Effect of rearing system and genotype on performance, carcass characteristics and meat quality of slow growing rabbits

Introduction - The conservation of local rabbit breeds, characterized by slow growth, is very important for organic farming, because in most cases production regulations prohibit the use of commercial hybrids. Aim - The aim of this study was to investigate the effect of two different housing systems on the productive performance, carcass characteristics and meat quality of the local grey coloured rabbit population of Tuscany (middle-west Italy) compared to commercial hybrids. Material and methods - 88 rabbits of local populations were housed in colony cages, in open air (GO) organic rearing system; 84 rabbits of the same autochthonous populations (GI) and 80 hybrids (HI) were housed in colony cages in conventional rearing system. An organic diet, composed by pelleted feed and alfalfa hay, was given ad libitum. Thirty animals of each group were slaughtered at 103 days (autochthonous) and 90 days of age (hybrids), and carcass and meat quality parameters were assessed. Results and discussion - The HI group showed the lowest live weight at slaughtering age, the poorest productive performance and the highest mortality. GI group showed the highest live weight and more favorable feed conversion ratio compared with GO group. GO and GI groups showed higher hot carcass and dressing out percentage and lower incidence of full gastrointestinal tract percentage than group HI. Hind leg meat-to-bone ratio was significantly higher in HI group than in GO and GI groups (4.7% vs. 4.0% and 3.8%, respectively; P<0.05). The lowest muscular acidification was found in group GO (pHu=5.79 vs. 5.59 and 5.63, for group GO, GI and HI, respectively; P<0.05). The muscles of GO group showed lower lightness (L*) than the other groups (GO = 54.4 vs. GI = 59.1 vs. HI = 63.4; P<0.05). The GO and GI groups showed higher redness and yellowness than HI group. Chemical composition and lipid oxidation did not show differences due to genotype or housing system. As far as fatty acid content concerns, differences were found only for miristic and vaccenic acid between GO and HI groups. Conclusions - The local rabbits yielded more coloured meat, which could add value for potential consumers, independently of the rearing system used in the study

J-PLUS:Photometric calibration of large area multi-filter surveys with stellar and white dwarf loci

We present the photometric calibration of the twelve optical passbands observed by the Javalambre Photometric Local Universe Survey (J-PLUS). The proposed calibration method has four steps: (i) definition of a high-quality set of calibration stars using Gaia information and available 3D dust maps; (ii) anchoring of the J-PLUS gri passbands to the Pan-STARRS photometric solution, accounting for the variation of the calibration with the position of the sources on the CCD; (iii) homogenization of the photometry in the other nine J-PLUS filters using the dust de-reddened instrumental stellar locus in (X - r) versus (g - i) colours, where X is the filter to calibrate. The zero point variation along the CCD in these filters was estimated with the distance to the stellar locus. Finally, (iv) the absolute colour calibration was obtained with the white dwarf locus. We performed a joint Bayesian modelling of eleven J-PLUS colour-colour diagrams using the theoretical white dwarf locus as reference. This provides the needed offsets to transform instrumental magnitudes to calibrated magnitudes outside the atmosphere. The uncertainty of the J-PLUS photometric calibration, estimated from duplicated objects observed in adjacent pointings and accounting for the absolute colour and flux calibration errors, are ~19 mmag in u, J0378 and J0395, ~11 mmag in J0410 and J0430, and ~8 mmag in g, J0515, r, J0660, i, J0861, and z. We present an optimized calibration method for the large area multi-filter J-PLUS project, reaching 1-2% accuracy within an area of 1 022 square degrees without the need for long observing calibration campaigns or constant atmospheric monitoring. The proposed method will be adapted for the photometric calibration of J-PAS, that will observe several thousand square degrees with 56 narrow optical filters

J-PLUS: Discovery and characterisation of ultracool dwarfs using Virtual Observatory tools

Ultracool dwarfs (UCDs) are objects with spectral types equal or later than M7. Most of them have been discovered using wide-field imaging surveys. The Virtual Observatory (VO) has proven to be of great utility to efficiently exploit these astronomical resources. We aim to validate a VO methodology designed to discover and characterize UCDs in the J-PLUS photometric survey. J-PLUS is a multiband survey carried out with the wide angle T80Cam optical camera mounted on the 0.83-m telescope JAST/T80 in the Observatorio Astrof\'isico de Javalambre. In this work we make use of the Internal Data Release (IDR) covering 528 deg$^2$. We complement J-PLUS photometry with other catalogues in the optical and IR using VOSA, a VO tool that estimates physical parameters from the spectral energy distribution fitting to collections of theoretical models. Objects identified as UCDs are distinguished from background M giants and highly reddened stars using parallaxes and proper motions from Gaia DR2. We identify 559 UCDs, ranging from i=16.2 to 22.4 mag, of which 187 are candidate UCDs not previously reported in the literature. This represents an increase in the number of known UCDs of about 50% in the studied region of the sky, particularly at the faint end of our sensitivity, which is interesting as reference for future wide and deep surveys such as Euclid. Three candidates constitute interesting targets for exoplanet surveys because of their proximity

