The features of the spatial structure of the gramicidine A-cesium complex

AbstractEarlier obtained two-dimensional 1H-NMR spectroscopy data were used to analyze the spatial structure and conformational mobility of the double right ↑↓ ππLD7.2 helix of the complex formed by gramicidine A and Cs+ ions in an organic solvent (a chloroform-methanol mixture). Analysis of the experimental data permitted the determination of a set of conformations for each of the high-mobility residue side chains in the solution. The energy refinement of the most probable conformation of the double right ↑↓ ππLD7.2 helix was made and conformational rearrangements of the tryptophan residue side chain were studied in detail

Consequences of Raising The Retirement Age for the Labor Market in the Regions of Russia

The article presents the results of a study aimed at assessing the consequences for the labor market of raising the retirement age in Russia. The foreign experience of raising the retirement age, on the basis of which a number of characteristic moments of this process are highlighted, is presented. The review of the scientific literature showed a polemical character of the problem under investigation and allowed to formulate a hypothesis of the study, which is as follows: raising the retirement age will lead to an increase in the supply of labor, which will entail the reduction of the labor price. The article presents an analysis of the current situation in the labor market. Since the raise of the retirement age will require the availability of vacant jobs in an amount not less than the number of people detained in the labor market, two tasks have been solved in this study. In the first task, the change in the average wage was calculated, provided that the number of jobs will meet the increased need, i.e. unemployment will remain at the same level. In the second task, the number of jobs is fixed to estimate the potential effect of raising the retirement age. Evaluation of the effect of raising the retirement age with a fixed number of jobs was carried out by constructing a regression relationship between wages and unemployment, differences in age groups were taken into account by introducing fictitious shift and tilt variables into the model. According to the calculations obtained under the first and second tasks, wages will decrease with the raising of the retirement age by one year for both sexes. The results of the study showed that the decision to raise the retirement age should be accompanied by a number of serious additional measures, primarily in the employment of population sector. © 2019, Economic Laboratory for Transition Research. All rights reserved.Russian Science Foundation, RSF: 14-18-00574The research is conducted with the support of the Russian Science Foundation, Project No. 14-18-00574 "Anti-Crisis Information and Analysis System: Diagnostics of Regions, Threat Assessment, and Scenario Forecasting in Order to Preserve and Enhance Economic Security and Improve Welfare of Russia, an information-analytical system.

Methods of Burning Solid Fuel Mixtures in Power Plants (Review)

В работе представлен один из наиболее доступных способов перехода к ресурсосберегающей и экологически безопасной выработке тепловой и электрической энергии угольными объектами теплоэнергетики, заключающийся в сжигании смесей топлив. Проведен обзор существующего опыта перевода действующего теплотехнического оборудования как в России, так и за рубежом, подробно описаны основные трудности в процессе сжигания твердотопливных смесей. Наиболее эффективные смеси по своим экологическим показателям получаются на основе угля и биомассы с ее добавлением по теплосодержанию не более 20 %. Горение остается одним из самых сложных и не исследованных процессов, а при совместном горении нескольких твердых топлив происходят дополнительные взаимодействия, которые влияют на основные характеристики горения, поэтому в работе отдельно рассмотрены методики исследований процесса горения и оборудование для проведения опытного сжигания твердотопливных смесейThe paper presents one of the most accessible ways to transition to resource-saving and environmentally safe generation of heat and electricity by coal-fired thermal power facilities, which consists in burning fuel mixtures. A review of the existing experience in the transfer of existing heat engineering equipment both in Russia and abroad is carried out, the main difficulties in the process of burning solid fuel mixtures are described in detail. The most effective mixtures in terms of their environmental performance are obtained on the basis of coal and biomass with its addition in terms of heat content of no more than 20 %. The combustion remains one of the most complex and unexplored processes, and during the joint combustion of several solid fuels, additional interactions occur that affect the main combustion characteristics, therefore, the paper separately considers the methods for studying the combustion process and equipment for experimental combustion of solid fuel mixture

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

Simulation of low dose positron emission mammography scanner for global breast health applications

Positron emission mammography ( PEM ) is a breast imaging modality that typically involves the administration of relatively high doses of radiotracer. In order to reduce tracer costs and consider PEM for global screening applications, it would be helpful to reduce the required amount of administered radiotracer so that patient dose would be comparable to conventional x-ray mammograms. We performed GATE Monte Carlo investigations of several possible camera configurations. Increasing the detector thickness from 10 to 30 mm, increasing the camera surface area from 5 x 20cm2 to 20 x 20cm2, and applying depth-ofinteraction information to increase the acceptance angle, increased the overall efficiency to radiation emitted from a breast cancer by a factor of 24 as compared to existing commercial system

The Features of Native Gold in Ore-Bearing Breccias with Realgar-Orpiment Cement of the Vorontsovskoe Deposit (Northern Urals, Russia)

This paper describes native gold in ore-bearing breccias with realgar-orpiment cement from the Vorontsovskoe gold deposit (Northern Urals, Russia). Particular attention is paid to the morphological features of native gold and its relation to other minerals. The latter include both common (orpiment, barite, pyrite, prehnite, realgar) and rare species (Tl and Hg sulfosalts, such as boscardinite, dalnegroite, écrinsite, gillulyite, parapierrotite, routhierite, sicherite, vrbaite, etc.). The general geological and geochemical patterns of the Turyinsk-Auerbakh metallogenic province, including the presence of small non-economic copper porphyry deposits and general trend in change of the composition of native gold (an increase in the fineness of gold from high-temperature skarns to low-temperature realgar-orpiment breccias) confirm that the Vorontsovskoe deposit is an integral part of a large ore-magmatic system genetically associated with the formation of the Auerbakh intrusion

Exome analysis of carotid body tumor

Abstract Background Carotid body tumor (CBT) is a form of head and neck paragangliomas (HNPGLs) arising at the bifurcation of carotid arteries. Paragangliomas are commonly associated with germline and somatic mutations involving at least one of more than thirty causative genes. However, the specific functionality of a number of these genes involved in the formation of paragangliomas has not yet been fully investigated. Methods Exome library preparation was carried out using Nextera® Rapid Capture Exome Kit (Illumina, USA). Sequencing was performed on NextSeq 500 System (Illumina). Results Exome analysis of 52 CBTs revealed potential driver mutations (PDMs) in 21 genes: ARNT, BAP1, BRAF, BRCA1, BRCA2, CDKN2A, CSDE1, FGFR3, IDH1, KIF1B, KMT2D, MEN1, RET, SDHA, SDHB, SDHC, SDHD, SETD2, TP53BP1, TP53BP2, and TP53I13. In many samples, more than one PDM was identified. There are also 41% of samples in which we did not identify any PDM; in these cases, the formation of CBT was probably caused by the cumulative effect of several not highly pathogenic mutations. Estimation of average mutation load demonstrated 6–8 mutations per megabase (Mb). Genes with the highest mutation rate were identified. Conclusions Exome analysis of 52 CBTs for the first time revealed the average mutation load for these tumors and also identified potential driver mutations as well as their frequencies and co-occurrence with the other PDMs