158 research outputs found
Single-parameter non-adiabatic quantized charge pumping
Controlled charge pumping in an AlGaAs/GaAs gated nanowire by
single-parameter modulation is studied experimentally and theoretically.
Transfer of integral multiples of the elementary charge per modulation cycle is
clearly demonstrated. A simple theoretical model shows that such a quantized
current can be generated via loading and unloading of a dynamic quasi-bound
state. It demonstrates that non-adiabatic blockade of unwanted tunnel events
can obliterate the requirement of having at least two phase-shifted periodic
signals to realize quantized pumping. The simple configuration without multiple
pumping signals might find wide application in metrological experiments and
quantum electronics.Comment: 4 pages, 4 figure
Target structure independent elastic scattering at low momentum transfers
Analyzing powers and cross sections for the elastic scattering of polarized
7Li by targets of 6Li, 7Li and 12C are shown to depend only on the properties
of the projectile for momentum transfers of less than 1.0 fm-1. The result of a
detailed analysis of the experimental data within the framework of the coupled
channels model with ground state reorientation and transitions to the excited
states of the projectile and targets included in the coupling schemes are
presented. This work suggests that nuclear properties of weakly-bound nuclei
can be tested by elastic scattering experiments, independent of the target
used, if data are acquired for momentum transfers less than ~1.0 fm-1.Comment: 9 pages, 4 figures, 1 table, accepted in Phys. Lett.
The Effects of Diesel Exhaust Particles (DEP) on the Release of TNF-α and IL-6 from Alveolar Macrophages<General discussion on present the knowledge concerning small airways>
Paleogene deepwater mass composition of the tropical Pacific and implications for thermohaline circulation in a greenhouse world
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94621/1/ggge1162.pd
Brief Exposure to Sensory Cues Elicits Stimulus-Nonspecific General Sensitization in an Insect
The effect of repeated exposure to sensory stimuli, with or without reward is well known to induce stimulus-specific modifications of behaviour, described as different forms of learning. In recent studies we showed that a brief single pre-exposure to the female-produced sex pheromone or even a predator sound can increase the behavioural and central nervous responses to this pheromone in males of the noctuid moth Spodoptera littoralis. To investigate if this increase in sensitivity might be restricted to the pheromone system or is a form of general sensitization, we studied here if a brief pre-exposure to stimuli of different modalities can reciprocally change behavioural and physiological responses to olfactory and gustatory stimuli. Olfactory and gustatory pre-exposure and subsequent behavioural tests were carried out to reveal possible intra- and cross-modal effects. Attraction to pheromone, monitored with a locomotion compensator, increased after exposure to olfactory and gustatory stimuli. Behavioural responses to sucrose, investigated using the proboscis extension reflex, increased equally after pre-exposure to olfactory and gustatory cues. Pheromone-specific neurons in the brain and antennal gustatory neurons did, however, not change their sensitivity after sucrose exposure. The observed intra- and reciprocal cross-modal effects of pre-exposure may represent a new form of stimulus-nonspecific general sensitization originating from modifications at higher sensory processing levels
Computational Models of the Notch Network Elucidate Mechanisms of Context-dependent Signaling
The Notch signaling pathway controls numerous cell fate decisions during development and adulthood through diverse mechanisms. Thus, whereas it functions as an oscillator during somitogenesis, it can mediate an all-or-none cell fate switch to influence pattern formation in various tissues during development. Furthermore, while in some contexts continuous Notch signaling is required, in others a transient Notch signal is sufficient to influence cell fate decisions. However, the signaling mechanisms that underlie these diverse behaviors in different cellular contexts have not been understood. Notch1 along with two downstream transcription factors hes1 and RBP-Jk forms an intricate network of positive and negative feedback loops, and we have implemented a systems biology approach to computationally study this gene regulation network. Our results indicate that the system exhibits bistability and is capable of switching states at a critical level of Notch signaling initiated by its ligand Delta in a particular range of parameter values. In this mode, transient activation of Delta is also capable of inducing prolonged high expression of Hes1, mimicking the “ON” state depending on the intensity and duration of the signal. Furthermore, this system is highly sensitive to certain model parameters and can transition from functioning as a bistable switch to an oscillator by tuning a single parameter value. This parameter, the transcriptional repression constant of hes1, can thus qualitatively govern the behavior of the signaling network. In addition, we find that the system is able to dampen and reduce the effects of biological noise that arise from stochastic effects in gene expression for systems that respond quickly to Notch signaling
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