Cambio de uso de suelo agrícola en la provincia de Mendoza: avances sobre la dinámica hortícola y las estrategias de reproducción social de sus agentes

En Mendoza, como en otras regiones del país y del mundo, el proceso de urbanización sobre tierras productivas se ha incrementado en los últimos años, expandiéndose la ciudad sobre los suelos tradicionalmente aptos para la producción. En particular, el oasis norte esto ha tenido esto como correlato la desarticulación el cinturón verde hortícola y la infraestructura de riego asociada, construidos a lo largo de la historia del oasis. Si bien el fenómeno no ha sido estudiado en profundidad, estudios recientes en base a datos extraídos del CNA 2008, identifican una expansión de explotaciones hacia áreas de frontera agropecuaria, que explicarían el mantenimiento de la superficie implantada, pese al avance de la urbanización. El objetivo del presente trabajo es mostrar los avances de investigación sobre el análisis de las nuevas configuraciones de los espacios rurales y articulación con los espacios urbanos y peri-urbanos, como resultado de estrategias de reproducción social de los agricultores. Para ello se analiza la dinámica hortícola reciente del Cinturón Verde mendocino, buscando dar cuenta de procesos de reconversión (hacia la horticultura) o de relocalización de explotaciones. En particular, se aborda el distrito de Fray Luis Beltrán (Maipú, Mendoza) como escenario de estas transformaciones.CR Mendoza-San JuanFil: Dalmasso, Caterina. Instituto Nacional de Tecnología Agropecuaria (INTA). Centro Regional Mendoza San Juan; ArgentinaFil: Aloy, Gustavo. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras; ArgentinaFil. Vitale Gutierrez, Javier Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Centro Regional Mendoza San Juan; Argentin

Internalization pathways into cancer cells of gadolinium-based radiosensitizing nanoparticles

International audienceOver the last few decades, nanoparticles have been studied in theranostic field with the objective of exhibiting a long circulation time through the body coupled to major accumulation in tumor tissues, rapid elimination, therapeutic potential and contrast properties. In this context, we developed sub-5 nm gadolinium-based nanoparticles that possess in vitro efficient radiosensitizing effects at moderate concentration when incubated with head and neck squamous cell carcinoma cells (SQ20B). Two main cellular internalization mechanisms were evidenced and quantified: passive diffusion and macropinocytosis. Whereas the amount of particles internalized by passive diffusion is not sufficient to inducein vitro a significant radiosensitizing effect, the cellular uptake by macropinocytosis leads to a successful radiotherapy in a limited range of particles incubation concentration. Macropinocytosis processes in two steps: formation of agglomerates at vicinity of the cell followed by their collect via the lamellipodia (i.e. the "arms") of the cell. The first step is strongly dependent on the physicochemical characteristics of the particles, especially their zeta potential that determines the size of the agglomerates and their distance from the cell. These results should permit to control the quantity of particles internalized in the cell cytoplasm, promising ambitious opportunities towards a particle-assisted radiotherapy using lower radiation doses

Viaje de estudios a la República Federal de Alemania

Fil: Alosi, Martha. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Aloy, Gustavo. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Ambrosini, Juan. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Brandi, Paola. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Cohn, Ricardo. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Ferllen, Eduardo. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Gómez, Gabriela. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: López, Verónica. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Minacapelli, Graciela. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Moreno, Andrés. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Pérez, Martín. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Reboredo, Natalia. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Rizzo, Pablo. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: García de Martín, Griselda. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de GeografíaFil: Schmidt, Margarita. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Instituto de Geografí

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Impact of volcanic processes on the cryospheric system of the Peteroa Volcano, Andes of southern Mendoza, Argentina

Soil temperatures of the active Volcanic Complex Peteroa situated in the Cordillera Principal between Chile and Argentina at 35°15′ S and 70°35′ W (approximately) were monitored in the area, and local geomorphology (periglacial geomorphology, presence of permafrost, and cryoforms) was studied. The present contribution also resulted in a comparison of two consecutive analyses of the volcano peak carried out with special thermocameras (AGEMA TVH 550, FUR P660) in order to study the thermal range of different hot and cold sites selected in 2009. The thermocameras were used ascending by foot and also during flights with a Cessna 180. A night expedition to the volcanic avalanche caldera, at up to 3900 m asl (approximately), completed the monitoring activity of 2010. Hot zones were associated to present volcanism and cold zones to the presence of glacier ice and shadowy slopes with possible presence of permafrost. Identifying and mapping uncovered and covered ice was possible with the help of monitoring and geomorphological interpretation related to the upper englacement, which is severely affected by volcanism. Glaciers are retreating toward the north or approaching the rims of the volcanic avalanche caldera leaving islands of ice associated with superficial permafrost. The cryogenic area with slope permafrost was identified through active protalus and sedimentary cryogenic slopes. Craters have undergone considerable thermal changes in comparison to the year 2009; and new, much more vigorous fumaroles have appeared in hot areas detected in 2009 following a tendency toward the west. New subaquatic heat columns that appeared in crater 3, crater walls, and glaciated areas vanished, supplying cold water and thus contributing to the formation of a new lake in crater 4. A possible post-seismic shift of the volcanic activity may provide geodynamical evidence of the changes registered in other areas after the earthquake of 27 February 2010.Fil: Trombotto, Dario Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Penas, Pablo. Comisión Nacional de Energía Atómica; ArgentinaFil: Aloy, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentin