402.7103E adsnote: Provided by the SAO/NASA Astrophysics Data SystemarticleTransitional disks are objects whose inner disk regions have undergone substantial clearing. The Spitzer Space Telescope produced detailed spectral energy distributions (SEDs) of transitional disks that allowed us to infer their radial dust disk structure in some detail, revealing the diversity of this class of disks. The growing sample of transitional disks also opened up the possibility of demographic studies, which provided unique insights. There now exist (sub)millimeter and infrared images that confirm the presence of large clearings of dust in transitional disks. In addition, protoplanet candidates have been detected within some of these clearings. Transitional disks are thought to be a strong link to planet formation around young stars and are a key area to study if further progress is to be made on understanding the initial stages of planet formation. Here we provide a review and synthesis of transitional disk observations to date with the aim of providing timely direction to the field, which is about to undergo its next burst of growth as ALMA reaches its full potential. We discuss what we have learned about transitional disks from SEDs, color-color diagrams, and imaging in the (sub)mm and infrared. We then distill the observations into constraints for the main disk clearing mechanisms proposed to date (i.e., photoevaporation, grain growth, and companions) and explore how the expected observational signatures from these mechanisms, particularly planet-induced disk clearing, compare to actual observations. Lastly, we discuss future avenues of inquiry to be pursued with ALMA, JWST, and next generation of ground-based telescopes.NAS

Canning Processes Reduce the DNA-Based Traceability of Commercial Tropical Tunas

Canned tuna is one of the most widely traded seafood products internationally and is of growing demand. There is an increasing concern over the vulnerability of canned tuna supply chains to species mislabelling and fraud. Extensive processing conditions in canning operations can lead to the degradation and fragmentation of DNA, complicating product traceability. We here employed a forensically validated DNA barcoding tool (cytochrome b partial sequences) to assess the effects of canning processes on DNA degradation and the identification of four tropical tuna species (yellowfin, bigeye, skipjack and longtail tuna) collected on a global scale, along their commercial chains. Each species was studied under five different canning processes i.e., freezing, defrosting, cooking, and canning in oil and brine, in order to investigate how these affect DNA-based species identification and traceability. The highest percentage of nucleotide substitutions were observed after brine-canning operations and were greatest for yellowfin and skipjack tuna. Overall, we found that DNA degradation significantly increased along the tuna canning process for most specimens. Consequently, most of the specimens canned in oil or brine were misidentified due to the high rate of nucleotide substitution in diagnostic sequences

Submillimeter Array Observations of the RX J1633.9-2442 Transition Disk: Evidence for Multiple Planets in the Making

We present continuum high resolution Submillimeter Array (SMA) observations of the transition disk object RX J1633.9-2442, which is located in the Ophiuchus molecular cloud and has recently been identified as a likely site of ongoing giant planet formation. The observations were taken at 340 GHz (880 micron) with the SMA in its most extended configuration, resulting in an angular resolution of 0.3" (35 AU at the distance of the target). We find that the disk is highly inclined (i ~50 deg) and has an inner cavity ~25 AU in radius, which is clearly resolved by our observations. We simultaneously model the entire optical to millimeter wavelength spectral energy distribution (SED) and SMA visibilities of RX J1633.9-2442 in order to constrain the structure of its disk. We find that an empty cavity ~25 AU in radius is inconsistent with the excess emission observed at 12, 22, and 24 micron. Instead, the mid-IR excess can be modeled by either a narrow, optically thick ring at ~10 AU or an optically thin region extending from ~7 AU to ~25 AU. The inner disk (r < 5 AU) is mostly depleted of small dust grains as attested by the lack of detectable near-IR excess. We also present deep Keck aperture masking observations in the near-IR, which rule out the presence of a companion up to 500 times fainter than the primary star (in K-band) for projected separations in the 5-20 AU range. We argue that the complex structure of the RX J1633.9-2442 disk is best explained by multiple planets embedded within the disk. We also suggest that the properties and incidence of objects such as RX J1633.9-2442, T Cha, and LkCa 15 (and those of the companions recently identified to these two latter objects) are most consistent with the runaway gas accretion phase of the core accretion model, when giant planets gain their envelopes and suddenly become massive enough to open wide gaps in the disk.Comment: Accepted for publication in Ap