J-PLUS: The javalambre photometric local universe survey

ABSTRACT: TheJavalambrePhotometric Local UniverseSurvey (J-PLUS )isanongoing 12-band photometricopticalsurvey, observingthousands of squaredegrees of theNorthernHemispherefromthededicated JAST/T80 telescope at the Observatorio Astrofísico de Javalambre (OAJ). The T80Cam is a camera with a field of view of 2 deg2 mountedon a telescopewith a diameter of 83 cm, and isequippedwith a uniquesystem of filtersspanningtheentireopticalrange (3500–10 000 Å). Thisfiltersystemis a combination of broad-, medium-, and narrow-band filters, optimallydesigned to extracttherest-framespectralfeatures (the 3700–4000 Å Balmer break region, Hδ, Ca H+K, the G band, and the Mg b and Ca triplets) that are key to characterizingstellartypes and delivering a low-resolutionphotospectrumforeach pixel of theobservedsky. With a typicaldepth of AB ∼21.25 mag per band, thisfilter set thusallowsforanunbiased and accuratecharacterization of thestellarpopulation in our Galaxy, itprovidesanunprecedented 2D photospectralinformationforall resolved galaxies in the local Universe, as well as accuratephoto-z estimates (at the δ z/(1 + z)∼0.005–0.03 precisionlevel) formoderatelybright (up to r ∼ 20 mag) extragalacticsources. Whilesomenarrow-band filters are designedforthestudy of particular emissionfeatures ([O II]/λ3727, Hα/λ6563) up to z < 0.017, theyalsoprovidewell-definedwindowsfortheanalysis of otheremissionlines at higherredshifts. As a result, J-PLUS has thepotential to contribute to a widerange of fields in Astrophysics, both in thenearbyUniverse (MilkyWaystructure, globular clusters, 2D IFU-likestudies, stellarpopulations of nearby and moderate-redshiftgalaxies, clusters of galaxies) and at highredshifts (emission-line galaxies at z ≈ 0.77, 2.2, and 4.4, quasi-stellarobjects, etc.). Withthispaper, wereleasethefirst∼1000 deg2 of J-PLUS data, containingabout 4.3 millionstars and 3.0 milliongalaxies at r <  21mag. With a goal of 8500 deg2 forthe total J-PLUS footprint, thesenumbers are expected to rise to about 35 millionstars and 24 milliongalaxiesbytheend of thesurvey.Funding for the J-PLUS Project has been provided by the Governments of Spain and Aragón through the Fondo de Inversiones de Teruel, the Spanish Ministry of Economy and Competitiveness (MINECO; under grants AYA2017-86274-P, AYA2016-77846-P, AYA2016-77237-C3-1-P, AYA2015-66211-C2-1-P, AYA2015-66211-C2-2, AYA2012-30789, AGAUR grant SGR-661/2017, and ICTS-2009-14), and European FEDER funding (FCDD10-4E-867, FCDD13-4E-2685

Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade

Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A1 receptors (A1Rs) and the less abundant, but widespread, facilitatory A2ARs. It is commonly assumed that A1Rs play a key role in neuroprotection since they decrease glutamate release and hyperpolarize neurons. In fact, A1R activation at the onset of neuronal injury attenuates brain damage, whereas its blockade exacerbates damage in adult animals. However, there is a down-regulation of central A1Rs in chronic noxious situations. In contrast, A2ARs are up-regulated in noxious brain conditions and their blockade confers robust brain neuroprotection in adult animals. The brain neuroprotective effect of A2AR antagonists is maintained in chronic noxious brain conditions without observable peripheral effects, thus justifying the interest of A2AR antagonists as novel protective agents in neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, ischemic brain damage and epilepsy. The greater interest of A2AR blockade compared to A1R activation does not mean that A1R activation is irrelevant for a neuroprotective strategy. In fact, it is proposed that coupling A2AR antagonists with strategies aimed at bursting the levels of extracellular adenosine (by inhibiting adenosine kinase) to activate A1Rs might constitute the more robust brain neuroprotective strategy based on the adenosine neuromodulatory system. This strategy should be useful in adult animals and especially in the elderly (where brain pathologies are prevalent) but is not valid for fetus or newborns where the impact of adenosine receptors on brain damage is different

Seguimiento de las guías españolas para el manejo del asma por el médico de atención primaria: un estudio observacional ambispectivo

