Discovery of the spectroscopic binary nature of the Cepheids X Puppis and XX Sagittarii

We present the analysis of photometric and spectroscopic data of two bright Galactic Cepheids, X Puppis and XX Sagittarii. Based on the available data in the literature as well as own observations spanning 75 years, we conclude that both Cepheids belong to spectroscopic binary systems. However, the data are not sufficient to determine the orbital periods nor other elements for the orbit. This discovery corroborates the statement on the high frequency of occurrence of binaries among the classical Cepheids, a fact to be taken into account when calibrating the period-luminosity relationship for Cepheids. The photometric data revealed that the pulsation period of X Pup is continuously increasing with Delta P=0.007559 d/century likely caused by stellar evolution. The pulsation period of XX Sgr turned out to be very stable in the last ~100 years.Comment: 6 pages, 5 figure

Tidally Induced Oscillations and Orbital Decay in Compact Triple-Star Systems

We investigate the nature of tidal effects in compact triple-star systems. The hierarchical structure of a triple system produces tidal forcing at high frequencies unobtainable in binary systems, allowing for the tidal excitation of high frequency p-modes in the stellar components. The tidal forcing exists even for circular, aligned, and synchronized systems. We calculate the magnitude and frequencies of three-body tidal forcing on the central primary star for circular and coplanar orbits, and we estimate the amplitude of the tidally excited oscillation modes. We also calculate the secular orbital changes induced by the tidally excited modes, and show that they can cause significant orbital decay. During certain phases of stellar evolution, the tidal dissipation may be greatly enhanced by resonance locking. We then compare our theory to observations of HD 181068, which is a hierarchical triply eclipsing star system in the Kepler field of view. The observed oscillation frequencies in HD 181068 can be naturally explained by three-body tidal effects. We then compare the observed oscillation amplitudes and phases in HD 181068 to our predictions, finding mostly good agreement. Finally, we discuss the past and future evolution of compact triple systems like HD 181068.Comment: 19 pages, 8 figures, published in MNRA

Variability of M giant stars based on Kepler photometry: general characteristics

M giants are among the longest period pulsating stars which is why their studies were traditionally restricted to analyses of low-precision visual observations, and, more recently, accurate ground-based data. Here we present an overview of M giant variability on a wide range of time-scales (hours to years), based on the analysis of 13 quarters of Kepler long-cadence observations (one point per every 29.4 min), with a total time-span of over 1000 d. About two-thirds of the sample stars have been selected from the All Sky Automated Survey (ASAS)-North survey of the Kepler field, with the rest supplemented from a randomly chosen M giant control sample. We first describe the correction of the light curves from different quarters, which was found to be essential. We use Fourier analysis to calculate multiple frequencies for all stars in the sample. Over 50 stars show a relatively strong signal with a period equal to the Kepler-year and a characteristic phase dependence across the whole field of view. We interpret this as a so far unidentified systematic effect in the Kepler data. We discuss the presence of regular patterns in the distribution of multiple periodicities and amplitudes. In the period-amplitude plane we find that it is possible to distinguish between solar-like oscillations and larger amplitude pulsations which are characteristic for Mira/semiregular stars. This may indicate the region of the transition between two types of oscillations as we move upward along the giant branch

Synthesis, in Vitro Biological Evaluation, and Oxidative Transformation of New Flavonol Derivatives: The Possible Role of the Phenyl-N,N-Dimethylamino Group

L

Accelerated retinal aging in PACAP knock-out mice

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophic and neuroprotective peptide. PACAP and its receptors are widely distributed in the retina. A number of reports provided evidence that PACAP is neuroprotective in retinal degenerations. The current study compared retina cell type-specific differences in young (3-4months) and aged adults (14-16months), of wild-type (WT) mice and knock-out (KO) mice lacking endogenous PACAP production during the course of aging. Histological, immunocytochemical and Western blot examinations were performed. The staining for standard neurochemical markers (tyrosine hydroxylase for dopaminergic cells, calbindin 28 kDa for horizontal cells, protein kinase Calpha for rod bipolar cells) of young adult PACAP KO retinas showed no substantial alterations compared to young adult WT retinas, except for the specific PACAP receptor (PAC1-R) staining. We could not detect PAC1-R immunoreactivity in bipolar and horizontal cells in young adult PACAP KO animals. Some other age-related changes were observed only in the PACAP KO mice only. These alterations included horizontal and rod bipolar cell dendritic sprouting into the photoreceptor layer and decreased ganglion cell number. Also, Muller glial cells showed elevated GFAP expression compared to the aging WT retinas. Furthermore, Western blot analyses revealed significant differences between the phosphorylation state of ERK1/2 and JNK in KO mice, indicating alterations in the MAPK signaling pathway. These results support the conclusion that endogenous PACAP contributes to protection against aging of the nervous system

Novel Neuroprotective Strategies in Ischemic Retinal Lesions

Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K+ channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques