1,417 research outputs found
Getting to the Point? Rethinking Arrows on Maps
Introduction. Maps help to form public opinion and build public morale. When the war is over, they will contribute to shaping the
thought and action of those responsible for the reconstruction of a shattered world. Hence it is important in these times
that the nature of the information they set forth should be well understood (Wright, 1942: 527)
Improving user access to Soviet military mapping: current issues in libraries and collections around the globe
Total Synthesis of the Bovine Pancreatic Trypsin Inhibitor (BPTI) and the Protein Diastereomer [Gly37D-Ala]BPTI using Boc Chemistry Solid Phase Peptide Synthesis
Bovine pancreatic trypsin inhibitor (BPTI) is a wellâstudied model for investigation of protein folding and stability. Here, we report the synthesis and characterization of wildâtype BPTI and a diastereomeric protein analogue [Gly37DâAla]BPTI. Each 58âresidue polypeptide chain was made by native chemical ligation of two peptide segments, BPTI[1â29]âαthioester and the appropriate version of the Cys30â58 BPTI peptide segment. Boc chemistry in situ neutralization solid phase synthesis was used to prepare the peptide segment reactants. The resulting fullâlength polypeptide chains were folded in a cysteine/cystine redox buffer to give synthetic protein molecules containing three disulfide bonds. The diastereomeric analogue [Gly37DâAla]BPTI folded as efficiently as the native protein. Synthetic proteins were characterized by analytical LCMS and by naturalâabundance 1Hâ15N HSQC NMR fingerprinting. These results illustrate the power of Boc chemistry peptide synthesis and its utility for the total chemical synthesis of protein molecules
Exile Vol. XXXVI No. 1
untitled by Nichola Gracille (Cover)
Words by Kent Lambert 1
Talk by Richard Latimer 2
Storm Passing by Ben Kell 3
untitled by Ed Stanley 4
I Again Awake by Sharnon Salser 5-6
Demigods and Demons by Kent Lambert 7
untitled by Tim Loving 8
Apology by Kelly Bondurant 9-10
Guest Speaker by Ann Mierson 11
untitled by Nicalas Gracilla 12
Watching for Minnows by Kent Lambert 13
Thunderbird by Kelly Bondurant 14-16
Glendalough (St. Kevin) by Ben Kell 17-18
Untitled by Craig Bagno 19
Flying Machines In Pieces On The Ground by Kelly Bondurant 20
Tuesday, December 13, 1988 Bill & Walt\u27s Toy Shoppe by Alexander Speyer 21
Weathered Wood by Kelly Bondurant 22
Above Grey Water by Susanna Duff 23-25
untitled by Ed Stanley 26
Contributor\u27s Notes 27
Editorial decision is shared equally among the Editorial Board -
The structure of the nuclear stellar cluster of the Milky Way
We present high-resolution seeing limited and AO NIR imaging observations of
the stellar cluster within about one parsec of Sgr A*, the massive black hole
at the centre of the Milky Way. Stellar number counts and the diffuse
background light density were extracted from these observations in order to
examine the structure of the nuclear stellar cluster.Our findings are as
follows: (a) A broken-power law provides an excellent fit to the overall
structure of the GC nuclear cluster. The power-law slope of the cusp is
, the break radius is or
pc, and the cluster density decreases with a power-law index of
outside of . (b) Using the best velocity
dispersion measurements from the literature, we derive higher mass estimates
for the central parsec than assumed until now. The inferred density of the
cluster at the break radius is . This high density agrees well with the small extent and flat slope
of the cusp. Possibly, the mass of the stars makes up only about 50% of the
total cluster mass. (c) Possible indications of mass segregation in the cusp
are found (d) The cluster appears not entirely homogeneous. Several density
clumps are detected that are concentrated at projected distances of and
from Sgr A*.(e) There appears to exist an under-density of horizontal
branch/red clump stars near , or an over-density of stars of similar
brightness at and . (f) The extinction map in combination with
cometary-like features in an L'-band image may provide support for the
assumption of an outflow from Sgr A*.Comment: accepted for publication by A&A; please contact first author for
higher quality figure
High-Rate Intercalation without Nanostructuring in Metastable Nb2O5 Bronze Phases.
Nanostructuring and nanosizing have been widely employed to increase the rate capability in a variety of energy storage materials. While nanoprocessing is required for many materials, we show here that both the capacity and rate performance of low-temperature bronze-phase TT- and T-polymorphs of Nb2O5 are inherent properties of the bulk crystal structure. Their unique "room-and-pillar" NbO6/NbO7 framework structure provides a stable host for lithium intercalation; bond valence sum mapping exposes the degenerate diffusion pathways in the sites (rooms) surrounding the oxygen pillars of this complex structure. Electrochemical analysis of thick films of micrometer-sized, insulating niobia particles indicates that the capacity of the T-phase, measured over a fixed potential window, is limited only by the Ohmic drop up to at least 60C (12.1 A·g(-1)), while the higher temperature (Wadsley-Roth, crystallographic shear structure) H-phase shows high intercalation capacity (>200 mA·h·g(-1)) but only at moderate rates. High-resolution (6/7)Li solid-state nuclear magnetic resonance (NMR) spectroscopy of T-Nb2O5 revealed two distinct spin reservoirs, a small initial rigid population and a majority-component mobile distribution of lithium. Variable-temperature NMR showed lithium dynamics for the majority lithium characterized by very low activation energies of 58(2)-98(1) meV. The fast rate, high density, good gravimetric capacity, excellent capacity retention, and safety features of bulk, insulating Nb2O5 synthesized in a single step at relatively low temperatures suggest that this material not only is structurally and electronically exceptional but merits consideration for a range of further applications. In addition, the realization of high rate performance without nanostructuring in a complex insulating oxide expands the field for battery material exploration beyond conventional strategies and structural motifs.K.J.G. gratefully acknowledges funding from The Winston Churchill Foundation of the United States and the Herchel Smith Scholarship. A.C.F. and J.M.G thank the EPSRC, via the Supergen consortium, for funding. A.C.F. is also thankful to the Sims Scholarship for support.This is the final version of the article. It first appeared in the American Chemical Society via http://dx.doi.org/10.1021/jacs.6b0434
Morphologies of AGN host galaxies using HST/ACS in the CDFS-GOODS field
Using HST/ACS images in four bands F435W, F606W, F775W and F850LP, we
identify optical counterparts to the X-ray sources in the Chandra Deep Field
South in the GOODS South field. A detailed study has been made of these sources
to study their morphological types. We use methods like decomposition of galaxy
luminosity profiles, color maps and visual inspection of 192 galaxies which are
identified as possible optical counterparts of Chandra X-ray sources in the
CDFS-GOODS field. We find that most moderate luminosity AGN hosts are bulge
dominated in the redshift range (z \approx 0.4-1.3), but not
merging/interacting galaxies. This implies probable fueling of the moderate
luminosity AGN by mechanisms other than those merger driven.Comment: pdflatex, accepted in ApSS. revisions in tex
Recommended from our members
Increasing intensities of Anisakis simplex third-stage larvae (L3) in Atlantic salmon of coastal waters of Scotland
Background: Red Vent Syndrome (RVS), a haemorrhagic inflammation of the vent region in Atlantic salmon, is associated with high abundance of Anisakis simplex (s.s.) third-stage larvae (L3) in the vent region. Despite evidence suggesting that increasing A. simplex (s.s.) intensity is a causative factor in RVS aetiology, the definitive cause remains unclear.Methods: A total of 117 Atlantic salmon were sampled from commercial fisheries on the East, West, and North coasts of Scotland and examined for ascaridoid parasites. Genetic identification of a subsample of Anisakis larvae was per-formed using the internal transcribed spacer (ITS) region of ribosomal DNA. To assess the extent of differentiation of feeding grounds and dietary composition, stable isotope analysis of carbon and nitrogen was carried out on Atlantic salmon muscle tissue.Results: In the present study, the obtained ITS rDNA sequences matched A. simplex (s.s.) sequences deposited in GenBank at 99â100%. Not all isolated larvae (n=30,406) were genetically identified. Therefore, the morphotype found in this study is referred to as A. simplex (sensu lato). Anisakis simplex (s.l.) was the most prevalent (100%) nematode with the highest mean intensity (259.9 ±197.3), in comparison to Hysterothylacium aduncum (66.7%, 6.4 ± 10.2) and Pseudoterranova decipiens (s.l.) (14.5%, 1.4 ±0.6). The mean intensity of A. simplex (s.l.) represents a four-fold increase compared to published data (63.6 ±31.9) from salmon captured in Scotland in 2009. Significant positive correlations between A. simplex (s.l.) larvae intensities from the body and the vent suggest that they play a role in the emergence of RVS. The lack of a significant variation in stable isotope ratios of Atlantic salmon indicates that diet or feeding ground are not driving regional differences in A. simplex (s.l.) intensities.Conclusions: This paper presents the most recent survey for ascaridoid parasites of wild Atlantic salmon from three coastal regions in Scotland. A significant rise in A. simplex (s.l.) intensity could potentially increase both natural mortal-ity rates of Atlantic salmon and possible risks for salmon consumers due to the known zoonotic role of A. simplex (s.s.) and A. pegreffii within the A. simplex (s.l.) species complex
- âŠ