Pitch production during the Roman period: an intensive mountain industry for a globalised economy?

The authors’ research project in the Pyrenees mountains has located and excavated Roman kilns for producing pitch from pine resin. Their investigations reveal a whole sustainable industry, integrated into the local environmental cycle, supplying pitch to the Roman network and charcoal as a spin-off to the local iron extractors. The paper makes a strong case for applying combined archaeological and palaeoenvironmental investigations in upland areas, showing mountain industries to have been not so much marginal and pastoral as key players in the economy of the Roman period and beyond it into the seventh century AD

Maternal residential pesticide use and risk of childhood leukemia in Costa Rica.

Evidence suggests that early-life exposure to pesticides inside the home may be associated with childhood leukemia, however data from Latin American countries are limited. We examined whether self-reported maternal residential pesticide use and nearby pesticide applications-before and after child's birth-were associated with acute lymphoblastic leukemia (ALL) in the Costa Rican Childhood Leukemia Study (CRCLS), a population-based case-control study (2001-2003). Cases (n = 251 ALL) were diagnosed between 1995 and 2000 (age <15 years at diagnosis) and were identified through the Costa Rican Cancer Registry and National Children's Hospital. Population controls (n = 577) were drawn from the National Birth Registry. We fitted unconditional logistic regression models adjusted for child sex, birth year, and socioeconomic status to estimate the exposure-outcome associations and also stratified by child sex. We observed that self-reported maternal insecticide use inside the home in the year before pregnancy, during pregnancy, and while breastfeeding was associated with increased odds of ALL among boys [adjusted Odds Ratio (aOR) = 1.63 (95% confidence interval [95% CI]: 1.05-2.53), 1.75 (1.13-2.73), and 1.75 (1.12-2.73), respectively. We also found evidence of exposure-response relationships between more frequent maternal insecticide use inside the home and increased odds of ALL among boys and girls combined. Maternal report of pesticide applications on farms or companies near the home during pregnancy and at any time period were also associated with ALL. Our study in Costa Rica highlights the need for education to minimize pesticide exposures inside and around the home, particularly during pregnancy and breastfeeding

LA COMPARABILIDAD DE LA INFORMACIÓN CONTABLE EN EUROPA: EFECTOS DE LA MANIPULACIÓN CONTABLE SOBRE EL NIVEL DE CONSERVADURISMO

This paper aims to study international differences in accounting conservatism, excluding the effect ofearnings management practices across three European countries (France, Germany and United Kingdom).These countries not only belong to different accounting regulatory regimes but also present significantinstitutional differences determinant on both the magnitude and sign of earnings management practices.Particularly, continental European countries included in our sample have institutional features that enhancemanagers to engage in income decreasing earnings management practices, thus, affecting the results ofearnings conservatism empirical studies, where the use of a lower “managed” earnings figure leads to anover valuation of accounting conservatism not driven by the recognition of “bad news”. Although higherlitigation risk and lower balance sheet conservatism suggest a higher level of earnings conservatism in theUK, previous empirical studies have not reported consistent results compared to continental Europeancountries. Using the Basu (1997) model, results show that, excluding discretionary accruals as a proxy forearnings management, that is, using an “unmanaged” earnings figure, earnings conservatism for France andGermany decreases, while it remains constant for the UK, compared to the results of a similar analysis usingas dependent variable the published and possibly “managed” earnings figure. In addition, discretionaryaccruals provide evidence of income-decreasing earnings management practices in France and Germany. El objetivo de este trabajo es analizar las diferencias internacionales en el nivel de conservadurismo contable, excluyendo el efecto de la manipulación del beneficio en tres países europeos, Francia, Alemania y Reino Unido. Estos países representan regímenes contables distintos y cuentan con diferencias institucionales determinantes, tanto en la magnitud como en el signo de las prácticas de manipulación. En concreto, los países de Europa continental incluidos en el análisis, presentan características institucionales que incentivan la manipulación del resultado contable a la baja, pudiendo afectar significativamente a los resultados de los trabajos empíricos sobre conservadurismo del resultado, quedando éste sobrevalorado al tener en cuenta cifras de beneficio ?manipuladas? a la baja por motivos muy distintos al reconocimiento de ?malas noticias?. Hasta el momento, los resultados procedentes de estudios anteriores no han apreciado un grado de conservadurismo del resultado superior en el Reino Unido, país que sin embargo, por su mayor riesgo de litigio y su menor conservadurismo del balance, hace prever un sesgo conservador del resultado superior al de los países de Europa continental. Aplicando el modelo de regresión inversa de Basu (1997), los resultados, comparados con los obtenidos utilizando como variable dependiente el resultado publicado, es decir, aquel sujeto a posibles manipulaciones, muestran que, una vez excluidos los ajustes discrecionales por devengo de la cifra de resultados, como aproximación al grado de manipulación contable, el nivel de conservadurismo decrece notablemente en Francia y Alemania, mientras que se mantiene en el Reino Unido. Asimismo, el cálculo de los ajustes discrecionales por devengo demuestra que en Francia y Alemania las prácticas de manipulación están dirigidas a la minoración del nivel de resultados.Manipulación del Resultado, Conservadurismo Contable, Factores Institucionales. Earnings Management, Earnings Conservatism, Institutional Factors.

