A multi-step Lagrangian scheme for spatially inhomogeneous evolutionary games

A multi-step Lagrangian scheme at discrete times is proposed for the approximation of a nonlinear continuity equation arising as a mean-field limit of spatially inhomogeneous evolutionary games, describing the evolution of a system of spatially distributed agents with strategies, or labels, whose payoff depends also on the current position of the agents. The scheme is Lagrangian, as it traces the evolution of position and labels along characteristics, and is a multi-step scheme, as it develops on the following two stages: First, the distribution of strategies or labels is updated according to a best performance criterion, and then, this is used by the agents to evolve their position. A general convergence result is provided in the space of probability measures. In the special cases of replicator-type systems and reversible Markov chains, variants of the scheme, where the explicit step in the evolution of the labels is replaced by an implicit one, are also considered and convergence results are provided

Konsep Pendidikan Esensialisme dalam Pembentukan Karakter Siswa pada Mata Pelajaran Pendidikan Agama Islam

Essentialism educational philosophy is one of the traditional educational philosophies which views that the values in education should be based on clear and long-lasting values, then the existing education in a country can remain stable and focused.The purpose of the essentialism educational philosophy is to improve the character of society through existing cultural heritage, so that later students can contribute to improving people's lives in the face of changing times that can kill the character values of students.The philosophy of essentialism also aims to form a happy person in the world and the hereafter through values of virtue (moral, character and morals) that are embedded in students, because school, teachers and students are the key to developing an advanced nation, and play a very important role for character building in the school and communities. This article seeks to conceptualize the goals of the philosophy of essentialism, namely to form a happy person in the world and the hereafter which includes science, art and all things that can move the human will through character building and the importance of the role of Islamic religious education teachers in shaping the character of students in schools and society

Five-year retrospective italian multicenter study of visceral leishmaniasis treatment

The treatment of visceral leishmaniasis (VL) is poorly standardized in Italy in spite of the existing evidence. All consecutive patients with VL admitted at 15 Italian centers as inpatients or outpatients between January 2004 and December 2008 were retrospectively considered; outcome data at 1 year after treatment were obtained for all but 1 patient. Demographic characteristics, underlying diseases, diagnostic procedures, treatment regimens and outcomes, as well as side effects were recorded. A confirmed diagnosis of VL was reported for 166 patients: 120 (72.3%) immunocompetent, 21 (12.6%) patients with immune deficiencies other than HIV infection, and 25 (15.1%) coinfected with HIV. Liposomal amphotericin B (L-AmB) was the drug almost universally used for treatment, administered to 153 (92.2%) patients. Thirty-seven different regimens, including L-AmB were used. The mean doses were 29.4 \ub1 7.9 mg/kg in immunocompetent patients, 32.9 \ub1 8.6 mg/kg in patients with non-HIV-related immunodeficiencies, and 40.8 \ub1 6.7 mg/kg in HIV-infected patients (P < 0.001). The mean numbers of infusion days were 7.8 \ub1 3.1 in immunocompetent patients, 9.6 \ub1 3.9 in non-HIV-immunodeficient patients, and 12.0 \ub1 3.4 in HIV-infected patients (P < 0.001). Mild and reversible adverse events were observed in 12.2% of cases. Responsive patients were 154 (93.3%). Successes were 98.4% among immunocompetent patients, 90.5% among non-HIV-immunodeficient patients, and 72.0% among HIV-infected patients. Among predictors of primary response to treatment, HIV infection and age held independent associations in the final multivariate models, whereas the doses and duration of L-AmB treatment were not significantly associated. Longer treatments and higher doses of L-AmB were not able to significantly modify treatment outcomes either in the immunocompetent or in the immunocompromised population

Properties of fly ash concrete containing tropical soil bacteria

The autonomous crack healing process using microbiologically induced calcium carbonate precipitation (MICP) is a sustainable alternative to overcome propagation of micro-cracks and restore the durability of concrete. This paper presents the potential use of tropical soil bacteria as a self-healing agent for fly ash concrete. A solution of 107 cells/mL Lysinibacillus sphaericus (L. sphaericus), was selected to be the self-healing agent by replacing partially the amount of water. Concrete cube specimens with 30% fly ash, were cured under two conditions, which are water and air curing. The potential effects of the self-healing agent was evaluated in terms of the ultrasonic pulse velocity (UPV), initial surface absorption test (ISAT) and compressive strength. The initial results show an improvement of UPV and between 12% and 54% improvement on the compressive strength for the bacterial concrete compared to the control specimen. It was probably due to the presence of the microbial calcium carbonate that fills the concrete pores through the inclusion of bacteria in the concrete. However, based on the ISAT value, the direct addition of bacterial solution increased the concrete's permeability. Thus, further investigation is suggested to assess the self-healing effect towards permeability and compressive strength of bacterial concrete

Nucleophilic Functionalization of the Calix[6]arene Para- and Meta-Position via p‑Bromodienone Route

It is here demonstrated that the p-bromodienone route, previously reported for calix[4]arenes, is also effective for the functionalization of the calix[6]arene macrocycle. Thus, alcoholic O-nucleophiles can be introduced at the calix[6]arene exo rim. In addition, the reaction of a calix[6]arene p-bromodienone derivative with an actived aromatic substrate, such as resorcinol, led to the first example of a meta-functionalized, inherently chiral calix[6]arene derivativ

A Prognostic Model for Estimating the Time to Virologic Failure in HIV-1 Infected Patients Undergoing a New Combination Antiretroviral Therapy Regimen

<p>Abstract</p> <p>Background</p> <p>HIV-1 genotypic susceptibility scores (GSSs) were proven to be significant prognostic factors of fixed time-point virologic outcomes after combination antiretroviral therapy (cART) switch/initiation. However, their relative-hazard for the time to virologic failure has not been thoroughly investigated, and an expert system that is able to predict how long a new cART regimen will remain effective has never been designed.</p> <p>Methods</p> <p>We analyzed patients of the Italian ARCA cohort starting a new cART from 1999 onwards either after virologic failure or as treatment-naïve. The time to virologic failure was the endpoint, from the 90^thday after treatment start, defined as the first HIV-1 RNA > 400 copies/ml, censoring at last available HIV-1 RNA before treatment discontinuation. We assessed the relative hazard/importance of GSSs according to distinct interpretation systems (Rega, ANRS and HIVdb) and other covariates by means of Cox regression and random survival forests (RSF). Prediction models were validated via the bootstrap and c-index measure.</p> <p>Results</p> <p>The dataset included 2337 regimens from 2182 patients, of which 733 were previously treatment-naïve. We observed 1067 virologic failures over 2820 persons-years. Multivariable analysis revealed that low GSSs of cART were independently associated with the hazard of a virologic failure, along with several other covariates. Evaluation of predictive performance yielded a modest ability of the Cox regression to predict the virologic endpoint (c-index≈0.70), while RSF showed a better performance (c-index≈0.73, p < 0.0001 vs. Cox regression). Variable importance according to RSF was concordant with the Cox hazards.</p> <p>Conclusions</p> <p>GSSs of cART and several other covariates were investigated using linear and non-linear survival analysis. RSF models are a promising approach for the development of a reliable system that predicts time to virologic failure better than Cox regression. Such models might represent a significant improvement over the current methods for monitoring and optimization of cART.</p