Electrochemotherapy for the palliative management of cutaneous metastases: A systematic review and meta-analysis.

BACKGROUND: Electrochemotherapy combines electroporation in conjunction with chemotherapeutic agents and is used to treat tumours in many localisations, including cutaneous metastases. The symptoms associated with cutaneous malignant wounds can be distressing for patients and their management is a challenge in healthcare. AIM: The purpose of this systematic review was to investigate the effectiveness of electrochemotherapy in the context of palliative care. DESIGN: All aspects of the systematic review were followed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. DATA SOURCES: The following databases were searched for English-language reviews; Medline, Embase, CINAHL, British Nursing Index and the Cochrane Library. The search was conducted between the publication of Standard Operating Procedures in 2006 and the third week of October 2017. Studies involving oral cancers and studies with fewer than 10 patients were excluded. The selected studies were assessed for risk of bias and sub-group data were synthesised in a random-effects meta-analysis. RESULTS: From 425 studies, 29 studies were included involving 1503 patients, the pooled results were 46.6% for complete response and 82.2% for objective response according to the Response Evaluation Criteria in Solid Tumours. The meta-analysis indicated that small tumours were over twice as likely (2.25) to have a complete response than large. CONCLUSIONS: Electrochemotherapy is an effective, repeatable and minimally invasive intervention within the palliative population that can reduce symptom burden. This review is an update of previous systematic reviews by Mali et al. [1,2] and highlights the need for tailored treatment depending on each individual case

The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitisA and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitisB in perforated diverticulitis (NTR2037)

Background: Recently, excellent results are reported on laparoscopic lavage in patients with purulent perforated diverticulitis as an alternative for sigmoidectomy and ostomy. The objective of this study is to determine whether LaparOscopic LAvage and drainage is a safe and effective treatment for patients with purulent peritonitis (LOLA-arm) and to determine the optimal resectional strategy in patients with a purulent or faecal peritonitis (DIVA-arm: perforated DIVerticulitis: sigmoidresection with or without Anastomosis). Methods/Design: In this multicentre randomised trial all patients with perforated diverticulitis are included. Upon laparoscopy, patients with purulent peritonitis are treated with laparoscopic lavage and drainage, Hartmann's procedure or sigmoidectomy with primary anastomosis in a ratio of 2:1:1 (LOLA-arm). Patients with faecal peritonitis will be randomised 1:1 between Hartmann's procedure and resection with primary anastomosis (DIVA-arm). The primary combined endpoint of the LOLA-arm is major morbidity and mortality. A sample size of 132:66:66 patients will be able to detect a difference in the primary endpoint from 25% in resectional groups compared to 10% in the laparoscopic lavage group (two sided alpha = 5%, power = 90%). Endpoint of the DIVA-arm is stoma free survival one year after initial surgery. In this arm 212 patients are needed to significantly demonstrate a difference of 30% (log rank test two sided alpha = 5% and powe

Table 2: Age information for the analyzed cores

Five plankton groups, including diatoms, radiolarians, coccolithophores, foraminifers, and dinoflagellate cysts, were synoptically analyzed in six sediment cores and two sediment traps from the Norwegian-Greenland Sea and the North Atlantic in order to provide more detailed insights into the paleoclimatic and paleoceanographic evolution and the development of plankton assemblages of the northern North Atlantic during the last 15,000 years. Based on Q-mode factor analyses, cold, warm, transitional, and relict assemblages were calculated for each of the plankton groups. Data from the different plankton groups complement one another, although they are not always consistent. However, the multiple plankton-group data set is able to bridge intervals in which single groups lack preservation or the ability to react to changes. Synoptically interpreted, the results provide a detailed picture of the response of plankton assemblages to environmental changes during the time period investigated, which includes the B0lling/Aller0d interstadial, the Younger Dryas cold spell, Termination IB, and, in all likelihood, also the "8,200 Event", and the Hypsithermal (approximately 8-4 14C ky BP)

Proischozhdenie grubozernistykh (>1 cm) oblomkov iz raiona khrebta Mendeleeva (Severnyi ledovityi okean) (engl.: Origin of the coarse-grained (> 1 cm) clasts from the Mendeleev Ridge area (Central Arctic Ocean)

The morphometric and petrographic characteristics of the coarse-grained clasts (> 1 cm) sampled from the sediments of the Amerasian Basin, Central Arctic Ocean, were studied. Most of the clasts are represented by dolomites (46,4%), sandstones (22,8%) and limestones (19,8%); the amount of other rocks fragments (chert, shale, igneous) is about 10%. A variety of lithological types were identified among the studied rock fragments. Limestones and dolomitic limestones often contain fragments of fauna. The majority of clasts is poorly rounded and characterized by a wide variety of shapes. More than half of the studied clasts have a size of 1-2 cm, a quarter - 2-3 cm, and larger clasts only occur in insignificant amounts. Geophysical surveys across the sampling sites showed a lack of bedrock outcrops, so the studied coarse-grained clasts are not of local origin. It is concluded that they were predominantly delivered from the Canadian Arctic Archipelago (likely from the platform area, e.g., Victoria Island), mainly due to iceberg rafting during deglaciation periods. The maximum possible contribution of the clasts from the Siberian sources is less than 23%. Distribution of the coarse-grained clasts argues for the existence of a quite stable ice drift path in the past, which is similar to the modern Beaufort Gyre

Quantum Emitters in Aluminum Nitride Induced by Zirconium Ion Implantation

The integration of solid-state single-photon sources with foundry-compatible photonic platforms is crucial for practical and scalable quantum photonic applications. This study investigates aluminum nitride (AlN) as a material with properties highly suitable for integrated on-chip photonics specifically due to AlN capacity to host defect-center related single-photon emitters. We conduct a comprehensive study of the creation and photophysical properties of single-photon emitters in AlN utilizing Zirconium (Zr) and Krypton (Kr) heavy ion implantation and thermal annealing techniques. Guided by theoretical predictions, we assess the potential of Zr ions to create optically addressable spin-defects and employ Kr ions as an alternative approach that targets lattice defects without inducing chemical doping effects. With the 532 nm excitation wavelength, we found that single-photon emitters induced by ion implantation are primarily associated with vacancy-type defects in the AlN lattice for both Zr and Kr ions. The emitter density increases with the ion fluence, and there is an optimal value for the high density of emitters with low AlN background fluorescence. Additionally, under shorter excitation wavelength of 405 nm, Zr-implanted AlN exhibits isolated point-like emitters, which can be related to Zr-based defect complexes. This study provides important insights into the formation and properties of single-photon emitters in aluminum nitride induced by heavy ion implantation, contributing to the advancement of the aluminum nitride platform for on-chip quantum photonic applications