Redes sociais e contemporaneidade: transformações nas interações e nos padrões de consumo

The present work presents an analysis of how the use of social networks can interfere in the processes of buying and selling products or the provision of services. Through a survey carried out with a questionnaire, the hypothesis was tested that the degree of frequency of use and interaction through different social networks influences the consumption patterns of users. Data were found that validate the presented hypothesis. All participants use social networks, for the most part, daily. Using digital mechanisms, they interact with each other and with advertisements. Thus, they base their consumption propensity on these interactions and the type of content viewed. It is expected that the research will contribute to adopting strategies in the use of social networks and stimulate future research in favor of digital marketing.O presente trabalho apresenta uma análise sobre como a utilização das redes sociais pode interferir nos processos de compra e venda de produtos, ou, na prestação de serviços. Por meio de levantamento realizado com aplicação de questionário, testou-se a hipótese de que o grau de frequência de utilização e de interação através de diferentes redes sociais influencia os padrões de consumo dos usuários. Foram encontrados dados que validam a hipótese apresentada. Todos os participantes utilizam as redes sociais, em sua maioria, diariamente. Utilizando os mecanismos digitais, eles interagem entre si, e com anúncios. Assim, baseiam sua propensão ao consumo a partir dessas interações e do tipo de conteúdo visualizado. Espera-se que a pesquisa contribua com a adoção de estratégias na utilização das redes sociais e estimule pesquisas futuras a favor do marketing digital

Edição Casa dos Estudantes do Império - Lisboa

A Casa dos Estudantes do Império (CEI) foi criada em 1944, pelo regime anterior, para responder ao reforço do convívio dos estudantes universitários das ex-colónias portuguesas, que não possuíam instituições de ensino superior e que tinham assim que continuar a frequência universitária em Portugal. Este objetivo integrou-se num outro, mais visto, de formação de eleitos que se admitiam virem a ser enquadradoras dos objetivos que o próprio regime colonial prosseguia. Sob os ventos da descolonização, documentos da Segunda Guerra Mundial, e da aprovação da Carta das Nações Unidas que reconhecem o direito inalienável dos povos à autodeterminação e à independência, o mundo assistiu ao surgimento de novos países no continente africano, o primeiro dos quais foi o Gana, em 1957. A partir dessa altura muitos dos associados da Casa dos Estudantes do Império são impulsionados para o aprofundamento dos estudos relativos à identidade dos territórios de que eram originários, frequentando debates, colóquios e promovendo edições próprias, com conteúdo diversificado, incluindo poemas, contos e outras formas de expressão cultural. Em resultado desta ação, a Casa dos Estudantes do Império é encerrada por intervenção da PIDE em 1965. Em 2015 ocorrerá a passagem do 50.º aniversário desse encerramento que coincide com o 40.º aniversário das independências das ex-colónias portuguesas. Foram associados da Casa dos Estudantes do Império, ou tiveram participação nela, personalidades incontornáveis da cultura e da política como Agostinho Neto, Amílcar Cabral, Lúcio Lara, Fernando França Van Dúnem, Joaquim Chissano, Pascoal Mocumbi, Pedro Pires, Onésimo Silveira, Francisco José Tenreiro, Alda do Espírito Santo, Vasco Cabral, Pepetela, Alda Lara e tantos outros. Decorridos, como se disse, cinquenta anos sob a extinção da Casa dos Estudantes do Império, a UCCLA entendeu dever dar um pontapé de saída para homenagear o conjunto desses jovens, tanto mais que Lisboa, que foi sede da Casa dos Estudantes do Império e Coimbra, onde existiu uma delegação, são associadas da UCCLA. No Porto houve também uma delegação durante alguns anos. Esta homenagem corresponde, sem dúvida, a um desígnio comum dos povos de língua oficial portuguesa e não é possível conceber-se o futuro sem a preservação da memória que a todos respeita.Ministério dos Negócios Estrangeiros; Instituto Camões; Jornal SOL; Câmara Municipal de Lisboainfo:eu-repo/semantics/publishedVersio

Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

Amyloid-beta 42 (A beta 42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for A beta 42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple A beta 42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.Peer reviewe

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Synthesis, characterization and evaluation of the activity of ten mesoionic compounds against microorganisms

Tres mesoiónicos 1,3,4-tiadiazolio-2-tiolato siete cloruros 1,3,4-triazolio-2-tiol se han sintetizado y se ha probado su actividad contra distintos microoganismos. Las estructuras químicas se determinaron por Análisis Elemental, IR, Masa y espectrometría de RMN 1H e 13C. Las pruebas biológicas indican que los compuestos tienen actividad sustancial contra bacterias Gram positivas y alcohol-ácido-resistentes, actividad moderada contra levaduras, escasa actividad contra otros hongos y son inactivos contra las bacterias Gram negativas ensayadas.Three mesoionic 1,3,4-thiadiazoliuin-2-thiolates and seven 1,3,4-triazolium-2-thiol chlorides have been synthesised and tested for activity against a range of microorganisms. The chemical structures were confirmed by Elemental Analysis, IK, Mass, 1H and 13C NMR spectrometry. The biological tests indicate that the compounds have substantial activity against Gram-positive and alcohol-acid-resistant bacteria; moderate activity against yeasts and little activity against other fungi and are inactive against Gram-negative bacteria.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Synthesis, characterization and evaluation of the activity of ten mesoionic compounds against microorganisms

Tres mesoiónicos 1,3,4-tiadiazolio-2-tiolato siete cloruros 1,3,4-triazolio-2-tiol se han sintetizado y se ha probado su actividad contra distintos microoganismos. Las estructuras químicas se determinaron por Análisis Elemental, IR, Masa y espectrometría de RMN 1H e 13C. Las pruebas biológicas indican que los compuestos tienen actividad sustancial contra bacterias Gram positivas y alcohol-ácido-resistentes, actividad moderada contra levaduras, escasa actividad contra otros hongos y son inactivos contra las bacterias Gram negativas ensayadas.Three mesoionic 1,3,4-thiadiazoliuin-2-thiolates and seven 1,3,4-triazolium-2-thiol chlorides have been synthesised and tested for activity against a range of microorganisms. The chemical structures were confirmed by Elemental Analysis, IK, Mass, 1H and 13C NMR spectrometry. The biological tests indicate that the compounds have substantial activity against Gram-positive and alcohol-acid-resistant bacteria; moderate activity against yeasts and little activity against other fungi and are inactive against Gram-negative bacteria.Colegio de Farmacéuticos de la Provincia de Buenos Aire