638 research outputs found
The grit in the oyster: using energy biographies to question socio-technical imaginaries of âsmartnessâ
It has been argued that responsible research and innovation (RRI) requires critique of the âworldsâ implicated in the future imaginaries associated with new technologies. Qualitative social science research can aid deliberation on imaginaries by exploring the meanings of technologies within everyday practices, as demonstrated by Yolande Strengersâ work on imaginaries of âsmartnessâ. In this paper, we show how a novel combination of narrative interviews and multimodal methods can help explore future imaginaries of smartness through the lens of biographical experiences of socio-technical changes in domestic energy use. In particular, this approach can open up a critical space around socio-technical imaginaries by exploring the investments that individuals have in different forms of engagement with the world. The paper works with a psychosocial conceptual framework that draws on theoretical resources from science and technology studies to explain how valued forms of subjectivity may be conceptualised as emerging out of the âfrictionâ of engagement with the world. Using this framework, we show how biographical narratives of engagement with technologies from the Energy Biographies project can extend into critical deliberation on future imaginaries. The paper demonstrates the value of âthickâ data relating to the affective dimensions of subjective experience for RRI
Evolution of the One CGIARâs research and innovation portfolio to 2030 : approaches, tools, and insights after the reform
In this perspective, we offer insights into the evolution of CGIARâs research and innovation portfolio from 2019 to 2023, underpinning the transformative journey towards One CGIAR. With this contribution, we aim to strengthen the social and environmental sustainability components of allied, future Research for Development (R4D) portfolios. We explore three interlinked operational frameworksâQuality of Research for Development (QoR4D), Comparative Advantage (CA) Analysis, and Inclusive Innovationâand present practical tools and lessons for enhancing the quality and impact of R4D initiatives. This work is based on insights gained by the Independent Science for Development Council (ISDC) during the review of proposals for the current One CGIAR research portfolio. QoR4Dâs four dimensions (relevance, scientific credibility, legitimacy, and effectiveness) guide research strategy, portfolio development, evaluation and performance standards, fostering intentional design and transparent assessment. CA Analysis leverages organisational strengths, facilitating purposeful partnerships, and strategic resource allocation. Inclusive Innovation emphasises stakeholder inclusivity, amplifying legitimacy, relevance, and effectiveness. Insights are drawn from the application of these frameworks, highlighting the importance of collaboration, the need for a mindset shift and institutional reform, specialisation, and impact maximisation. By adopting these lessons, CGIAR and allied organisations can collectively address global food system challenges more effectively, driving sustainable agricultural innovation and societal transformation. This article aims to contribute to advancing sustainable agriculture and underscores the significance of systemic collaborations in creating more resilient and equitable food systems.Publisher PDFPeer reviewe
Gamma-Ray and Radio Observations of PSR B1509-58
Abstract : We report concurrent radio and gamma-ray observations of PSR B1509-58 carried out by the Parkes Radio Telescope and by the Burst and Transient Source Experiment (BATSE) and the Oriented Scintillation Spectrometer Experiment (OSSE) on the Compton Gamma Ray Observatory (CGRO-Gamma-ray light curves fitted at several energies between ~ 20-500 keV yield a phase offset with respect to the radio pulse that is independent of energy, with an average value 0.32 plus or minus 0.02. Although this value is larger by 0.07 than that reported by Kawai et al., the difference is not statistically significant (only~2 sigma) when account is taken of the uncertainty associated with their result. We briefly discuss the possibility that the energy-independence of the gamma-ray pulse phase is a signature of non-thermal radiation in the X-ray/gamma-ray range and the suggestion of a dependence of pulsar radio-gamma-ray phase offset on pulse period
Epigenetic age acceleration and cognitive function in African-American adults in midlife:The Atherosclerosis Risk in Communities Study
Pleistocene climate variability in eastern Africa influenced hominin evolution
AbstractDespite more than half a century of hominin fossil discoveries in eastern Africa, the regional environmental context of hominin evolution and dispersal is not well established due to the lack of continuous palaeoenvironmental records from one of the proven habitats of early human populations, particularly for the Pleistocene epoch. Here we present a 620,000-year environmental record from Chew Bahir, southern Ethiopia, which is proximal to key fossil sites. Our record documents the potential influence of different episodes of climatic variability on hominin biological and cultural transformation. The appearance of high anatomical diversity in hominin groups coincides with long-lasting and relatively stable humid conditions from ~620,000 to 275,000 years bp (episodes 1â6), interrupted by several abrupt and extreme hydroclimate perturbations. A pattern of pronounced climatic cyclicity transformed habitats during episodes 7â9 (~275,000â60,000 years bp), a crucial phase encompassing the gradual transition from Acheulean to Middle Stone Age technologies, the emergence of Homo sapiens in eastern Africa and key human social and cultural innovations. Those accumulative innovations plus the alignment of humid pulses between northeastern Africa and the eastern Mediterranean during high-frequency climate oscillations of episodes 10â12 (~60,000â10,000 years bp) could have facilitated the global dispersal of H. sapiens.</jats:p
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Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF â„5%) and nine low-frequency or rare (MAF <5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants
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Genome-wide association study identifies 30 loci associated with bipolar disorder.
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with Pâ<â1âĂâ10-4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (Pâ<â5âĂâ10-8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder
Fermi Large Area Telescope Constraints on the Gamma-ray Opacity of the Universe
The Extragalactic Background Light (EBL) includes photons with wavelengths
from ultraviolet to infrared, which are effective at attenuating gamma rays
with energy above ~10 GeV during propagation from sources at cosmological
distances. This results in a redshift- and energy-dependent attenuation of the
gamma-ray flux of extragalactic sources such as blazars and Gamma-Ray Bursts
(GRBs). The Large Area Telescope onboard Fermi detects a sample of gamma-ray
blazars with redshift up to z~3, and GRBs with redshift up to z~4.3. Using
photons above 10 GeV collected by Fermi over more than one year of observations
for these sources, we investigate the effect of gamma-ray flux attenuation by
the EBL. We place upper limits on the gamma-ray opacity of the Universe at
various energies and redshifts, and compare this with predictions from
well-known EBL models. We find that an EBL intensity in the optical-ultraviolet
wavelengths as great as predicted by the "baseline" model of Stecker et al.
(2006) can be ruled out with high confidence.Comment: 42 pages, 12 figures, accepted version (24 Aug.2010) for publication
in ApJ; Contact authors: A. Bouvier, A. Chen, S. Raino, S. Razzaque, A.
Reimer, L.C. Reye
Primitive layered gabbros from fast-spreading lower oceanic crust
Three-quarters of the oceanic crust formed at fast-spreading ridges is composed of plutonic rocks whose mineral assemblages, textures and compositions record the history of melt transport and crystallization between the mantle and the sea floor. Despite the importance of these rocks, sampling them in situ is extremely challenging owing to the overlying dykes and lavas. This means that models for understanding the formation of the lower crust are based largely on geophysical studies and ancient analogues (ophiolites) that did not form at typical mid-ocean ridges. Here we describe cored intervals of primitive, modally layered gabbroic rocks from the lower plutonic crust formed at a fast-spreading ridge, sampled by the Integrated Ocean Drilling Program at the Hess Deep rift. Centimetre-scale, modally layered rocks, some of which have a strong layering-parallel foliation, confirm a long-held belief that such rocks are a key constituent of the lower oceanic crust formed at fast-spreading ridges. Geochemical analysis of these primitive lower plutonic rocks-in combination with previous geochemical data for shallow-level plutonic rocks, sheeted dykes and lavas-provides the most completely constrained estimate of the bulk composition of fast-spreading oceanic crust so far. Simple crystallization models using this bulk crustal composition as the parental melt accurately predict the bulk composition of both the lavas and the plutonic rocks. However, the recovered plutonic rocks show early crystallization of orthopyroxene, which is not predicted by current models of melt extraction from the mantle and mid-ocean-ridge basalt differentiation. The simplest explanation of this observation is that compositionally diverse melts are extracted from the mantle and partly crystallize before mixing to produce the more homogeneous magmas that erupt
Presidential Commission on the Supreme Court of the United States Final Report
On April 9, 2021, President Joseph R. Biden, Jr. issued Executive Order 14023 establishing this Commission, to consist of âindividuals having experience with and knowledge of the Federal judiciary and the Supreme Court of the United States.â The Order charged the Commission with producing a report for the President that addresses three sets of questions. First, the Report should include â[a]n account of the contemporary commentary and debate about the role and operation of the Supreme Court in our constitutional system and about the functioning of the constitutional process by which the President nominates and, by and with the advice and consent of the Senate, appoints Justices to the Supreme Court.â Second, the Report should consider the âhistorical background of other periods in the Nationâs history when the Supreme Courtâs role and the nominations and advice-and-consent process were subject to critical assessment and prompted proposals for reform.â Third, the Report should provide an analysis of the principal arguments for and against particular proposals to reform the Supreme Court, âincluding an appraisal of [their] merits and legality,â and should be informed by âa broad spectrum of ideas.â
The Report begins by explaining the genesis of todayâs Court reform debate, including by identifying developments that gave rise to President Bidenâs decision to issue the April 2021 Executive Order, particularly the debates surrounding the most recent nominations. This Introduction emphasizes that the Courtâs composition and jurisprudence long have been subjects of public controversy and debate in the nationâs civic life: The Court serves as a crucial guardian of the rule of law and also plays a central role in major social and political conflicts. Its decisions have profound effects on the life of the nation. Though conflict surrounding the processes by which the President nominates and the Senate confirms Justices is not new, it has become more intensely partisan in recent years.
The Introduction also articulates three common and interrelated ideas frequently invoked in reform debates and throughout the Chapters of the Report: the importance of protecting or enhancing the Courtâs legitimacy; the role of judicial independence in our system of government; and the value of democracy and its relationship to the Supreme Courtâs decisionmaking. These important ideas can mean different things to different people. The Introduction discusses the range of meanings ascribed to these terms, with the aim of clarifying how they are deployed in arguments for and against reform
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