Skyrmions, Hadrons and isospin chemical potential

Using the Hamiltonian formulation, in terms of collective variables, we explore the evolution of different skyrmionic parameters as function of the isospin chemical potential ($\mu$), such as the energy density, the charge density, the isoscalar radius and the isoscalar magnetic radius. We found that the radii start to grow very fast for $\mu \gtrsim 140$ MeV, suggesting the occurrence of a phase transition.Comment: 10 pages, 5 figure

GNP-GAPDH1-22 nanovaccines prevent neonatal listeriosis by blocking microglial apoptosis and bacterial dissemination

Clinical cases of neonatal listeriosis are associated with brain disease and fetal loss due to complications in early or late pregnancy, which suggests that microglial function is altered. This is believed to be the first study to link microglial apoptosis with neonatal listeriosis and listeriosis-associated brain disease, and to propose a new nanovaccine formulation that reverses all effects of listeriosis and confers Listeria monocytogenes (LM)-specific immunity. We examined clinical cases of neonatal listeriosis in 2013-2015 and defined two useful prognostic immune biomarkers to design listeriosis vaccines: high anti-GAPDH1-22 titres and tumor necrosis factor (TNF)/interleukin (IL)-6 ratios. Therefore, we developed a nanovaccine with gold glyco-nanoparticles conjugated to LM peptide 1-22 of GAPDH (Lmo2459), GNP-GAPDH1-22 nanovaccinesformulated with a pro-inflammatory Toll-like receptor 2/4-targeted adjuvant. Neonates born to non-vaccinated pregnant mice with listeriosis, showed brain and vascular diseases and significant microglial dysfunction by induction of TNF-?-mediated apoptosis. This programmed TNF-mediated suicide explains LM dissemination in brains and livers and blocks production of early pro-inflammatory cytokines such as IL-1? and interferon-?/?. In contrast, neonates born to GNP-GAPDH1-22-vaccinated mothers before LM infection, did not develop listeriosis or brain diseases and had functional microglia. In nanovaccinated mothers, immune responses shifted towards Th1/IL-12 pro-inflammatory cytokine profiles and high production of anti-GAPDH1-22 antibodies, suggesting good induction of LM-specific memory

Relationship between Indebtedness and profitability in industrial manufacturing companies in Ecuador

Manufacturing companies oversee converting raw materials into finished products, characterized by the intervention of machinery and labor force. The article analyzes, through correlation of variables, the relationship between indebtedness and profitability of a group of companies in the Ecuadorian manufacturing sector.  The results showed an average debt ratio of 332.70%, which indicates that most of the companies work with money from suppliers or with credits offered by financial institutions. The return on investment shows an average of 113.57%, which indicates that the companies have excellent earnings in terms of what they invest in their economic activity. Correlational analysis showed little or no relationship between return on equity and debt ratio at 21.9%. Likewise, a weak negative relationship between profit margin and indebtedness was evidenced with a -42.4% correlation.  In conclusion, the research data indicate that the manufacturing companies have not improved their profitable level by making adequate use of debt.

Quantifying image distortion based on Gabor filter bank and multiple regression analysis

Image quality assessment is indispensable for image-based applications. The approaches towards image quality assessment fall into two main categories: subjective and objective methods. Subjective assessment has been widely used. However, careful subjective assessments are experimentally difficult and lengthy, and the results obtained may vary depending on the test conditions. On the other hand, objective image quality assessment would not only alleviate the difficulties described above but would also help to expand the application field. Therefore, several works have been developed for quantifying the distortion presented on a image achieving goodness of fit between subjective and objective scores up to 92%. Nevertheless, current methodologies are designed assuming that the nature of the distortion is known. Generally, this is a limiting assumption for practical applications, since in a majority of cases the distortions in the image are unknown. Therefore, we believe that the current methods of image quality assessment should be adapted in order to identify and quantify the distortion of images at the same time. That combination can improve processes such as enhancement, restoration, compression, transmission, among others. We present an approach based on the power of the experimental design and the joint localization of the Gabor filters for studying the influence of the spatial/frequencies on image quality assessment. Therefore, we achieve a correct identification and quantification of the distortion affecting images. This method provides accurate scores and differentiability between distortions

ABORDAGEM TERAPÊUTICA DA HIPOMINERALIZAÇÃO INCISIVO MOLARREVISÃO SISTEMÁTICA INTEGRATIVA

Introdução: Os defeitos de esmalte são um dos grandes desafios nos dias de hoje, em nossas clínicas dentárias, especialmente em crianças. Uma condição específica desses defeitos de esmalte é a hipomineralização incisivo molar (HIM). Existem várias possibilidades de tratamentos e vários fatores a serem analisados antes da escolha do tratamento adequado. Objetivo: O objetivo desta revisão sistemática integrativa foi procurar e avaliar os distintos tratamentos para a hipomineralização incisivo-molar nos distintos estádios da doença. Materiais e métodos: Foi realizada uma pesquisa eletrónica na base de dados PUBMED, EBSCO, SCIELO, RESEARCHGATE e JISC LIBRARY HUB DISCOVERY de publicações científicas, utilizando as seguintes palavras-chave “Dental enamel hypoplasia”, “Dental materials”, “Dental care for children”. A pesquisa limitou-se a estudos publicados em inglês entre 2012 e 2022. Discussão: O tratamento varia desde a aplicação tópica de flúor, a restaurações e extrações. As decisões de tratamento dependem do grau de envolvimento dentário da HIM. O uso de verniz fluoretado é essencial no início de qualquer tratamento para reduzir a suscetibilidade presente nesses casos. Conclusão: A prevenção e o tratamento precoce são a base para a preservação dos elementos dentários sendo necessário fazer a melhor escolha em cada estádio desta doença

Situacion de la mujer casada en regimen de sociedad conyugal

73 p.En la presente memoria se expone el sistema de subsidio habitacional chileno, dentro del cual, el objetivo general es realizar un análisis exhaustivo acerca de su evolución, inserción y aplicación dentro de la sociedad. Así como servir de base y apoyo para lograr un entendimiento mas acabado de el, por parte de la población. Además como objetivo especifico se busca revelar la situación en que se encuentra la mujer casada bajo régimen de sociedad conyugal, en relación al subsidio, y las implicancias legales de ello. En cuánto a la metodología a utilizar, para lograr los objetivos establecidos, será una investigación documental en base a un método Lógico deductivo. Los resultados obtenidos concluyen que la institución ha evolucionado, Llegando a ser masiva su postulación y conocimiento. Pero, a la vez, es necesario un cambio cultural e informativo que permita a la mujer acceder a los beneficios que posee y que desconoce

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

Stem-cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human pluripotent stem cells (hPSCs) differentiate into pancreatic islets in vitro by profiling DNA methylation, chromatin accessibility, and histone modification changes. We find that enhancer potential is reset upon lineage commitment and show how pervasive epigenetic priming steers endocrine cell fates. Modeling islet differentiation and maturation regulatory circuits reveals genes critical for generating endocrine cells and identifies circadian control as limiting for in vitro islet function. Entrainment to circadian feeding/fasting cycles triggers islet metabolic maturation by inducing cyclic synthesis of energy metabolism and insulin secretion effectors, including antiphasic insulin and glucagon pulses. Following entrainment, hPSC-derived islets gain persistent chromatin changes and rhythmic insulin responses with a raised glucose threshold, a hallmark of functional maturity, and function within days of transplantation. Thus, hPSC-derived tissues are amenable to functional improvement by circadian modulation

Predictive model based on sentiment analysis for peruvian smes in the sustainable tourist sector

In the sustainable tourist sector today, there is a wide margin of loss in small and medium-sized enterprise (SMEs) because of a poor control in logistical expenses. In other words, acquired goods are note being sold, a scenario which is very common in tourism SMEs. These SMEs buy a number of travel packages to big companies and because of the lack of demand of said packages, they expire and they become an expense, not the investment it was meant to be. To solve this problem, we propose a Predictive model based on sentiment analysis of a social networks that will help the sales decision making. Once the data of the social network is analyzed, we also propose a prediction model of tourist destinations, using this information as data source it will be able to predict the tourist interest. In addition, a case study was applied to a real Peruvian tourist enterprise showing their data before and after using the proposed model in order to validate the feasibility of proposed model

Del campo a la ciudad: la migración y la busqueda de nuevas oportunidades

Trabalho de Conclusão de Curso apresentado ao Instituto Latino-Americano de Economia, Sociedade e Política da Universidade Federal da Integração Latino-Americana, como requisito parcial à obtenção do título de Bacharel em Desenvolvimento Rural e Segurança Alimentar. Orientadora: Prof. Silvia Aparecida ZimmermannEl presente trabajo presenta definiciones sobre migración, éxodo rural y pobreza que buscan acercarnos a la investigación realizada en el barrio 8 de diciembre de Ciudad del Este, República del Paraguay. Para la elaboración del trabajo fue hecha revisión bibliográfica y la elaboración y aplicación de un cuestionario semiestructurado a 15 familias en el barrio. El objetivo del trabajo es entender las razones por las cuales las personas pasan del campo a la ciudad, así, utilice los datos de la investigación bibliográfica en la primera parte del mismo donde se trae a conocimiento lo conceptos de migración y pobreza. La segunda parte del trabajo presenta los datos recolectados en las encuestas y nos ayudan a entender el hecho por el cual las personas deciden migrar del rural al urbano y cuáles son las principales consecuencias que acarrean dichas mudanzas en el estilo de vida de las personas. La mayoría dice que se trata de una búsqueda de una mejor vida y buscar un nuevo rumbo para sus familias. Ya estando en las ciudades se dan cuenta que la realidad es completamente diferente a la que ellos imaginaban y, aunque hay personas que logran salir adelante y desarrollarse económicamente, otras quedan sin tener oportunidades sobre todo por la falta de educación y capacitación. Viven a merced de trabajos informales con remuneraciones bajas, que sirven más que para vivir en situaciones precarias sin poder garantizar las llamadas necesidades básicas para tener una vida digna. Además las respuestas a las encuestas destacan que la razón principal por la cual migran las personas es a causa de búsqueda de un trabajo que genere un mejor ingreso económico para mantener a la familia ya que en el campo se ven opacados por las grandes plantaciones, y prefieren vender sus tierras y mudarse.Este trabalho apresenta definições de migração, êxodo rural e pobreza que buscam abordar a pesquisa realizada no bairro de 8 de dezembro de Ciudad del Este, República do Paraguai. Para a elaboração do trabalho foi realizada uma revisão bibliográfica e elaborado um questionário semiestruturado aplicado em 15 famílias do bairro. O objetivo do trabalho é entender as razões pelas quais as pessoas se mudam do campo para a cidade. Portanto, usei os dados da pesquisa bibliográfica na primeira parte, onde os conceitos de migração e pobreza são discutidos. A segunda parte do trabalho apresenta os dados coletados nos questionários e nos ajudam a entender os motivos que levam as pessoas decidirem migrar do rural para o urbano e quais são as principais consequências dessas mudanças no estilo de vida das pessoas. Muitos dizem que a mudança ocorre em busca de uma vida melhor e uma nova direção para suas famílias. Já estando nas cidades, percebem que a realidade é completamente diferente do que imaginavam e, embora existam pessoas que conseguem avançar e se desenvolver economicamente, outras ficam sem oportunidades, principalmente por falta de educação e capacitação. Vivem à mercê de empregos informais com baixos salários, que servem apenas para viver em locais precários, sem poder garantir as chamadas necessidades básicas para uma vida decente. Além disso, as respostas dos questionários destacam que a principal razão pela qual as pessoas migram é a busca de um emprego que permita uma melhor renda econômica para sustentar a família, já que no campo elas são ofuscadas por grandes plantações, e preferem vender suas terras e se mudar

Long noncoding RNAs during normal and malignant hematopoiesis

Long noncoding RNAs (lncRNAs) are increasingly recognized to contribute to cellular development via diverse mechanisms during both health and disease. Here, we highlight recent progress on the study of lncRNAs that function in the development of blood cells. We emphasize lncRNAs that regulate blood cell fates through epigenetic control of gene expression, an emerging theme among functional lncRNAs. Many of these noncoding genes and their targets become dysregulated during malignant hematopoiesis, directly implicating lncRNAs in blood cancers such as leukemia. In a few cases, dysregulation of an lncRNA alone leads to malignant hematopoiesis in a mouse model. Thus, lncRNAs may be not only useful as markers for the diagnosis and prognosis of cancers of the blood, but also as potential targets for novel therapies.National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (Grant DK068348)National Heart, Lung, and Blood Institute (Grant 5P01 HL066105