What Neanderthals and AMH ate: reassessment of the subsistence across the Middle–Upper Palaeolithic transition in the Vasco-Cantabrian region of SW Europe

Recent research in northern Spain has revealed the disappearance of Neanderthal populations in the Vasco Cantabrian region a few millennia earlier than in eastern and southern Iberia and discovered a short period of overlap with modern humans, at least, in terms of radiocarbon dates. However, the causes of Neanderthal decline understood as a regional and temporal process remain open. Despite the abundance of technological studies, modern?quality chronological dating, and the availability of archaeofaunal and palaeoenvironmental data, there is a lack of consensus about how climatic and environmental conditions could have affected ungulate prey and, therefore, Neanderthal subsistence strategies. In this paper, an analytical summary of the archaeofaunal and taphonomic data available for the Vasco?Cantabrian region, combined with the most recent chronological evidence, present general knowledge about animal biogeography and ecology during the Middle?Upper Palaeolithic transition, and provides an interpretation of the behaviour of both human species in the region. This work reviews the palaeomammal community of animals represented in the record as exploited by human groups in several caves and rock shelters and pointing to continuing lacunae in knowledge. Further research is needed to verify and potentially explain the apparent hominin population gap and the ultimate fate of the NeanderthalsThis research is funded by the European Research Council under the European Union's Horizon 2020 Research and Innovation Programme (grant agreement No. 818299‐ SUBSILIENCE project (https://www.subsilience.eu) and the Ministerio de Ciencia, Innovación y Universidades (ABRUPT ‐ HAR2017‐84997‐P) to ABMA. ASR's PhD is supported within the SUBSILIENCE project. The authors would like to thank J. García Sanchez (Instituto de Arqueología‐ Merida, CSIC‐Junta de Extramadura) for technical assistance with catchment areas analysis and Figs. 1, 5 and 6. Special thanks to L. Agudo (EvoAdapta‐University of Cantabria) for her technical assistance and G. Terlato for comments on the final version of the manuscript. The authors wish to acknowledge L. Straus for editing the manuscript and for his suggestions to improve this manuscript, as kind and effective as always

Violence against women in Islamic contexts. Representation and discourse of Spanish reference press

Las violencias que sufren las mujeres en cualquier contexto y parte del mundo son un fenómeno estructural, complejo y mediatizado. Los últimos acontecimientos políticos y bélicos relacionados con contextos islámicos han provocado una sobreatención informativa respecto a la situación de las mujeres musulmanas y las formas de violencia que sufren. Este trabajo ha tomado una muestra de noticias de la prensa española generalista de mayor tirada entre 2005 y 2015 para, a partir del Análisis de Contenido, realizar una mirada panorámica sobre cómo se denominan, representan y transmiten estas violencias. Los resultados apuntan a que existe una cada vez mayor presencia de este tema en la agenda informativa, pero sin homogeneidad por la dependencia de las fuentes de agencia o el carente uso terminológico claro y la conceptualización socialmente beneficiosa.Violence against women in any context and in anywhere is a structural, complex and mediated phenomenon. Recent political and military developments related to Islamic contexts have caused too much informational attention about the situation of Muslim women and the specific forms of violence against them. In this article, a simple of general Spanish news reference media has been taken, between 2005 and 2015 and using Content Analysis, for making a panoramic look at how this violence is called, represented and transmitted. The results suggest that there is a growing presence of this issue in the news agenda, but nevertheless, the violence it presented homogenized, due to dependence on agency sources and lack of a clear terminological use and socially beneficial conceptualization

The Use of Digital Storytelling for ESP in a Technical English Course for Aerospace Engineers

[EN] Digital Storytelling is a powerful pedagogical tool for both students and educators, which started to be used for teaching and learning purposes a few years ago, becoming more and more popular over time. The use of digital storytelling in non-specific language learning contexts has been widely explored, as shown in the literature. However, its use in technical-scientific contexts of English for Specific Purposes (ESP) has not been so widely studied. This paper explores a project of digital storytelling for ESP carried out at the Universitat Politècnica de València, in Spain. The methodology was divided into several stages: completing a pre- and a post-survey, learning about digital storytelling by doing a WebQuest, making decisions about their digital stories (topic, plot, software and media), sharing their stories with their classmates through the PoliformaT LMS, watching their classmates' digital stories, using the forum to write their comments about their digital stories and their classmates', keeping a log and preparing and presenting their “making of” in front of the class, and assessing both their peers’ digital stories and their oral presentations. The overall results were very positive, as students were highly satisfied with their progress in learning and developing different skills, these being mainly linguistic, research, writing, organisation, digital, presentation, interpersonal, problem-solving and critical-thinking skills.Sevilla-Pavón, A.; Serra-Cámara, B.; Gimeno-Sanz, A. (2012). The Use of Digital Storytelling for ESP in a Technical English Course for Aerospace Engineers. The EuroCALL Review. 20(2):68-79. https://doi.org/10.4995/eurocall.2012.113796879202Bruner J. (2003). Making Stories: Law, Literature, Life. Cambridge, MA: Harvard University Press.Bruner, J. (1996). The Culture of Education. Cambridge, MA: Harvard University Press.Bruner, J. S. (1987). Life as narrative. Social Research, 54: 1-17.Robin, B. R. (2012). The Educational Uses of Digital Storytelling, http://digitalliteracyintheclassroom.pbworks.com/f/Educ-Uses-DS.pdf. Last accessed 29/06/2012.Council of Europe (2001). Common European Framework of Reference for Languages. Cambridge: Cambridge University Press.Lowenthal, P. R. (2009). Digital storytelling: An emerging institutional technology? In K. McWilliam & J. Hartley (Eds.), Story circle: Digital storytelling around the world. Malden, MA: Wiley-Blackwell, pp. 252-259. https://doi.org/10.1002/9781444310580.ch18Lowenthal, P. R. y Dunlap, J. C. (2010). From pixel on a screen to real person in your students' lives: Establishing social presence using digital storytelling. Internet and Higher Education, No. 13, pp. 70-72. https://doi.org/10.1016/j.iheduc.2009.10.004Rex, L. Al, Murnen, T., Hobbs, J., y McEachen, D. (2002). Teachers' pedagogical stories and the shaping of classroom participation: "The Dancer" and "Graveyard Shift at the 7-11". American Education Research Journal, 39(3), pp. 765-796. https://doi.org/10.3102/00028312039003765Sevilla-Pavón, A., Martínez-Sáez, A., & Siquiera-Rocha, J. M. (2011). Self-assessment and Tutor Assessment in Online Language Learning Materials: InGenio FCE Online Course & Tester. In S. Thouësny & L. Bradley (Eds.), Second Language Teaching and Learning with Technology. Dublin: Research-publishing.net, pp.45-69. https://doi.org/10.14705/rpnet.2011.000006Shank, R. C. (1990). Tell me a story: Narrative and intelligence. Evanston, IL: Northwestern University Process.Zull, J. (2002) The Art of Changing the Brain. Sterling, VA: Stylus Publishing

MXRA5 is a TGF-β1-regulated human protein with anti-inflammatory and anti-fibrotic properties

