Grundsätze zum Umgang mit Forschungsdaten

Die Schwerpunktinitiative "Digitale Forschungsinformation" der „Allianz der deutschen Wissenschaftsorganisationen" wurde 2008 ins Leben gerufen mit dem Ziel, die Informationsversorgung in Forschung und Lehre zu verbessern. Im Mittel¬punkt stehen die Handlungsfelder (1) Lizenzierung, (2) Open Access, (3) Nationale Hostingsstrategie, (4) Forschungsdaten, (5) Virtuelle Rahmen¬be¬dingungen und (6) Rechtliche Rahmenbedingungen der Informationsinfrastruktur. Als ein Zwischen¬ergebnis im Handlungsfeld „Forschungsdaten“ wurden 2010 „Grund¬sätze zum Umgang mit Forschungsdaten“ verabschiedet, die alle wissen¬¬schaftlichen Disziplinen umfassen. Da diese Grundsätze für den Kreis der Leserinnen und Leser der "Working Papers" des Rats für Sozial- und Wirtschaftsdaten von besonderem Interesse sind, werden sie hier auch als "Working Paper" veröffentlicht.

Review and analysis of fire and explosion accidents in maritime transportation

The globally expanding shipping industry has several hazards such as collision, capsizing, foundering, grounding, stranding, fire, and explosion. Accidents are often caused by more than one contributing factor through complex interaction. It is crucial to identify root causes and their interactions to prevent and understand such accidents. This study presents a detailed review and analysis of fire and explosion accidents that occurred in the maritimetransportation industry during 1990–2015. The underlying causes of fire and explosion accidents are identified and analysed. This study also reviewed potential preventative measures to prevent such accidents. Additionally, this study compares properties of alternative fuels and analyses their effectiveness in mitigating fire and explosionhazards. It is observed that Cryogenic Natural Gas (CrNG), Liquefied Natural Gas (LNG) and methanol have properties more suitable than traditional fuels in mitigating fire risk and appropriate management of their hazards could make them a safer option to traditional fuels. However, for commercial use at this stage, there exist several uncertainties due to inadequate studies, and technological immaturity. This study provides an insight into fire and explosion accident causation and prevention, including the prospect of using alternative fuels for mitigating fire and explosion risks in maritime transportation

Effects of Transport Inhibitors on the Cellular Uptake of Carboxylated Polystyrene Nanoparticles in Different Cell Lines

Nanotechnology is expected to play a vital role in the rapidly developing field of nanomedicine, creating innovative solutions and therapies for currently untreatable diseases, and providing new tools for various biomedical applications, such as drug delivery and gene therapy. In order to optimize the efficacy of nanoparticle (NP) delivery to cells, it is necessary to understand the mechanisms by which NPs are internalized by cells, as this will likely determine their ultimate sub-cellular fate and localisation. Here we have used pharmacological inhibitors of some of the major endocytic pathways to investigate nanoparticle uptake mechanisms in a range of representative human cell lines, including HeLa (cervical cancer), A549 (lung carcinoma) and 1321N1 (brain astrocytoma). Chlorpromazine and genistein were used to inhibit clathrin and caveolin mediated endocytosis, respectively. Cytochalasin A and nocodazole were used to inhibit, respectively, the polymerisation of actin and microtubule cytoskeleton. Uptake experiments were performed systematically across the different cell lines, using carboxylated polystyrene NPs of 40 nm and 200 nm diameters, as model NPs of sizes comparable to typical endocytic cargoes. The results clearly indicated that, in all cases and cell types, NPs entered cells via active energy dependent processes. NP uptake in HeLa and 1321N1 cells was strongly affected by actin depolymerisation, while A549 cells showed a stronger inhibition of NP uptake (in comparison to the other cell types) after microtubule disruption and treatment with genistein. A strong reduction of NP uptake was observed after chlorpromazine treatment only in the case of 1321N1 cells. These outcomes suggested that the same NP might exploit different uptake mechanisms to enter different cell types

IAFSS agenda 2030 for a fire safe world

The International Association of Fire Safety Science (IAFSS) is comprised of members from some 40 countries. This paper presents the Association's thinking, developed by the Management Committee, concerning pressing research needs for the coming 10 years presented as the IAFSS Agenda 2030 for a Fire Safe World. The research needs are couched in terms of two broad Societal Grand Challenges: (1) climate change, resiliency and sustainability and (2) population growth, urbanization and globalization. The two Societal Grand Challenges include significant fire safety components, that lead both individually and collectively to the need for a number of fire safety and engineering research activities and actions. The IAFSS has identified a list of areas of research and actions in response to these challenges. The list is not exhaustive, and actions within actions could be defined, but this paper does not attempt to cover all future needs

Technische Dienstleistungen fuer Kraftwerke

Available from TIB Hannover: HA 1138 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Schwingungsueberwachung von Turbosaetzen - ein Weg zur Erkennung von Wellenrissen Revidierter Bericht der Diskussionstagung im Allianz-Zentrum fuer Technik in Ismaning am 5./6. und 13./14. Mai 1986

With 154 figs., 9 tabs.Available from Allianz Versicherungs-A.G., Muenchen (Germany, F.R.). Vertrieb - Redaktion/TI / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman