51 research outputs found
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
T2K ECAL Test–beam Proposal
The T2K experiment will search for the last unknown element of the neutrino mixing matrix. An crucial component of the near detector for this experiment is the electromagnetic calorimeter which is being built in the UK. Testbeam time is requested to test the full ECAL system, validate calibration techniques, and determine the hadronic and electromagnetic energy scale of the calorimeter
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A First measurement of the interaction cross-section of the tau neutrino
The DONuT experiment collected data in 1997 and published first results in 2000 based on four observed {nu}{sub {tau}} charged-current (CC) interactions. The final analysis of the data collected in the experiment is presented in this paper, based on 3.6 x 10{sup 17} protons on target using the 800 GeV Tevatron beam at Fermilab. The number of observed {nu}{sub {tau}} CC interactions is 9, from a total of 578 observed neutrino interactions. We calculated the energy-independent part of the tau-neutrino CC cross section ({nu} + {bar {nu}}), relative to the well-known {nu}{sub e} and {nu}{sub {mu}} cross sections. The ratio {sigma}({nu}{sub {tau}})/{sigma}({nu}{sub e,{mu}}) was found to be 1.37 {+-} 0.35 {+-} 0.77. The {nu}{sub {tau}} CC cross section was found to be 0.72 {+-} 0.24 {+-} 0.36 x 10{sup -38} cm{sup 2} GeV{sup -1}. Both results are in agreement with expectations from the Standard Model
First muon-neutrino disappearance study with an off-axis beam
We report a measurement of muon-neutrino disappearance in the T2K experiment. The 295-km muon-neutrino beam from Tokai to Kamioka is the first implementation of the off-axis technique in a long-baseline neutrino oscillation experiment
Local treatment of experimental Pseudomonas aeruginosa osteomyelitis with a biodegradable dilactide polymer releasing ciprofloxacin
A biodegradable system of poly-D,L-dilactide releasing ciprofloxacin was
assessed in a Pseudomonas aeruginosa osteomyelitis model after
inoculation of the test pathogen into the left tibia of 76 New Zealand
White rabbits; 31 were controls (group A), and 45 were implanted with
the polymer at the infection site (group B). The rabbits were killed on
a weekly basis, and cancellous bone was harvested for histopathology and
for estimation of bacterial growth and the concentrations of
ciprofloxacin. Tibial X ray was performed immediately before the animals
were killed. The total number of fistulas with purulent discharge that
developed after inoculation of the pathogen was counted, and fistulas
with purulent discharge were found in 16 animals in group A (51.6%) and
3 animals in group B (6.7%) (P < 0.0001). The animals in group A had a
profound loss of body weight compared to the animals in group B. The
main radiological finding was the presence of sequestra in 25 animals
(80.6%) in group A and 6 animals in group B (13.3%) (P < 0.0001). The
bacterial load in group B was significantly reduced compared to that in
group A, possibly due to the prolonged local antibiotic release at
concentrations exceeding even 80 times the MIC for the test pathogen.
The histology of animals killed after week 49 revealed a mild
inflammatory reaction accompanied by difuse fibrosis and new bone
formation in group A animals and the presence of small polymer particles
in group B animals. It is concluded that the system described achieved
eradication of the pathogen, accompanied by clinical and radiologically
confirmed benefits, so this treatment may be a candidate for the
management of difficult orthopedic infections
Local Treatment of Experimental Pseudomonas aeruginosa Osteomyelitis with a Biodegradable Dilactide Polymer Releasing Ciprofloxacin▿
A biodegradable system of poly-d,l-dilactide releasing ciprofloxacin was assessed in a Pseudomonas aeruginosa osteomyelitis model after inoculation of the test pathogen into the left tibia of 76 New Zealand White rabbits; 31 were controls (group A), and 45 were implanted with the polymer at the infection site (group B). The rabbits were killed on a weekly basis, and cancellous bone was harvested for histopathology and for estimation of bacterial growth and the concentrations of ciprofloxacin. Tibial X ray was performed immediately before the animals were killed. The total number of fistulas with purulent discharge that developed after inoculation of the pathogen was counted, and fistulas with purulent discharge were found in 16 animals in group A (51.6%) and 3 animals in group B (6.7%) (P < 0.0001). The animals in group A had a profound loss of body weight compared to the animals in group B. The main radiological finding was the presence of sequestra in 25 animals (80.6%) in group A and 6 animals in group B (13.3%) (P < 0.0001). The bacterial load in group B was significantly reduced compared to that in group A, possibly due to the prolonged local antibiotic release at concentrations exceeding even 80 times the MIC for the test pathogen. The histology of animals killed after week 49 revealed a mild inflammatory reaction accompanied by diffuse fibrosis and new bone formation in group A animals and the presence of small polymer particles in group B animals. It is concluded that the system described achieved eradication of the pathogen, accompanied by clinical and radiologically confirmed benefits, so this treatment may be a candidate for the management of difficult orthopedic infections
The T2K experiment
The T2K experiment is a long baseline neutrino oscillation experiment. Its main goal is to measure the last unknown lepton sector mixing angle θ13 by observing νe appearance in a νμ beam. It also aims to make a precision measurement of the known oscillation parameters, and sin22θ23, via νμ disappearance studies. Other goals of the experiment include various neutrino cross-section measurements and sterile neutrino searches. The experiment uses an intense proton beam generated by the J-PARC accelerator in Tokai, Japan, and is composed of a neutrino beamline, a near detector complex (ND280), and a far detector (Super-Kamiokande) located 295 km away from J-PARC. This paper provides a comprehensive review of the instrumentation aspect of the T2K experiment and a summary of the vital information for each subsystem
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