Objetivo Evaluar el grado de seguimiento de las recomendaciones de las versiones de la Guía española para el manejo del asma (GEMA 2009 y 2015) y su repercusión en el control de la enfermedad. Material y métodos Estudio observacional y ambispectivo realizado entre septiembre del 2015 y abril del 2016, en el que participaron 314 médicos de atención primaria y 2.864 pacientes. Resultados Utilizando datos retrospectivos, 81 de los 314 médicos (25, 8% [IC del 95%, 21, 3 a 30, 9]) comunicaron seguir las recomendaciones de la GEMA 2009. Al inicio del estudio, 88 de los 314 médicos (28, 0% [IC del 95%, 23, 4 a 33, 2]) seguían las recomendaciones de la GEMA 2015. El tener un asma mal controlada (OR 0, 19, IC del 95%, 0, 13 a 0, 28) y presentar un asma persistente grave al inicio del estudio (OR 0, 20, IC del 95%, 0, 12 a 0, 34) se asociaron negativamente con tener un asma bien controlada al final del seguimiento. Por el contrario, el seguimiento de las recomendaciones de la GEMA 2015 se asoció de manera positiva con una mayor posibilidad de que el paciente tuviera un asma bien controlada al final del periodo de seguimiento (OR 1, 70, IC del 95%, 1, 40 a 2, 06). Conclusiones El escaso seguimiento de las guías clínicas para el manejo del asma constituye un problema común entre los médicos de atención primaria. Un seguimiento de estas guías se asocia con un control mejor del asma. Existe la necesidad de actuaciones que puedan mejorar el seguimiento por parte de los médicos de atención primaria de las guías para el manejo del asma. Objective: To assess the degree of compliance with the recommendations of the 2009 and 2015 versions of the Spanish guidelines for managing asthma (Guía Española para el Manejo del Asma [GEMA]) and the effect of this compliance on controlling the disease. Material and methods: We conducted an observational ambispective study between September 2015 and April 2016 in which 314 primary care physicians and 2864 patients participated. Results: Using retrospective data, we found that 81 of the 314 physicians (25.8%; 95% CI 21.3–30.9) stated that they complied with the GEMA2009 recommendations. At the start of the study, 88 of the 314 physicians (28.0%; 95% CI 23.4–33.2) complied with the GEMA2015 recommendations. Poorly controlled asthma (OR, 0.19; 95% CI 0.13–0.28) and persistent severe asthma at the start of the study (OR, 0.20; 95% CI 0.12–0.34) were negatively associated with having well-controlled asthma by the end of the follow-up. In contrast, compliance with the GEMA2015 recommendations was positively associated with a greater likelihood that the patient would have well-controlled asthma by the end of the follow-up (OR, 1.70; 95% CI 1.40–2.06). Conclusions: Low compliance with the clinical guidelines for managing asthma is a common problem among primary care physicians. Compliance with these guidelines is associated with better asthma control. Actions need to be taken to improve primary care physician compliance with the asthma management guidelines

J-PLUS: The Javalambre Photometric Local Universe Survey

The Javalambre Photometric Local Universe Survey (J-PLUS) is an ongoing 12-band photometric optical survey, observing thousands of square degrees of the Northern Hemisphere from the dedicated JAST/T80 telescope at the Observatorio Astrofisico de Javalambre (OAJ). The T80Cam is a camera with a field of view of 2 deg(2) mounted on a telescope with a diameter of 83 cm, and is equipped with a unique system of filters spanning the entire optical range (3500-10 000 angstrom). This filter system is a combination of broad-, medium-, and narrow-band filters, optimally designed to extract the rest-frame spectral features (the 3700-4000 angstrom Balmer break region, H delta, Ca H+K, the G band, and the Mg b and Ca triplets) that are key to characterizing stellar types and delivering a low-resolution photospectrum for each pixel of the observed sky. With a typical depth of AB similar to 21.25 mag per band, this filter set thus allows for an unbiased and accurate characterization of the stellar population in our Galaxy, it provides an unprecedented 2D photospectral information for all resolved galaxies in the local Universe, as well as accurate photo-z estimates (at the delta z/(1 + z) similar to 0.005-0.03 precision level) for moderately bright (up to r similar to 20 mag) extragalactic sources. While some narrow-band filters are designed for the study of particular emission features ([O II]/lambda 3727, H alpha/lambda 6563) up to z < 0.017, they also provide well-defined windows for the analysis of other emission lines at higher redshifts. As a result, J-PLUS has the potential to contribute to a wide range of fields in Astrophysics, both in the nearby Universe (Milky Way structure, globular clusters, 2D IFU-like studies, stellar populations of nearby and moderate-redshift galaxies, clusters of galaxies) and at high redshifts (emission-line galaxies at z approximate to 0.77, 2.2, and 4.4, quasi-stellar objects, etc.). With this paper, we release the first similar to 1000 deg(2) of J-PLUS data, containing about 4.3 million stars and 3.0 million galaxies at r < 21 mag. With a goal of 8500 deg(2) for the total J-PLUS footprint, these numbers are expected to rise to about 35 million stars and 24 million galaxies by the end of the survey

Delayed intracerebral hemorrhage after ventriculoperitoneal shunt insertion: case report and literature review

Presentamos un caso de hemorragia intracerebral tardía tras la colocación de una derivación ventriculoperitoneal. Una paciente de 64 años de edad, con hidrocefalia secundaria a una hemorragia subaracnoidea, sufre una hemorragia intraparenquimatosa occipital derecha con hemorragia intraventricular secundaria seis días después de la intervención quirúrgica. Se trata de una complicación rara de la derivación ventriculoperitoneal, con pocos casos publicados anteriormente. El mecanismo supuesto es la erosión de un vaso sanguíneo secundaria a un íntimo contacto con el catéter proximal de la derivación; trastornos sanguíneos, malformaciones vasculares cerebrales, traumatismo craneal o tumor cerebral fueron excluidos en esta pacient