A novel microfluidic liposomal formulation for the delivery of the SN-38 camptothecin: characterization and in vitro assessment of its cytotoxic effect on two tumor cell lines

Purpose: Irinotecan (CPT-11) and SN-38 - its active metabolite - are alkaloid-derived topoisomerase I interactive compounds widely used in various cancer therapy protocols. To solve the problems associated with the instability of their lactone ring at physiological pH and with the extreme insolubility of SN-38, the development of delivery carriers (eg, liposomes) has been considered a subject of unquestionable medical interest. This article focuses on the development of an alternative protocol to the classical lipid-film hydration procedures to obtain a pharmaceutical formulation for SN-38. Methods: SN-38-loaded liposomes (SN-38lip) were produced by microemulsification, without a prior lipid-film preparation step, and characterized by different methods. Formulation parameters were determined by photon correlation spectroscopy, and the SN-38 entrapment efficiency was evaluated by absorbance spectroscopy. SN-38lip was obtained as a dry, white powder by lyophilization. MTT and LDH assays were conducted to assess the cytotoxic effect of SN-38, both in liposomal (SN-38lip) and solubilized form (SN-38sol); flow cytometry was used to quantify SN-38 uptake and to analyze cell-cycle phase distribution after drug exposure. Results: Microfluidic, stable, and controlled sized, negatively charged liposomes, with high SN-38 incorporation efficiency into egg yolk phosphatidylcholine (EPC)/L-α-dioleoyl-phospathidylserine (DOPS) (9:1) vesicles (SN-38lip), were prepared. A lyophilized powder of SN-38lip, easily reconstitutable while retaining physicochemical parameters, was finally obtained. The efficacy of SN-38lip was assessed by in vitro studies with two tumor cell lines (HeLa and Caco-2) and compared with that of SN-38sol. It demonstrated the highest uptake of SN-38lip, in accordance with its highest cytotoxicity effect, in comparison with that of SN-38sol. In addition, different cell-cycle alterations were induced in both cell lines by the liposomal formulation. Conclusion: The results highlight the potential usefulness of the procured SN-38 liposomal formulation and provide the basis for conducting in vivo studies that allow the development of alternative strategies for colorectal cancer treatment

Problematic, absent and stigmatizing diagnoses in current mental disorders classifications: Results from the WHO-WPA and WHO-IUPsyS Global Surveys