Current therapy for chronic kidney disease (CKD) is unsatisfactory because of an insufficient understanding of its pathogenesis. Matrix remodelling-associated protein 5 (MXRA5, adlican) is a human protein of unknown function with high kidney tissue expression, not present in rodents. Given the increased expression of MXRA5 in injured tissues, including the kidneys, we have suggested that MXRA5 may modulate kidney injury. MXRA5 immunoreactivity was observed in tubular cells in human renal biopsies and in urine from CKD patients. We then explored factors regulating MXRA5 expression and MXRA5 function in cultured human proximal tubular epithelial cells and explored MXRA5 expression in kidney cancer cells and kidney tissue. The fibrogenic cytokine transforming growth factor-β1 (TGFβ1) up-regulated MXRA5 mRNA and protein expression. TGFβ1-induced MXRA5 up-regulation was prevented by either interference with TGFβ1 activation of the TGFβ receptor 1 (TGFBR1, ALK5) or by the vitamin D receptor agonist paricalcitol. By contrast, the pro-inflammatory cytokine TWEAK did not modulate MXRA5 expression. MXRA5 siRNA-induced down-regulation of constitutive MXRA5 expression resulted in higher TWEAK-induced expression of chemokines. In addition, MXRA5 down-regulation resulted in a magnified expression of genes encoding extracellular matrix proteins in response to TGFβ1. Furthermore, in clear cell renal cancer, von Hippel–Lindau (VHL) regulated MXRA5 expression. In conclusion, MXRA5 is a TGFβ1- and VHL-regulated protein and, for the first time, we identify MXRA5 functions as an anti-inflammatory and anti-fibrotic molecule. This information may yield clues to design novel therapeutic strategies in diseases characterized by inflammation and fibrosis.This work was supported by grants from the Instituto de Salud Carlos III (FEDER funds ISCIII RETIC REDINREN RD12/0021, PI13/00047, PI15/00298, PIE13/00051, Comunidad de Madrid (CIFRA S2010/BMD-2378), Sociedad Española de Nefrología. Programa Intensificación Actividad Investigadora (ISCIII/Agencia Laín-Entralgo/CM) to AO, ISCIII Joan Rodes JR14/00028 to BFF and Miguel Servet MS12/03262, MS14/00133, MECD to JP, and Biobanco IIS-FJD PT13/0010/001

Clinical proteomics in kidney disease as an exponential technology: Heading towards the disruptive phase

Exponential technologies double in power or processing speed every year, whereas their cost halves. Deception and disruption are two key stages in the development of exponential technologies. Deception occurs when, after initial introduction, technologies are dismissed as irrelevant, while they continue to progress, perhaps not as fast or with so many immediate practical applications as initially thought. Twenty years after the first publications, clinical proteomics is still not available in most hospitals and some clinicians have felt deception at unfulfilled promises. However, there are indications that clinical proteomics may be entering the disruptive phase, where, once refined, technologies disrupt established industries or procedures. In this regard, recent manuscripts in CKJ illustrate how proteomics is entering the clinical realm, with applications ranging from the identification of amyloid proteins in the pathology lab, to a new generation of urinary biomarkers for chronic kidney disease (CKD) assessment and outcome prediction. Indeed, one such panel of urinary peptidomics biomarkers, CKD273, recently received a Food and Drug Administration letter of support, the first ever in the CKD field. In addition, a must-read resource providing information on kidney disease-related proteomics and systems biology databases and how to access and use them in clinical decision-making was also recently published in CKJ.Grant support was received from: ISCIII and FEDER funds PI13/00047; EUTOX, CP12/03262, CP14/00133, PI15/00298, PI14/00386, PI15/01460, PI16/01900, PI16/02057; Diabetes Cancer Connect PIE13/00051; Sociedad Española de Nefrologia; FRIAT; and ISCIII-RETIC REDinREN RD016/009. Salary support was received from: ISCIII Miguel Servet to A.B.S., A.M.R. and M.D.S.-N.; Joan Rodes to B.F.-F; and Programa Intensificación Actividad Investigadora (ISCIII/Agencia Laín-Entralgo/CM) to A.O

Cinemática con mi cuerpo

El presente trabajo expone los resultados y la experiencia obtenida en el desarrollo de una investigación sobre la metodología y los problemas existentes al introducir y abordar la cinemática con alumnos de 14 y 15 años. Se presenta una metodología que pretende partir de una experiencia práctica sencilla empleando el modelo de investigación - acción docente, comenzando con una fundamentación teórica que se emplea de base para el diseño y desarrollo de las sesiones con los alumnos. Se presenta el desarrollo del trabajo a modo de diario docente para finalmente, concluir con la evaluación de la progresión del grupo y la reflexión realizada durante el proceso y las posibles aplicaciones e implicaciones

Liter·Alia : Literaturas Hispánicas en contexto. Una propuesta de edición digital anotada de textos literarios hispánicos para su uso en la clase de ELE

Con gran frecuencia, los estudiantes de español como lengua extranjera encuentran dificultades de comprensión lectora en textos literarios debido a la riqueza de vocabulario y sus expresiones idiomáticas, así como por la dificultad de comprender elementos contextuales históricos y estéticos como apoyo para reflexionar sobre el texto. Una edición del texto anotada digitalmente puede desarrollar la comprensión lectora y la interacción multimodal con materiales audiovisuales que potencien el desarrollo de las habilidades de comprensión oral e incluso la producción escrita. Describimos en este artículo qué tipo de edición digital puede cubrir las necesidades de los estudiantes con un nivel medio avanzado de español (B2) y escasa formación literaria o histórica, a través de un proyecto práctico de anotación digital de textos literarios hispánicos en el marco de un curso de introducción a los textos literarios contemporáneos (siglos XIX-XXI) para estudiantes de grado de lengua y literatura española en la Universidad de Oslo.Frequently, students of Spanish as a second language struggle when they must read works of fiction. This critical situation on reading comprehension often happens because learners have a limited knowledge of vocabulary, and they lack enough historical and aesthetic contextual background data. As a solution, creating a tailored online digital annotated edition can help to develop comprehension skills, support informative and critical reading, and enhance writing discussions. This can be reached when we build around a particular text a net of multimodal interaction fueled by audiovisual resources, written explanations, and topic-based enquiries which are placed as annotations linked to meaningful key-words in the main text. Thus, this paper focuses on describing an online digital annotated edition prepared for Spanish students of language and literature (level B2) in the framework of an introductory course of Contemporary Spanish Literature taught at the University of Oslo (Norway) on 2017

Los límites de la ludificación en la enseñanza de la arquitectura. La técnica del Escape Room

En la actualidad, buena parte de la comunidad universitaria coincide con la afirmación de que “Aprender no es un juego, pero se aprende jugando”. Es innegable que las actuales generaciones de estudiantes universitarios han crecido rodeados de la ludificación aplicada a actividades de lo más dispares y, por tanto, han desarrollado la predisposición al juego, puesto que éste proporciona placer y felicidad, así como las habilidades necesarias para participar en él, competitividad, actitud resolutiva, espíritu de equipo y muchas más. Con esta perspectiva en mente y con el objetivo de remarcar los conceptos más importantes que se han impartido durante el curso, el equipo de profesores de la asignatura Bases para la Técnica del primer curso de arquitectura en la Escuela Técnica Superior de Arquitectura de Barcelona (Universidad Politécnica de Cataluña), hemos desarrollado un juego basado en la técnica del Escape Room. Este artículo describe la metodología llevada a cabo en las pruebas realizadas durante 3 cuatrimestres por más de 500 alumnos, analiza los resultados en cuanto al cumplimiento de los objetivos didácticos planteados y plantea una reflexión sobre los límites de la ludificación aplicada a la enseñanza de la arquitectura.Peer ReviewedPostprint (author's final draft

Financial Fraud, Mental Health, and Quality of Life: A Study on the Population of the City of Madrid, Spain

Over the past few decades, the financial system has engaged in abusive practices that meet the definition of fraud. Our objective is to compare the prevalence of psychological distress and levels of health-related quality of life according to having been exposed to financial fraud and its economic impact on family finances. The City of Madrid Health Survey 2017 included specific questions on exposure to financial fraud-this section was administered to half of the participants (n = 4425). Mental health need or caseness was defined by a score greater than two on the 12-item version of the Goldberg health questionnaire. Health-related quality of life was assessed by the Darmouth Coop Functional Health Assessment Charts/WONCA (COOP/WONCA). The prevalence of financial fraud was 10.8%. The prevalence rate ratio for caseness of those who experienced severe economic impact due to fraud was 1.62 (95%, CI 1.17-2.25; reference: no fraud), after adjustment by age, sex, social class, and immigrant status. Women experienced a decreased quality of life, even with a moderate impact of fraud, while men experienced a decreased quality of life related to fraud with severe economic impact. The current study contributes to a growing body of literature showing the effects of economic shocks on health as a result of financial fraud.This research was funded by IMIENS—Joint Research Institute National Distance Education University and Health Institute Carlos III (IMIENS 2017-002).S