42 research outputs found

    Investigating Mercury's Environment with the Two-Spacecraft BepiColombo Mission

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    The ESA-JAXA BepiColombo mission will provide simultaneous measurements from two spacecraft, offering an unprecedented opportunity to investigate magnetospheric and exospheric dynamics at Mercury as well as their interactions with the solar wind, radiation, and interplanetary dust. Many scientific instruments onboard the two spacecraft will be completely, or partially devoted to study the near-space environment of Mercury as well as the complex processes that govern it. Many issues remain unsolved even after the MESSENGER mission that ended in 2015. The specific orbits of the two spacecraft, MPO and Mio, and the comprehensive scientific payload allow a wider range of scientific questions to be addressed than those that could be achieved by the individual instruments acting alone, or by previous missions. These joint observations are of key importance because many phenomena in Mercury's environment are highly temporally and spatially variable. Examples of possible coordinated observations are described in this article, analysing the required geometrical conditions, pointing, resolutions and operation timing of different BepiColombo instruments sensors.Peer reviewe

    The Earth: Plasma Sources, Losses, and Transport Processes

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    This paper reviews the state of knowledge concerning the source of magnetospheric plasma at Earth. Source of plasma, its acceleration and transport throughout the system, its consequences on system dynamics, and its loss are all discussed. Both observational and modeling advances since the last time this subject was covered in detail (Hultqvist et al., Magnetospheric Plasma Sources and Losses, 1999) are addressed

    Extra-Intestinal Manifestations of Familial Adenomatous Polyposis

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    Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disorder, which results from a germ line mutation in the APC (adenomatous polyposis coli) gene. FAP is characterized by the formation of hundreds to thousands of colorectal adenomatous polyps. Although the development of colorectal cancer stands out as the most prevalent complication, FAP is a multisystem disorder of growth. This means, it is comparable to other diseases such as the MEN syndromes, Von Hippel-Lindau disease and neurofibromatosis. However, the incidence of many of its clinical features is much lower. Therefore, a specialized multidisciplinary approach to optimize health care—common for other disorders—is not usually taken for FAP patients. Thus, clinicians that care for and counsel members of high-risk families should have familiarity with all the extra-intestinal manifestations of this syndrome. FAP-related complications, for which medical attention is essential, are not rare and their estimated lifetime risk presumably exceeds 30%. Affected individuals can develop thyroid and pancreatic cancer, hepatoblastomas, CNS tumors (especially medulloblastomas), and various benign tumors such as adrenal adenomas, osteomas, desmoid tumors and dental abnormalities. Due to improved longevity, as a result of better prevention of colorectal cancer, the risk of these clinical problems will further increase

    Ionic liquids at electrified interfaces

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    Until recently, “room-temperature” (<100–150 °C) liquid-state electrochemistry was mostly electrochemistry of diluted electrolytes(1)–(4) where dissolved salt ions were surrounded by a considerable amount of solvent molecules. Highly concentrated liquid electrolytes were mostly considered in the narrow (albeit important) niche of high-temperature electrochemistry of molten inorganic salts(5-9) and in the even narrower niche of “first-generation” room temperature ionic liquids, RTILs (such as chloro-aluminates and alkylammonium nitrates).(10-14) The situation has changed dramatically in the 2000s after the discovery of new moisture- and temperature-stable RTILs.(15, 16) These days, the “later generation” RTILs attracted wide attention within the electrochemical community.(17-31) Indeed, RTILs, as a class of compounds, possess a unique combination of properties (high charge density, electrochemical stability, low/negligible volatility, tunable polarity, etc.) that make them very attractive substances from fundamental and application points of view.(32-38) Most importantly, they can mix with each other in “cocktails” of one’s choice to acquire the desired properties (e.g., wider temperature range of the liquid phase(39, 40)) and can serve as almost “universal” solvents.(37, 41, 42) It is worth noting here one of the advantages of RTILs as compared to their high-temperature molten salt (HTMS)(43) “sister-systems”.(44) In RTILs the dissolved molecules are not imbedded in a harsh high temperature environment which could be destructive for many classes of fragile (organic) molecules

    Search for Spatial Correlations of Neutrinos with Ultra-high-energy Cosmic Rays

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    For several decades, the origin of ultra-high-energy cosmic rays (UHECRs) has been an unsolved question of high-energy astrophysics. One approach for solving this puzzle is to correlate UHECRs with high-energy neutrinos, since neutrinos are a direct probe of hadronic interactions of cosmic rays and are not deflected by magnetic fields. In this paper, we present three different approaches for correlating the arrival directions of neutrinos with the arrival directions of UHECRs. The neutrino data are provided by the IceCube Neutrino Observatory and ANTARES, while the UHECR data with energies above ∌50 EeV are provided by the Pierre Auger Observatory and the Telescope Array. All experiments provide increased statistics and improved reconstructions with respect to our previous results reported in 2015. The first analysis uses a high-statistics neutrino sample optimized for point-source searches to search for excesses of neutrino clustering in the vicinity of UHECR directions. The second analysis searches for an excess of UHECRs in the direction of the highest-energy neutrinos. The third analysis searches for an excess of pairs of UHECRs and highest-energy neutrinos on different angular scales. None of the analyses have found a significant excess, and previously reported overfluctuations are reduced in significance. Based on these results, we further constrain the neutrino flux spatially correlated with UHECRs

    Evaluation of skin absorption of drugs from topical and transdermal formulations

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    Demanda energética nas operaçÔes mecanizadas na silagem de milho no sistema de "silo bag" Energy demand in the mechanized operations in the corn silage in the silo bag system

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    Foi avaliado o consumo energĂ©tico das operaçÔes mecanizadas envolvidas na produção de silagem de planta inteira e silagem de "grĂŁo Ășmido" de milho, tendo como referĂȘncia o processamento seco desse cereal. O ensaio foi conduzido na Fazenda Experimental Lageado, pertencente Ă  Faculdade de CiĂȘncias AgronĂŽmicas, e nas instalaçÔes da Faculdade de Medicina VeterinĂĄria e Zootecnia - UNESP, localizada no municĂ­pio de Botucatu - SP. O delineamento experimental foi em blocos ao acaso, com parcelas subdivididas no tempo (trĂȘs Ă©pocas de colheita: silagem de planta inteira, silagem de "grĂŁo Ășmido" e colheita de grĂŁos secos), com 10 repetiçÔes. As anĂĄlises estatĂ­sticas foram realizadas por meio do programa ESTAT, pelo teste de mĂ©dia de Tukey, a 5% de probabilidade. A silagem de planta inteira teve o maior consumo de combustĂ­vel por ĂĄrea. A secagem dos grĂŁos de 15,5% para 13% foi responsĂĄvel por 87% do gasto de energia por ĂĄrea. A silagem de "grĂŁo Ășmido" demandou o menor uso de energia por ĂĄrea nas operaçÔes mecanizadas.<br>This work aims to evaluate the energy consumption of the mechanized operations involved in the silage production of entire plant and silage of humid maize, having as reference the dry processing of this cereal. The experiment was on Lageado Experimental Farm of the Agronomy School, and the Education Research and Production Farm, of the Veterinary School of - UNESP - SĂŁo Paulo State University - Botucatu Campus. The experiment design was in randomized blocks with parts subdivided in time (three times of harvest: silage of entire plant, silage of humid grains and harvest of dry grains), with 10 repetitions. The statistical analyses were performed with ESTAT software, and Tukey test at 5% of probability. The highest fuel consumption per area was reported for the ensilage of entire plant. The highest energy demand per area was reported for the processing of dry grain, as drying is responsible for 87% of the energy expense. The ensilage of humid grain demanded the lesser use of energy per area in the mechanized operations

    Kelvin-Helmholtz waves at the Earth's magnetopause: Multiscale development and associated reconnection

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    International audienceWe examine traversals on 20 November 2001 of the equatorial magnetopause boundary layer simultaneously at 1500 magnetic local time (MLT) by the Geotail spacecraft and at 1900 MLT by the Cluster spacecraft, which detected rolled-up MHD-scale vortices generated by the Kelvin-Helmholtz instability (KHI) under prolonged northward interplanetary magnetic field conditions. Our purpose is to address the excitation process of the KHI, MHD-scale and ion-scale structures of the vortices, and the formation mechanism of the low-latitude boundary layer (LLBL). The observed KH wavelength (>4 × 104 km) is considerably longer than predicted by the linear theory from the thickness (1000 km) of the dayside velocity shear layer. Our analyses suggest that the KHI excitation is facilitated by combined effects of the formation of the LLBL presumably through high-latitude magnetopause reconnection and compressional magnetosheath fluctuations on the dayside, and that breakup and/or coalescence of the vortices are beginning around 1900 MLT. Current layers of thickness a few times ion inertia length 100 km and of magnetic shear 60° existed at the trailing edges of the vortices. Identified in one such current sheet were signatures of local reconnection: AlfvĂ©nic outflow jet within a bifurcated current sheet, nonzero magnetic field component normal to the sheet, and field-aligned beam of accelerated electrons. Because of its incipient nature, however, this reconnection process is unlikely to lead to the observed dusk-flank LLBL. It is thus inferred that the flank LLBL resulted from other mechanisms, namely, diffusion and/or remote reconnection unidentified by Cluster
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