Food Insecurity Across the First Five Years: Triggers of Onset and Exit

Very low food security among young children is associated with developmental deficiencies. However, little is known about the factors that predict entry into or exit from very low food security during early childhood. This study seeks to: (1) Understand the triggers that explain movements into or out of very low food security among children from birth to age five; (2) Examine the first aim using different definitions of food insecurity. The analysis relies on the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B), a longitudinal, nationally representative dataset of approximately 10,700 children, to estimate linear probability models. Results suggest that residential moves and declines in maternal or child health are associated with transitioning into food insecurity, whereas increases in the number of adults in the household are associated with exits from food insecurity. Changes in income and maternal depression are associated with both entrances and exits. These findings are robust to different definitions of food insecurity and model specifications. Findings can help nutrition assistance programs target parents and their children for assistance and information on coping strategies when they are most at risk of experiencing food insecurity

SDF-1 chemokine signalling modulates the apoptotic responses to iron deprivation of clathrin-depleted DT40 cells.

We have previously deleted both endogenous copies of the clathrin heavy-chain gene in the chicken pre B-cell-line DT40 and replaced them with clathrin under the control of a tetracycline-regulatable promoter (Tet-Off). The originally derived cell-line DKO-S underwent apoptosis when clathrin expression was repressed. We have also described a cell-line DKO-R derived from DKO-S cells that was less sensitive to clathrin-depletion. Here we show that the restriction of transferrin uptake, resulting in iron deprivation, is responsible for the lethal consequence of clathrin-depletion. We further show that the DKO-R cells have up-regulated an anti-apoptotic survival pathway based on the chemokine SDF-1 and its receptor CXCR4. Our work clarifies several puzzling features of clathrin-depleted DT40 cells and reveals an example of how SDF-1/CXCR4 signalling can abrogate pro-apoptotic pathways and increase cell survival. We propose that the phenomenon described here has implications for the therapeutic approach to a variety of cancers.The work was supported by the following: Department of Biochemistry, University of Cambridge, BBSRC, and Marie Curie Fellowship (FRMW). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.This is the final version of the article. It was first available from PLOS via http://dx.doi.org/10.1371/journal.pone.010627

The role of selection and evolution in changing parturition date in a red deer population.

Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions of phenotypic plasticity versus evolutionary responses-is difficult. To our knowledge, no study has yet reported evidence that evolutionary change underlies the most widely reported phenotypic response to climate change: the advancement of breeding times. In a wild population of red deer, average parturition date has advanced by nearly 2 weeks in 4 decades. Here, we quantify the contribution of plastic, demographic, and genetic components to this change. In particular, we quantify the role of direct phenotypic plasticity in response to increasing temperatures and the role of changes in the population structure. Importantly, we show that adaptive evolution likely played a role in the shift towards earlier parturition dates. The observed rate of evolution was consistent with a response to selection and was less likely to be due to genetic drift. Our study provides a rare example of observed rates of genetic change being consistent with theoretical predictions, although the consistency would not have been detected with a solely phenotypic analysis. It also provides, to our knowledge, the first evidence of both evolution and phenotypic plasticity contributing to advances in phenology in a changing climate

Lessons learnt from a discontinued randomised controlled trial:Adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC)

Background Adalimumab, a biological treatment targeting tumour necrosis factor α, might be useful in sciatica. This paper describes the challenges faced when developing a new treatment pathway for a randomised controlled trial of adalimumab for people with sciatica, as well as the reasons why the trial discussed was stopped early. Methods A pragmatic, parallel group, randomised controlled trial with blinded (masked) participants, clinicians, outcome assessment and statistical analysis was conducted in six UK sites. Participants were identified and recruited from general practices, musculoskeletal services and outpatient physiotherapy clinics. They were adults with persistent symptoms of sciatica of 1 to 6 months’ duration with moderate to high level of disability. Eligibility was assessed by research physiotherapists according to clinical criteria, and participants were randomised to receive two doses of adalimumab (80 mg then 40 mg 2 weeks later) or saline placebo subcutaneous injections in the posterior lateral thigh. Both groups were referred for a course of physiotherapy. Outcomes were measured at baseline, 6-week, 6-month and 12-month follow-up. The main outcome measure was disability measured using the Oswestry Disability Index. The planned sample size was 332, with the first 50 in an internal pilot phase. Results The internal pilot phase was discontinued after 10 months from opening owing to low recruitment (two of the six sites active, eight participants recruited). There were several challenges: contractual delays; one site did not complete contract negotiations, and two sites signed contracts shortly before trial closure; site withdrawal owing to patient safety concerns; difficulties obtaining excess treatment costs; and in the two sites that did recruit, recruitment was slower than planned because of operational issues and low uptake by potential participants. Conclusions Improved patient care requires robust clinical research within contexts in which treatments can realistically be provided. Step changes in treatment, such as the introduction of biologic treatments for severe sciatica, raise complex issues that can delay trial initiation and retard recruitment. Additional preparatory work might be required before testing novel treatments. A randomised controlled trial of tumour necrosis factor-α blockade is still needed to determine its cost-effectiveness in severe sciatica

Twin Imperial Disasters. The invasions of Khiva and Afghanistan in the Russian and British official mind, 1839–1842

This paper examines two linked cases of abortive Imperial expansion. The British invasion of Afghanistan and the Russian winter expedition to Khiva both took place in 1839, and both ended in disaster. These events were linked, not merely by coincidence, but by mutual reactions to intelligence received in Orenburg, St Petersburg, Calcutta, London, and Tehran. British and Russian officials shared similar fears about each other's ambitions in Central Asia, similar patterns of prejudice, arrogance and ignorance, and a similar sense of entitlement as the self-conscious agents of two ‘Great Powers’. By examining the decision-making process which preceded these twin cases of expansion, and the British and Russian attitudes to Central Asian rulers and informants, the paper provides not only a deeper understanding of what provoked these particular disasters, but also of the wider process of European imperial expansion in the early nineteenth century

PRIMUS: Enhanced Specific Star Formation Rates In Close Galaxy Pairs

Tidal interactions between galaxies can trigger star formation, which contributes to the global star formation rate density of the universe and could be a factor in the transformation of blue, star-forming galaxies to red, quiescent galaxies over cosmic time. We investigate tidally-triggered star formation in isolated close galaxy pairs drawn from the Prism Multi-Object Survey (PRIMUS), a low-dispersion prism redshift survey that has measured ~120,000 robust galaxy redshifts over 9.1 deg^2 out to z ~ 1. We select a sample of galaxies in isolated galaxy pairs at redshifts 0.25 < z < 0.75, with no other objects within a projected separation of 300 h^-1 kpc and dz/(1+z) = 0.01, and compare them to a control sample of isolated galaxies to test for systematic differences in their rest-frame FUV-r and NUV-r colors as a proxy for relative specific SFR. We find that galaxies in r_p < 50 h^-1 kpc pairs have bluer dust-corrected UV-r colors on average than the control galaxies by -0.134 +/- 0.045 magnitudes in FUV-r and -0.075 +/- 0.038 magnitudes in NUV-r, corresponding to a ~15-20% increase in SSFR. This indicates an enhancement in SSFR due to tidal interactions. We also find that this relative enhancement is greater for a subset of r_p < 30 h^-1 kpc pair galaxies, for which the average colors offsets are -0.193 +/- 0.065 magnitudes in FUV-r and -0.159 +/- 0.048 magnitudes in NUV-r, corresponding to a ~25-30% increase in SSFR. We test for evolution in the enhancement of tidally-triggered star formation with redshift across our sample redshift range and find marginal evidence for a decrease in SSFR enhancement from 0.25 < z < 0.5 to 0.5 < z < 0.75. This indicates that a change in enhanced star formation triggered by tidal interactions in low density environments is not a contributor to the decline in the global star formation rate density across this redshift range.Comment: Accepted for publication in ApJ, emulateapj format, 12 pages, 9 figures, 2 table