Inherited basement structures and their influence in foreland evolution: A case study in Central Patagonia, Argentina

Continental crust exhibits areas of recurrent deformation and reactivation of faults that can be persistent for hundreds of millions of years. Associated with weak lithospheric zones, the characterization of long-lived deformational zones and inherited structures are critical aspects in the construction of orogens and rift systems, playing a major role in magmatism and basin evolution. Central Patagonia, which is situated in the Andean foreland of southern South America, presents a complex and multi-episodic tectonic history related to intraplate deformation at a significant distance from the Andean trench. Its ∼NW-SE structural trend, which is anomalously oblique to the Andean orogen, has been proposed as an inherited crustal anisotropy that controlled Mesozoic basins and Cenozoic volcano-sedimentary foreland basins development. However, a systematic regional study focused on the basement structural anisotropy has not been undertaken so far. In this contribution, we use aeromagnetic and gravimetric datasets that are integrated with field geological and structural data to address this issue. We define a series of ∼NW-SE regional structures which governed the present-day basement-block architecture of the foreland and exerted an important control in the deposition of Mesozoic-Cenozoic sedimentary and volcanic sequences. The tectonic significance of these structures and their paleogeographic implications in the context of the Late Paleozoic Gondwanide magmatic arc are also discussed.Fil: Renda, Emiliano Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Alvarez, Dolores. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; ArgentinaFil: Prezzi, Claudia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Oriolo, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Vizan, Haroldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; Argentin

Glycosaminoglycans modulate C6 glioma cell adhesion to extracellular matrix components and alter cell proliferation and cell migration

BACKGROUND: Adhesion to extracellular matrix (ECM) components has been implicated in the proliferative and invasive properties of tumor cells. We investigated the ability of C6 glioma cells to attach to ECM components in vitro and described the regulatory role of glycosaminoglycans (GAGs) on their adhesion to the substrate, proliferation and migration. RESULTS: ECM proteins (type IV collagen, laminin and fibronectin) stimulate rat C6 glioma cell line adhesion in vitro, in a dose-dependent manner. The higher adhesion values were achieved with type IV collagen. Exogenous heparin or chondroitin sulfate impaired, in a dose-dependent manner the attachment of C6 glioma cell line to laminin and fibronectin, but not to type IV collagen. Dextran sulfate did not affect C6 adhesion to any ECM protein analyzed, indicating a specific role of GAGs in mediating glioma adhesion to laminin and fibronectin. GAGs and dextran sulfate did not induce C6 glioma detachment from any tested substrate suggesting specific effect in the initial step of cell adhesion. Furthermore, heparin and chondroitin sulfate impaired C6 cells proliferation on fibronectin, but not on type IV collagen or laminin. In contrast, both GAGs stimulate the glioma migration on laminin without effect on type IV collagen or fibronectin. CONCLUSION: The results suggest that GAGs and proteoglycans regulate glioma cell adhesion to ECM proteins in specific manner leading to cell proliferation or cell migration, according to the ECM composition, thus modulating tumor cell properties

Investigando el estilo personal del terapeuta: Correspondencia entre las autodescripciones y la observación de jueces externos

Abstract: Correspondence between self-descriptions and observations of external judges: A study on the personal style of the therapist. The personal style of the therapist (PST) is defined as the set of characteristics that lead the therapist to behave in a particular professional way. This empirical study aims to provide evidence of the concurrent validity of the EPT-C, an instrument to assess PST. Cluster analysis was performed with data from 79 audio-taped recorded sessions of 20 psychotherapists. The contrasting groups’ method was applied to compare EPT-C scores with the scores of the Guide for the Observation of the Therapist Aiglé (GOTA-v) as the criterion variable. The mean values, obtained in the EPT-C dimensions of three therapists’ clusters arising from the sessions’ observations and codification of emerging categories, were compared. Significant differences were found in two EPT-C dimensions: attentional and operative. These results are evidence of the concurrent validity of the EPT-C questionnaire.Resumen: El estilo personal del terapeuta (EPT) se conceptualiza como el conjunto de condiciones singulares que conducen a un terapeuta a operar en su desempeño profesional. El objetivo de este estudio empírico es aportar evidencia sobre la validez concurrente de un instrumento que evalúa el EPT (EPT-C). Se realizó un análisis de cluster a partir de 79 sesiones transcriptas de 20 psicoterapeutas. Para ello, se aplicó metodología de grupos contrastados para comparar los puntajes del EPT-C con los valores de la Guía de Observación del Terapeuta Aiglé (GOTA-v) como variable criterio. Se compararon las medias obtenidas en las dimensiones EPT-C para tres clusters de terapeutas, identificados a partir de la observación de las sesiones y la codificación de las categorías emergentes. Se obtuvieron diferencias significativas en dos dimensiones del el EPT-C: la atencional y la operativa. Los resultados evidencian la validez concurrente del instrumento EPT-C para evaluar el EPT

Bloom-forming cyanobacteria and dinoflagellates in five Argentinian reservoirs: Multi-year sampling

Harmful algal blooms are important threats to reservoir condition. Over a 15-year period, we sampled fiveArgentinian reservoirs to identify the responsible species for harmful algal blooms and determine the waterquality factors driving their occurrence. These reservoirs exhibit diverse morphological and hydrological characteristics and are distributed across varying climatic zones. Cyanobacterial blooms included an array of species,including toxin producers such as Raphidiopsis raciborskii, Aphanizomenon gracile, and Microcystis aeruginosa. Incontrast, dinoflagellate blooms were predominantly characterized by Ceratium. The cyanobacterial blooms primarily occurred in the shallower reservoirs located in warmer regions, whereas dinoflagellate blooms occurredwhere temperatures were lower. The most intense blooms occurred during the summer, and although cyanobacterial and chlorophyte blooms co-occurred, they never coexisted with dinoflagellate blooms. We identifiedcyanotoxins in the reservoirs over the past three years, a phenomenon previously unreported in the region. Giventhat these reservoirs are drinking water sources for human populations, ongoing and systematic monitoring isneeded to protect public health. Controlling the proliferation of algae and cyanobacteria in reservoirs requiresresource management at the watershed level, and in the case of the Itiyuro and El Limon, requires binational management with Bolivia.Fil: Alvarez Dalinger, Florencia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Salta; ArgentinaFil: Borja, Claudia Nidia. Universidad Nacional de Salta. Facultad de Cs.naturales. Catedra Biologia y Diversidad de Protistas Autotrofos y Fungi.; ArgentinaFil: Lozano, Verónica Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Salta; ArgentinaFil: Moraña, Liliana Beatriz. Universidad Nacional de Salta. Facultad de Cs.naturales. Catedra Biologia y Diversidad de Protistas Autotrofos y Fungi.; ArgentinaFil: Salusso, Maria Monica. Universidad Nacional de Salta. Facultad de Cs.naturales. Catedra Biologia y Diversidad de Protistas Autotrofos y Fungi.; Argentin

Rapid determination of total metals: synergic effect of ultrasound energy and ionic liquids on the digestion of sediment samples

Purpose: The aim of this study was to develop a new and rapid sample digestion procedure for metal extraction using ultrasonic energy together with a combination of an ionic liquid and mineral acids as extractants. Methods: A fixed mass of sediment (about 0.50 g) was extracted with a combination of low volumes of NaHCO3, HCl, HNO3, HF and the ionic liquid Bmim[BF4]. Afterwards, the mixture was sonicated for 20 min. After neutralizing the hydrofluoric acid excess, the extracts were filtered and measured by ICP OES where Cd, Cr, Cu, Ni, Pb and Zn were determined. Results: The recoveries in certified reference materials ranged from 92 to 102% for LGC-6137, from 88 to 98% for IAEA SL-1 and from 81 to 98% for MURST-ISS-A1, with a good precision (relative standard deviation (RSD) < 10.0% for all the certified reference materials). The new digestion procedure was successfully applied to the determination of metals in estuarine sediment samples, with a satisfactory precision (RSD < 9.5%). The results showed no significant statistical differences compared to those obtained by the conventional digestion procedure (with an α-error of 0.05). Conclusion: This approach has led to satisfactory results in the determination of the total metal concentrations for most of the elements studied using shorter analysis times than the conventional procedure, and small volumes of hydrofluoric acid. The new pretreatment method made it possible to satisfactorily assess the total metal concentrations in estuarine sediments.Fil: Alvarez, Silvana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Llamas, Natalia Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Álvarez, Mónica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Marcovecchio, Jorge Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; Argentina. Universidad Tecnológica Nacional; Argentina. Academia Nacional de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Garrido, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Domini, Claudia Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentin

First time identification of Pandoraea sputorum from a patient with cystic fibrosis in Argentina: a case report

Background: Pandoraea species are considered emerging pathogens in the context of cystic fibrosis (CF) and are difficult to identify by conventional biochemical methods. These multidrug resistant bacteria remain poorly understood particularly in terms of natural resistance, mechanisms of acquired resistance and impact on the prognosis of the disease and the lung function. Among them, Pandoraea sputorum has been previously described in few cases of CF patients from Spain, Australia, France and United States, underlining the need of more clinical data for a better knowledge of its pathogenicity. This is the first report relating to P. sputorum in a CF patient in Argentina. Case presentation: Pandoraea sputorum was identified in a nine-year-old cystic fibrosis patient from Argentina, after treatment failure during an exacerbation. The isolates were successfully identified by combining molecular techniques based on 16S rRNA sequencing and mass spectrometry (MS) methods, after reassessing previous misidentified isolates by conventional methods. After first isolation of P. sputorum, patient´s clinical condition worsened but later improved after a change in the treatment. Although isolates showed susceptibility to trimethoprim-sulfamethoxazole and imipenem, in our case, the antibiotic treatment failed in the eradication of P. sputorum. Conclusions: All combined data showed a chronic colonization with P. sputorum associated to a deterioration of lung function. We noted that the presence of P. sputorum can be underestimated in CF patients and MALDI-TOF MS appears to be a promising means of accurate identification of Pandoraea species.Fil: Martina, Pablo F.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; ArgentinaFil: Martínez, Mónica Elisabeth. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital público provincial de pediatría de autogestión Dr. Fernando Barreyro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaFil: Frada, Guillermo. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital público provincial de pediatría de autogestión Dr. Fernando Barreyro; ArgentinaFil: Alvarez, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Leguizamon, Lorena Beatriz. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital público provincial de pediatría de autogestión Dr. Fernando Barreyro; ArgentinaFil: Prieto, Claudia Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Barrias, Carolina. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital público provincial de pediatría de autogestión Dr. Fernando Barreyro; ArgentinaFil: Bettiol, Marisa. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños ; ArgentinaFil: Lagares, Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Bosch, María Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Ferreras, Julian Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; ArgentinaFil: Von Specht, Martha Helena. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital público provincial de pediatría de autogestión Dr. Fernando Barreyro; Argentin

Revista ES “Economía Social”

La ES es una Revista de Economía Social que surge como iniciativa del proyecto Trabajo Autogestionado de la Universidad Nacional de Quilmes  con organizaciones sociales, ante la necesidad de las instituciones y espacios universitarios en publicar lo que se realiza desde la práctica en economía social tanto sea en trabajo autogestionado,  autoconstrucción de vivienda, comercio justo, consumo responsable, tecnologías sociales, mercados solidarios, monedas sociales. Por eso la ES está dirigida a todos los trabajadores/as de la socioeconomía; productores, estudiantes, organizaciones, profesionales, investigadores. Además se utiliza como material de estudio en Capacitaciones Docentes y Bachilleratos Populares. La revista ES sale cada tres meses en formato papel y digital, rescata los saberes que en autogestión y asociativismo nos enseñó la historia del movimiento obrero, el movimiento cooperativista, los pueblos originarios y las enormes experiencias de los barrios que autogestionan y construyen todos los días una economía humana y ecológicamente sustentable. La revista se realiza con el aporte de las organizaciones intervinientes, el financiamiento de la Secretaría de Extensión Universitaria de la Universidad Nacional de Quilmes y el Programa de Voluntariado 2011 de la Secretaría de Políticas Universitarias. Conforman el Consejo Editorial la Cooperativa Unión Solidaria de Trabajadores de Wilde, Avellaneda, Cooperativa de Consumo y Vivienda Quilmes, Culebrón Timbal Productora comunitaria de Moreno Bs. As, Asociación civil BePe de Catamarca, Mutual Primavera, Asociación Civil Incluir, Bodegón Cultural Casa de Pocho Club Federal y Club Luchador de Rosario, la Mesa de Productores Familiares de la provincia de Buenos Aires e INCUPO de Santa Fe. Entre los proyectos están:  el Proyecto Tecnologías para la Inclusión Social y Políticas Públicas en América Latina perteneciente al  Área de Estudios Sociales de la Tecnología y la Innovación del Instituto de Estudios sobre la Ciencia y la Tecnología UNQ y el Proyecto Trabajo Autogestionado dependiente de la dirección de vinculación Social de la Secretaría de Extensión Universitaria de la Universidad Nacional de Quilmes.

Secreted phospholipase A2-IIA modulates transdifferentiation of cardiac fibroblast through EGFR transactivation: An inflammation–fibrosis link

Producción CientíficaSecreted phospholipase A2-IIA (sPLA2-IIA) is a pro-inflammatory protein associated with cardiovascular disorders, whose functions and underlying mechanisms in cardiac remodelling are still under investigation. We herein study the role of sPLA2-IIA in cardiac fibroblast (CFs)-to-myofibroblast differentiation and fibrosis, two major features involved in cardiac remodelling, and also explore potential mechanisms involved. In a mice model of dilated cardiomyopathy (DCM) after autoimmune myocarditis, serum and cardiac sPLA2-IIA protein expression were found to be increased, together with elevated cardiac levels of the cross-linking enzyme lysyl oxidase (LOX) and reactive oxygen species (ROS) accumulation. Exogenous sPLA2-IIA treatment induced proliferation and differentiation of adult rat CFs. Molecular studies demonstrated that sPLA2-IIA promoted Src phosphorylation, shedding of the membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) ectodomain and EGFR phosphorylation, which triggered phosphorylation of ERK, P70S6K and rS6. This was also accompanied by an up-regulated expression of the bone morphogenic protein (BMP)-1, LOX and collagen I. ROS accumulation were also found to be increased in sPLA2-IIA-treated CFs. The presence of inhibitors of the Src/ADAMs-dependent HB-EGF shedding/EGFR pathway abolished the CF phenotype induced by sPLA2-IIA. In conclusion, sPLA2-IIA may promote myofibroblast differentiation through its ability to modulate EGFR transactivation and signalling as key mechanisms that underlie its biological and pro-fibrotic effects.Ministerio de Economía, Industria y Competitividad (grants SAF2012-34460 and SAF2016-81063)Instituto de Salud Carlos III (grant PI18/010257729

Metastatic Seminoma in a Male Alpine Goat: Clinical and Histopathological Approach

Background: Seminomas are germ cell tumors mainly originating from spermatogonia in the seminiferous tubules and has been described in several domestic animal species, even though has rarely been described in goats. Moreover, seminomas tumors are not usually metastatic and rarely trigger paraneoplastic syndrome. In this sense, this is a case report of a 12-year-old male Alpine goat, suspected of testicular neoplasm based on clinical examination and ultrasound imaging, diagnosed as a seminoma with metastasis in liver by histopathology upon necropsy.Case: A 12-year-old male Alpine goat presented a 10 month history of progressive weight loss, prostration, and scrotal sac enlargement. The major clinical findings were pale conjunctival mucus, bilateral nasal catarrhal secretion, obstructive dyspnea, an increased abdominal component, crackling at trachea auscultation, silence upon lung auscultation of the ventral area and wheezing upon auscultation of the dorsal area, and enlargement of the left testicle with contralateral atrophy. At the Ultrasonography scan, the enlarged left testicle presented architecture loss, as well as circumscribed masses differing in echogenicity and echotexture with scattered small hyperechoic nodules. The shrunken right testicle showed acoustic shading across the surface suggestive of calcification. Due to the poor prognosis and regard for animal welfare, the goat was euthanized. The main necropsy findings on testicles were: enlarged left testicle with white parenchyma on the dorsal side as well as diffuse yellow elliptical lesions of 0.5-2.5 cm on the surface in association with two circumscribed areas at the cranial and caudal poles, firm upon cutting. The right testicle was half the typical size, slightly pale, firm at cutting of the tunica albuginea, and presented dark parenchyma with abundant calcification dots suggestive of microlithiasis. The histological findings included diffuse tumoral stroma of the left testicle composed of large, polyhedral, discretely demarcated circular cells exhibiting a large nucleus varying in size with little cytoplasm and a high mitotic rate. The right testicle exhibited areas of necrosis and fibrosis of the testicular parenchyma, contiguous with the area of degeneration and normal parenchyma, caseous necrosis, and focal calcification. The liver presented some foci of the same cellular pattern of the seminoma, as described in the parenchyma. The findings summarized at necropsy and histopathological evaluation were seminoma in the left testicle, with metastasis to the liver; degeneration and necrosis of the right testicle with abscess and calcification.Discussion: Seminoma has been described in several species, even though rarely in goats. This report was the second ever seminoma reported in caprine species, and particularly this case presented liver metastasis, showing the pathologic potential of this neoplasia for this species, and it differed from first reported which described ulcerative lesions in, and adhesion of the skin covering the testis. Regarding the US scan, even though this technique cannot be considered as a conclusive diagnostic, it may help to reach a prognosis by the tumor’s characteristics. An US scan along with cytology or biopsy enables an earlier diagnosis of testicular lesions and prognosis. Orchidectomy, when unilateral, can be carried out to increase the animal's productive life

A search for the Zγ decay mode of the Higgs boson in pp collisions at √s = 13 TeV with the ATLAS detector

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UA