This study examined English- and Spanish-speaking psychologists' and psychiatrists' opinions regarding problematic, absent and stigmatizing diagnoses in current mental disorders classifications (ICD-10 and DSM-IV), and their perceived need for a national classification of mental disorders. Answers to open-ended questions included in WHO-WPA and WHO-IUPsyS surveys were examined using an inductive content-analysis method. A total of 3,222 participants from 35 countries were included. The most problematic diagnostic group was personality disorders, especially among psychiatrists, because of poor validity and lack of specificity. Complex posttraumatic stress disorder was the most frequent diagnosis suggested for inclusion, mainly by psychologists, to better account for the distinct processes and consequences of complex trauma. Schizophrenia was the diagnosis most frequently identified as stigmatizing, particularly by psychiatrists, due to lack of public understanding or knowledge about the diagnosis. Of the 14.4% of participants who perceived a need for a national classification system, two-thirds were from Africa or Latin America. The rationales provided were that mental disorders classifications should consider cultural and socio-historical diversity in the expression of psychopathology, differences in the perception of what is and is not pathological in different nations, and the existence of culture-bound syndromes. Implications for ICD-11 development and dissemination are discussed. © 2014 Asociación Española de Psicología Conductual

Variability and predictors of weekly pesticide exposure in applicators from organic, sustainable and conventional smallholder farms in Costa Rica

Estimates of pesticide exposure among applicators from low- and middle-income countries (LMICs) are scarce, and exposure assessment methods are sometimes costly or logistically unfeasible. We examined the variability in weeklong pesticide exposure among applicators in Costa Rica and its predictors.; We conducted a cross-sectional survey among 221 pesticide applicators from organic, sustainable and conventional farms in 2016. We administered structured questionnaires to assess pesticide application practices at two time points (4-6 weeks apart). We adapted an existing algorithm to fit the context of smallholders and derive weekly pesticide exposure scores. We used linear mixed-effect models to examine within-worker and between-worker score variability. We then identified sociodemographic and occupational predictors of weekly pesticide exposure scores.; We observed high within-worker and between-worker variability in weekly pesticide exposures (eg, up to 180-fold and 70-fold differences in average weekly exposures within and between workers, respectively; intraclass correlation coefficient=0.4). Applicators working on conventional and sustainable farms had exposure scores twofold and 1.5-fold higher than those working in organic farms, respectively. Farm workers who received training on pesticide use had weekly pesticide exposure scores of 33% (95% CI 1% to 55%) lower than those who did not receive any training.; In this study of applicators from smallholder farms in Costa Rica, we determined the importance of collecting questionnaire data on self-reported pesticide use repeatedly due to its high variability within workers and absence of application records. Our questionnaire-based exposure algorithm could allow the calculation of semiquantitative estimates of average pesticide exposure for applicators from other LMICs

An overview of the health effects of bisphenol a from a one health perspective

Bisphenol A (BPA) is a chemical compound, considered as an “emerging pollutant”, that appears ubiquitously, contaminating the environment and food. It is an endocrine disruptor, found in a multitude of consumer products, as it is a constituent of polycarbonate used in the manufacture of plastics and epoxy resins. Many studies have evaluated the effects of BPA, using a wide range of doses and animal models. In this work, we carried out a review of relevant research related to the effects of BPA on health, through studies performed at different doses, in different animal models, and in human monitoring studies. Numerous effects of BPA on health have been described; in different animal species, it has been reported that it interferes with fertility in both females and males and causes alterations in their offspring, as well as being associated with an increase in hormone-dependent pathologies. Similarly, exposure to BPA has been related to other diseases of great relevance in public health such as obesity, hypertension, diabetes, or neurodevelopmental disorders. Its ubiquity and nonmonotonic behavior, triggering effects at exposure levels considered “safe”, make it especially relevant when both animal and human populations are constantly and inadvertently exposed to this compound. Its effects at low exposure levels make it essential to establish safe exposure levels, and research into the effects of BPA must continue and be focused from a “One Health” perspective to take into account all the factors that could intervene in the development of a disease in any exposed organism

Analysis of Indirect Biomarkers of Effect after Exposure to Low Doses of Bisphenol A in a Study of Successive Generations of Mice

Bisphenol A (BPA) is considered as being an emerging pollutant, to which both animal and human populations are continuously and inadvertently exposed. The identification of indirect biomarkers of effect could be a key factor in determining early adverse outcomes from exposure to low doses of BPA. Thus, this study on mice aims to evaluate and identify indirect biomarkers of effect through the analysis of their blood biochemistry, and of certain reproduction parameters after exposure to different BPA concentrations (0.5, 2, 4, 50, and 100 µg/kg BW/day) in drinking water over generations. Our results showed that there were no modifications in the reproductive parameters evaluated, like estrous cycle duration, litter size, or the percentage of the young alive at reaching the weaning stage, at the exposure levels evaluated. However, there were modifications in the biochemical parameters, e.g., alterations in the glucose levels, that increased significantly (p < 0.05) in the breeders at the higher exposure doses (50 and 100 µg/kg BW/day in F1; 50 µg/kg BW/day in F2 and 100 µg/kg BW/day in F3), that would suggest that the BPA could induce hyperglycemia and its complications in adult animals, probably due to some damage in the pancreas cells; albumin, that increased in the breeders exposed to the highest dose in F1 and F3, inferring possible hepatic alterations. Further, total proteins showed a diminution in their values in F1 and F2, except the group exposed to 100 µg/kg BW/day, whereas in F3 the values of this parameter increased with respect to the control group, this aspect likely being related to a possible hepatic and renal alteration. Based on these results, glucose, albumin, and total proteins could initially be considered as early indicators of indirect effect after prolonged exposure to low BPA doses over generations

Ventajas de la gestión activa de la demanda (Demand management) en el control de Smart-grids

La gestión del sistema eléctrico por las utilities se ve afectado por varios factores, como un aumento del consumo, una mayor penetración de las energías renovables y la tendencia a la generación distribuida (para minimizar pérdidas asociadas al transporte y distribución). Obviamente, el consumo no es constante, produciéndose valles y picos. Habitualmente, dicha curva no se ajusta a la de generación, obligando a sobredimensionar la generación o desplegar sistemas de almacenamiento que amortigüen este desfase. Desafortunadamente, estas soluciones son costosas y finalmente repercuten en el cliente. Una solución en auge es aplicar los sistemas de “Demand Response” (DR), que convierten el consumo del cliente en un activo controlable por el operador del sistema de distribución, permitiendo ajustar de forma dinámica su consumo energético, adaptándolo a las necesidades de la red y mejorando la eficiencia. Para lograr esto debe establecerse una comunicación utility-usuario, mediante la cual pueda solicitarse una reducción del consumo en ciertas franjas horarias, aplicándole al cliente bonificaciones por ello. Por todo esto, se estima que la tecnología DR será clave en el futuro del sistema eléctrico, y en la cual el TIC-150, a través de la colaboración con diversas utilities de ámbito internacional, está trabajando activamenteThe management of the electric system is affected by many factors, such as the rising of the consumption, the growing of renewable energies and the apparition of distributed generation (in order to reduce losses in transmission and distribution). Obviously, the consumption is not constant. The consumption curve contains “valleys” (low demand periods) and “peaks” (high demand periods). Traditionally, the generation curve does not fit with the consumption curve, so the electric generation system must be oversizing, or electric storage must be installed. Unfortunately, these solutions are expensive and they increase customer bill. A new solution is applying Demand Response systems. They transform the consumption into an asset that the distribution system can manage, adjusting this consumption dynamically, adjusting it to the needs of the system and improving efficiency. Obviously, to achieve this objective there must exist a utility-customer communication. This allows to request a reduction of customer consumption when it is needed. Customers would reduce their bill thanks to this. This is why DR technology is expected to be key in the electric system future. The TIC-150 is collaborating actively with diverse international utilities in this field.Plan Propio de la Universidad de Sevilla Proyecto: 2017/0000096